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Search Results: 1 - 10 of 608 matches for " Yasuyuki Morishita "
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An Integrated Expression Profiling Reveals Target Genes of TGF-β and TNF-α Possibly Mediated by MicroRNAs in Lung Cancer Cells
Akira Saito, Hiroshi I. Suzuki, Masafumi Horie, Mitsuhiro Ohshima, Yasuyuki Morishita, Yoshimitsu Abiko, Takahide Nagase
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056587
Abstract: EMT (epithelial-mesenchymal transition) is crucial for cancer cells to acquire invasive phenotypes. In A549 lung adenocarcinoma cells, TGF-β elicited EMT in Smad-dependent manner and TNF-α accelerated this process, as confirmed by cell morphology, expression of EMT markers, capacity of gelatin lysis and cell invasion. TNF-α stimulated the phosphorylation of Smad2 linker region, and this effect was attenuated by inhibiting MEK or JNK pathway. Comprehensive expression analysis unraveled genes differentially regulated by TGF-β and TNF-α, such as cytokines, chemokines, growth factors and ECM (extracellular matrices), suggesting the drastic change in autocrine/paracrine signals as well as cell-to-ECM interactions. Integrated analysis of microRNA signature enabled us to identify a subset of genes, potentially regulated by microRNAs. Among them, we confirmed TGF-β-mediated induction of miR-23a in lung epithelial cell lines, target genes of which were further identified by gene expression profiling. Combined with in silico approaches, we determined HMGN2 as a downstream target of miR-23a. These findings provide a line of evidence that the effects of TGF-β and TNF-α were partially mediated by microRNAs, and shed light on the complexity of molecular events elicited by TGF-β and TNF-α.
Analogies between Knots and Primes, 3-Manifolds and Number Rings
Masanori Morishita
Mathematics , 2009,
Abstract: This is an expository article of our work on analogies between knot theory and algebraic number theory. We shall discuss foundational analogies between knots and primes, 3-manifolds and number rings mainly from the group-theoretic point of view.
Thermally Induced Nanocrystal Array of Poly(N-Vinylcarbazole) on Si-Wafer Substrate  [PDF]
Kazushi Yamada, Yasuyuki Tsuboi
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.55032

Recently, nanostructures such as nanocrystals and nanoaggregates have attracted much attention in many quarters of materials, electronics, and biology to create higher-value-added functional nanoscale materials and films. In this research, the fabrication of nanoaggregates on ultrathin photoconductive films of poly(N-vinylcarbazole) (PVCz) by applying thermal treatment is demonstrated. The structure and size are discussed on the basis of the results of atomic force microscope images. As a result, after thermal treatment of these films above the glass transition temperature (Tg) of PVCz, different types of surface morphological changes were induced showing a dependence on the tacticity of PVCz. Radically polymerized PVCz(r) ultrathin film showed small aggregates with heights of ~8 nm on the film surface after thermal treatment, while cationically polymerized PVCz(c), which has higher isotactic diad fractions than PVCz(r), indicated similar aggregates on the film surface, although the number of aggregates was smaller than PVCz(r). It is considered that these different phenomena depend on the tacticity of PVCz and the interaction between PVCz molecules and the substrate surface.

Effect of Dehydrated Digested Effluent of Manure on Yield and Quality of Annual Forages and Soil Chemical Properties in Southern Kyushu, Japan  [PDF]
Sachiko Idota, Yasuyuki Ishii
Agricultural Sciences (AS) , 2014, DOI: 10.4236/as.2014.510090

Digested effluent of manure (DEM) produced by biogas-plants contains many macro- and micro-nutrients. In an experiment conducted in southern Kyushu (Japan), forage crops cultivated after receiving DEM and chemical fertilizers exhibited similar dry matter yields. From a logistical standpoint, however, DEM in liquid form is difficult to handle and apply due to the low concentration of nutrients. To overcome this shortcoming, we prepared dehydrated DEM (DDEM) by adding DEM to cattle manure without disturbing the manure fermentation process. The objective of this research was to evaluate the effect of DDEM on dry matter yield and nitrogen recovery rate in annual dual-cropping systems (summer crop of maize or sorghum and winter crop of Italian ryegrass) that are typical of the region and to compare these results to commercial cattle manure alone, in combination with chemical fertilizer (CM or CM + CF), or no fertilizer application (NF). In both cropping systems, the DDEM treatment produced similar dry matter yields (2.6 to 3.02 kg·m-2) and apparent nitrogen recovery rates (43% to 53%) as the CM + CF and CM treatments. This suggests that DDEM can potentially replace chemical fertilizers and commercial cattle manure in the region.

Performance Evaluation of Heat Exchangers in OTEC Using Ammonia/Water Mixture as Working Fluid  [PDF]
Takafumi Morisaki, Yasuyuki Ikegami
Open Journal of Fluid Dynamics (OJFD) , 2013, DOI: 10.4236/ojfd.2013.34037
Abstract: The ocean thermal energy conversion (OTEC) system is a promising solution to provide stable electricity supply. Although the available temperature difference in OTEC systems is small, an ammonia/water mixture as working fluid is expected to decrease irreversible losses in the heat exchangers and to improve system performance. However, in actual heat exchangers, an adequate temperature crossing does not occur in the condenser but in the evaporator. Therefore, clarification of this characteristic is important. To date, the logarithmic temperature difference (LMTD) method is used in performance evaluations of OTEC heat exchangers. This method is of limited use if physical properties of fluids vary. A generalized mean temperature difference (GMTD) method is introduced to perform this evaluation. As changes in fluid property values can be considered in the GMTD method, method dependencies on heat exchanger characteristics, effectiveness, and system characteristics can be studied. In particular, GMTD and LMTD using a pure substance were found to be almost equal. Mean temperature differences using mixtures as working fluid were higher in the evaporator, but lower in the condenser, from the GMTD method than from the LMTD method. For higher ammonia concentrations in ammonia/water mixtures, the mean temperature differences from both methods are different.
Sound Source Measurement of a Semi-Circular Cylinder in a Uniform Flow by Particle Image Velocimetry  [PDF]
Yasuyuki Oguma, Nobuyuki Fujisawa
Journal of Flow Control, Measurement & Visualization (JFCMV) , 2016, DOI: 10.4236/jfcmv.2016.44014
Abstract: In this paper, the measurement of an aerodynamic sound source for a semi-circular cylinder in a uniform flow is described using Particle Image Velocimetry (PIV). This experimental technique is based on vortex sound theory, where the time derivative of vorticity is evaluated with the aid of two sets of standard PIV systems. The experimental results indicate that the sound source for the semi-circular cylinder is located around the shear layer near the edge of the semi-circular cylinder. The sound source intensity and the area are reduced in the semi-circular cylinder compared with those of a circular cylinder. This result indicates that the aerodynamic sound of the semi- circular cylinder is smaller than that of the circular cylinder, which supports the microphone measurement result.
A Modification of the Relative Weightings of Symptoms Utilizing a Logistic Function to Enhance the Linearity of the Brief Psychiatric Rating Scale: A Retrospective Analysis  [PDF]
Jitsuki Sawamura, Shigeru Morishita, Jun Ishigooka
Journal of Behavioral and Brain Science (JBBS) , 2012, DOI: 10.4236/jbbs.2012.22026
Abstract: Introduction: Although the Brief Psychiatric Rating Scale (BPRS) is widely used for evaluating patients with schizophrenia, the meaning of the weights of the individual symptoms is ambiguous. The aims of the study were 1) to investigate whether the modification of relative weights of items of the BPRS is able to enhance its correlation with the Clinical Global Impression-Schizophrenia scale (CGI-SCH) and 2) to construct a potential modified BPRS. Methods: We evaluated 200 schizophrenia patients using the BPRS and the CGI-SCH and drew the scatter plot distributions of the two scales. Next, univariate regression for the CGI-SCH using individual symptoms of the BPRS was performed. Multivariate regression utilizing the ‘logistic function’ was then conducted to allocate marks to each item and Pearson’s r correlation coefficient and r-squared between the two scales were assessed. After that, we constructed an example of a potential modified BPRS. Results: With the scatter plot for the two scales, a logarithmic curve was obtained; this was described by [CGI-SCH] = 3.2248 × ln[18-item BPRS] – 7.2044 (p < 0.001). Pearson’s r for the relationship between the scales was 0.8216 and r-squared was 0.7718 (both p < 0.001). The univariate regression indicated a positive associa- tion between all symptoms of the BPRS and the CGI-SCH, although some of them were significant (p < 0.05) and others were not (p ≥ 0.05). Multivariate regression utilizing a logistic function provided the values “Pi” that could express the relative weights of individual symptoms. Subsequently, modification of point allocations according to “Pi” yielded a Pearson’s r of 0.8491 and an r-squared of 0.7718 (not changed) (both p < 0.001). An example of a potential modified BPRS was constructed. Conclusions: Within the limits of our data, the weightings of items of the BPRS improved the correlation of the BPRS with the CGI-SCH for evaluating schizophrenia.
Consideration on the Flow Velocity in the Experimental Analysis of the Flame Displacement Speed Using DNS Data of Turbulent Premixed Flames with Different Lewis Numbers  [PDF]
Kazuya Tsuboi, Shingo Morishita, Eiji Tomita
Open Journal of Fluid Dynamics (OJFD) , 2014, DOI: 10.4236/ojfd.2014.43021
Abstract: The flame displacement speed is one of the major characteristics in turbulent premixed flames. The flame displacement speed is experimentally obtained from the displacement normal to the flame surface, while it is numerically evaluated by the transport equation of the flame surface. The flame displacement speeds obtained both experimentally and numerically cannot be compared directly because their definitions are different. In this study, two kinds of experimental flame displacement speeds—involving the mean inflow velocity and the local flow velocity—were simulated using the DNS data with the different Lewis numbers, and were compared with the numerical flame displacement speed. The simulated experimental flame displacement speed involving the mean inflow velocity had no correlation with the numerical flame displacement speed, while the simulated displacement speed involving the local flow velocity had a clear correlation with the numerical displacement speed in the cases of higher Lewis number than unity. The correlation coefficient of the simulated displacement speed involving the local flow velocity with the numerical displacement speed had a maximum value on the isosurface of the reaction progress variable with the maximum temperature gradient where the dilation effect of the flame is strongest.
Proton Conductivity of Ni, Y Co-Doped BaZrO3  [PDF]
Hiroya Morishita, Yumiko Ikebe, Eriko Ban
Journal of Materials Science and Chemical Engineering (MSCE) , 2018, DOI: 10.4236/msce.2018.66002
Abstract: Dense sintered bodies of proton conducting BaZrO3 (BZ) and Y-doped BaZrO3 (BZ-Y) were obtained at 1600℃ for a short sintering time of 5 hours, by the addition of NiO as a sintering promotion agent. The relative density and grain growth of samples, Ni-doped BaZrO3 (BZ-N) and Ni, Y co-doped BaZrO3 (BZ-NY), were increased with increasing Ni addition. The sinterability of BZ-NY was greatly improved just to add only 0.6 mol% Ni and the relative density of this sample was more than 98%, in contrast to that of 60% at most for BZ-Y without Ni addition. Electrical conductivity of BZ-NY added Ni 1.0 mol%, BaZr0.91Ni0.01Y0.08O3-α, was more than 10-3 S.cm-2 at 900℃?in a wet 1% hydrogen atmosphere, which value was 10 times higher than that of BZ-Y. In addition, the kind of electrical conduction carrier and an ionic transport number were also examined by employing various concentration cells. It was found that the proton conduction was dominant for both BZ-N and BZ-NY samples, although BZ-NY showed scarcely oxygenion conduction approximately 10% in a high temperature range higher than 800℃. From these results, as mall amount of Ni addition found to be effective for improvement of both the sinterability and the electrical conductivity.
Mechanical and Thermal Characteristics of Bio-Nanocomposites Consisting of Poly-L-lactic Acid and Self-Assembling Siloxane Nanoparticles with Three Phases
Masatoshi Iji,Naoki Morishita
Journal of Nanotechnology , 2012, DOI: 10.1155/2012/137614
Abstract: Biopolymer nanocomposites (bio-nanocomposite) consisting of poly-L-lactic acid (PLLA) and siloxane nanoparticles with three phases, a high-density siloxane phase (plural cores), an elastomeric silicone phase, and a caprolactone oligomer phase, were developed to increase the mechanical properties of PLLA. The nanoparticles, average size of 13?nm, were self-assembled by aggregation and condensation of an organosiloxane with three units: isocyanatepropyltrimethoxysilane (IPTS), polymethylpropyloxysiloxane (PMPS), and a caprolactone oligomer (CLO), which form each phase. The bio-nanocomposite was produced using PLLA and the nanoparticles. Bending and tensile testing showed that the use of these nanoparticles (5?wt% in PLLA) greatly increases the tenacity (breaking strain) of PLLA while maintaining its relatively high breaking (maximum) strength. The elongation of the nanocomposite was more than twice that of PLLA while the elasticity modulus and breaking (maximum) strength were comparable to those of PLLA. The nanoparticles also increased the impact strength of PLLA. The use of the nanoparticles almost did not show adverse affect on the thermal resistance of PLLA. The nanocomposite’s heat resistance indicated by the glass transition temperature and heat distortion temperature was fairly kept. The decomposition temperature of the nanocomposite somewhat increased. 1. Introduction Polymer nanocomposites, usually consisting of polymers and nanometer-sized particles, have gathered high attentions because of their attracting characteristics [1]. In particular, inorganic nanometer-sized particles (nanoparticles) are mainly used as reinforcing fillers because they improve key characteristics of these composites at a relatively low content [2, 3]. For example, clay nanoparticles [4], metal oxide nanoparticles such as silica [5] and titania nanoparticles [6], and carbon nanotubes [7] increase the mechanical properties, especially the elasticity modulus, of many kinds of polymer composites. However, currently available nanoparticles insufficiently improve the tenacity (elongation at breaking point) of nanocomposites, which is necessary if nanocomposites are used in durable products such as electronic equipments and automobiles. This is mainly because these nanoparticles lack rubber-like elasticity although they have an affinity for a polymer matrix. Adding a typical elastomer such as rubber or plasticizer (e.g., a long chain alkyl ester) with a high affinity for a polymer matrix, however, reduces the breaking strength and elasticity modulus of the composite due to
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