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Search Results: 1 - 10 of 78322 matches for " Yingming Chen "
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Necrosis: An Energy-Dependent Programmed Cell Death?
Yingming Chen
University of Toronto Medical Journal , 2009, DOI: 10.5015/utmj.v86i3.383
Abstract:
Vision Screening in the Elderly: Current Literature and Recommendations
Yingming Amy Chen,Mary Thomas
University of Toronto Medical Journal , 2010, DOI: 10.5015/utmj.v87i3.1237
Abstract: Vision impairment is one of the leading causes of morbidity in the elderly population. Major causes of vision loss include presbyopia, cataract, age-related macular degeneration, glaucoma, and diabetic retinopathy. A vision screening program has the potential to identify millions of adults at risk for vision loss and vision-related co-morbidities. Previous guidelines in the 1990s recommended routine visual acuity screening by primary care physicians. However, subsequently published data have demonstrated a lack of effectiveness in quality-of-life outcomes with current screening strategies, likely due to the low sensitivity of the screening tests. Until further studies establish the accuracy of any vision test in predicting visual function, routine vision screening in the elderly in the primary care setting is not warranted. The introduction of other vision tests into the screening protocol, including low contrast VA assessment, stereoptic testing, and visual field testing, warrants further investigation and cost-benefit evaluation.
Stage II/III Rectal Cancer Patients Benefit from Extremely Early Initiation of Postoperative Adjuvant Chemotherapy: A Retrospective Study  [PDF]
Liuniu Xiao, Li Zhu, Yingming Chen, Zhenlin Hou, Lingwei Jia, Junbo Hu, Yongdong Feng
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.101004
Abstract: Background: For Stage II/III rectal cancer patients, curative resection is the primary treatment, prescribing of postoperative adjuvant chemotherapy (PAC) is regarded as a standard therapy. The interval between surgery and the initiation of PAC is usually within 8 weeks. However, the optimal cut-off is still controversial. This study aimed to explore the impact of extremely early initiation of PAC for II/III rectal cancer. Methods: Patients with Stage II/III rectal cancer treated from January 2013 to December 2015 were retrospectively collected at the Department of Tongji Hospital. According to the starting point of PAC, patients were categorized into two groups: extremely early group (The interval of PAC ≤ 2 weeks) and normal group (The interval of PAC within 3 - 5 weeks). For the sake of evaluating the effectiveness of different intervals, Overall Survival rate (OS), Progress-Free Survival rate (PFS) and Recurrence or Metastasis Rate (RMR) were analyzed, as well as the Quality of Life Score. To estimate the safety of the extremely early PAC, we evaluated the first post chemotherapy adverse reactions and defecation ability, and analyzed the variance laboratory indexes around the first postoperative adjuvant chemotherapy. Results: A total of 267 patients were included in this study. Compared to normal group (192 cases), extremely early group (75 cases) of patients attained a better tendency of OS and PFS, although there were no significant statistical differences (OS: P = 0.0930; PFS: P = 0.1058). However, the RMR was significant lower (P = 0.0452) and the Quality of Life Score was significantly higher (P = 0.0090) in extremely early group. Multivariate analysis also showed that extremely early group had better defecation ability (P = 0.0149) and less side reactions of post
Ecological Conservation and Construction in China: Progress and Situation  [PDF]
Yingming Li, Haibo Qin
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.51006
Abstract:

Since late 1990s, China has made smooth progress in ecological conservation and construction. Now, the following characteristics of ecological protection are presented: 1) China is still facing severe challenges in ecological conservation and construction; 2) The advanced areas with extensive growth model and the underdeveloped areas that are ecologically sensitive co-exist in China; and 3) As a country in transition, China needs to explore national pathway for ecological protection, while facing the trends of being institutionalized, integrated and necessitated for the global ecological protection efforts. The key of ecological protection in China is to seek an optimal model and an effective pathway which can balance economic growth and environmental protection, to recognize the difference and non-replicability of ecosystems, and to effectively combine the institutional development and engineering construction of ecological protection.

Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
Mingxiong Tan,Jinchan Zhu,Yingming Pan,Zhenfeng Chen,Hong Liang,Huagang Liu,Hengshan Wang
Bioinorganic Chemistry and Applications , 2009, DOI: 10.1155/2009/347872
Abstract: Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL2(H2O)2]?nH2O (1–3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while complex 3 is 46% and 36%, respectively. The interactions of complex 1 and its ligand Hsp with calf thymus DNA were investigated by UV-Vis, fluorescence, and CD spectra. Both complex 1 and Hsp were found to bind DNA in intercalation modes, and the binding affinity of complex 1 was stronger than that of free ligand.
Dorsal Visual Pathway Changes in Patients with Comitant Extropia
Xiaohe Yan,Xiaoming Lin,Qifeng Wang,Yuanchao Zhang,Yingming Chen,Shaojie Song,Tianzi Jiang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010931
Abstract: Strabismus is a disorder in which the eyes are misaligned. Persistent strabismus can lead to stereopsis impairment. The effect of strabismus on human brain is not unclear. The present study is to investigate whether the brain white structures of comitant exotropia patients are impaired using combined T1-weighted imaging and diffusion tensor imaging (DTI).
Catheter-Based Intramyocardial Delivery (NavX) of Adenovirus Achieves Safe and Accurate Gene Transfer in Pigs
Bo Chen, Zhengxian Tao, Yingming Zhao, Hongwu Chen, Yonghong Yong, Xiang Liu, Hua Wang, Zuze Wu, Zhijian Yang, Li Yuan
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053007
Abstract: Background Hepatocyte growth factor (HGF) is one of the major angiogenic factors being studied for the treatment of ischemic heart diseases. Our previous study demonstrated adenovirus-HGF was effective in myocardial ischemia models. The first clinical safety study showed a positive effect in patients with severe and diffused triple coronary disease. Methods 12 Pigs were randomized (1:1) to receive HGF, which was administered as five injections into the infarcted myocardium, or saline (control group). The injections were guided by EnSite NavX left ventricular electroanatomical mapping. Results The catheter-based injections caused no pericardial effusion, malignant arrhythmia or death. During mapping and injection, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, serum creatinine and creatine kinase-MB levels have no significant increase as compared to those before and after the injection in HGF group(P>0.05). HGF group has high HGF expression with Western blot, less myocardial infarct sizes by electroanatomical mapping (HGF group versus after saline group, 5.28±0.55 cm2 versus 9.06±1.06 cm2, P<0.01), better cardiac function with Gated-Single Photon Emission Computed Tomography compared with those in saline group. Histological, strongly increased lectin–positive microvessels and microvessel density were found in the myocardial ischemic regions in HGF group. Conclusion Intramyocardial injection guided by NavX system provides a method of feasible and safe percutaneous gene transfer to myocardial infarct regions.
Overexpression of RBBP6, Alone or Combined with Mutant TP53, Is Predictive of Poor Prognosis in Colon Cancer
Jian Chen, Huamei Tang, Zehua Wu, Chongzhi Zhou, Tao Jiang, Yingming Xue, Guoyu Huang, Dongwang Yan, Zhihai Peng
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066524
Abstract: Retinoblastoma binding protein 6 (RBBP6) plays an important role in chaperone-mediated ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic significance of RBBP6 expression in colon cancer is unknown; in particular, the prognostic value of RBBP6 combined with TP53 expression has not been explored. Therefore, quantitative real-time PCR and western blot analyses were performed to detect RBBP6 expression in colon cancer tissues. RBBP6 and TP53 expression were assessed by immunohistochemistry in a tissue microarray format, in which the primary colon cancer tissue was paired with noncancerous tissue. Tissue specimens were obtained from 203 patients. We found that RBBP6 was overexpressed in colon tumorous tissues and was significantly associated with clinical stage, depth of tumor invasion, lymph node metastasis (LNM), distant metastasis, and histologic grade. Further studies revealed that a corresponding correlation between RBBP6 overexpression and mutant TP53 was evident in colon cancer (r = 0.450; P<0.001). RBBP6 expression was an independent prognostic factor for overall survival (OS) and disease free survival (DFS). Interestingly, patients with tumors that had both RBBP6 overexpression and mutant TP53 protein accumulation relapsed and died within a significantly short period after surgery (P<0.001). Multivariate analysis showed that patients with LNM and patients with both RBBP6- and TP53-positive tumors had extremely poor OS (HR 6.75; 95% CI 2.63–17.35; P<0.001) and DFS (HR 8.08; 95% CI 2.80–23.30; P<0.001). These clinical findings indicate that the assessment of both RBBP6 and mutant TP53 expression will be helpful in predicting colon cancer prognosis.
Study of Comparative Advantages of Chinese and Indian Pharmaceutical Industries under Globalization
Feifei YUE,Yingming YUE
Management Science and Engineering , 2010,
Abstract: The authors explore the background and major factors that have promoted the growth of Pharmaceutical industry in India. Government policy and globalization strategy have played critical roles in positioning India as a pharmaceutical powerhouse. China, facing similar challenges and opportunities in the global economy, could draw valuable lessons from India’s growth story. There are also synergy and strategic fit between the two emerging economy in the pharmaceutical industry. Key words: China; India; Intellectual Property Rights (IPR); Pharmaceutical industry; MNE
Web Service Matching Based on Natural Semantic Annotation
Xia Jiang,Yingming Li
Information Technology Journal , 2013,
Abstract: To quickly and accurately find a needed Web service in service composition, a novel service matching method is proposed based on the nature semantic annotation in this paper. The natural semantic description is added in WSDL and the expanded WSDL is called as a WSDL-NS (WSDL with Natural Semantics). The computing method of semantic similarity is improved and the matching services are found by the service similarity. Finally, a simulation example is given to illustrate the correctness and effectiveness of the proposed method.
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