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Search Results: 1 - 10 of 42026 matches for " YI Gen-yun "
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Risk factors for alcohol-related liver injury in the island population of China: A population-based case-control study
Zhe Shen, You-Ming Li, Chao-Hui Yu, Yi Shen, Lei Xu, Cheng-Fu Xu, Jin-Jin Chen, Hua Ye, Gen-Yun Xu
World Journal of Gastroenterology , 2008,
Abstract: AIM: To investigate the association of alcohol dose, duration of drinking and obesity with abnormal alcohol-related liver injury indicators, the prevalence of alcohol-related liver injury in the island population of China.METHODS: Randomized multistage stratified cluster sampling from the island population of China was used in the population-based case-control study. Then interview, physical examination, laboratory assessments and ultrasonography were done.RESULTS: Daily alcohol intake ≥ 20 g, duration of drinking ≥ 5 years and obesity were closely related to alcohol-related liver injury (P < 0.05). The odds-ratio (OR) (95% CI) was 1.965 (1.122-3.442), 3.412 (1.789-6.507) and 1.887 (1.261-2.824), respectively. The prevalence rate of alcohol-related liver injury in ≥ 20 g daily alcohol intake group and < 20 g daily alcohol intake group was 37.14% and 12.06%, respectively. The prevalence rate of alcohol-related liver injury in ≥ 5 years drinking group and < 5 years drinking group was 34.44% and 8.53%, respectively. No significant dose-response relation was found between daily alcohol intake and abnormal alcohol-related liver injury indicators as well as between duration of drinking and abnormal alcohol-related liver injury indicators. There was no significant difference in the prevalence of alcohol-related liver injury between beer drinking group and yellow rice wine drinking group, hard liquor drinking group, multiple drinking group.CONCLUSION: The risk threshold of daily alcohol intake is 20 g and duration of drinking inducing alcohol-related liver injury 5 years in the island population of China. Liver injury induced by obesity should be concerned.
牙周炎与冠心病之间联系机制的研究进展
Research Progress on the Link Mechanism between Periodontitis and Coronary Heart Disease.

李爽, 易根云, 李志强, 周建业
LI Shuang
, YI Gen-yun, LI Zhi-qiang, ZHOU Jian-ye.

- , 2017, DOI: 10.13701/j.cnki.kqyxyj.2017.04.027
Abstract: 摘要 牙周炎已成为成人失牙的首要原因,调查显示全球约有44%~57%和10%的成人患有中度和重度牙周炎。而冠状动脉粥样硬化性心脏病(CHD)是临床上死亡率较高的疾病之一,严重危害着人类健康,其主要病理学基础是动脉粥样硬化(AS)和在斑块破裂基础上形成的血栓。牙周炎和冠心病之间存在着一定的联系,牙周致病菌通过直接作用定植在冠状动脉;通过间接作用产生各种细胞因子、黏附分子,引起全身炎症状态、脂质异常和凝血状态;激活固有免疫系统,分别形成生物性炎症、化学性炎症、免疫性炎症,最终形成和加重动脉粥样硬化,继而形成冠心病。本文旨在对牙周炎与冠心病之间联系机制的研究进展作一综述
枯草芽孢杆菌TLO3的全基因组测序及与枯草芽孢杆菌168和XF-1的比较基因组学研究
Whole Genome Sequence of Bacillus Subtilis TLO3 and Comparative Genomics Analysis among That Strain, B.subtilis 168 and B.subtilis XF-1

张小凤, 黄慧敏, 易根云, 吴生荣, 周建业, 李志强, 包广洁
ZHANG Xiao-feng
, HUANG Hui-min, YI Gen-yun, WU Sheng-rong, ZHOU Jian-ye, LI Zhi-qiang, BAO Guang-jie

- , 2018, DOI: 10.13701/j.cnki.kqyxyj.2018.06.007
Abstract: 摘要 目的:为了解枯草芽孢杆菌 TLO3的全基因组及分子生物学功能。方法:通过三代联合二代测序技术对枯草芽孢杆菌TLO3进行全基因组测序并使用相关软件对其进行基因组组装、基因预测与功能注释;并与B.subtilis168及XF-1进行比较基因组学分析。结果:枯草芽孢杆菌TLO3全基因组由1条环状染色体和质粒组成;比较基因组研究发现TLO3在细胞复制、重组和修复等过程的基因数量明显高于XF-1和168,抗菌基因簇与XF-1相似。结论:枯草芽孢杆菌TLO3在具有抗菌性的同时,还有更强的生存能力,可能更好地适应口腔复杂环境
慢性牙周炎患者血清中TGF-β各亚型的定量分析
Quantitative Analysis of Serum TGF-β Isoforms in Chronic Periodontitis Patients.

李爽, 孟晓雪, 周建业, 易根云, 黄慧敏, 张小凤, 李志强, 余占海
LI Shuang
, MENG Xiao-Xue , ZHOU Jian-Ye, YI Gen-Yun , HUANG Hui-Min, ZHANG Xiao-Feng, LI Zhi-Qiang, YU ZHAN Hai.

- , 2017, DOI: 10.13701/j.cnki.kqyxyj.2017.06.010
Abstract: 摘要 目的:检测慢性牙周炎患者血清中TGF-β各亚型(TGF-β1、TGF-β2、TGF-β3)的表达差异,探讨三者在慢性牙周炎中的作用。方法:研究对象分为中度牙周炎组(n=9)、重度牙周炎组(n=18)和健康对照组(n=19),基于Lumninex 200多重分析仪对其血清进行定量分析。结果:对照组血清中TGF-β1浓度(41053.26±8318.65) ng/L及TGF-β3浓度(2454.58±552.73) ng/L含量水平均高于中度牙周炎组分别为(32112.22±7153.87) ng/L,P<0.01;(1991.11±532.22) ng/L,P<0.05)和重度牙周炎组分别为(30652.89±8245.31) ng/L,P<0.01;(1829.17±483.68) ng/L,P<0.01);TGF-β1和TGF-β3分别与CAL、PD、BOP、PLI呈明显负相关;TGF-β1与TGF-β3呈明显正相关。结论:血清中浓度较高的TGF-β1可能对慢性牙周炎的发生发展起一定的抑制作用,而TGF-β3不仅对慢性牙周炎的发生发展起一定的抑制作用而且可能与TGF-β1存在协同作用
牙周健康状况和民族因素对口腔微生物多样性的协同作用
Co-effects of Ethnicity and Periodontal Health Status on Oral Microbiome Diversity.

马瑞, 施文, 易根云, 张小凤, 黄慧敏, 周建业, 余占海, 李志强
MA Rui
, SHI Wen, YI Gen-yun, ZHANG Xiao-feng, HUANG Hui-min, ZHOU Jian-ye, YU Zhan-hai, LI Zhi-qiang.

- , 2017, DOI: 10.13701/j.cnki.kqyxyj.2017.07.014
Abstract: 摘要 目的:通过高通量测序探寻牙周健康状况和民族对口腔微生物多样性产生的影响。方法:采集12名牙周炎患者(5名汉族和7名裕固族)和10名健康者(5名汉族和5名裕固族)的唾液,提取细菌总DNA,用Illumina MiSeq高通量测序平台对16S rRNA基因序列进行测序分析。结果:在UniFrac距离总变化中,牙周因素在未加权分析中有差异(P=0.02),民族因素在加权分析中有差异(P=0.03),两种因素的相互作用在加权和未加权分析中均有差异(P<0.05)。结论:牙周健康状况及民族因素对口腔微生物多样性均有影响作用,并可能存在协同作用,但牙周健康状况是引起细菌组成变化的主要因素
Relational analysis of leaf characteristics and photosynthetic capacities of plants
植物叶片特征与光合性能的关系

CHENG Jian-Feng,CHEN Gen-Yun,SHEN Yun-Gang,
程建峰
,陈根云,沈允钢

中国生态农业学报 , 2012,
Abstract: Southeast-facing matured leaves of five plants Viburnum odoratissimum (VO), Ginkgo biloba (GB), Oxalis triangularis cv Purpurea (OTP), Ficus elastica cv. Decora Burgundyi (FEDB) and Morus alba (MA)] were used to determine the characteristics and photosynthetic capacities of plant leaves in sunny days. The Li-Cor 6400 Portable Photosynthesis Measuring System, Modulated Chlorophyll Fluorescence System (IMAGING-PAM M-Series), Dual-PAM-100 Measuring System and conventional methods were used to analyze the relationships among leaf characteristics and photosynthetic capacities. The results showed significant differences (P < 0.05 or P < 0.01) in leaf characteristics and photosynthetic capacities among different plants. Differences in specific leaf dry weight 35~215 g (DW)·m-2] among plants were higher than those in specific leaf fresh weight 0.28~1.04 kg (FW)·m-2]. Leaf chloroplast pigment contents chlorophyll a (Chla), chlorophyll b (Chlb), total chlorophyll (Chl) and carotenoid (Xc)] of MA and VO were the highest, followed by GB and FEDB and those of OTP were the lowest. While anthocyanin (Ant) content of OTP was maximum for 0.122 mg·g-1(FW) and 0.488 mg·g-1(DW), those of the others plants were low and similar. While OTP leaf Chla/Chlb (6.27), MA leaf Chl/Xc (9.97), MA leaf Chl/Ant (43.81) and VO leaf Xc/Ant (7.17) were the highest, OTP leaf Chl/Ant (0.49) and Xc/Ant (2.46) were the lowest. The orders of stomata conduction, transpiration rate, intercellular CO2 concentration and net photosynthetic rate (Pn) of the plants were MA > GB > OTP > VO > FEDB. MA and VO leaf practical quantum PSII Y(II)] was the highest and that of GB was low. Although MA, OTP and FEDB PSI were high, MA and FEDB PSI photo-protection was weak and that of OTP strong. Correlation analysis indicated that the effects of Ant and Xc on Pn were insignificant. Also stomata characteristics and chlorophyll content positively regulated P>/i>n. Y(II) mainly depended on chloroplast pigment content (especially Chla) and the relationship between Y(I) and Chl/Xc was positive. Leaf stomata opening and chlorophyll content negatively regulated PSII and PSI photo-protection. It, however, positively regulated PSII photo-damage. The effect of Xc was the exact reverse of that of Chl.
A Ship Detection Method in SAR Image Based on Gravity Enhancement
基于引力场增强的SAR图像舰船检测方法研究

TIAN Si-rui,SUN Gen-yun,WANG Chao,ZHANG Hong,
田巳睿
,孙根云,王超,张红

遥感学报 , 2007,
Abstract: Automatic ship detection with SAR imagery is one of the important applications with SAR data,and it is widely used in many areas,such as fishery monitoring,environment protection,coastal security and military application.A large amount of ship targets detection researches using SAR data have been conducted since 1980s,and many detection techniques have been proposed.However,most of the traditional ship detection methods can be affected by the SAR speckle and background clutter,and many false alarms may be introduced in the detection results.To improve the ship detection capability,a new ship detection method,which is based on the gravity enhancement,is proposed in this paper.Initially,the targets pixels are enhanced by the interactions between themselves and their neighbors,and it is proved that SAR speckle and background clutter will be suppressed after the enhancement as well as the contrasts between targets and clutter have been greatly increased.Then,as the enhanced SAR imagery may not satisfy the homogenous hypothesis,an improved K-CFAR detector based on an adaptive segmentation algorithm is applied to the enhance imagery.The adaptive segmentation algorithm segments the whole marine area into a series of homogenous sub-images by the homogenous test,and the improved K-CFAR detector,which can adaptively choose probability density function(pdf),will be applied to each sub-image to detect the ship targets.Finally,some Radarsat-1 data and Envisat ASAR data are used to validate the algorithm mentioned in this paper.Experimental results demonstrate that the ship detection algorithm based on gravity enhancement can effectively enhance ship targets as well as suppress speckle and clutter,therefore,detection rate will be increased and the false alarm rate will be reduced.
GIS-based automatic extracting isohyets of the sandbar at the Yellow River estuary
基于GIS黄河口拦门沙区域水深线的自动提取

HUANG Bing-hu,YANG Xiao-yang,ZHAO Jian,SUN Gen-yun,
黄丙湖
,杨晓阳,赵健,孙根云

海洋科学 , 2010,
Abstract: In order to interpolate monitoring points and to extract isohyets automatically, we analyzed isohyets extraction steps and the main idea based on ArcGIS Engine, and realized isohyets extraction of the Yellow River estuary Sandbar and applied it in the Yellow River estuary geographic information system.
The Reduced Plastid-Encoded Polymerase-Dependent Plastid Gene Expression Leads to the Delayed Greening of the Arabidopsis fln2 Mutant
Chao Huang, Qing-Bo Yu, Ruo-Hong Lv, Qian-Qian Yin, Gen-Yun Chen, Ling Xu, Zhong-Nan Yang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073092
Abstract: In Arabidopsis leaf coloration mutants, the delayed greening phenomenon is common. Nonetheless, the mechanism remains largely elusive. Here, a delayed greening mutant fln2–4 of FLN2 (Fructokinase-Like Protein2) was studied. FLN2 is one component of Transcriptionally Active Chromosome (TAC) complex which is thought to contain the complete plastid-encoded polymerase (PEP). fln2–4 displayed albino phenotype on medium without sucrose. The PEP-dependent plastid gene expression and chloroplast development were inhibited in fln2–4. Besides interacting with thioredoxin z (TRX z), we identified that FLN2 interacted with another two members of TAC complex in yeast including its homologous protein FLN1 (Fructokinase-Like Protein1) and pTAC5. This indicates that FLN2 functions in regulation of PEP activity associated with these TAC components. fln2–4 exhibited delayed greening on sucrose-containing medium. Comparison of the PEP-dependent gene expression among two complete albino mutants (trx z and ptac14), two yellow mutants (ecb2–2 and ys1) and the fln2–4 showed that fln2–4 remains partial PEP activity. FLN2 and FLN1 are the target proteins of TRX z involved in affecting the PEP activity. Together with the data that FLN1 could interact with itself in yeast, FLN1 may form a homodimer to replace FLN1–FLN2 as the TRX z target in redox pathway for maintaining partial PEP activity in fln2–4. We proposed the partial PEP activity in the fln2 mutant allowed plastids to develop into fully functional chloroplasts when exogenous sucrose was supplied, and finally the mutants exhibited green phenotype.
Application of catastrophe progression method in ecological suitability assessment: A case study on Zhenjiang new area
突变级数法在生态适宜度评价中的应用——以镇江新区为例

CHEN Yun-Feng,SUN Dian-Yi,LU Gen-Fa,
陈云峰
,孙殿义,陆根法

生态学报 , 2006,
Abstract: Ecological suitability assessment has been listed as a important part of content in regional environmental impact assessment according to (HJ/T2003), which only requires to set up three-hierarchy indicators system but without appointed approaches to integrate these indicators. In current practice, several approaches have been attempted to apply, such as arranging and comparison technology, analytic hierarchy process and fussy evaluation. However, due to the subjectivity in weight evaluation, these approaches are afraid of the objectivity of their results. Catastrophe progression method is an approach dealing with multiple indicators integration, which is suitable for the complex system decision because of its simpleness and objectiveness. With a case study on Zhenjiang New Area, the basic principle for catastrophe progression method and its applying steps in ecological suitability assessment are introduced in this paper. The case study shows the applicability of catastrophe progression method in ecological suitability assessment. What is more important, through analyzing and contrasting the mathematical essence of the three above-mentioned approaches, catastrophe progression method demonstrates obvious comparative advantages of two following respects mainly: on one hand, it does not use any weight, only need to arrange indicators in an order of important degree according to the inherent logic relationship among indicators, this avoids making the subjectivity of the artificial weight evaluation in very large limit; on the other hand, as a technological approach that combine qualitative analysis and quantitative analysis together, catastrophe progression method is not only suitable to judge whether a piece of land is suitable for its using patterns, but also provide models to calculate out the concrete number value of ecological suitability, and help to carry on the quantitative contrast of ecological suitability among different pieces of land. However, what should be pointed out objectively is, in the course of arranging indicators in the order of important degree and hierarchizing indicators, the artificial subjectivity in catastrophe progression method can't be avoided completely, so it would be necessary to combine other technological approaches to improve the future application of catastrophe progression method in ecological suitability assessment.
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