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The Effect on Some Biochemical Levels the Plasma and Cervical Mucus of PGF2 Alpha in the Cows
Hamit Yildiz,Muhterem Aydin
Journal of Animal and Veterinary Advances , 2012,
Abstract: It was aimed to determine the effect of PFG2 alpha on estrus cervical mucus, total protein, malondialdehide (MDA), vitamin A, plasma MDA, vitamin A, E, ?-carotene, reduced glutation (GSH) and cholesterol levels applied for the synchronization in cows. Seven cows were used in this study. Estruses were synchronized with dinoprost trometamin as a PFG2 alpha analogue. Cervical mucus and blood samples were taken from the cows exasperated. The same cows were taken cervical mucus and blood samples again after 21 days in their usual estrus. The levels of cervical mucus, MDA, total protein, Vitamin A, plasma MDA, cholesterol, ?-carotene, GSH, vitamin A and E were determined. Total protein levels of the cervical mucus that are stimulated by PGF2 alpha were higher compared to natural estrus (P<0.01), however, no difference was observed for vitamin A and MDA levels. Plasma vitamin A, E, ?-carotene, GSH, MDA and cholesterol levels of the same animals were determined, and no difference (P>0.05) was observed between the groups. In addition, positive correlation was determined both in the stimulated and natural estrus cervical mucus and plasma vitamin A levels (P<0.01, P<0.05 respectively), and a positive correlation between natural estrus cervical mucus and plasma MDA levels (P<0.05). As a result, it was considered that PFG2 alpha that is used to stimulate estrus in cows affected cervical mucus total protein level, but had no effect on the other parameters.
Presynaptic Inhibition and Disynaptic Reciprocal 1a Inhibition in Parkinson's Disease, The Effect of The Dopaminergic Treatment
Journal of Neurological Sciences , 2010,
Abstract: Objective: In recent years, increasing number of studies about the spinal cord pathology in Parkinson's disease had been conducted. H reflex investigation is an important choice in the studies dealing with neurophysiological and interneuronal alterations of the spinal cord. The effect of the dopaminergic treatment on the spinal interneuronal reflex pathways is a relatively less investigated issue. This study has been adressed to assess the presynaptic and disynaptic inhibition levels in Parkinson's disease, and the effect of dopaminergic treatment.Methods: Presynaptic inhibition and dysynaptic reciprocal 1a inhibition is investigated by double stimulation of the tibial nerve at the popliteal fossa and peroneal nerve at the fibular head in patients with Parkinson's disease and also in control subjects for the 1-100 ms conditioning test intervals. The amplitude changes of the test and the conditioned H reflex responses were calculated and compared in the affected and less affected sides in both before and under dopaminergic treatment.Results: Disynaptic and presynaptic inhibitions existed in all subjects. Disynaptic reciprocal 1a inhibition was shortened only at 2 ms conditioning interval. The conditioned and test H reflex ratio (Hc/Ht) for the 20 ms conditioning test interval (presynaptic inhibition) was significantly smaller in the affected side than the controls (p: 0.046). The percentages of the inhibitions for the 20-10-5-3-2 ms conditioning intervals significantly increased in the affected side under treatment when compared with the ones obtained in the pretreatment period (p: 0.031, 0.027, 0.014, 0.026, 0.037).Conclusion: Presynaptic inhibition was decreased and disynaptic inhibition duration was shortened in the affected side of the patients with Parkinson's disease, dopaminergic treatment caused significant increases in both periods of inhibition. These findings indicate an abnormal supraspinal influence on the spinal cord in Parkinson's disease, and also the role of some dopa responsive neural mechanisms.
c-KIT in thyroid papillary carcinomas
O?uz AYDIN,Levent YILDIZ,Mehmet KEFEL?,Canan YüKSEL
Türk Patoloji Dergisi , 2006,
Abstract: In this study, slides of 91 thyroid papillary carcinoma cases, which were recruited from the archives of the Department of Pathology, Faculty of Medicine, Ondokuz Mayis University, between years 1990 and 2006 were examined. Seventy eight of 91 cases were considered as classical type and the remaining 13 as follicular variant. Immunohistochemistry with c-kit (CD117) was applied on the selected appropriate blocks. Seventy six of 91 cases (83,51%) were positively stained. The cases were evaluated comparatively for their histological subtypes in terms of the density and intensity of the staining. Ckit showed stronger and more diffuse staining in thyroid papillary carcinomas compared to adjacent non-neoplastic thyroid tissue and also to the follicular variant of the classical type. This finding suggests that c-kit can provide new evolutionary information related to thyroid papillary carcinomas in terms of diagnostic and therapeutic perspectives.
Nuclear morphometry in typing and grading urothelial neoplasms of urinary bladder
Mehmet KEFEL?,Levent YILDIZ,O?uz AYDIN,Sancar BARI?
Türk Patoloji Dergisi , 2007,
Abstract: In this study, by using image analyzer, the different diagnostic categories for urinary tumors described in WHO/ISUP 1998 classification were analyzed for the nuclear morphometric features and the data were statistically compared. Fifty six cases of urothelial neoplasia of urinary bladder diagnosed between 2002 and 2006 were selected from the archives of Ondokuz Mayis University, Department of Pathology. The cases were re-classified according to WHO/ISUP 1998 criteria. In each case morphometric assessment was performed for average 100-150 tumor cell nuclei and 10 largest tumor cell nuclei on the digitalized image. For each the selected cell, nuclear area (μm2), perimeter (μm), form factor, maximum and minimum diameters (μm) were determined. We have found that morphometric analysis and WHO/ISUP 1998 classification show parallelism in the typing/grading of urothelial neoplasia of the urinary bladder. The standard use of nuclear morphometric features as an ancillary method for the classification of urinary neoplasms in difficult cases can be considered, however further studies that will include the prognostic data are needed.
Sarcomatoid carcinomas of the lung: Report of three cases
Mehmet KEFEL?,Levent YILDIZ,O?uz AYDIN,O?uz UZUN
Türk Patoloji Dergisi , 2008,
Abstract: Sarcomatoid carcinoma is a rare tumor group accounting for 0.3-1.3% of all malignant lung neoplasms. It is a heterogeneous group of nonsmall cell lung carcinomas containing a sarcoma or sarcoma-like component. In this paper, we describe three cases of sarcomatoid carcinoma of the lung and the histopathologic and clinical features of this rare tumor are discussed.
Systemic lupus erythematosus with an erythema multiforme-like lesions
Aydin Fatma,Senturk Nilgun,Yuksel Esra,Yildiz Levent
Indian Journal of Dermatology , 2007,
Abstract: Patients with lupus erythematous may develop an acute eruption clinically similar to toxic epidermal necrolysis or erythema multiforme. The presence of erythema multiforme-like lesions and characteristic pattern of immunological abnormalities including antinuclear antibody (speckled pattern), anti-Ro antibody or anti-La antibody and positive rheumatoid factor in lupus patients has been termed as Rowell′s syndrome. Although diagnostic criteria of this syndrome have been reviewed recently, definite mechanisms of pathogenesis is still unknown. Here we reported a 29-year-old female patient who had systemic lupus erythematosus developed erythema multiforme-like lesions.
The Prevalence of Chronic Impingement Syndrome and SLAP Lesion and the Sensitivity of O’Brien’s Test
Vahit Yildiz,Ali Aydin,Fatih Kalali,Murat Topal
Eurasian Journal of Medicine , 2012,
Abstract: Objective: In this study, we aimed to investigate the prevalence of SLAP lesions in patients with chronic impingement syndrome. We also examined the sensitivity of O’Brien’s test.Materials and Methods: The study included 48 patients with a preliminary chronic impingement syndrome diagnosis to whom arthroscopic decompression had been planned. All patients underwent preoperative Neer’s, Hawkins’ and O’Brien’s tests. We performed shoulder arthroscopy on all patients and evaluated chronic impingement syndrome and SLAP lesions. Then, we compared the statistical sensitivities of these tests.Results: The mean age of patients with chronic impingement was 45.8 years (range, 35-69 years). O’brien’s test was positive in 34 (70.8%) of the patients, and Neer’s test and Hawkins’ test were positive in 46 (95.8%) of the patients before shoulder arthroscopy. Shoulder arthroscopy revealed that 44 (91.7%) of 48 patients had subacromial impingement; 32 (66.7%) had SLAP lesions and internal impingement. In chronic impingement syndrome, sensitivity rates were 95.6% for Neer’s test and Hawkins’ test, whereas in internal impingement syndrome and slap lesions, the sensitivity of O’brien’s test was 94.1%. There was no statistical difference between the tests (p>0.05). Conclusion: 72.72% of the patients with chronic impingement syndrome had concomitant SLAP lesions. We suggest that O’Brien’s test should be used with Neer’s and Hawkins’ tests for diagnosis of this condition.
Yavuz Yildiz,Taner Aydin,Ufuk Sekir,Bulent Hazneci
Journal of Sports Science and Medicine , 2003,
Abstract: The aim of this study was to evaluate the alterations in eccentric evertor/concentric invertor strength ratio and their importance in the chronically unstable ankle. Eight patients with chronic ankle instability (CAI) and nine healthy individuals participated in this study. Isokinetic concentric and eccentric invertor and evertor muscle strength measurement was carried out at an angular velocity of 120°·sec-1 by measuring maximal force moments (torque) during isokinetic ankle inversion and eversion movements. Functionally, evertor/invertor muscle strength ratios (E/I strength ratio) were calculated separately based on peak moment and angle-specific moments obtained at 0°, 5°, 10°, 15°, 20° ankle joint angles. Peak and angle-specific eccentric evertor strength values at 0°, 5°, 10°, 15°, 20° were significantly lower in the chronic ankle instability (CAI) group. In spite of this, no differences were obtained for peak and angle-specific concentric invertor torque values. Eccentric evertor/concentric invertor strength (Eecc/Icon) ratios were also significantly lower in the CAI group, but only at 15° and 20°. Eccentric evertor muscle torque and end range (15°-20°) Eecc/Icon strength ratio for the chronically unstable ankle were significantly different from those for the healthy ankle. For this reason, measurements of end range eccentric/concentric strength ratios are more valuable in monitoring chronic ankle injuries and rehabilitation should include not only concentric muscle strengthening but also eccentric muscle strengthening, particularly for the evertor muscles
Determination of serum adenosine deaminase and xanthine oxidase levels in patients with crimean-congo hemorrhagic fever
Celik, V. Kenan;Sari, Ismail;Engin, Aynur;Gürsel, Yildiz;Aydin, Hüseyin;Bakir, Sevtap;
Clinics , 2010, DOI: 10.1590/S1807-59322010000700008
Abstract: objective: crimean-congo hemorrhagic fever is an acute viral hemorrhagic fever with a high mortality rate. despite increasing knowledge about hemorrhagic fever viruses, little is known about the pathogenesis of crimean-congo hemorrhagic fever. in this study, we measured serum adenosine deaminase and xanthine oxidase levels in crimean-congo hemorrhagic fever patients. methods: serum adenosine deaminase levels were measured with a sensitive colorimetric method described by giusti and xanthine oxidase levels by the method of worthington in 30 consecutive hospitalized patients (mean age 42.6 ± 21.0). laboratory tests confirmed their diagnoses of crimean-congo hemorrhagic fever. thirty-five subjects (mean age 42.9 ± 19.1) served as the control group. results: there was a significant difference in adenosine deaminase and xanthine oxidase levels between cases and controls (p<0.05). however, neither adenosine deaminase nor xanthine oxidase levels varied with the severity of disease in the cases assessed (p>0.05). conclusion: adenosine deaminase and xanthine oxidase levels were increased in patients with crimean-congo hemorrhagic fever. elevated serum xanthine oxidase activity in patients with crimean-congo hemorrhagic fever may be associated with reactive oxygen species generated by the xanthine/xanthine oxidase system during inflammatory responses. in addition, elevated lipid peroxidation may contribute to cell damage and hemorrhage. the association of cell damage and hemorrhage with xanthine oxidase activity should be further investigated in large-scale studies.
Quantitative Evaluation of Arthroscopic Subacromial Decompression via MRI and its Consistency with Clinical Status in Patients
Ali Aydin,Vahit Yildiz,Omer Selim Yildirim,Fatih Kalali,Mesut Kilic,Aysenur Dostbil
Surgery Journal , 2012, DOI: 10.3923/sjour.2011.18.20
Abstract: The objective of the present study was to evaluate the relationship between subacromial distance measures before and after Arthroscopic Subacromial Decompression (ASD) using MRI and clinical status in patients with chronic impingement. About 44 patients with chronic impingements at stage 2 and 3 were evaluated using UCLA shoulder scale and the Constant-Murley shoulder assessment and their subacromial distances were measured using MRI before ASD. The average duration of follow-up was 30.48 months (12-49) after ASD. The same evaluations and measurements were obtained at the end of the follow-up period. The initial and final subacromial distances were different [9.23 (5-12) vs. 10.77 (6-14) mm, respectively]. The Constant-Murley shoulder assessment and UCLA shoulder scale scores also increased from 15.14-72.48 and from 8.09-30.89, respectively. The t-test confirmed statistical improvement in all these variables upon ASD (p<0.001). In conclusion, clinical remission was associated with the subacromial distance elongation in patients with chronic impingement upon ASD.
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