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Search Results: 1 - 10 of 79306 matches for " Yang Zheng "
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The pattern of co-existed posttranslational modifications-A case study  [PDF]
Zheng-Rong Yang
Journal of Biomedical Science and Engineering (JBiSE) , 2009, DOI: 10.4236/jbise.2009.21011
Abstract: Posttranslational modifications are a class of important cellular activities in various bio-chemical processes including signalling trans-duction, gene/metabolite networks, and disease development. It has been found that multiple posttranslational modifications with the same or different modification residues can co-exist in the same protein and this co-occurrence is critical to signalling networks in cells. Although some biological studies have spotted this phe-nomenon, little bioinformatics study has been carried out for understanding its mechanism. Four data sets were downloaded from NCBI for the study. The joint probabilities of any two neighbouring posttranslational modification sites of different modification residues were analyzed. The Bayesian probabilistic network was derived for visualizing the relationship be-tween a target modification and the contributing modifications as the predictive factors.
The Impact of Predation Risk on the Marginal Value of Cash Holdings: An Empirical Perspective  [PDF]
Xinbao Yang, Jiguang Zheng
Journal of Financial Risk Management (JFRM) , 2017, DOI: 10.4236/jfrm.2017.62012
Abstract: As an important external governance mechanism, product market competition has considerable impact on the marginal value of a company’s cash holdings in various aspects. This paper examines the impact of predatory risk on the marginal value of cash holdings in product market by sampling Chinese A-share listed companies from 2000 to 2013. It shows that the predation risk in the product market increases the marginal value of cash holdings by 0.2 Yuan.
Predicting sulfotyrosine sites using the random forest algorithm with significantly improved prediction accuracy
Zheng Yang
BMC Bioinformatics , 2009, DOI: 10.1186/1471-2105-10-361
Abstract: A new approach has been developed for predicting sulfotyrosine sites using the random forest algorithm after a careful evaluation of seven machine learning algorithms. Peptides are formed by consecutive residues symmetrically flanking tyrosine sites. They are then encoded using an amino acid hydrophobicity scale. This new approach has increased the sensitivity by 22%, the specificity by 3%, and the total prediction accuracy by 10% compared with the previous predictor using the same blind data. Meanwhile, both negative and positive predictive powers have been increased by 9%. In addition, the random forest model has an excellent feature for ranking the residues flanking tyrosine sites, hence providing more information for further investigating the tyrosine sulfation mechanism. A web tool has been implemented at http://ecsb.ex.ac.uk/sulfotyrosine webcite for public use.The random forest algorithm is able to deliver a better model compared with the Hidden Markov Model, the support vector machine, artificial neural networks, and others for predicting sulfotyrosine sites. The success shows that the random forest algorithm together with an amino acid hydrophobicity scale encoding can be a good candidate for peptide classification.Tyrosine sulfation is a posttranslational modification (PTM), which introduces a sulfate group to a tyrosine residue in a protein [1-3]. During the modification process, sulfation is catalysed by tyrosylprotein sulfotransferase [4]. A targeted tyrosine for sulfation is normally required to be exposed on a protein surface [5]. Previous studies have indicated that Sulfation is an important anticipator for extracellular protein-protein interactions [6,7]. Studies have shown that sulfation is related to various diseases when a malfunction of a cellular activity occurs. For instance, sulfotyrosine can alter the affinity in some chemokine receptors leading to a downstream signalling cascade which affects the cells involved in acute and chronic events o
Sequencing, annotation, and comparative analysis of nine BACs of the giant panda (Ailuropoda melanoleuca)
Yang Zheng
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-010-9999-3
Abstract:
Influence of sampling on face measuring system based on composite structured light  [PDF]
Yang Shen, Hai-Rong Zheng
Journal of Biomedical Science and Engineering (JBiSE) , 2009, DOI: 10.4236/jbise.2009.28087
Abstract: Human face can be rebuilt to a three-dimensional (3 D) digital profile based on an optical 3D sensing system named Composite Fourier-Transform Profilometry (CFTP) where a composite structured light will be used. To study the sampling effect during the digitization process in practical CFTP, the pectinate function and convolution theorem were introduced to discuss the potential phase errors caused by sampling the composite pattern along two orthogonal directions. The selecting criterions of sampling frequencies are derived and the results indicate that to avoid spectral aliasing, the sampling frequency along the phrase variation direction must be at least four times as the baseband and along the orthogonal direction it must be at least three times as the larger frequency of the two carrier frequencies. The practical experiment of a model face reconstruction verified the theories.
Qualities Required for Civil Engineering Students from a Project Accident  [PDF]
Jingshu Zhang, Yuanlong Yang, Fangmeng Zheng
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B043
Abstract:

Civil engineering educational circles have always been focusing on the professional qualities and cultivation of civil engineering students, which is also problems in civil engineering teaching. In the beginning of professional course teaching, the author introduced an real project accident and specially emphasized that responsibility, teamwork, seriousness, carefulness, comprehensively applying of knowledge, working in accordance with codes are considered as quality requirements of civil engineering students. This teaching thought is carried out through the whole teaching process, which brings deep impression to students and good teaching effect. The teaching thought is introduced in this paper.

Combining Gene-Phenotype Association Matrix with KEGG Pathways to Mine Gene Modules Using Data Set in GAW17  [PDF]
Hua Lin, Yang Zheng, Ping Zhou
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B067
Abstract:

Currently, genome-wide association studies have been proved to be a powerful approach to identify risk loci. However, the molecular regulatory mechanisms of complex diseases are still not clearly understood. It is therefore important to consider the interplay between genetic factors and biological networks in elucidating the mechanisms of complex disease pathogenesis. In this paper, we first conducted a genome-wide association analysis by using the SNP genotype data and phenotype data provided by Genetic Analysis Workshop 17, in order to filter significant SNPs associated with the diseases. Second, we conducted a bioinformatics analysis of gene-phenotype association matrix to identify gene modules (biclusters). Third, we performed a KEGG enrichment test of genes involved in biclusters to find evidence to support their functional consensus. This method can be used for better understanding complex diseases.

Some Advances in the Application of Weathering and Cold-Formed Steel in Transmission Tower  [PDF]
Fengli Yang, Junke Han, Jingbo Yang, Zheng Li
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2009, DOI: 10.4236/jemaa.2009.11005
Abstract: Application of weathering and cold-formed steel in transmission lines can reduce steel consumption and environmental pollution. Some advances in the studies on the weathering and cold-formed steel in transmission tower are introduced. Firstly, corrosion-resistant tests of weathering steel samples under different simulating technical atmospheres were carried out separately for 240 hours. It shows that the corrosion degree of joint samples is higher than that of single chip samples, and the corrosion-resistant performance of weathering steel is superior to common carbon steel. The corrosion-resistance of weathering steel meets with the requirement of transmission tower. Secondly, experiments and finite element analysis for cold-formed angles and a 220kV prototype tower were completed, and the stability coeffi-cient fitting curves as well as the modification formulas of slenderness ratio for cold-formed members were determined. According to the structural characteristics of transmission towers, four sections of cold-formed angles with different sections and slenderness ratios were selected in this study. The finite element model well predicted the buckling behav-iour of the cold-formed members. Ultimate loads calculating by the fitting curve were well agreed to the experimental values, especially for the members with small slenderness ratios. Weight of the cold-formed steel tower can be reduced by more than 5 percent after considering the strength enhancement. Cost of the weathering and cold-formed steel transmission tower is nearly equivalent to that of hot-rolled steel tower with hot galvanizing.
Intervention-point principle of meshless method
JianJun Yang,JianLong Zheng
Chinese Science Bulletin , 2013, DOI: 10.1007/s11434-012-5471-x
Abstract: Meshless method is a type of promising numerical approach. But for the method, the convergence is still lack of common theoretical explanations, and the technique of numerical implementation also remains to be improved. It is worth noting that a kind of uniformly defined intervention point is used in many existing schemes. Therefore, the intervention-point principle is proposed. The viewpoint is likely to give a reasonable explanation for the inaccuracy and instability of the collocation method. Based on the principle, a design process for a new scheme was demonstrated. Some initial numerical tests were also offered. The results have revealed the intervention point to take effect on convergence, suggested a construction concept using intervention point for meshless collocation method, and presented a new scheme of meshless method for application.
An improved method for measuring the stability of a three-state unfolding protein
XiaoYan Zheng,BinSheng Yang
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-010-4242-9
Abstract: In the current three-state protein unfolding model, the two transitions are considered to be independent and each transition is fitted to a two-state unfolding model. This three-state unfolding process is therefore composed of two sequential two-state unfolding processes. In this paper, a modified method is presented to determine the value of the unfolding free energy [δG total 0 (H2O)] for the three-state unfolding equilibrium of proteins. This method is demonstrated on the apoCopC protein mutant, Y79W-W83F-Cu, which unfolds via a three-state process. The value of ΔG total 0 (H2O) calculated using the modified method was found to be more accurate in determining ΔG total 0 (H2O) than the previously reported method.
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