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Search Results: 1 - 10 of 20070 matches for " Yeong Wook Song "
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Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis
Eun Ha Kang, Dong Jo Kim, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Yeong Wook Song
Arthritis Research & Therapy , 2009, DOI: 10.1186/ar2797
Abstract: Targeted knock-down of Hsp70 was performed by RNA interference in RA FLSs at passage 3-7. After SNP treatment, the morphological features of apoptosis were observed by phase-contrast microscopy. Cell survival was measured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays and by flow cytometric analysis after propidium iodide (PI) staining. Bcl-2 expression and signaling pathways (Akt, extracellular signal-regulated kinase, p38, c-Jun N-terminal kinase) were examined with or without Hsp70 downregulation.Hsp70 downregulation in RA FLSs, induced by small interfering RNA (siRNA), was confirmed by reverse transcriptase-polymerase chain reaction and Western blotting. When treated with SNP, Hsp70 downregulated cells showed markedly less cell blebbing, cytoplasmic condensation, and nuclear shrinkage than non-downregulated control cells. Furthermore, Hsp70 downregulated cells were found to survive better than control cells in MTT assays (mean of absorbance ratio, 4.39 in target cells versus 1.00 in control siRNA-treated cells versus 1.09 in lipofectamine-treated cells, P = 0.001) and according to PI staining results (mean M1 ratio, 0.21 in target cells versus 1.00 in control siRNA-treated cells versus 1.03 in lipofectamine-treated cells, P = 0.001). Bcl-2 expression and Akt phosphorylation were higher in Hsp70 downregulated RA FLSs than in control cells. When cells were treated with LY294002, a potent phosphoinositide 3-kinase inhibitor, Akt phosphorylation and Bcl-2 levels were reduced and Hsp70 downregulation no longer had a cytoprotective effect.Knock-down of Hsp70 protects RA FLSs from nitric oxide-induced apoptosis by activating the Akt signaling pathway. These results suggest that Hsp70 has a pro-apoptotic role in RA FLSs.Rheumatoid arthritis (RA) is a chronic inflammatory disorder that involves mainly joint synovium. One of the major characteristics of RA synovium is the tumor-like growth of fibroblast-like synoviocytes (FLSs) that invade ad
The Effect of Deposition Temperature of Pb(Zr,Ti)O3(PZT)Thin Films with Thicknesses of around 100 nm on the Piezoelectric Response for Nano Storage Applications  [PDF]
Wook Song Han
World Journal of Condensed Matter Physics (WJCMP) , 2012, DOI: 10.4236/wjcmp.2012.22009
Abstract: We investigated the effect of the deposition temperature of PZT thin films with thicknesses of around 100 nm on the piezoelectric response using an atomic force microscope (AFM). The preferred orientation of the PZT thin film was changed from (001) to (110) as the deposition temperature increased. The surface roughness of PZT thin films decreased with the increase of deposition temperature. The maximum amplitude of the piezoelectric response of PZT thin films decreased till the deposition temperature increased to 350°C. This tendency seems to be due to the change of the preferred orientation form (001) to (110). At over 450°C, this maximum value decreased due to both the increase of the surface roughness and the degradation of the crystallinity.
Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease
Eun Ha Kang, Jeong Yeon Kim, Fujio Takeuchi, Joon Wan Kim, Kichul Shin, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Myoung Hee Park, Yeong Wook Song
Arthritis Research & Therapy , 2011, DOI: 10.1186/ar3292
Abstract: Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1,398 healthy controls.The phenotypic frequencies of HLA-A*02:07 (odds ratio (OR) = 2.03, P = 0.002), A*26:01 (OR = 1.85, P = 0.008), and A*30:04 (OR = 2.51, P = 0.006) tended to be higher in BD patients than in normal controls, but the frequency of A*33:03 (OR = 0.59, P = 0.003) tended to be lower in BD patients. A meta-analysis adopting our and the Japanese data confirmed the associations of HLA-A*02:07, A*26:01, and A*33:03 with BD. Furthermore, the frequencies of the HLA-A*02:07, A*26:01, and A*30:04 were significantly higher in patients with skin lesions (OR = 2.37, P < 0.0005, Pc < 0.012) and arthritis (OR = 2.32, P = 0.002, Pc = 0.048), with uveitis (OR = 3.01, P < 0.0005, Pc < 0.012), and with vascular lesions (OR = 9.80, P < 0.0005, Pc < 0.012) and a positive pathergy test (OR = 4.10, P = 0.002, Pc = 0.048), respectively, than in controls. In HLA-B*51 non-carriers, these associations were also significant, being much stronger between HLA-A*26:01 and uveitis (OR = 4.19, P < 0.0005, Pc < 0.012) and between HLA-A*30:04 and vascular lesions (OR = 13.97, P < 0.00005, Pc < 0.0012). In addition, HLA-A*30:04 was associated with genital ulcers in HLA-B*51 non-carriers (OR = 3.89, P = 0.002, Pc = 0.048).HLA-A*02:07, A*26:01, and A*30:04 were associated with increased risk for BD, while HLA-A*33:03 with decreased risk. HLA-A*02:07, A*26:01, and A*30:04 were associated with skin lesions and arthritis, with uveitis, and with vascular lesions, genital ulcers, and a positive pathergy test, respectively.Behcet's disease (BD) is a chronic relapsing inflammatory disease characterized by oro-genital ulcers, cutaneous inflammation, and uveitis. In addition to its typical muco-cutaneous and ocular manifestations, BD targets the musculoskeletal, vascular, nervous, and gastrointestinal systems [1]. Although the etiology of BD remains unclear, strong famili
A Proposed Scale-Dependent Cosmology for the Inhomogeneous Cosmology
Chung Wook Kim,JeongHyeon Song
Physics , 1995, DOI: 10.1142/S0218271896000205
Abstract: We propose a scale-dependent cosmology in which the Robertson--Walker metric and the Einstein equation are modified in such a way that $\Omega_0$, $H_0$ and the age of the Universe all become scale-dependent. Its implications on the observational cosmology and possible modifications of the standard Friedmann cosmology are discussed. For example, the age of the Universe in this model is longer than that of the standard model.
Simple and Versatile Molecular Method of Copy-Number Measurement Using Cloned Competitors
Hyun-Kyoung Kim, Hai-Li Hwang, Seong-Yeol Park, Kwang Man Lee, Won Cheol Park, Han-Seong Kim, Tae-Hyun Um, Young Jun Hong, Jin Kyung Lee, Sun-Young Joo, Ju-Young Seoh, Yeong-Wook Song, Soo-Youl Kim, Yong-Nyun Kim, Kyeong-Man Hong
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069414
Abstract: Variations and alterations of copy numbers (CNVs and CNAs) carry disease susceptibility and drug responsiveness implications. Although there are many molecular methods to measure copy numbers, sensitivity, reproducibility, cost, and time issues remain. In the present study, we were able to solve those problems utilizing our modified real competitive PCR method with cloned competitors (mrcPCR). First, the mrcPCR for ERBB2 copy number was established, and the results were comparable to current standard methods but with a shorter assay time and a lower cost. Second, the mrcPCR assays for 24 drug-target genes were established, and the results in a panel of NCI-60 cells were comparable to those from real-time PCR and microarray. Third, the mrcPCR results for FCGR3A and the FCGR3B CNVs were comparable to those by the paralog ratio test (PRT), but without PRT's limitations. These results suggest that mrcPCR is comparable to the currently available standard or the most sensitive methods. In addition, mrcPCR would be invaluable for measurement of CNVs in genes with variants of similar structures, because combination of the other methods is not necessary, along with its other advantages such as short assay time, small sample amount requirement, and applicability to all sequences and genes.
3 - 10 GHz Ultra-Wideband Low-Noise Amplifier Using Inductive-Series Peaking Technique with Cascode Common-Source Circuit  [PDF]
Chia-Song Wu, Tah-Yeong Lin, Chien-Huang Chang, Hsien-Ming Wu
Wireless Engineering and Technology (WET) , 2011, DOI: 10.4236/wet.2011.24034
Abstract: The objective of this paper is to investigate a ultra-wideband (UWB) low noise amplifier (LNA) by utilizing a two-stage cascade circuit schematic associated with inductive-series peaking technique, which can improve the bandwidth in the 3-10 GHz microwave monolithic integrated circuit (MMIC). The proposed UWB LNA amplifier was implemented with both co-planer waveguide (CPW) layout and 0.15-μm GaAs D-mode pHEMT technology. Based on those technologies, this proposed UWB LNA with a chip size of 1.5 mm x 1.4 mm, obtained a flatness gain 3-dB bandwidth of 4 - 8 GHz, the constant gain of 4 dB, noise figure lower than 5 dB, and the return loss better than –8.5 dB. Based on our experimental results, the low noise amplifier using the inductive-series peaking technique can obtain a wider bandwidth, low power consumption and high flatness of gain in the 3 - 10 GHz. Finally, the overall LNA characterization exhibits ultra-wide bandwidth and low noise characterization, which illustrates that the proposed UWB LNA has a compact size and favorable RF characteristics. This UWB LNA circuit demonstrated the high RF characterization and could provide for the low noise micro-wave circuit applications.
Well-integrated ZnO nanorod arrays on conductive textiles by electrochemical synthesis and their physical properties
Yeong Hwan Ko, Myung Sub Kim, Wook Park and Jae Su Yu
Nanoscale Research Letters , 2013, DOI: 10.1186/1556-276X-8-28
Abstract: We reported well-integrated zinc oxide (ZnO) nanorod arrays (NRAs) on conductive textiles (CTs) and their structural and optical properties. The integrated ZnO NRAs were synthesized by cathodic electrochemical deposition on the ZnO seed layer-coated CT substrate in ultrasonic bath. The ZnO NRAs were regularly and densely grown as well as vertically aligned on the overall surface of CT substrate, in comparison with the grown ZnO NRAs without ZnO seed layer or ultrasonication. Additionally, their morphologies and sizes can be efficiently controlled by changing the external cathodic voltage between the ZnO seed-coated CT substrate and the counter electrode. At an external cathodic voltage of 2 V, the photoluminescence property of ZnO NRAs was optimized with good crystallinity and high density.
Pure nongestational choriocarcinoma of the ovary: a case report
Choi Youn Jin,Chun Keun Young,Kim Yong Wook,Ro Duck Yeong
World Journal of Surgical Oncology , 2013, DOI: 10.1186/1477-7819-11-7
Abstract: Pure ovarian choriocarcinoma can be gestational or nongestational in origin. Nongestational choriocarcinoma of the ovary is extremely rare, and its diagnosis is very difficult during the reproductive years. We present a case of a 33-year-old woman diagnosed with pure nongestational ovarian choriocarcinoma. Following surgery, multiple courses of a chemotherapy regimen of etoposide, methotrexate, and actinomycin-D (EMA) were effective.
Isolated MicroGrid’s Voltage and Frequency Characteristic with Induction Generator Based Wind Turbine  [PDF]
Woo-Kyu Chae, Hak-Ju Lee, Sung-Wook Hwang, Il-Keun Song, Jae-Eon Kim
Smart Grid and Renewable Energy (SGRE) , 2014, DOI: 10.4236/sgre.2014.57017

To save on the island area's power supply cost and protect the clean environment, the Isolated MicroGrid is being duly considered. Consisting of the Wind Turbine Generator (WT), photovoltaic generator, battery system, back-up diesel generator, etc., Isolated MicroGrid, which usually uses the inverter to maintain voltage and frequency of the system, is very weak in terms of voltage and frequency stability compared to the large-scale electrical power system. If wind turbine generator is applied to this weak power system, it could experience many problems in terms of maintaining its voltage and frequency. In this paper, the measurement result of voltage and frequency is presented for MicroGrid, which consists of the Wind Turbine Generator adopting the induction generator and the battery system. MicroGrid’s voltage waveform distortion and Wind Turbine Generator’s output oscillation problems are analyzed using PSCAD/EMTDC. Based on the analyzed result, the importance of type and capacity choice has been suggested in case the Wind Turbine Generator is applied to the Isolated MicroGrid.

Comparison of Depth Dose Distributions Using Cerenkov Fiber-Optic Dosimeter and Monte Carlo Simulation for HDR Brachytherapy  [PDF]
Sang Hun Shin, Young Beom Song, Mingeon Kim, Hye Jin Kim, Wook Jae Yoo, Kyoung Won Jang, Bongsoo Lee
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.48157
In this study, we fabricated a Cerenkov fiber-optic dosimeter (CFOD) without any scintillator to measure Cerenkov radiation signals owing to gamma-rays. The relative depth dose (RDD) distributions of Ir-192 HDR brachytherapy source were obtained by using the CFOD based on a subtraction method and the RDD curve was compared with the simulation result of Monte Carlo N-particle extended transport code (MCNPX). Finally, we demonstrated that the CFOD can be used to measure real-time dose information for HDR brachytherapy.
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