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Search Results: 1 - 10 of 39489 matches for " Yi-Ran Ding "
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Research on the Establishment of Chinese Rural Drinking Water Market  [PDF]
Jian-Fei Leng, Yi-Ran Ding
American Journal of Industrial and Business Management (AJIBM) , 2013, DOI: 10.4236/ajibm.2013.31001
Abstract:


The aim of this paper is to research the establishment of Chinese rural drinking water market. On the basis of prior research on rural drinking water and water market, we study the market establishment and analyze trading elements, procedure and modes of Chinese rural drinking water market. Then we explore the operating mechanism of the market, such as the supply and demand mechanism, the price mechanism, the competition mechanism and the support mechanism. This study will conduce to the optimization of the allocation of water resources.


Renal Tissue Thawed for 30 Minutes Is Still Suitable for Gene Expression Analysis
Yi Ma, Xiao-Nan Kang, Wen-Bin Ding, Hao-Zheng Yang, Ye Wang, Jin Zhang, Yi-Ran Huang, Hui-Li Dai
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093175
Abstract: Some biosamples obtained from biobanks may go through thawing before processing. We aim to evaluate the effects of thawing at room temperature for different time periods on gene expression analysis. A time course study with four time points was conducted to investigate the expression profiling on 10 thawed normal mice renal tissue samples through Affymetrix GeneChip mouse gene 2.0 st array. Microarray results were validated by quantitative real time polymerase chain reactions (qPCR) on 6 candidate reference genes and 11 target genes. Additionally, we used geNorm plus and NormFinder to identify the most stably expressed reference genes over time. The results showed RNA degraded more after longer incubation at room temperature. However, microarray results showed only 240 genes (0.91%) altered significantly in response to thawing at room temperature. The signal of majority altered probe sets decreased with thawing time, and the crossing point (Cp) values of all candidate reference genes correlated positively with the thawing time (p<0.05). The combination of B2M, ACTB and PPIA was identified as the best choice for qPCR normalization. We found most target genes were stable by using this normalization method. However, serious gene quantification errors were resulted from improper reference genes. In conclusion, thirty minutes of thawing at room temperature has a limited impact on microarray and qPCR analysis, gene expression variations due to RNA degradation in early period after thawing can be largely reduced by proper normalization.
Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma
Yi-Ran Cai, Li Gong, Xiao-Ying Teng, Hong-Tu Zhang, Cheng-Feng Wang, Guo-Lian Wei, Lei Guo, Fang Ding, Zhi-Hua Liu, Qin-Jing Pan, Qin Su
World Journal of Gastroenterology , 2009,
Abstract: AIM: To identify clonality and genetic alterations in focal nodular hyperplasia (FNH) and the nodules derived from it.METHODS: Twelve FNH lesions were examined. Twelve hepatocellular adenomas (HCAs) and 22 hepatocellular carcinomas (HCCs) were used as references. Nodules of different types were identified and isolated from FNH by microdissection. An X-chromosome inactivation assay was employed to describe their clonality status. Loss of heterozygosity (LOH) was detected, using 57 markers, for genetic alterations.RESULTS: Nodules of altered hepatocytes (NAH), the putative precursors of HCA and HCC, were found in all the FNH lesions. Polyclonality was revealed in 10 FNH lesions from female patients, and LOH was not detected in any of the six FNH lesions examined, the results apparently showing their polyclonal nature. In contrast, monoclonality was demonstrated in all the eight HCAs and in four of the HCCs from females, and allelic imbalances were found in the HCAs (9/9) and HCCs (15/18), with chromosomal arms 11p, 13q and 17p affected in the former, and 6q, 8p, 11p, 16q and 17p affected in the latter lesions in high frequencies (≥ 30%). Monoclonality was revealed in 21 (40%) of the 52 microdissected NAH, but was not found in any of the five ordinary nodules. LOH was found in all of the 13 NAH tested, being highly frequent at six loci on 8p, 11p, 13q and 17p.CONCLUSION: FNH, as a whole, is polyclonal, but some of the NAH lesions derived from it are already neoplastic and harbor similar allelic imbalances as HCAs.
Effects of dorsal root ganglion destruction by adriamycin in patients with postherpetic neuralgia
Chun-jing, He;yi-ran, Luo;hao-xiong, Nie;
Acta Cirurgica Brasileira , 2012, DOI: 10.1590/S0102-86502012000600008
Abstract: purpose: to investigate the effects of dorsal root ganglion destruction in patients with postherpetic neuralgia (phn). methods: seventy-two patients with phn selected were randomly divided into two groups (n=36). group a was the control group (treated by injection) and group b was the group of dorsal root ganglion destruction by adriamycin. visual analog scale scores (vas), sas, sf-mpq scores. clinical effects and therapy safety were evaluated before therapy, one week, three and six months after therapy. forty-four patients were available for intention-to-treat analysis. results: the average pain scores on the likert scale were significantly reduced at each point in group b. patients in group b reported clinical effectiveness at six months as excellent response, good response, improved but unsatisfactory or unchanged 16, 12 and 8.vas scores at each time point after the operation were lower than that before operation and in group a, there was significant difference. patients showed significant improvement in sleep scores in group b. there was significant difference at t2 in group a than t1. there was no significant difference in group a at t3, t4 after the operation than that before operation. between group comparison: there was significant difference between group a and group b at each time point after the operation. conclusions: dorsal root ganglion destruction by adriamycin under guidance of c-arm perspective, the puncture operation was accurate without any adverse reaction or serious complications, which could effectively relieve pain of patients with postherpetic neuralgia, but the long-term effects needed further study.
One Tag Time-weighted Recommend Approach on Tripartite Graphs Networks
一种三部图网络中标签时间加权的推荐方法

GU Yi-ran,CHEN Min,
顾亦然
,陈敏

计算机科学 , 2012,
Abstract: Social tags can provide highly abstract information about not only item contents but also personalized prefe- rences,hence using labels could improve the accuracy of personalized recommendation. As a result of user preferences changes over time, network resources also will be increased as time goes by. How to recommend the network resources in which users have immediate interest based on the user preferences changes becomes a new research problems in the recommendation system Combined with using tag frectuency and label time on user-object tag tripartite graphs,we pro- posed a recommendation algorithm based on tag timcweighted network. Experimental results dcxnonstrate that the usage of tag timcweighted can significantly improve accuracy and diversification of recommendations.
Phase transformation behavior of titanium during carbothermic reduction of titanomagnetite ironsand
Yi-ran Liu,Jian-liang Zhang,Zheng-jian Liu,Xiang-dong Xing
- , 2016, DOI: https://doi.org/10.1007/s12613-016-1290-4
Abstract: The reduction of titanomagnetite (TTM) ironsand, which contains 11.41wt% TiO2 and 55.63wt% total Fe, by graphite was performed using a thermogravimetric analysis system under an argon gas atmosphere at 1423–1623 K. The behavior and effects of titanium in TTM ironsand during the reduction process were investigated by means of thermogravimetric analysis, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. During the reduction procedure, the titanium concentrated in the slag phase, where the phase transformation followed this sequence: FeO + FeTiO3 → Fe2TiO4 → FeTiO3 → FeTi2O5 → TiO2. The calculated results for the reduction kinetics showed that the carbothermic reduction was controlled by the diffusion of ions through the product layer. Furthermore, the apparent activation energy was 170.35 kJ·mol?1.
Pre-Existing Diseases of Patients Increase Susceptibility to Hypoxemia during Gastrointestinal Endoscopy
Yanhua Long, Hui-Hui Liu, Changhong Yu, Xia Tian, Yi-Ran Yang, Cheng Wang, Yajuan Pan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037614
Abstract: Hypoxemia is the most common adverse event that happened during gastrointestinal endoscopy. To estimate risk of hypoxemia prior to endoscopy, American Society of Anesthesiology (ASA) classification scores were used as a major predictive factor. But the accuracy of ASA scores for predicting hypoxemia incidence was doubted here, considering that the classification system ignores much information about general health status and fitness of patient that may contribute to hypoxemia. In this retrospective review of clinical data collected prospectively, the data on 4904 procedures were analyzed. The Pearson’s chi-square test or the Fisher exact test was employed to analyze variance of categorical factors. Continuous variables were statistically evaluated using t-tests or Analysis of variance (ANOVA). As a result, only 245 (5.0%) of the enrolled 4904 patients were found to present hypoxemia during endoscopy. Multivariable logistic regressions revealed that independent risk factors for hypoxemia include high BMI (BMI 30 versus 20, Odd ratio: 1.52, 95% CI: 1.13–2.05; P = 0.0098), hypertension (Odd ratio: 2.28, 95% CI: 1.44–3.60; P = 0.0004), diabetes (Odd ratio: 2.37, 95% CI: 1.30–4.34; P = 0.005), gastrointestinal diseases (Odd ratio: 1.77, 95% CI: 1.21–2.60; P = 0.0033), heart diseases (Odd ratio: 1.97, 95% CI: 1.06–3.68; P = 0.0325) and the procedures that combined esophagogastroduodenoscopy (EGD) and colonoscopy (Odd ratio: 4.84, 95% CI: 1.61–15.51; P = 0.0292; EGD as reference). It is noteworthy that ASA classification scores were not included as an independent predictive factor, and susceptibility of youth to hypoxemia during endoscopy was as high as old subjects. In conclusion, some certain pre-existing diseases of patients were newly identified as independent risk factors for hypoxemia during GI endoscopy. High ASA scores are a confounding predictive factor of pre-existing diseases. We thus recommend that youth (≤18 yrs), obese patients and those patients with hypertension, diabetes, heart diseases, or GI diseases should be monitored closely during sedation endoscopy.
Numerical Simulation of Airflow Fields in Two Typical Nasal Structures of Empty Nose Syndrome: A Computational Fluid Dynamics Study
Meng-Yang Di, Zhe Jiang, Zhi-Qiang Gao, Zhi Li, Yi-Ran An, Wei Lv
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084243
Abstract: Background The pathogenesis of empty nose syndrome (ENS) has not been elucidated so far. Though postulated, there remains a lack of experimental evidence about the roles of nasal aerodynamics on the development of ENS. Objective To investigate the nasal aerodynamic features of ENS andto explore the role of aerodynamic changes on the pathogenesis of ENS. Methods Seven sinonasal models were numerically constructed, based on the high resolution computed tomography images of seven healthy male adults. Bilateral radical inferior/middle turbinectomy were numerically performed to mimic the typical nasal structures of ENS-inferior turbinate (ENS-IT) and ENS-middle turbinate (ENS-MT). A steady laminar model was applied in calculation. Velocity, pressure, streamlines, air flux and wall shear stress were numerically investigated. Each parameter of normal structures was compared with those of the corresponding pathological models of ENS-IT and ENS-MT, respectively. Results ENS-MT: Streamlines, air flux distribution, and wall shear stress distribution were generally similar to those of the normal structures; nasal resistances decreased. Velocities decreased locally, while increased around the sphenopalatine ganglion by 0.20±0.17m/s and 0.22±0.10m/s during inspiration and expiration, respectively. ENS-IT: Streamlines were less organized with new vortexes shown near the bottom wall. The airflow rates passing through the nasal olfactory area decreased by 26.27%±8.68% and 13.18%±7.59% during inspiration and expiration, respectively. Wall shear stresses, nasal resistances and local velocities all decreased. Conclusion Our CFD simulation study suggests that the changes in nasal aerodynamics may play an essential role in the pathogenesis of ENS. An increased velocity around the sphenopalatine ganglion in the ENS-MT models could be responsible for headache in patients with ENS-MT. However, these results need to be validated in further studies with a larger sample size and more complicated calculating models.
自身免疫性肝炎遗传学研究进展
Progress in genetics of autoimmune hepatitis#br#

魏怡然,马雄,唐茹琦
WEI Yi-ran
, MA Xiong, TANG Ru-qi

- , 2017, DOI: 10.3969/j.issn.1674-8115.2017.09.017?
Abstract: 自身免疫性肝炎(AIH)是一种由异常自身免疫反应介导的慢性炎症性肝病。AIH 确切的病因和发病机制尚不清楚,环境因 素、遗传背景均可能参与 AIH 的发生和发展。近年来,AIH 的遗传学研究越来越受到关注,多个 AIH 相关的基因已被报道。目前人 类白细胞抗原(HLA)多态性位点是 AIH 最明确的遗传风险因子,且与疾病临床表型相关。全基因组关联分析发现了 2 个非 HLA 区 域的遗传易感基因,即 SH2B3 和 CARD10。AIH 遗传学研究有助于进一步揭示 AIH 的遗传发病机制。
:Autoimmune hepatitis (AIH) is an autoimmune liver disorder characterized by chronic inflammation of liver. Although the etiology of AIH remains obscure, genetic and environmental factors may contribute to the development of AIH. In the past years, investigators have attempted to uncover the genetic architecture of AIH. Multiple genetic loci have been reported to be associated with AIH, in which human leukocyte antigen (HLA) alleles were strongly associated with disease onset and clinical manifestations for decades. A recent genome wide association study identified that two loci (SH2B3 and CARD10) increased susceptibility of AIH, in addition to the HLA loci. The genetic study is aiming to help to elucidate the genetic pathogenesis for AIH
Study on the Reconstitution in vitro and Photochemical Activities of Phytochrome from the Synechocystis sp.PCC6803
集胞藻PCC6803细菌光敏色素体外重组和光化学活性研究

DONG Yi-Ran RAN Yong ZHAO Kai_Hong ZHOU Ming,
董依然
,冉勇,赵开弘,周明

生物工程学报 , 2004,
Abstract:
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