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Search Results: 1 - 10 of 146326 matches for " Yan-Hsiung Wang "
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Effect of Low Level Laser Therapy on Chronic Compression of the Dorsal Root Ganglion
Yi-Jen Chen, Yan-Hsiung Wang, Chau-Zen Wang, Mei-Ling Ho, Po-Lin Kuo, Mao-Hsiung Huang, Chia-Hsin Chen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089894
Abstract: Dorsal root ganglia (DRG) are vulnerable to physical injury of the intervertebral foramen, and chronic compression of the DRG (CCD) an result in nerve root damage with persistent morbidity. The purpose of this study was to evaluate the effects of low level laser therapy (LLLT) on the DRG in a CCD model and to determine the mechanisms underlying these effects. CCD rats had L-shaped stainless-steel rods inserted into the fourth and fifth lumbar intervertebral foramen, and the rats were then subjected to 0 or 8 J/cm2 LLLT for 8 consecutive days following CCD surgery. Pain and heat stimuli were applied to test for hyperalgesia following CCD. The levels of TNF-α, IL-1β and growth-associated protein-43 (GAP-43) messenger RNA (mRNA) expression were measured via real-time PCR, and protein expression levels were analyzed through immunohistochemical analyses. Our data indicate that LLLT significantly decreased the tolerable sensitivity to pain and heat stimuli in the CCD groups. The expression levels of the pro-inflammatory cytokines TNF-α and IL-1β were increased following CCD, and we found that these increases could be reduced by the application of LLLT. Furthermore, the expression of GAP-43 was enhanced by LLLT. In conclusion, LLLT was able to enhance neural regeneration in rats following CCD and improve rat ambulatory behavior. The therapeutic effects of LLLT on the DRG during CCD may be exerted through suppression of the inflammatory response and induction of neuronal repair genes. These results suggest potential clinical applications for LLLT in the treatment of compression-induced neuronal disorders.
Low-Power GaAlAs Laser Irradiation Promotes the Proliferation and Osteogenic Differentiation of Stem Cells via IGF1 and BMP2
Jyun-Yi Wu, Yan-Hsiung Wang, Gwo-Jaw Wang, Mei-Ling Ho, Chau-Zen Wang, Ming-Long Yeh, Chia-Hsin Chen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044027
Abstract: Low-power laser irradiation (LPLI) has been found to induce various biological effects and cellular processes. Also, LPLI has been shown to promote fracture repair. Until now, it has been unclear how LPLI promotes bone formation and fracture healing. The aim of this study was to investigate the potential mechanism of LPLI-mediated enhancement of bone formation using mouse bone marrow mesenchymal stem cells (D1 cells). D1 cells were irradiated daily with a gallium-aluminum-arsenide (GaAlAs) laser at dose of 0, 1, 2, or 4 J/cm2. The lactate dehydrogenase (LDH) assay showed no cytotoxic effects of LPLI on D1 cells, and instead, LPLI at 4 J/cm2 significantly promoted D1 cell proliferation. LPLI also enhanced osteogenic differentiation in a dose-dependent manner and moderately increased expression of osteogenic markers. The neutralization experiments indicated that LPLI regulated insulin-like growth factor 1 (IGF1) and bone morphogenetic protein 2 (BMP2) signaling to promote cell proliferation and/or osteogenic differentiation. In conclusion, our study suggests that LPLI may induce IGF1 expression to promote both the proliferation and osteogenic differentiation of D1 cells, whereas it may induce BMP2 expression primarily to enhance osteogenic differentiation.
Low-Power Laser Irradiation Suppresses Inflammatory Response of Human Adipose-Derived Stem Cells by Modulating Intracellular Cyclic AMP Level and NF-κB Activity
Jyun-Yi Wu, Chia-Hsin Chen, Chau-Zen Wang, Mei-Ling Ho, Ming-Long Yeh, Yan-Hsiung Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054067
Abstract: Mesenchymal stem cell (MSC)-based tissue regeneration is a promising therapeutic strategy for treating damaged tissues. However, the inflammatory microenvironment that exists at a local injury site might restrict reconstruction. Low-power laser irradiation (LPLI) has been widely applied to retard the inflammatory reaction. The purpose of this study was to investigate the anti-inflammatory effect of LPLI on human adipose-derived stem cells (hADSCs) in an inflammatory environment. We showed that the hADSCs expressed Toll-like Receptors (TLR) 1, TLR2, TLR3, TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly induced the production of pro-inflammatory cytokines (Cyclooxygenase-2 (Cox-2), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Interleukin-8 (IL-8)). LPLI markedly inhibited LPS-induced, pro-inflammatory cytokine expression at an optimal dose of 8 J/cm2. The inhibitory effect triggered by LPLI might occur through an increase in the intracellular level of cyclic AMP (cAMP), which acts to down-regulate nuclear factor kappa B (NF-κB) transcriptional activity. These data collectively provide insight for further investigations of the potential application of anti-inflammatory treatment followed by stem cell therapy.
Species and global change-assessing the extinction point of albacore stocks  [PDF]
Chien-Hsiung Wang, Shyh-Bin Wang
Natural Science (NS) , 2012, DOI: 10.4236/ns.2012.47057
Abstract: Global change determines the environmental condition and leads to decide the carrying capacity. While carrying capacity determines the extinction of the species, it is an important issue to estimate the extinction point of the species, the minimal carrying capacity, or the tolerant limitation of the species. If it is possible to estimate the tolerant limitation of the species, it will be possible to control the global change. Applied the above idea to the albacore stocks, it revealed that extinction point was about 0.0018% of the present status. From these results, it implies that this method may also suitable to other species for estimating their carrying capacities.
Remarks on the Optimal Probing Lot Size for Probing the Semiconductor Wafers
Chih-Hsiung Wang
Lecture Notes in Engineering and Computer Science , 2008,
An Overview on the Team Interaction Process  [PDF]
Yan Wang
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.612001
Abstract: Team interaction process contains three stages: input, process and output. The effectiveness of team interaction is the decisive factor of team competition. Nowadays, many scholars study on team interaction process based on a particular view, but few scholars put up with an overview on the whole team interaction process research results. Based on the predecessors’ researches and centered on the team interaction process, this paper outlines the three stages and its elements, the influence to team performance and measurements of team interaction. This paper also puts forward some prospects finally.
The Relationship between the Management Intervention of Venture Capital Institutions and the Performance of Start-Up Enterprises  [PDF]
Yan Wang
Modern Economy (ME) , 2019, DOI: 10.4236/me.2019.103045
Abstract: Based on the two theoretical hypotheses of “screening theory” and “cultivation theory”, this paper reviews the concepts and motivations of venture capital institutions’ management intervention, and summarizes the two modes of venture capital institution management intervention: supervisory control intervention and operational management intervention. Based on two management intervention modes, this paper divides the management involvement into three levels: no management intervention, moderate management intervention, and deep management intervention. This paper systematically analyzes the influence mechanism of the two management intervention modes and the degree of involvement on the performance of venture enterprises, and constructs a comprehensive theoretical framework of venture capital and entrepreneurial enterprise performance, which provides theoretical support and research direction for follow-up research.
POINeT: protein interactome with sub-network analysis and hub prioritization
Sheng-An Lee, Chen-Hsiung Chan, Tzu-Chi Chen, Chia-Ying Yang, Kuo-Chuan Huang, Chi-Hung Tsai, Jin-Mei Lai, Feng-Sheng Wang, Cheng-Yan Kao, Chi-Ying F Huang
BMC Bioinformatics , 2009, DOI: 10.1186/1471-2105-10-114
Abstract: We have constructed an integrated web service, POINeT, to simplify the process of PPI searching, analysis, and visualization. POINeT merges PPI and tissue-specific expression data from multiple resources. The tissue-specific PPIs and the numbers of research papers supporting the PPIs can be filtered with user-adjustable threshold values and are dynamically updated in the viewer. The network constructed in POINeT can be readily analyzed with, for example, the built-in centrality calculation module and an integrated network viewer. Nodes in global networks can also be ranked and filtered using various network analysis formulas, i.e., centralities. To prioritize the sub-network, we developed a ranking filtered method (S3) to uncover potential novel mediators in the midbody network. Several examples are provided to illustrate the functionality of POINeT. The network constructed from four schizophrenia risk markers suggests that EXOC4 might be a novel marker for this disease. Finally, a liver-specific PPI network has been filtered with adult and fetal liver expression profiles.The functionalities provided by POINeT are highly improved compared to previous version of POINT. POINeT enables the identification and ranking of potential novel genes involved in a sub-network. Combining with tissue-specific gene expression profiles, PPIs specific to selected tissues can be revealed. The straightforward interface of POINeT makes PPI search and analysis just a few clicks away. The modular design permits further functional enhancement without hampering the simplicity. POINeT is available at http://poinet.bioinformatics.tw/ webcite.Protein-protein interactions (PPIs) are critical for virtually every biological process. Diverse experimental techniques for detecting PPIs have been developed and have improved dramatically in the last decade, i.e., yeast two hybrid (Y2H), affinity chromatography, co-immunoprecipitation (Co-IP), and fluorescence resonance energy transfer (FRET) [1,2]. Ad
A Measure to Fight China’s Worsening Income Distribution  [PDF]
Hsiung Bingyuan
Chinese Studies (ChnStd) , 2013, DOI: 10.4236/chnstd.2013.22013
Abstract: China’s income distribution has worsened along with its rapid economic development. It is suggested that the government issues an ID card with a chip and store money in the chip as calculated by a formula based on tax revenues. People can use the money stored for consumption. The measure is likely to prove an effective tool in bringing about a direct and immediate improvement in income distribution.
A Novel Multifunction CFOA-Based Inverse Filter  [PDF]
Hung-Yu Wang, Sheng-Hsiung Chang, Tzu-Yi Yang, Po-Yang Tsai
Circuits and Systems (CS) , 2011, DOI: 10.4236/cs.2011.21003
Abstract: We present a novel multifunction inverse biquad configuration based on current feedback operational amplifiers (CFOAs) and grounded passive elements. The proposed scheme can be used to realize inverse lowpass, inverse bandpass and inverse highpass filter functions. The relevant coefficients of the inverse filters are orthogonal adjustable by independent passive elements. All the passive elements in the proposed scheme are grounded to benefit easier electronic tunability. With the high input impedance and low output impedance properties, the scheme is input and output cascadable for voltage operation. The feasibility of the proposed scheme is demonstrated by HSPICE simulations.
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