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Four a-galactosyl phytosphingosine 2,6’-diamide analogs
were prepared from 2,6’-diamino a-galactosylphytosphingosine
and the aromatic-bearing carboxylic acids. After purification with High
Performance Liquid Chromatography, a flowcytometry for the four compounds for
stimulation of human Va24+/Vb11+ NKT cell populations was carried out. Additional keto groups on the acyl
chains of the 2,6’-diamide compound was associated with the enhanced stimulating effect.
6-azidogalactosyl imidate has been used as a donor to
generate 1-(4-aminobutyl)-6-aminogalactose, 6-aminothiotolyl- glycosides
of disaccharide, trisaccharide and tetrasaccharide that incorporates 6-azido
group and 1-(4-tolyl)thio group. Trisaccharide and tetrasaccharide were
obtained from lactosyl-based acceptor. The anomeric 1-(4-tolyl)thio group could
be used to conjugate with sphingosine analogs to provide the alpha-Gal Sph analogs for library
extension from the azido group.