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Search Results: 1 - 10 of 127032 matches for " Yingjun Li "
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Effect of mammogenic hormones on the expression of FGF7, FGF10 and their receptor in mouse mammary gland
YingJun Cui,QingZhang Li
Science China Life Sciences , 2008, DOI: 10.1007/s11427-008-0092-y
Abstract: To investigate the regulation of estrogen, progesterone and prolactin stimulating the development of mammary gland, the Kunming mice were used as experimental animals in this study. Through the experiment in vitro, the effect of mammogenic hormones were systematically investigated on expression of FGF7 and FGF10 and their receptor in different periods. The results are as follows: in mammary glands of mice, 17 beta-estradiol increased the expression of FGF7; progesterone did not affect the expression of FGF7; prolactin up-regulated the expression of FGF7 significantly in pregnancy and lactation. 17 beta-estradiol increased the expression of FGF10; progesterone and prolactin reduced the expression of FGF10 significantly in virgin; prolactin significantly increased the expression of FGF10 in pregnancy. When 17 beta-estradiol in the body was in relatively high proportion, it would lower the expression of KGFR; while 17 beta-estradiol in the body was in relatively low proportion, it would increase the expression of KGFR. Low concentration of progesterone increased the expression of KGFR and high progesterone did not affect the expression of KGFR. Prolactin increased the expression of KGFR significantly in pregnancy and lactation.
Expression and Functions of Fibroblast Growth Factor 10 in the Mouse Mammary Gland
Yingjun Cui,Qingzhang Li
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14024094
Abstract: Fibroblast growth factor 10 (FGF10) is important as a mesenchymal mediator of epithelial growth and morphogenesis. In this study, the expression and localization of the FGF10 protein were detected by laser scanning confocal microscopy during mouse postnatal mammary gland development. Mammary explants were cultured to investigate the functions of FGF10. The results revealed that FGF10 localizes mainly in the mesenchyme near the ductal epithelial cells and the alveolar epithelial cells of the mammary gland. Peak FGF10 expression levels were observed at lactation day 10. FGF10 induced FGFR2-IIIb expression in the mammary epithelium, except in virgin or pregnant mice. FGF10 promoted the proliferation of mammary gland epithelial cells and reduced apoptosis. FGF10 is important during the mouse mammary gland growth, development, and reconstruction, and its effects are mediated by FGFR2-IIIb.
Do Water Matrix and Particulate Buffering Capacity Affect the Rate and Extent of P Release?  [PDF]
Jinbo Zhao, Yingjun Xu, Li Xu, Qian Li
Journal of Water Resource and Protection (JWARP) , 2018, DOI: 10.4236/jwarp.2018.101004
Abstract: The aim of this study was to investigate the release of inorganic and organic phosphorus species from particles in rivers and estuaries during resuspension events such as storm, wind and tidal induced turbulence. To achieve this aim, laboratory beaker experiments were designed with autoanalyzer 3 (AA3). The study first investigates phosphorus equilibration in ultra-pure water (UHP) water, biotic river water and abiotic river water under short term and long term conditions. Then, three typical organic and inorganic phosphorus compounds were selected (orthophosphate, phytic acid (PTA) and β-D-glucose-6-phosphate monosodium salt (G-6-P)) to simulate the effect of addition input to river and estuaries in the time period of 150 h. The results show that in a turbulent river, dissolved inorganic phosphorus (DIP) and dissolved organic phosphorus (DOP) will reach equilibrium between the particulate matter and the water column within 24 h. Additional input of DIP or DOP to the river, has different effects to the river nutrients balance. The buffering capacity of the suspended particulate matter (SPM) plays an important role and behavior difference to the inorganic and various organic phosphorus compounds.
γ-Al2O3 Supported SO42-/ZrO2 Solid Superacid Catalysts for n-Pentane Isomerization  [PDF]
Li Zhao, Xiaoshuang Cheng, Ye Hu, Shuqing Ma, Yingjun Wang
Modern Research in Catalysis (MRC) , 2014, DOI: 10.4236/mrc.2014.33011
Abstract:

A solid superacid catalyst Pt-SO42-/ZrO2-A12O3 for n-pentane isomerization, was prepared by incipient-wetness impregnation. Preparetion conditions, namely, calcination temperature, concentration of sulfuric acid solution used in impregnation and Al2O3 concentration, were varied to investigate the effects on catalytic performance of Pt-SO42-/ZrO2-A12O3. The results showed that the PtSZA catalyst exhibited excellent catalytic performance for n-pentane isomerization. Under optimized preparation conditions of calcination temperature of 650°C, reaction time for 3 h, concentration of sulfuric acid solution for 0.5 mol/L, 30% of Al2O3 concentration and 0.3% of Pt concentration, the n-pentane conversion and isopentane selectivity of Pt-SO42-/ZrO2-A12O

Preparation and Property of Ni/TiO2-SAPO-11 Catalyst for N-Heptane Isomerization  [PDF]
Li Zhao, Ye Hu, Yingjun Wang, Shuqing Ma
Modern Research in Catalysis (MRC) , 2014, DOI: 10.4236/mrc.2014.33009
Abstract:

For enhancing the activity of Ni/TiO2-SAPO-11 catalyst, SAPO-11, the precursor was prepared by hydrothermal crystallization, and TiO2-SAPO-11 complex carrier was prepared by sol-gel method, then Ni/TiO2-SAPO-11 was produced by the final product. The catalytic performance of Ni/TiO2-SAPO-11 was studied in n-heptane isomerization, and the impact of catalyst preparation conditions on n-heptane isomerization was discussed in detail. The results showed that, with 20% of TiO2 composition, 2% of Ni capacity percentage and calcined temperature at 500°C, conversion of n-heptane and isomerization selectivity was up to 40.94% and 88.97% respectively.

Effect of Turbulence on Phosphorus Release from Estuarine Sediment  [PDF]
Jinbo Zhao, Mengyuan Liu, Li Xu, Yingjun Xu
Journal of Environmental Protection (JEP) , 2019, DOI: 10.4236/jep.2019.101003
Abstract: Phosphorus (P) is an essential element for growth in aquatic ecosystems but the dynamics of phosphorus cycling within catchments is poorly constrained. The aim of this study was therefore to develop analytical tools to investigate the release of inorganic and organic phosphorus species in rivers and estuaries during resuspension events such as storm, wind and tidal induced turbulence. To achieve this aim, laboratory simulations using a mini-annular flume coupled with segmented flow analyser detection were performed. To collect SPM (suspended particulate matter), a specially designed specimen box was deployed in the River Tamar (Devon, UK). Inorganic and total phosphorus were determined using segmented flow analyser methods adapted for use with acidified persulfate digests. The segmented flow analyser had a detection limit (3 s.d.) of 0.53 μg P L-1 for inorganic P and 1.5 μg P L-1 for total P. The mini-annular flume provides a suitable method for laboratory simulations, e.g. we managed to get low blanks and good experimental reproducibility, and are also able to see changes in P species within analytical precision. Results showed that increase of shear stress (or SPM) caused release of inorganic P from sediment. This could be used as a fact to build a model to study P dynamics during resuspension events in the river and estuaries environment.
Effect of mammogenic hormones on the expression of dFGF7, FGF10 and their receptor in mouse mammary gland

CUI YingJun &,LI QingZhang,

中国科学C辑(英文版) , 2008,
Abstract: To investigate the regulation of estrogen, progesterone and prolactin stimulating the development of mammary gland, the Kunming mice were used as experimental animals in this study. Through the experiment in vitro, the effect of mammogenic hormones were systematically investigated on expression of FGF7 and FGF10 and their receptor in different periods. The results are as follows: in mammary glands of mice, 17 beta-estradiol increased the expression of FGF7; progesterone did not affect the expression of FGF7; prolactin up-regulated the expression of FGF7 significantly in pregnancy and lactation. 17 beta-estradiol increased the expression of FGF10; progesterone and prolactin reduced the expression of FGF10 significantly in virgin; prolactin significantly increased the expression of FGF10 in pregnancy. When 17 beta-estradiol in the body was in relatively high proportion, it would lower the expression of KGFR; while 17 beta-estradiol in the body was in relatively low proportion, it would increase the expression of KGFR. Low concentration of progesterone increased the expression of KGFR and high progesterone did not affect the expression of KGFR. Prolactin increased the expression of KGFR significantly in pregnancy and lactation.
Corporate Criminal Responsibility in China: Legislations and Its Deficiency  [PDF]
Yingjun Zhang
Beijing Law Review (BLR) , 2012, DOI: 10.4236/blr.2012.33013
Abstract: The Chinese corporate criminal responsibility is featured by the “Double Punishments” imposed both on the Unit who commit a crime and the persons who are directly in charge. As an attributable liability, corporate criminal responsibility requires more precise and detailed principles of attribution in the national criminal law. Unfortunately, it has not archived yet in Chinese Criminal Law. As well, at current, only one kind of monetary penalty, the fine, can be imposed on the Unit who commit a crime. It is far from enough to prevent corporate offences. On enumerating and analyzing Chinese criminal legislations concerning corporate criminal responsibility, the author finds the main deficiency in it and recommend on how to perfect it.
Evaluation of Benzamide Derivatives as New Influenza A Nucleoprotein Inhibitors  [PDF]
Jinxi Liao, Huimin Cheng, Junting Wan, Panyu Chen, Yingjun Li, Ke Ding, Micky D. Tortorella, Zhengchao Tu, Yanmei Zhang
Open Journal of Medicinal Chemistry (OJMC) , 2016, DOI: 10.4236/ojmc.2016.63004
Abstract: Virus nucleoprotein (NP) is an emerging target for drug development for Influenza. We designed benzamide derivatives as new inhibitors of NP that demonstrate good potency in blocking influenza A. Screening revealed that compound 39 was the most potent molecule in the series, exhibiting IC50 values of 0.46 and 0.27 μM in blocking the replication of H3N2 (A/HK/8/68) and (A/WSN/33) influenza A viral strains. The observed inhibition of viral replication correlated well with cytopathic protection. Furthermore, based on computational analysis and fluorescence microscopy, it was determined that compound 39 inhibited nuclear accumulation by targeting influenza A viral nucleoproteins. Finally, the rodent pharmacokinetic profile of compound 32 displayed half-life of greater than 4 hours and bioavailability greater than 20%, suggesting this class of molecules had drug-like properties.
Using of the surface plasmon resonance cytosensor for real-time and non-invasive monitoring of cellular effects in living C6 cells induced by PMA
Chunyan Wang,Yinghui Li,Jianghui Xiong,Yingjun Tan,Jianru Yu
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-006-0927-5
Abstract: Developing novel instruments and technologies for spatio-temporal and dynamic measurements of the intricate cellular effects involving molecular translocation, signal transduction, and molecular interactions inside living cells is essential for the cell and molecular biology science. For the purpose of monitoring and investigating molecular events in living cells at real-time, the surface plasmon resonance based cytosensor (SBCS) for cell culturing and signal monitoring was established, and on the basis of it, the corresponding technology was also established by monitoring and analyzing SPR responses induced in rat C6 glioma cells by phorbol 12-myristate 13-acetate (PMA). The SPR signals induced by PMA in living C6 cells were significantly different from those groups without cells. These responses were strongly dependent on and saturable to the concentrations of PMA, and could be suppressed by the specific and potent PKC inhibitors, which indicated that the measured signal could be the reflection of the redistribution of intracellular components near the cell membrane triggered by the activation of PKC. This research provides a quantitative and non-invasive technique to study the spatio-temporal characteristics of the cellular effects in living cells at real-time. Furthermore, this technology could also be widely used in the basic research as well as applied realms, such as space effects evaluation, environmental safety assessment, biological weapon detection, cellular and molecular research, and drug screening.
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