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Search Results: 1 - 10 of 210423 matches for " Yasmin N. El Sakhawy "
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Role of Immunostaining in Detecting Extra-Pattern and Subtle Lymphomatous Infiltration in Bone Marrow Biopsies of NHL Patients  [PDF]
Noha Bassiouny Hassan, Yasmin N. El Sakhawy, Gehan M. Hamed
Open Journal of Blood Diseases (OJBD) , 2018, DOI: 10.4236/ojbd.2018.82004
Abstract: Introduction: Immunohistochemistry (IHC) enables the examination of a greater number of trephine biopsy levels and is helpful in determining additional scattered malignant cells. The aim of this study is to detect extra-pattern and subtle lymphomatous infiltration in bone marrow biopsies using CD20 and CD3 immunostaining. Patients and Methods: This study was conducted on 100 newly diagnosed Non Hodgkin Lymphoma (NHL) patients. Their bone marrow trephine biopsies were assessed on routine histology [Hematoxylin and Eosin (H & E)], and were further subjected to IHC using CD20 and CD3. Results: Pattern of involvement by H & E was highlighted by IHC. It showed additional interstitial pattern in 9 cases, parasinusoidal streaks in one case and highlighted a patchy pattern in another case with interstitial involvement on H & E. IHC also detected subtle infiltrations on additional 5.5% cases compared with histology alone. It helped in differentiating reactive (12 cases) and malignant lymphoid infiltration (33 cases). Conclusion: CD20 and CD3 immunostaining performed routinely on bone marrow trephine biopsies has the ability to reveal extra-pattern of infiltration and improve detection of subtle lymphoid involvement. A combined procedure identifying several distinctive features, in particular histotopography and IHC, provides a promising way of discriminating reactive from neoplastic lymphoid infiltrates in bone marrow trephine biopsies.
Immunophenotyping of chronic B-cell neoplasms: flow cytometry versus immunohistochemistry
Afaf Abdel-Aziz Abdel-Ghafar,Manal Ahmed Shams El Din El Telbany,Hanan Mohamed Mahmoud,Yasmin Nabil El-Sakhawy
Hematology Reports , 2012, DOI: 10.4081/hr.2012.e3
Abstract: Morphological differentiation between benign and malignant lymphoproliferative disorders (LPDs) can be challenging. Immunophenotyping (IPT) by either technique, flow cytometry or immunohistochemistry (IHC), is an important step in solving such difficulty. Thirty-five newly diagnosed patients with chronic B-cell neoplasms (11 chronic lymphocytic leukemia, 22 non Hodgkin lymphoma and 2 hairy cell leukemia) were included in this study with age range from 20 to 70 years. Monoclonal antibodies surface expression using lymphoproliferative disorders panel (CD45, CD19, CD5, CD10, CD11c, CD20, CD22, CD23, CD38, CD79b, FMC7, CD103, CD25, kappa and lambda light chains) by flow cytometry was done on bone marrow samples. CD20, CD5, CD23, Bcl-2, Bcl-6, kappa and lambda light chain immunostaining were performed on fixed bone marrow trephine biopsy specimen. The sensitivity of IHC was 81.8% in chronic lymphocytic leukemia (CLL) and 100% in non Hodgkin lymphoma (NHL) as regards CD20, 100% in both groups as regards CD5, 46% in CLL and 66.7% in NHL as regards CD23, 33.3% in CLL and 50% in NHL as regards kappa chain, 20% in CLL and 33.3% in NHL as regards lambda chain. We found that IHC and flow cytometry are equally effective in diagnosing CLL; however, IHC might be slightly more sensitive than flow cytometry in detecting bone marrow infiltration in NHL and hairy cell leukemia (HCL).
Carboxymethyl Cellulose Acetate Butyrate: A Review of the Preparations, Properties, and Applications
Mohamed El-Sakhawy,Samir Kamel,Ahmed Salama,Hebat-Allah Sarhan
Journal of Drug Delivery , 2014, DOI: 10.1155/2014/575969
Abstract: Carboxymethyl cellulose acetate butyrate (CMCAB) has gained increasing importance in several fields, particularly in coating technologies and pharmaceutical research. CMCAB is synthesized by esterification of CMC sodium salt with acetic and butyric anhydrides. CMCAB mixed esters are relatively high molecular weight (MW) thermoplastic polymers with high glass transition temperatures (Tg). CMCAB ester is dispersible in water and soluble in a wide range of organic solvents, allowing varied opportunity to the solvent choice. It makes application of coatings more consistent and defect-free. Its ability to slow down the release rate of highly water-soluble compounds and to increase the dissolution of poorly soluble compounds makes CMCAB a unique and potentially valuable tool in pharmaceutical and amorphous solid dispersions (ASD) formulations. 1. Introduction Cellulose is the most abundant regenerated biopolymer in the planet, with annual production of about 5 × 1011 metric tons. Most of the cellulose is utilized in industry as a raw material in paper production. Only about 4 from 108 million tons of annually produced pulp are used for chemical production [1]. Hydroxyl groups of cellulose can be reacted to form esters or ethers of different physical and chemical properties suitable for various applications [2]. Cellulose derivatives have significant roles in industry; they represent a main source for fibers, textiles, coatings, thermoplastic films, food additives [1], and pharmaceutical technologies [3]. Cellulose derivatives are usually classified as two main classes, esters and ethers, according to the reactant nature. Cellulose derivatives usually contain free hydroxyl groups available for additional treatments to yield mixed esters. The mixed esters have several improved properties over all neat esters. Cellulose acetate propionate (CAP) and cellulose acetate butyrate (CAB) are the most commercially important mixed esters [4]. Mixed cellulose derivatives with both ester and ether groups could be also attained. Due to their low degree of substitution and high hydrolytic stability, carboxymethyl cellulose can be further esterified with organic acid anhydrides to add either single or mixed ester groups [5]. Cellulose esters in coating compositions improved many properties as hardness, aluminum flake orientation, flow and leveling, redissolving resistance, clarity, and gloss while it reduced dry-to-touch time, cratering, and blocking [6–9]. Mixed cellulose derivatives afford the benefits of conventional cellulose esters with a moderate increase in viscosity
Prevalence of Brucellosis in the Sultanate of Oman with Reference to Some Middle-East Countries
Yasmin El Hag El Tahir,Remya R. Nair
Veterinary Research , 2012, DOI: 10.3923/vr.2011.71.76
Abstract: Brucellosis is a worldwide zoonotic disease with special impact on the Middle East including Oman where it is significantly prevalent in Dhofar region. The disease has been reported in most species in the country but surveys and investigations are sporadic. The prevalence of the disease is of particular importance in goats, camels and sheep where higher rates have been reported. In humans, children constitute the most vulnerable sector of the population. The disease is prevalent in neighboring countries in a pattern similar to that in Oman, though some countries in the Middle-East show significantly higher rates. Available data reflect that Oman is at higher risk considering prevalence rates in bordering countries and other regions with higher prevalence. This issue is of special importance due to increasing international agro-economical trade and travel which may lead to a change in the pattern of brucellosis prevalence. A regional strategy would provide timely data and accurate information on prevalence and help in control measures. This review was intended to highlight the need for further investigations on the disease prevalence in view of future agricultural development plans.
Investigation of the Quaternion Dynamical System  [PDF]
Yasmin Omar
Journal of Applied Mathematics and Physics (JAMP) , 2017, DOI: 10.4236/jamp.2017.51014
Abstract: The quaternion Mandelbrot set is one of the most important sets in mathematics. In this paper we first give some properties of the quaternion algebra. Then, we introduce the quternion dynamical system. We are concerned with analytical and numerical investigation of the quaternion dynamical system.
Lack of estrogen receptors expression in malignant and pre-malignant colorectal lesions in Egyptian patients  [PDF]
Mohamed Said, Marwa Khairy, Aly El-Hendawy, Osama A. Khalf, Mohamed S. Abdelbary, Yasmin Saadi, Ayman Yosry
Open Journal of Gastroenterology (OJGas) , 2013, DOI: 10.4236/ojgas.2013.32026

Background: incidence of Colorectal cancer (CRC) is increasing globally. In Egypt, CRC ranks the sixth most common cancer in males and the fifth in females. Aim: To assess the expression of estrogen receptors (alpha and beta) in pre-malignant (adenomatous polyps and IBD), malignant colorectal lesions and normal colonic mucosa in group of Egyptian patients. Methods: This prospective study was done on 45 patients presenting with colonic symptoms, patients were divided into four groups; 15 CRC patients, 10 patients with adenomatous polyps, 10 IBD patients and 10 patients in the control group. Patients subjected to: Stool analysis, FOBT, CBC, CEA, Abdominal ultrasound & colonoscopy and biopsy (number = 80), Pathological, immunohistochemistry and RT- PCR quantification of ERα and ERβ were done. Results: Mean age: 39.2 (12 - 73), gender: M/F: 28/17. Bleeding per rectum was the commonest presentation; 29/45 (64.4%). CEA was significantly elevated in the CRC group compared with other studied groups (1692 mg/L vs. 4.0, 4.0 and 4.4 mg/L). Ultrasonography of the studied patients showed that metastatic CRC: 3/15 (20%); Colonic wall thickening: 5/15 (33.3%), 1/10 showed colonic polypoidal lesions in adenomatous polyps groups, in IBD group: 4/10 (40%) showed colonic and ileocecal thicknening. All the studied patients showed negative results for estrogen receptors (alpha and beta) by the use of immunohistochemistry staining and RT-PCR technique. Conclusion: Role of estrogen receptors in the colonic mucosa, precancerous and colorectal cancer is doubtful, contradictory results with some literature data could be due to racial and genetic difference in the studied population.

Prevalence of occult hepatitis C in egyptian patients with non alcoholic fatty liver disease  [PDF]
Yasmin Saad, Soheir Zakaria, Iman Ramzy, Maissa El Raziky, Olfat Shaker, Wafaa elakel, Mohamed Said, Mona Noseir, Mai El-Daly, Mohamed Abdel Hamid, Gamal Esmat
Open Journal of Internal Medicine (OJIM) , 2011, DOI: 10.4236/ojim.2011.12009
Abstract: This study aim is to assess the prevalence of occult HCV infection among Egyptian patients with non alcoholic fatty liver disease (NAFLD) with elevated AST and ALT, and to correlate presence of occult HCV with severity of liver disease. Patients and Methods: After informed consent 27 patients with elevateed liver enzymes diagnosed as NAFLD were examined for demographic, clinical, laboratory data and Ultrasonography. Liver biopsy was done and tested for HCV RNA in tissue. Genotyping using RFLP analysis of PCR products in the 5’NCR was done for positive cases. Results: HCV RNA in tissue was positive in 11/27 patients (40.7%); genotype was 4a in all positive cases. AST and ALT values showed significantly lower values in occult HCV than the non HCV NAFLD group. Liver biopsy of studied patients showed no significant difference as regard inflammation and fibrosis according to METAVIR score. Conclusions: Occult HCV is highly prevalent among Egyptian NAFLD patients. It seems to induce a mild liver disease. Patients with elevated ALT and negative HCV RNA in sera might be investigated for tissue HCV RNA. Follow up is recommended for the occult HCV patients to monitor progression to overt disease.
Learning-Based Spectrum Sensing for Cognitive Radio Systems
Yasmin Hassan,Mohamed El-Tarhuni,Khaled Assaleh
Journal of Computer Networks and Communications , 2012, DOI: 10.1155/2012/259824
Learning-Based Spectrum Sensing for Cognitive Radio Systems
Yasmin Hassan,Mohamed El-Tarhuni,Khaled Assaleh
Journal of Computer Networks and Communications , 2012, DOI: 10.1155/2012/259824
Abstract: This paper presents a novel pattern recognition approach to spectrum sensing in collaborative cognitive radio systems. In the proposed scheme, discriminative features from the received signal are extracted at each node and used by a classifier at a central node to make a global decision about the availability of spectrum holes for use by the cognitive radio network. Specifically, linear and polynomial classifiers are proposed with energy, cyclostationary, or coherent features. Simulation results in terms of detection and false alarm probabilities of all proposed schemes are presented. It is concluded that cyclostationary-based schemes are the most reliable in terms of detecting primary users in the spectrum, however, at the expense of a longer sensing time compared to coherent based schemes. Results show that the performance is improved by having more users collaborating in providing features to the classifier. It is also shown that, in this spectrum sensing application, a linear classifier has a comparable performance to a second-order polynomial classifier and hence provides a better choice due to its simplicity. Finally, the impact of the observation window on the detection performance is presented. 1. Introduction In the past few years, there have been remarkable developments in wireless communications technology leading to a rapid growth in wireless applications. However, this dramatic increase in wireless applications is severely limited by bandwidth scarcity. Traditionally, fixed spectrum assignments, in which frequency bands are statically assigned to licensed users are employed. The static spectrum allocation prevents from assigning vacant spectrum bands to new users and services. Further, spectrum occupancy measurements have shown that some licensed bands are significantly underutilized. For example, the Spectral Policy Task Force reported that radio channels are typically occupied 15% of the time [1]. Hence, the limitation in the available spectrum bands occurs mainly due the underutilization of available spectrum resulting from the inefficient static allocation techniques. This underutilization of available spectrum resources has led regulatory bodies to urge the development of dynamic spectrum allocation paradigms, called cognitive radio (CR) networks. A CR network senses the operating environment for vacant spectrum opportunities and dynamically utilize the available radio resources [2, 3]. In CR technology, unlicensed (secondary) users are allowed to share the spectrum originally assigned to licensed (primary) users. Hence, frequency
Taxonomic significance of leaf epidermal anatomy of selected Persicaria Mill. species of family Polygonaceae from Pakistan
G Yasmin, MA Khan, N Shaheen, MQ Hayat
African Journal of Biotechnology , 2010,
Abstract: Leaf epidermal anatomy of selected Persicaria Mill. species of the family Polygonaceae revealed variation in size and shape of epidermal cells, stomata, glandular and non glandular trichomes. This study proves to be taxonomically important tool in the delimitation of taxa. Epidermal cell shapes are variable but mostly polygonal. Five different stomatal patterns are reported for Persicaria Mill. Two types of non glandular trichomes are observed only in P. barbata, P. stagnina and P. orientalis which serve as their distinguishing characters. Glandular trichomes are 1, 2 and 4-celled peltate, capitate and spheroidal. Cluster analyses elucidate relationship among different taxa by utilization of leaf epidermal characters.
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