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Search Results: 1 - 10 of 52170 matches for " Yi-Jang Lee "
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The Asset Pricing System  [PDF]
Yi-Jang Yu
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.35062
Abstract: Mainstream asset pricing models are all inappropriate when they consistently insist on applying one single model to deal with a reality filled with different aspects of asset pricing. In addition, those models also treat the right environ-ment variable too lightly hence can not rightly do the job of asset pricing. In this study, based on the portfolio theory and the principle of supply and demand, a more reasonable asset pricing system including five different models will be suggested to provide a necessary function of automatic price stabilization and to better serve our financial market.
Option Pricing with Economic Feasibility  [PDF]
Yi-Jang Yu
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.41009
Abstract:

Asset pricing under the certainty equivalent approach framework always raises the current value of the asset with the riskless rate first, followed immediately by risk adjustments. Clearly, this type of arrangement does not apply to assets that are expecting to lose values if it were to adhere to feasible economic reasoning. By using the put-call parity relationship and its underlying law of no arbitrage, the needed expected rates of return for the job of option pricing can thus be obtained. This study suggests a new model in old fashion, which can better satisfy the empirical criticism of the Black-Scholes option pricing model.

Economic Natural Laws and Economics  [PDF]
Yi-Jang Yu
Modern Economy (ME) , 2015, DOI: 10.4236/me.2015.61002
Abstract: Human activity causes extensive destruction to nature. However, nature is necessary to us; continuing to damage it regardless of consequence is unwise. Microeconomic and macroeconomic natural laws were introduced by [1], but the global economy is not operating in compliance with the microeconomic natural law. If ignorance of the importance and feasibility of the microeconomic natural law is the reason for the global economy to not adhere to it, then more explanations must be provided. The current mainstream school of economics has already resolved the threat of resource scarcity; therefore, reinforcing the shortage of this school is necessary to undertake the new mission of addressing the threat of environmental destruction.
Microeconomic Natural Law, Portfolio Principle and Economics Textbooks  [PDF]
Yi-Jang Yu
Modern Economy (ME) , 2016, DOI: 10.4236/me.2016.75063
Abstract: This study explains that, after combining the microeconomic natural law with the portfolio principle and a few bases in general economic analyses, the capability of managing all fundamental challenges in business operation, financing, and marketing can be directly established in economics textbooks. It is impossible to cover all critical topics; however, restoring economics as the foundation of all major disciplines for economic management can still be practically achieved. More crucially, by endogenizing the economic environment, such new economic textbooks can guide the chaotic economic world back to its normal conditions. The illustrated methodology is still far from perfect because the real synergistic effects cannot be quantitatively studied, and natural and social environments are still treated as exogenous factors in the analytical framework. Clearly, economics still has numerous challenges to overcome.
Beyond the No Free Lunch Principle: A New Combination of Arbitrage and Investment  [PDF]
Yi-Jang Yu
Modern Economy (ME) , 2018, DOI: 10.4236/me.2018.94046
Abstract: In the financial market, within both extremities of asset investment and arbitrage, there are sufficient rooms to contain something else other than speculation. The first aim of this study is thus to introduce a new sector which although cannot violate the common sense of “no free lunch” as can arbitrage, still is capable of surmounting general beliefs about the trade-off between risk and return that accompanies speculation. The second aim of this study is intended to reduce the ingredients of unfair games in the financial market.
Adding a New Category of “Individual vs System” to the Economics  [PDF]
Yi-Jang Yu
Modern Economy (ME) , 2018, DOI: 10.4236/me.2018.911117
Abstract: After the industrial revolution, the long-term effort of resolving the threat of resource scarcity was accomplished globally in the 1950s. However, the threat of environmental destruction was, and still is, accumulating along the way. As mainstream economics is the main culprit of environmental destruction, it cannot be expected also to be the correct solution. Accordingly, it is suggested that a new category of “individual vs system” should be added to the economics. As the inability of the mainstream microeconomics to endogenise the environmental variable and to construct the right foundation for microeconomic analyses can be remedied based on the microeconomic natural laws within the new category, so too, can the incapability to resolve the threat of environmental destruction from the mainstream macroeconomics be reversed based on the macroeconomic natural laws also within the new category.
Focus on ADF/Cofilin: Beyond Actin Cytoskeletal Regulation
Cheng-Han Tsai,Yi-Jang Lee
ISRN Cell Biology , 2012, DOI: 10.5402/2012/597876
Abstract:
Focus on ADF/Cofilin: Beyond Actin Cytoskeletal Regulation
Cheng-Han Tsai,Yi-Jang Lee
ISRN Cell Biology , 2012, DOI: 10.5402/2012/597876
Abstract: Actin depolymerizing factor (ADF)/cofilin, an actin-binding protein ubiquitously expressed in a variety of organisms, is required for regulation of actin dynamics. The activity of ADF/cofilin is dependent on serine 3 phosphorylation by LIM kinase (LIMK), which is regulated by the Rho small GTPase signaling pathway. ADF/cofilin is strongly associated with several important cell biological functions, including cell cycle, morphological maintenance, and locomotion. These functions affect several biological events, including embryogenesis, oncology, nephropathy, and neurodegenerations. Here, we focus on the biochemical and pathophysiological role of ADF/cofilin in mammals. 1. Introduction ADF/cofilin has been reported to be involved in several cellular functions via regulation of actin dynamics. For instance, ADF/cofilin is required for actin reorganization at the contractile ring for cytokinesis and is essential for cell cycle progression. ADF/cofilin regulates actin dynamics through a depolymerization or severing of actin filaments. The only known mechanism for regulating the activity of ADF/cofilin activity is protein phosphorylation. ADF/cofilin becomes inactive when it is phosphorylated at serine 3 residue by LIM kinase (LIMK) or testis-specific kinase (TESK) 1 and 2 [1–3]. For LIMK, a series of signal transduction pathway for ADF/cofilin activity is primarily controlled by Rho family of small GTPase. Cells stimulated by growth factors lead to activation of the receptor tyrosine kinase (RTK) that recruits Rho small GTPase and Rho-associated protein kinase (ROCK) to phosphorylate LIM kinase and subsequent ADF/cofilin [4]. Also, dephosphorylation of ADF/cofilin is mediated by slingshot (SSH) phosphatase, chronophin (CIN) phosphatase, and protein phosphatase 1 and 2A (PP1 and PP2A) [5]. In addition to protein phosphorylation, the activity of ADF/cofilin is also regulated by intracellular pH and its association with phosphatidyl inositol bisphosphate (PIP2) [6]. Recent studies have shown that the activity of ADF/cofilin is increased at the telophase of mitosis to regulate the dynamics of actomyosin-based contractile ring and maintain the cleavage furrow for cell division [7, 8]. In addition to mitotic phase, optimal expression of ADF/cofilin is also critical for G1 to S phase progression. Forced expression of ADF/cofilin can result in G1 phase arrest through destabilization of actin cytoskeleton and upregulation of cell cycle inhibitor p 2 7 k i p 1 [9]. ADF/cofilin is involved in migration, locomotion and metastasis of cancerous cells. It has been
Involvement of Notch1 inhibition in serum-stimulated glia and oligodendrocyte differentiation from human mesenchymal stem cells
Yi-Jang Lee, Shih-Chieh Hung, Mien-Sheng Chu
Stem Cells and Cloning: Advances and Applications , 2010, DOI: http://dx.doi.org/10.2147/SCCAA.S14388
Abstract: volvement of Notch1 inhibition in serum-stimulated glia and oligodendrocyte differentiation from human mesenchymal stem cells Original Research (2539) Total Article Views Authors: Yi-Jang Lee, Shih-Chieh Hung, Mien-Sheng Chu Published Date November 2010 Volume 2010:3 Pages 165 - 173 DOI: http://dx.doi.org/10.2147/SCCAA.S14388 Yi-Jang Lee1, Shih-Chieh Hung2–5, Mien-Sheng Chu4 1Department of Biomedical Imaging and Radiological Sciences, 2Institute of Clinical Medicine, 3Institute of Pharmacology, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; 4Stem Cell Laboratory, Department of Medical Research and Education, 5Department of Orthopedics, Taipei Veterans General Hospital, Taipei 112, Taiwan Abstract: The use of in vitro oligodendrocyte differentiation for transplantation of stem cells to treat demyelinating diseases is an important consideration. In this study, we investigated the effects of serum on glia and oligodendrocyte differentiation from human mesenchymal stem cells (KP-hMSCs). We found that serum deprivation resulted in a reversible downregulation of glial- and oligodendrocyte-specific markers. Serum stimulated expression of oligodendrocyte markers, such as galactocerebroside, as well as Notch1 and JAK1 transcripts. Inhibition of Notch1 activation by the Notch inhibitor, MG132, led to enhanced expression of a serum-stimulated oligodendrocyte marker. This marker was undetectable in serum-deprived KP-hMSCs treated with MG132, suggesting that inhibition of Notch1 function is additive to serum-stimulated oligodendrocyte differentiation. Furthermore, a dominant-negative mutant RBP-J protein also inhibited Notch1 function and led to upregulation of oligodendrocyte-specific markers. Our results demonstrate that serum-stimulated oligodendrocyte differentiation is enhanced by the inhibition of Notch1-associated functions.
Involvement of Notch1 inhibition in serum-stimulated glia and oligodendrocyte differentiation from human mesenchymal stem cells
Yi-Jang Lee,Shih-Chieh Hung,Mien-Sheng Chu
Stem Cells and Cloning: Advances and Applications , 2010,
Abstract: Yi-Jang Lee1, Shih-Chieh Hung2–5, Mien-Sheng Chu41Department of Biomedical Imaging and Radiological Sciences, 2Institute of Clinical Medicine, 3Institute of Pharmacology, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; 4Stem Cell Laboratory, Department of Medical Research and Education, 5Department of Orthopedics, Taipei Veterans General Hospital, Taipei 112, TaiwanAbstract: The use of in vitro oligodendrocyte differentiation for transplantation of stem cells to treat demyelinating diseases is an important consideration. In this study, we investigated the effects of serum on glia and oligodendrocyte differentiation from human mesenchymal stem cells (KP-hMSCs). We found that serum deprivation resulted in a reversible downregulation of glial- and oligodendrocyte-specific markers. Serum stimulated expression of oligodendrocyte markers, such as galactocerebroside, as well as Notch1 and JAK1 transcripts. Inhibition of Notch1 activation by the Notch inhibitor, MG132, led to enhanced expression of a serum-stimulated oligodendrocyte marker. This marker was undetectable in serum-deprived KP-hMSCs treated with MG132, suggesting that inhibition of Notch1 function is additive to serum-stimulated oligodendrocyte differentiation. Furthermore, a dominant-negative mutant RBP-J protein also inhibited Notch1 function and led to upregulation of oligodendrocyte-specific markers. Our results demonstrate that serum-stimulated oligodendrocyte differentiation is enhanced by the inhibition of Notch1-associated functions.Keywords: mesenchymal stem cells, glia and oligodendrocyte differentiation, Notch1 signaling, serum deprivation
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