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Search Results: 1 - 10 of 1037 matches for " Yasushi Yoneda "
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A New Rotator Interval Approach for Antegrade Humeral Nailing: A Technical Note  [PDF]
Naxin Liu, Toshikazu Mohri, Junzou Hayashi, Ryo Orito, Tsuyoshi Nakai, Yasushi Yoneda
Open Journal of Orthopedics (OJO) , 2014, DOI: 10.4236/ojo.2014.411049
Abstract: The lateral and anterior lateral approaches are the most commonly used for antegrade nailing of humerus fractures. However, the surgical exposure is restricted by the bony acromion. The iatrogenic injury to the rotator cuff can also cause post-operative pain and compromise shoulder function. This article describes a new rotator interval approach that we used for central entry point nailing. In this approach, the skin incision starts from the midpoint between the acromion and coracoid process. A trans-rotator interval split in front of the anterior border of the supraspinatus (SSP) tendon is then made to open the glenohumeral joint. With the SSP retracted laterally and the long head of the biceps (LHB) retracted medially, the humeral head is directly visualized. The entry point can thus be determined and confirmed by intra-operative fluoroscopy in both axial and AP planes. We recommend this rotator interval approach as an alternative nailing technique for 2-part humeral neck fractures and humeral shaft fractures.
Truncated SSX Protein Suppresses Synovial Sarcoma Cell Proliferation by Inhibiting the Localization of SS18-SSX Fusion Protein
Yasushi Yoneda, Sachio Ito, Toshiyuki Kunisada, Yuki Morimoto, Hirotaka Kanzaki, Aki Yoshida, Kenji Shimizu, Toshifumi Ozaki, Mamoru Ouchida
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077564
Abstract: Synovial sarcoma is a relatively rare high-grade soft tissue sarcoma that often develops in the limbs of young people and induces the lung and the lymph node metastasis resulting in poor prognosis. In patients with synovial sarcoma, specific chromosomal translocation of t(X; 18) (p11.2;q11.2) is observed, and SS18-SSX fusion protein expressed by this translocation is reported to be associated with pathogenesis. However, role of the fusion protein in the pathogenesis of synovial sarcoma has not yet been completely clarified. In this study, we focused on the localization patterns of SS18-SSX fusion protein. We constructed expression plasmids coding for the full length SS18-SSX, the truncated SS18 moiety (tSS18) and the truncated SSX moiety (tSSX) of SS18-SSX, tagged with fluorescent proteins. These plasmids were transfected in synovial sarcoma SYO-1 cells and we observed the expression of these proteins using a fluorescence microscope. The SS18-SSX fusion protein showed a characteristic speckle pattern in the nucleus. However, when SS18-SSX was co-expressed with tSSX, localization of SS18-SSX changed from speckle patterns to the diffused pattern similar to the localization pattern of tSSX and SSX. Furthermore, cell proliferation and colony formation of synovial sarcoma SYO-1 and YaFuSS cells were suppressed by exogenous tSSX expression. Our results suggest that the characteristic speckle localization pattern of SS18-SSX is strongly involved in the tumorigenesis through the SSX moiety of the SS18-SSX fusion protein. These findings could be applied to further understand the pathogenic mechanisms, and towards the development of molecular targeting approach for synovial sarcoma.
Effects of Pitavastatin on the Intima-Media Thickness of the Carotid Artery in Patients with Ischemic Stroke: The Pitavastatin Efficacy Study on Surrogate Markers and Imaging for Stroke (PESSMIST)  [PDF]
Yasushi Shibata
World Journal of Neuroscience (WJNS) , 2014, DOI: 10.4236/wjns.2014.44034
Abstract:

Pitavastatin is a strong statin that was developed in Japan. The clinical impact of pitavastatin treatment in patients with ischemic stroke has not been reported. We conducted a prospective, open label, clinical case-control study to determine the secondary preventive effects of pitavastatin for patients with cerebral infarction and hyperlipidemia. The pitavastatin group included 20 Japanese patients diagnosed with cerebral infarction and hyperlipidemia without previous statin intake. The control group included 22 patients diagnosed with cerebral infarction without hyperlipidemia. The pitavastatin group of patients received 2 mg of pitavastatin once a day after dinner. The mean age of the patients was 69.3 and 75.5 years for the pitavastatin and control groups, respectively, and the age of the pitavastatin group was significantly younger than that of the control group (P < 0.05). The serum TCho and LDL-C levels significantly decreased two months after the initiation of pitavastatin treatment. The mean and maximum intima-media thickness (IMT) also decreased after the initiation of pitavastatin. The mean and maximum IMT did not show any significant changes in the control group. The change of IMT %/year was less than zero for the pitavastatin group, and was almost zero or higher for the control group. Pitavastatin showed beneficial effects by improving the surrogate makers of stroke. These surrogate makers were effective to evaluate the efficacy of pitavastatin to prevent secondary stroke. Although a prospective randomized study is required to elucidate the long-term effects of pitavastatin, the current study suggests that pitavastatin may be effective to prevent secondary stroke in patients with stroke and hyperlipidemia.

Optimum-Welfare and Maximum-Revenue Tariffs in Vertically Related Markets  [PDF]
Yasushi Kawabata
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.55055
Abstract:

This paper compares the optimum-welfare tariffs with the maximum-revenue tariffs in a model of vertically related markets characterized by Cournot competition. It shows that the optimum-welfare tariff on the intermediate good exceeds the maximum-revenue tariff if the home intermediate-good firm is much more cost-competitive than the foreign intermediate-good firm. Further, the optimum-welfare tariff on the final good exceeds the maximum-revenue tariff if the home intermediate-good firm is significantly inefficient compared to the foreign intermediate-good firm. It is less likely that the optimum-welfare tariffs on the intermediate and the final good, respectively, exceed the maximum-revenue tariffs on the intermediate and the final good in the presence of vertical trade structures than in their absence.

Macroscopic extent of gastric mucosal atrophy: increased risk factor for esophageal squamous cell carcinoma in Japan
Tomoyuki Akiyama, Masahiko Inamori, Hiroshi Iida, Hiroki Endo, Kunihiro Hosono, Kyoko Yoneda, Koji Fujita, Masato Yoneda, Hirokazu Takahashi, Ayumu Goto, Yasunobu Abe, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Kensuke Kubota, Satoru Saito, Yasushi Rino, Atsushi Nakajima
BMC Gastroenterology , 2009, DOI: 10.1186/1471-230x-9-34
Abstract: Two hundred and fifty-three patients who were diagnosed as having esophageal squamous cell carcinoma, and 253 sex- and age-matched controls were enrolled in the present study. The macroscopic extent of gastric mucosal atrophy was evaluated based on the Kimura and Takemoto Classification. A conditional logistic regression model with adjustment for potential confounding factors was used to assess the associations.Body gastritis, defined endoscopically, was independently associated with an increased risk for esophageal squamous cell carcinoma.Our findings suggest that macroscopic body gastritis may be a risk factor for esophageal squamous cell carcinoma in Japan. Further studies are needed to confirm these findings.Esophageal cancer is the world's eighth most common malignancy, affecting approximately 500,000 individuals worldwide each year [1]. In Japan, the age-standardized mortality rate of this cancer in 2000 was 10.4/100,000 for men, approximately eight times that of women, and the sixth most frequent cause of death from cancer in Japanese men [2]. There are two major histological types of esophageal cancer, squamous cell carcinoma and adenocarcinoma, and their epidemiological features differ considerably. Esophageal squamous cell carcinoma (ESCC) has a predilection for black and Asian populations and, worldwide, more than 80% of esophageal cancers are squamous cell carcinomas. In contrast, esophageal adenocarcinoma affects white populations predominantly. The frequency of squamous cell carcinoma in Western countries has declined while there has been a dramatic rise in the frequency of esophageal adenocarcinoma over the past several decades [3,4]. Meanwhile more than 90% of esophageal cancers in Japan have been squamous cell carcinoma, and no significant changes have been identified [5].Recently, a large population-based case-control study in Sweden has demonstrated that cytotoxin-associated gene A (CagA)-positive H. pylori infection is an increased risk factor fo
A mathematical clue to the separation phenomena on the two-dimensional Navier-Stokes equation
Tsuyoshi Yoneda
Mathematics , 2012,
Abstract: In general, before separating from a boundary, the flow moves toward reverse direction near the boundary against the laminar flow direction. Here in this paper, a clue to such reverse flow phenomena (in the mathematical sense) is observed. More precisely, the non-stationary two-dimensional Navier-Stokes equation with an initial datum having a parallel laminar flow (we define it rigorously in the paper) is considered. We show that the direction of the material differentiation is opposite to the initial flow direction and effect of the material differentiation (inducing the reverse flow) becomes bigger when the curvature of the boundary becomes bigger. We also show that the parallel laminar flow cannot be a stationary Navier-Stokes flow near a portion of the boundary with nonzero curvature.
Fungal Isolate “KMI” Is a New Type of Orchid Mycorrhizal Fungus  [PDF]
Tomoko Matsubara, Motohito Yoneda, Takaaki Ishii
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.38135
Abstract: We analyzed an isolate of fungus that seems to be a new type orchid mycorrhizal fungus, “KMI (refers to Kyoto-Ma- tsubara-Ishii)”, obtained from the roots of Paphiopedilum thailandense Fowl. KMI has hyphal branching into right angle similar to Rhizoctonia-like fungi, but its spore formation resembled Nectoria, which is known as a teleomorph of Fusarium rather than Rhizoctonia. Its ribosomal DNA sequences of 18S and ITS have no similarity with any known fungal species. Proteins in molecular weight of 53 and 24 kDa, which are common to mycorrhizal fungi, were detected in KMI. When KMI was inoculated onto orchids, however it didn’t form pelotons or coils, but the hyphae in the root tissues were observed and the tissues were not decayed. No significant symptoms of Rhizoctonia or Fusarium disease, however, were developed on tomato and cucumber plants. The evidences suggest that KMI is a new type of orchid mycorrhizal fungus.
Does Embankment Improve Quality of a River? A Case Study in To Lich River Inner City Hanoi, with Special Reference to Heavy Metals  [PDF]
Nguyen Thi Thuong, Minoru Yoneda, Yasuto Matsui
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.44043
Abstract:

To Lich River (TLR) system receives wastewaters from a population of nearly two million people and 100 manufactories of five industrial zones in inner city Hanoi, Vietnam. To improve quality of TLR, the embankment was carried out in 1998 and finished in 2002, resulted in width of 20 - 45 m, depth of 2 - 4 m, and maximum water flow capacity of 30 m3/s. Water and sediment quality indices based on heavy metal concentrations were used to evaluate current river environment compared to that of pre-embankment. Mass balance model was employed to estimate total metal loads for specific river reaches, which corresponds to various types of wastewater discharged along the river. The results indicated that currently there is about284,000 m3sediment accumulated in TLR bed, which is under high contamination of Cr, Mn, Fe, Ni Cu, Zn, As, Cd, and Pb with a total of 7347 tons of all concerned metals. Domestic-discharged river reaches received much lower metal loads, roughly 8% - 28% compared to river reaches of both domestic and industrial inputs. Total load of all nine concerned metals at the end of TLR is161.7 kg/day, which is finally discharged to Nhue River at South Hanoi. Water quality was improved much right after finishing embankment, then it gradually deteriorated. Meanwhile, sediment quality became even much worse after embankment. Relative river quality index as equal weight for both water and sediment quality indices indicated that quality of TLR was not much improved after the embankment. It even became worse due to the urbanization in recent years.

Economic Evaluation Method of Photovoltaic Power Generation Installed in Ordinary Homes  [PDF]
Yasushi Iwasaki, Kayoko Yamamoto
Smart Grid and Renewable Energy (SGRE) , 2014, DOI: 10.4236/sgre.2014.56013
Abstract:

This study aims to develop an economic evaluation method for installing photovoltaic power generation in ordinary homes using GIS (Geographic Information Systems). The conclusions can be summarized in the following three points: 1) This method determines the profit and loss and payback period in order to evaluate the installation of photovoltaic power generation, taking into account the price of equipment, solar battery module conversion efficiency, subsidy, electricity purchase price, service life and rate for selling electricity. 2) The proposed evaluation method was applied to Kanagawa Prefecture in Japan, providing plural scenarios. Using a solar battery module conversion efficiency of more than 15%, it is possible to make the payback period shorter than the 20-year service life and anticipate a profit in almost the whole area. 3) The areas suitable for photovoltaic power generation are Kawasaki City and Ninomiya-machi. It is necessary to adopt measures to increase the subsidy and install photovoltaic power generating systems in specific places in areas where subsidies are not provided in enough amounts.

Transcervical Interstitial Microwave Ablation Therapy for the Treatment of Adenomyosis: A Novel Alternative to Hysterectomy  [PDF]
Yasushi Kanaoka, Hirosumi Imoto
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.414118
Abstract: Objectives: To investigate the clinical effects of transcervical interstitial microwave irradiation of adenomyotic tissues as an alternative to hysterectomy. Methods: Thirty-three patients who were candidates for hysterectomy for the treatment of adenomyosis associated with menorrhagia were treated by interstitial microwave irradiation using a specifically developed transabdominal ultrasound probe attachment for transcervical puncture along with microwave endometrial ablation, as an alternative to hysterectomy. Primary outcomes were changes in the venous hemoglobin level and the volume of the uterine body before and after treatment. Secondary outcomes were the visual-analogue scale (VAS) score for menorrhagia and dysmenorrhea after treatment. Results: At 3 months after surgery, the average hemoglobin level significantly increased by 4.6 g/dL. The volume of the uterine body significantly decreased to 53% and 52% of the volume before treatment at 3 and 12 months, respectively. VAS scores indicated an improvement in menorrhagia and dysmenorrhea. Conclusions: Transcervical interstitial microwave ablation therapy combined with microwave endometrial ablation reduced the uterine body volume and relieved menorrhagia and dysmenorrheal caused by adenomyosis. This strategy is a promising alternative to hysterectomy for the treatment of symptomatic adenomyosis.
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