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Search Results: 1 - 10 of 51655 matches for " Yi-Horng Lee "
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The Effects of Preoperative Imaging on Surgical Outcome for Pediatric Appendicitis Patients Special Issue: Pediatric Surgery  [PDF]
Henry Su, Laura Nally, Jennifer Maddison, Yi-Horng Lee
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.47A2007
Abstract: Computed tomography (CT) has been the major imaging modality for the diagnosis of appendicitis because of its excellent imaging resolution and the ease of interpretation, but a concern has been raised regarding radiation exposure. We have shifted from CT to ultrasonography (US) as the primary imaging modality because of this concern. A retrospective review is conducted to determine whether a combined US/CT strategy can reduce radiation exposure while maintaining the same surgical outcome. Five hundred eighty-six patients between 10 and 18 years of age who underwent an appendectomy from 2007-2011wereincluded in our study. The patients were classified as Early (prior to 7/1/2009) or Late (after 7/1/2009) with the knowledge that a conscientious institutional effort was made to start utilizing US as the primary imaging modality, limiting CT use to selective cases in 2009. The diagnostic imaging studies performed (CT, US or no imaging) were recorded. Operative findings, pathology reports and clinical course were reviewed. The rates of acute appendicitis (AA), negative appendectomies (NA) and perforated appendicitis (PA) were calculated. During the Early period, 49.3% of patients (n = 150) had undergone CT scans prior to their appendectomy whereas only 37.9% (n = 107) had CT scans during the Late period. Of the CT scans obtained during the Late period, only 18.4% of patients (n = 52) had a CT scan first, and 55 CT scans were done after an initial US. Patient disease patterns were similar between Early and Late years. While no difference in NA rates for boys was found between the Early and Late periods, a
The study of technology acceptance for e-wallets application of clinic fees payment  [PDF]
Yi-Horng Lai
Health (Health) , 2012, DOI: 10.4236/health.2012.411165
Abstract: The purpose of this study was to investigate the demand of application of e-wallet in domestic retail industry by examining the needs of adoption of small amount paying method and the reasons for customers’ using of IC stored value card in this industry and aimed at providing suggestions on the e-development of small amount paying methods for domestic retail and banking industries. This study was developed in a way that the model constructs in TAM were adapted to the context of using e-wallets for clinic fees. Scale items on the survey include those measuring perceived usefulness, perceived ease of use, a user's attitude toward using and intention. The questionnaire contains no identifying information about the individual participants. A total of 320 Taipei City Hospital patients’ feedbacks were collected. Results indicate most of the relationships in the proposed model are statistically significant and in the predicted directions. Each observed variables influence with two ways: direct effect and indirect effect, and the total effect is the sum of direct effect and indirect effect. The Main effect of most of these observed variables is direct effect, but the information technology experience with the perceived usefulness. In this study, it could be finding that the perceived usefulness, the perceiver ease of use is positively associated with users’ attitude toward using, and the perceiver ease of use is positively associated with the perceived usefulness. It means the useful and easily operation of payment clinic fees with e-wallet products (such as Taipei Easy Card) is very important for the users. Besides, the easier for e-wallet using, the more people think it is usefulness. This suggestion is the same as the point at issue of Davis [1]. The users’ attitude toward using is positively associated with the intention using.
Structural Insights Into DNA Repair by RNase T—An Exonuclease Processing 3′ End of Structured DNA in Repair Pathways
Yu-Yuan Hsiao,Woei-Horng Fang,Chia-Chia Lee,Yi-Ping Chen,Hanna S. Yuan
PLOS Biology , 2014, DOI: 10.1371/journal.pbio.1001803
Abstract: DNA repair mechanisms are essential for preservation of genome integrity. However, it is not clear how DNA are selected and processed at broken ends by exonucleases during repair pathways. Here we show that the DnaQ-like exonuclease RNase T is critical for Escherichia coli resistance to various DNA-damaging agents and UV radiation. RNase T specifically trims the 3′ end of structured DNA, including bulge, bubble, and Y-structured DNA, and it can work with Endonuclease V to restore the deaminated base in an inosine-containing heteroduplex DNA. Crystal structure analyses further reveal how RNase T recognizes the bulge DNA by inserting a phenylalanine into the bulge, and as a result the 3′ end of blunt-end bulge DNA can be digested by RNase T. In contrast, the homodimeric RNase T interacts with the Y-structured DNA by a different binding mode via a single protomer so that the 3′ overhang of the Y-structured DNA can be trimmed closely to the duplex region. Our data suggest that RNase T likely processes bulge and bubble DNA in the Endonuclease V–dependent DNA repair, whereas it processes Y-structured DNA in UV-induced and various other DNA repair pathways. This study thus provides mechanistic insights for RNase T and thousands of DnaQ-like exonucleases in DNA 3′-end processing.
The Study of Mobility Solution System Design on China Direct Selling Industry  [PDF]
Horng-Jinh Chang, Ta-Ching Lee
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.37023
Abstract:

The article designs a mobility solution for direct selling industry by smartphone. The design of the mobility solution focuses on Mobile Learning (M-Learing) that assists the direct selling company and direct sales to enhance their sales performance and company operation anytime and anywhere with mobile smartphone. It also applies the key concept of enhancing the selling skill to familiar with direct sell company’s product anytime. On the other hand, Mobile Learning can play a role of standardization with multi-media contact. In the study, prototype systems were designed with a set of smartphone user interfaces. The study selected two groups of participants: one used existing learning content in personal computer, and another one used the same content with modified format via smartphone, 300 people in total. The evaluation of the result found that there were more than 80% of mobile solution participants getting higher scores in the evaluation of learning result and 12 times higher visibility of product than traditional way on personal computer. This is a proven mobile solution which can increase the performance of sales in direct selling industry.

An Adaptive Video-on-Demand Framework for Multimedia Cross-Platform Cloud Services  [PDF]
Chao-Hsien Hsieh, Chih-Horng Ke, Chiang Lee
Journal of Software Engineering and Applications (JSEA) , 2016, DOI: 10.4236/jsea.2016.95013
Abstract: Although Video-On-Demand (VOD) has been in existence for years, its cross-platform applicability in cloud service environments is still in increasing need. In this paper, an Adaptive Video-On-Demand (AVOD) framework that is suitable for private cloud environments is proposed. Private cloud has the key advantage of satisfying the real need of both consumers and providers. Hence, demands such as reasonable benefits for provider and high quality for consumers are essential design considerations in this framework. The difficulty is that these two factors are always high in one end and low in the other, and hard to find a delicate balance. Cloud service could be an opportunity for the multimedia providers to obtain higher benefits and cost less for the consumers but with an even better quality in service. An adaptive framework for such a cloud service environment is proposed to resolve this problem. Some interesting phenomena are observed from the experimental results including CPU utilization, data reading and writing speed, memory usage, port configuration execution time, and bandwidth.
Ultrasound Mediated Delivery of Liposomal Doxorubicin in Mice with Glioma  [PDF]
Feng-Yi Yang, Shih-Cheng Horng
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.410B018
Abstract:

Malignant brain tumors remain difficult to treat with chemotherapy because the blood–brain barrier (BBB) limits the amounts of potent agents that can reach the tumor, such that the drugs are unable to reach therapeutic dosage. Although various targeted carriers that encapsulate chemotherapeutic agents have been shown to improve drug delivery to brain tumors, the BBB is still a major obstacle in the use of chemotherapy for the treatment of these tumors. Human glioblastoma-bearing mice were injected intravenously with doxorubicin (Dox) encapsulated in atherosclerotic plaque-specific peptide-1 (AP-1)-conjugated liposomes or unconjugated liposome. These treatments took place with or without BBB disruption induced by transcranial pulsed high-intensity focused ultrasound (pulsed HIFU). This study showed that the treatment with Dox encapsulated in AP-1-conjugated liposomes followed by pulsed HIFU enhanced the accumulation of the cytotoxic drug in cells and inhibited the growth of brain tumors in vivo. Combining pulsed HIFU with cytotoxic agents might improve their efficacy in patients with brain tumors while simultaneously reducing the drug side effects. Further investigation is required to provide a comprehensive physical characterization of the sonication process and to determine its bioeffects.

Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei
Horng-Yunn Dou, Fan-Chen Tseng, Chih-Wei Lin, Jia-Ru Chang, Jun-Ren Sun, Wen-Shing Tsai, Shi-Yi Lee, Ih-Jen Su, Jang-Jih Lu
BMC Infectious Diseases , 2008, DOI: 10.1186/1471-2334-8-170
Abstract: A total of 356 isolates were genotyped by standard spoligotyping and the strains were compared with in the international spoligotyping database (SpolDB4). All isolates were also categorized using the 15 loci MIRU-VNTR typing method and combin with NTF locus and RD deletion analyses.Of 356 isolates spoligotyped, 290 (81.4%) displayed known spoligotypes and 66 were not identified in the database. Major spoligotypes found were Beijing lineages (52.5%), followed by Haarlem lineages (13.5%) and EAI plus EAI-like lineages (11%). When MIRU-VNTR was employed, 140 patterns were identified, including 36 clusters by 252 isolates and 104 unique patterns, and the largest cluster comprised 95 isolates from the Beijing family. The combination of spoligotyping and MIRU-VNTR revealed that 236 (67%) of the 356 isolates were clustered in 43 genotypes. Strains of the Beijing family was more likely to be of modern strain and a higher percentage of multiple drug resistance than other families combined (P = 0.08). Patients infected with Beijing strains were younger than those with other strains (mean 58.7 vs. 64.2, p = 0.02). Moreover, 85.3% of infected persons younger than 25 years had Beijing modern strain, suggesting a possible recent spread in the young population by this family of TB strain in Taipei.Our data on MTB genotype in Taipei suggest that MTB infection has not been optimally controlled. Control efforts should be reinforced in view of the high prevalence of the Beijing strain in young population and association with drug resistance.Tuberculosis (TB) remains a worldwide healthcare concern and has been characterized as an epidemic by World Health Organization (WHO). It is estimated one third of the world's population has been infected with Mycobacterium tuberculosis (MTB) and that 3 million people will die of the disease per year between now and 2010. The distribution of TB in different geographic regions is characterized by the prevalence of different MTB strains with varied v
Electronically Tunable Third-Order Quadrature Oscillator Using CDTAs
J. Horng,H. Lee,J. Wu
Radioengineering , 2010,
Abstract: A current/voltage-mode third-order quadrature oscillator based on current differencing transconductance amplifiers (CDTAs) is presented in this paper. Outputs of two current-mode and two voltage-mode sinusoids each with 90o phase difference are available in the quadrature oscillator circuit. The oscillation condition and oscillation frequency are independently controllable. The proposed circuit employs only grounded capacitors and is ideal for integration. Simulation results are included to confirm the theoretical analysis.
Molecular and clinical analyses of 84 patients with tuberous sclerosis complex
Chia-Cheng Hung, Yi-Ning Su, Shu-Chin Chien, Horng-Huei Liou, Chih-Chuan Chen, Pau-Chung Chen, Chia-Jung Hsieh, Chih-Ping Chen, Wang-Tso Lee, Win-Li Lin, Chien-Nan Lee
BMC Medical Genetics , 2006, DOI: 10.1186/1471-2350-7-72
Abstract: Mutational analysis of TSC1 and TSC2 genes was performed in 84 Taiwanese TSC families using denaturing high-performance liquid chromatography (DHPLC) and direct sequencing.Mutations were identified in a total of 64 (76 %) cases, including 9 TSC1 mutations (7 sporadic and 2 familial cases) and 55 TSC2 mutations (47 sporadic and 8 familial cases). Thirty-one of the 64 mutations found have not been described previously. The phenotype association is consistent with findings from other large studies, showing that disease resulting from mutations to TSC1 is less severe than disease due to TSC2 mutation.This study provides a representative picture of the distribution of mutations of the TSC1 and TSC2 genes in clinically ascertained TSC cases in the Taiwanese population. Although nearly half of the mutations identified were novel, the kinds and distribution of mutation were not different in this population compared to that seen in larger European and American studies.Tuberous sclerosis complex (TSC) is an autosomal dominant disorder having an incidence of 1 in 6,000 to 1 in 10,000 live births [1]. The severity of TSC and its impact on the quality of life are extremely variable among patients [2]. Common clinical manifestations of this disease include intellectual handicap, autistic disorders, and epilepsy due to the frequent, widespread occurrence of cortical tubers, which are focal disruptions of the cortical architecture due to undifferentiated giant cells. Hamartomas are also found in multiple other organ systems, including the heart, lungs, kidneys, and skin [3].Patients often seek medical attention for dermal lesions or frequent seizures. The clinical diagnostic guidelines on TSC were prepared based on clinical features, radiographic findings, and histopathological findings [3]. Accurate clinical diagnoses are relatively easy in patients with classic multisystem involvement, but are often difficult due to the diversity of clinical findings in TSC patients.The genetic b
Direct observation of the transition from indirect to direct bandgap in atomically thin epitaxial MoSe2
Yi Zhang,Tay-Rong Chang,Bo Zhou,Yong-Tao Cui,Hao Yan,Zhongkai Liu,Felix Schmitt,James Lee,Rob Moore,Yulin Chen,Hsin Lin,Horng-Tay Jeng,Sung-Kwan Mo,Zahid Hussain,Arun Bansil,Zhi-Xun Shen
Physics , 2014, DOI: 10.1038/nnano.2013.277
Abstract: Quantum systems in confined geometries are host to novel physical phenomena. Examples include quantum Hall systems in semiconductors and Dirac electrons in graphene. Interest in such systems has also been intensified by the recent discovery of a large enhancement in photoluminescence quantum efficiency and a potential route to valleytronics in atomically thin layers of transition metal dichalcogenides, MX2 (M = Mo, W; X = S, Se, Te), which are closely related to the indirect to direct bandgap transition in monolayers. Here, we report the first direct observation of the transition from indirect to direct bandgap in monolayer samples by using angle resolved photoemission spectroscopy on high-quality thin films of MoSe2 with variable thickness, grown by molecular beam epitaxy. The band structure measured experimentally indicates a stronger tendency of monolayer MoSe2 towards a direct bandgap, as well as a larger gap size, than theoretically predicted. Moreover, our finding of a significant spin-splitting of 180 meV at the valence band maximum of a monolayer MoSe2 film could expand its possible application to spintronic devices.
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