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Search Results: 1 - 10 of 50517 matches for " Y Tabardel "
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Corticosteroids reduce neuron-specific-enolase liberation after cardiopulmonary bypass in men
D Schmartz, Y Tabardel, L Barvais, A d'Hollander, JM De Smet, J Duchateau
Critical Care , 2000, DOI: 10.1186/cc685
Abstract: After institutional approval, 45 patients scheduled for nonemergency coronary artery bypass grafting (CABG) with CPB were divided into four groups: the control group (CTRL; n = 17) received no corticosteroids; the DXM group (n = 7) received 2 mg/kg dexamethasone; and the MPS10 group (n = 14) received 10 mg/kg and the MPS30 (n = 7) group received 30 mg/kg methylprednisolone intravenously 2 h before surgery. CPB was conducted under moderate hypothermia (29-30 °C) using a cold crystalloid cardioplegia and a nonpulsatile flow. Anaesthesia consisted of a continuous infusion of sufentanil, midazolam and pancuronium. No aprotinin was used. We measured NSE levels before induction of anaesthesia and 4 h after CPB. For each patient we calculated the change in NSE concentration as follows: NSE (at 4 h)-NSE (baseline). We also measured tumor necrosis factor (TNF) and interleukin (IL)-8 at the same time. There were no differences between the groups regarding age, duration of CPB, aortic cross-clamping time or number of grafts.The CTRL group showed a significant increase in NSE after CPB, whereas in all three corticosteroid groups NSE was significantly lower (Fig. 1).TNF and IL-8 liberation were significantly and equally reduced in all three treatment groups. This suppression of the inflammatory response might lead to less neutrophil adhesion and migration, resulting in less tissue damage by proteolytic enzymes and oxygen-free radicals.Corticosteroids, even at moderate doses, are able to reduce the amount of NSE liberation during CPB. This may indicate less brain injury during CPB. Whether this reduction in NSE liberation translates into improved neurological outcome remains to be studied.
Aprotinin does not influence the inflammatory reaction to cardiopulmonary bypass in humans
D Schmartz, Y Tabardel, JC Preiser, L Barvais, A d'Hollander, J Duchateau, JL Leclerc, JL Vincent
Critical Care , 1999, DOI: 10.1186/cc321
Abstract: After institutional approval and written informed consent, 60 male patients, scheduled for primary coronary artery bypass grafting, were enrolled in this prospective double-blinded study. The patients were randomized into three groups: Group high dose aprotinin (HD) received 2 × 106 KIU followed by 0.5 × 106 KIU/h and 2 × 106 KIU added to the pump prime; group low dose (LD) received half that dose and the control group (CTRL) received no aprotinin. No corticosteroids were given. Anesthesia consisted of a high dose sufentanil infusion. The CPB circuit was primed with gelatin and the flow rate was maintained at 2.4 l/min/m2 using a non-pulsatile flow. An anterograde, cold, crystalloid cardioplegic solution was used and mild hypothermia (30°C) was maintained during CPB. We measured tumor necrosis factor (TNF), interleukin 6, 8, 10 (IL6, IL8, IL10), endotoxin, prekallikrein, and prostaglandin D2 (PGD2) at the following time points: 30 min after study drug loading, 10min after beginning of CPB, before end of CPB, 4h after CPB, 1st postoperative day (POD1) and 2nd postoperative day (POD2). Data were analyzed using an analysis of variance for repeated measurements after logarithmic transformation to achieve normalization. There was no significant difference between groups in number of anastomosis, duration of CPB and aortic clamping. All three groups showed a significant inflammatory reaction characterized by an increase of TNF up to 46 pg/ml, IL6 up to 600 pg/ml, IL8 up to 27 pg/ml with no difference between the treatment and the placebo groups. This inflammatory reaction started at the beginning of CPB, was maximal 4 h post-CPB and resolved on POD1 and POD2. Endotoxin levels at end of CPB as well as the maximum increase were slightly lower in the treated than in the CTRL group. However, this difference was essentially due to one CTRL patient with very high endotoxin levels. The proinflammatory reaction was accompanied by a significant increase in the anti-inflammatory cy
A New Paradigm for Metallic Alloys in Materials Science  [PDF]
Y. Ustinovshikov
Advances in Materials Physics and Chemistry (AMPC) , 2015, DOI: 10.4236/ampc.2015.57025
Abstract: In the article, taking into account the phase transition “ordering-phase separation” discovered in alloys, new concepts about the diffusion phase transformations in alloys are formulated: chemical interaction between dissimilar atoms exists always in all alloys and at any temperature of heating; alloys offer a surprising and not previously known property of changing the sign of the chemical interaction between dissimilar atoms at a change of the temperature or composition of alloys; diffusion processes occurring in alloys at different temperatures depend on the sign and the absolute magnitude of the energy of the chemical interaction between dissimilar atoms. All these three concepts are analyzed in detail, by the example of Ni-based and Co-based binary alloys using experimental results obtained by transmission electron microscopy. It is shown, on these ideas, how to carry out heat treatment of alloys more rationally, what principles should underpinned in the base of the construction of phase diagrams, how the microstructures of ordering and phase separation affect some properties of alloys.
Quasi-Square Wave Mode Phase-Shifted PWM LCC Resonant Converter for Regulated Power Supply  [PDF]
Engineering (ENG) , 2009, DOI: 10.4236/eng.2009.13024
Abstract: This paper presents an improved self sustained oscillating controller circuit using LCC components for improving the overall efficiency of the system. It has a micro controller based active controller, which controls the performance from no-load up to full-load. The steady state characteristics are developed and a design example is given in detail. The proposed controller allows zero current switching at any loading condition which results in a reasonable reduction of power loss during switching with a promising efficiency. Analytical and experimental results verify the achievement the design specifications.
After the Treatment Phase of Colorectal Cancer Care: Survivorship and Follow-Up  [PDF]
Maria Y. Ho, Winson Y. Cheung
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.326125
Abstract: The number of long-term colorectal cancer (CRC) survivors has increased substantially over the past three decades due to both ongoing advances in early detection and improvements in cancer therapies. Adult survivors of CRC experience chronic health conditions due to normal issues associated with aging, which is further compounded by the long-term adverse effects of having had cancer and anti-cancer therapies. In addition, they are at a higher risk for CRC recurrences, new primary cancers, and other co-morbidities. This article will provide an overview of the clinical care of adult survivors of CRC. Epidemiologic data will be presented followed by a discussion of the approach to the care of long-term adult survivors of CRC, including surveillance of recurrences and new primary cancers, interventions to manage both physical and psychological consequences of cancer and its treatments, and strategies to address concerns related to unemployment and disability. Finally, we will explore the challenges of healthcare delivery, especially with respect to the coordination of follow-up between cancer specialists and primary care physicians, so as to ensure that all of the survivor’s health needs are met promptly and appropriately.
Electronic states and pairing symmetry in the two-dimensional 16 band d-p model for iron-based superconductor
Y. Yanagi,Y. Yamakawa,Y. ōno
Physics , 2008, DOI: 10.1143/JPSJS.77SC.149
Abstract: The electronic states of the FeAs plane in iron-based superconductors are investigated on the basis of the two-dimensional 16-band d-p model, where the tight-binding parameters are determined so as to fit the band structure obtained by the density functional calculation for LaFeAsO. The model includes the Coulomb interaction on a Fe site: the intra- and inter-orbital direct terms U and U', the exchange coupling J and the pair-transfer J'. Within the random phase approximation (RPA), we discuss the pairing symmetry of possible superconducting states including s-wave and d-wave pairing on the U'-J plane.
Detecting the light of the night sky in Mars  [PDF]
Nebil Y. Misconi
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.34036
Abstract: In this paper a new methodology is outlined to detect the dust content in the Martian atmosphere during nighttime. In the previous Lander missions to Mars, scientists were able to determine the dust load in the Martian atmosphere during daylight using spectral lines of the Sun. Since the dynamics of Martian dust storms had been determined to be very rapid changing over times of hours and not days, it is imperative to determine the dust load during nighttime, so future astronauts to Mars can take protective measures for their equipment. They can also factor this effect for their planned activities during daytime. The new methodology greatly improves on the classical method for determining the extinction in the Earth’s atmosphere. The classical method uses observations of bright stars from which the optical depth, ?total, can then be deduced from the classical brightness equation. The classical method succeeds reasonably well at high elevation angles from the horizon but fails dramatically at low elevation angles. It also determines ?total from the slope of a plot of observed brightness of a bright star vs. air mass at all elevations. The plot shows a straight line at high elevations angles, which then curves and becomes uncertain at low elevation angles. The new methodology bypasses this severe difficulty by simply eliminating this plot, and by acquiring the brightness of a bright star above the atmosphere (no extinction) and compares it to the observed bright- ness of the same star below the atmosphere at all elevations.
The Effects of Dimension Ratio and Horizon Length in the Micropolar Peridynamic Model  [PDF]
Y. Ferhat, I. Ozkol
Engineering (ENG) , 2011, DOI: 10.4236/eng.2011.36071
Abstract: The aim of this study is to investigate the effects of horizon selection on the elastic behaviour of plate type structures in the micropolar peridynamic theory. Plates with various lengths and widths have been investi-gated using micropolar peridynamic model for different horizon selections. The mathematical model of plates has been provided applying the micropolar peridynamic theory and solution of this model has been obtained by finite element methods. The displacement fields have been computed for the different horizons and dimension ratios of plates. To compute the displacement field a program code has been developed by using the software package MATHEMATICA. The results obtained have been compared with the analytical solution of the classical elasticity theory and with the solution of displacement based finite element methods. For displacement based finite element method solution the software package ANSYS has been used. Ac-cording to results it has been observed that the displacement fields of the plates are strongly affected by ho-rizon selection. Therefore a question raises that which horizon length should be used with the problem in hand or is there any method to find the appropriate/best horizon length.
Distortion of Space and Time during Saccadic Eye Movements  [PDF]
M. Suzuki, Y. Yamazaki
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.22011
Abstract: The space-time distortion perceived subjectively during saccadic eye movements is an associative phenomenon of a transient shift of observer’s visual frame of reference from one position to another. Here we report that the lines of subjective simultaneity defined as two spatially separated flashes perceived during saccades were nearly uniformly tilted along the physical time-course. The causality of the resulting space-time compression may be explained by the Minkowski space-time diagram in physics.
Byuons, Quantum Information Channel, Consciousness and Universe  [PDF]
Y. A. Baurov
Open Journal of Microphysics (OJM) , 2011, DOI: 10.4236/ojm.2011.12007
Abstract: The physics of consciousness and universal mind is shown on the base of theory of byuons, the theory of “life’ of special unobservable discrete objects—byuons from which the surrounding space and the world of elementary particles are formed. An essential distinction of that theory from the modern models in the classical and quantum field theories is that the potentials of physical fields (gravitational, electromagnetic, asf.) gain exactly fixable, measurable values. Basic axioms and some conclusions of this theory are discussed. The theory of byuons predicts the existence of a new force and a new quantum information channel in nature. All objects of the Universe are shown to be united into the unique information field due to the huge interval of uncertainty in the coordinate (Δx = L = 1028 cm) of objects 4b (object formed during four-contact byuon-byuon interaction ( mc24b = 33 eV)) forming the surrounding physical space. It is a new quantum information channel.
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