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Search Results: 1 - 10 of 18752 matches for " Xuguang Gao "
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Elevated Plasma Levels but Decreased Platelet-Associated Expression of LIGHT in Patients with Acute Atherothrombotic Stroke  [PDF]
Guangzhi Liu, Yang He, Tingting Yang, Hong Jiang, Yajuan Xiang, Qi Zhang, Xiangjun He, Peter Hjelmstrom, Xuguang Gao
World Journal of Neuroscience (WJNS) , 2014, DOI: 10.4236/wjns.2014.44042
Abstract: Background: As a member of the tumor necrosis factor superfamily (TNFSF), LIGHT (TNFSF14) is expressed by a variety of immune cells and exists in membrane-bound and soluble forms. Recently, LIGHT was found to be associated with platelets and released upon activation. Activation of endothelia cells by recombinant LIGHT protein results in pro-inflammatory and pro-thrombotic changes. Several studies have reported increased plasma levels of LIGHT in patients with stroke and cardiovascular diseases. However, the form-associated roles of LIGHT in ischemic atherosclerotic stroke remain unclear. Mater?als and Methods: In this study, the platelet LIGHT expression and soluble LIGHT protein were analyzed by flow cytometry and enzyme-linked immunosorbent assay (ELISA) in peripheral blood of patients with acute ischemic atherosclerotic stroke, asymptomatic carotid stenosis (ACS) and normal controls. RESULTS: During the initial 24 h after onset, the stroke patients had decreased LIGHT expression on their platelets (5.9% ± 4.9%) and increased plasma LIGHT levels (36.1 ± 21.0 pg/ml) as compared with normal controls (9.5% ± 3.0%, p < 0.05; 20.4 ± 13.4 pg/ml, p < 0.05). Moreover, the platelet LIGHT expression correlated with total plaque area in the stroke patients (r = 0.4572, p = 0.0247). Conclus?ons: The dysregulated LIGHT expression reflects a persistent chronic inflammatory
Optical Properties, Electronic Energy Level Structure and Electro-luminescent Characteristics of Salicylaldehyde Anil Zinc
Optical Properties, Electronic Energy Level Structure and Electroluminescent Characteristics of Salicylaldehyde Anil Zinc

Yuying HAO,Bingshe XU,Zhixiang GAO,Hua WANG,Hefeng ZHOU,Xuguang LIU,

材料科学技术学报 , 2006,
Abstract: A new electroluminescent material, salicylaldehyde anil zinc (SAZ) was synthesized, which can form high quality, thermal stability, nano-scale amorphous films by vacuum evaporation. Its structure, thermal stability were characterized by infrared (IR) spectra, differential thermal analysis-thermogravimetry (DTA-TG) analysis,respectively. The optical properties of SAZ were investigated by UV absorption spectra, Photoluminescence (PL) excitation and emission spectra. The highest occupied molecular orbits (HOMO), lowest unoccupied molecular orbits (LUMO) and optical band gap were evaluated by cyclic voltammetry curve and optical absorption band edge. The electroluminescent devices using SAZ as the emissive layer emit green light with a peak wavelength at 509 nm and a brightness of about 3.1 cd/m2.
A Novel Bioassay for the Activity Determination of Therapeutic Human Brain Natriuretic Peptide (BNP)
Lei Yu, Chunming Rao, Xinchang Shi, Yonghong Li, Kai Gao, Xuguang Li, Junzhi Wang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049934
Abstract: Background Recombinant human brain natriuretic peptide (rhBNP) is an important peptide-based therapeutic drug indicated for the treatment of acute heart failure. Accurate determination of the potency of therapeutic rhBNP is crucial for the safety and efficacy of the drug. The current bioassay involves use of rabbit aortic strips, with experiments being complicated and time-consuming and markedly variable in results. Animal-less methods with better precision and accuracy should be explored. We have therefore developed an alternative cell-based assay, which relies on the ability of BNP to induce cGMP production in HEK293 cells expressing BNP receptor guanylyl cyclase-A. Methodology/Principal Findings An alternative assay based on the measurement of BNP-induced cGMP production was developed. Specifically, the bioassay employs cells engineered to express BNP receptor guanylyl cyclase-A (GCA). Upon rhBNP stimulation, the levels of the second messager cGMP in these cells drastically increased and subsequently secreted into culture supernatants. The quantity of cGMP, which corresponds to the rhBNP activity, was determined using a competitive ELISA developed by us. Compared with the traditional assay, the novel cell-based assay demonstrated better reproducibility and precision. Conclusion/Significance The optimized cell-based assay is much simpler, more rapid and precise compared with the traditional assay using animal tissues. To our knowledge, this is the first report on a novel and viable alternative assay for rhBNP potency analysis.
Panel Unit Root Tests by Combining Dependent Values: A Comparative Study
Xuguang Sheng,Jingyun Yang
Journal of Probability and Statistics , 2011, DOI: 10.1155/2011/617652
Abstract: We conduct a systematic comparison of the performance of four commonly used value combination methods applied to panel unit root tests: the original Fisher test, the modified inverse normal method, Simes test, and the modified truncated product method (TPM). Our simulation results show that under cross-section dependence the original Fisher test is severely oversized, but the other three tests exhibit good size properties. Simes test is powerful when the total evidence against the joint null hypothesis is concentrated in one or very few of the tests being combined, but the modified inverse normal method and the modified TPM have good performance when evidence against the joint null is spread among more than a small fraction of the panel units. These differences are further illustrated through one empirical example on testing purchasing power parity using a panel of OECD quarterly real exchange rates. 1. Introduction Combining significance tests, or values, has been a source of considerable research in statistics since Tippett [1] and Fisher [2]. (For a systematic comparison of methods for combining values from independent tests, see the studies by Hedges and Olkin [3] and Loughin [4].) Despite the burgeoning statistical literature on combining values, these techniques have not been used much in panel unit root tests until recently. Maddala and Wu [5] and Choi [6] are among the first who attempted to test unit root in panels by combining independent values. More recent contributions include those by Demetrescu et al. [7], Hanck [8], and Sheng and Yang [9]. Combining values has several advantages over combination of test statistics in that (i) it allows different specifications, such as different deterministic terms and lag orders, for each panel unit, (ii) it does not require a panel to be balanced, and (iii) observed values derived from continuous test statistics have a uniform distribution under the null hypothesis regardless of the test statistic or distribution from which they arise, and thus it can be carried out for any unit root test derived. While the formulation of the joint null hypothesis ( : all of the time series in the panel are nonstationary) is relatively uncontroversial, the specification of the alternative hypothesis critically depends on what assumption one makes about the nature of the heterogeneity of the panel. (Recent contributions include O’Connell [10], Phillips and Sul [11], Bai and Ng [12], Chang [13], Moon and Perron [14] and Pesaran [15].) The problem of selecting a test is complicated by the fact that there are many
Numerical Modeling of a Teeth-shaped Nano-plasmonic Waveguide Filter
Xianshi Lin,Xuguang Huang
Physics , 2009, DOI: 10.1364/JOSAB.26.001263
Abstract: In this paper, tooth-shaped and multiple-teeth-shaped plasmonic filters in the metal-insulator-metal (MIM) waveguides are demonstrated numerically. By introducing a three-port waveguide splitter, a modified model based on the multiple-beam-interference and the scattering matrix is given. The ransmittance spectrum as a function of teeth width, depth, period and period number are respectively addressed. The result shows the new structure not only performs the filtering function as well as MIM grating-like structures, but also is of submicrometer size for ultra-high integration and relatively easy fabrication.
Tooth-shaped plasmonic waveguide filters with nanometeric sizes
Xianshi Lin,Xuguang Huang
Physics , 2009, DOI: 10.1364/OL.33.002874
Abstract: A novel nanometeric plasmonic filter in a tooth-shaped Metal-Insulator-Metal waveguide is proposed and demonstrated numerically. An analytic model based on the scattering matrix method is given. The result reveals that the single tooth-shaped filter has a wavelength filtering characteristic and an ultra-compact size in the length of a few hundred nanometers, compared to grating-like SPPs filters. Both analytic and simulation results show that the wavelength of the trough of the transmission has linear and nonlinear relationships with the tooth depth and the tooth width, respectively. The waveguide filter could be utilized to develop ultra-compact photonic filters for high integration.
Analysis of Chinese Family Education Investment and Its Demographic Variables  [PDF]
Xuguang Sun, Ailing Huang
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.76002
Abstract: In order to study the situation of Chinese family’s investment in children’s education, and what factors will affect parents’ educational investment, this study used 338 undergraduate and graduate students to conduct a survey of demographic variables using the self-compiled Family Education Input Scale. The results showed that parents of undergraduate and postgraduate students mainly focus on two types of investment in academic education and investment in internal literacy. However, in terms of household education investment, different families have large differences in demographic variables. Among them, the income of family education is higher than that of girls; the family of non-agricultural households is higher than the family of agricultural households; the family of single-child families is higher than the family of non-only children; the parents of this special education are investing in their children’s education. The upper level is higher than that of the parents below the high school; the higher the family level, the higher the educational investment of the children. In view of the situation of different families in education investment, families should pay attention to family education investment, taking into account work and family education. Local governments should encourage their children to attend school on an equal footing and eliminate the gender “crowding out effect” of education from the source. The state should speed up family education legislation, regulate the family education investment behavior from the system, and clarify the content of family education. We will work together to create a good and positive environment for family education.
Research on the Efficacy of College Students’ Choosing Jobs from the Perspective of Family Education Investment  [PDF]
Xuguang Sun, Ailing Huang
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.76003
Abstract: Family education investment is an important part of human capital investment, and one of the most important factors affecting children’s talents. The sense of career effectiveness is the expected return of education investment, and it is also an important indicator to measure college students’ career choice. However, there is little research on the relationship between family education investment and college students’ job-seeking efficacy. On the basis of summarizing the previous studies, based on Schultz’s human capital theory, this paper analyzes the influencing factors and studies the relationship between family education investment and college students’ career satisfaction from the perspective of family education investment. The conclusions are as follows: First, there is a certain degree of correlation between family education investment and college students’ job-seeking efficacy, but it is not the only decisive factor. Second, family education investment will have an impact on college students’ job-seeking efficacy.
On measure solutions of the Boltzmann equation, Part II: Rate of convergence to equilibrium
Lu Xuguang,Clément Mouhot
Mathematics , 2013,
Abstract: The paper considers the convergence to equilibrium for measure solutions of the spatially homogeneous Boltzmann equation for hard potentials with angular cutoff. We prove the exponential sharp rate of strong convergence to equilibrium for conservative measure solutions having finite mass and energy. The proof is based on the regularizing property of the iterated collision operators, exponential moment production estimates, and some previous results on the exponential rate of strong convergence to equilibrium for square integrable initial data. We also obtain a lower bound of the convergence rate and deduce that no eternal solutions exist apart from the trivial stationary solutions given by the Maxwellian equilibrium. We finally use these convergence rates in order to deduce global-in-time strong stability of measure solutions.
On Measure Solutions of the Boltzmann Equation, part I: Moment Production and Stability Estimates
Xuguang Lu,Clément Mouhot
Mathematics , 2011, DOI: 10.1016/j.jde.2011.10.021
Abstract: The spatially homogeneous Boltzmann equation with hard potentials is considered for measure valued initial data having finite mass and energy. We prove the existence of \emph{weak measure solutions}, with and without angular cutoff on the collision kernel; the proof in particular makes use of an approximation argument based on the Mehler transform. Moment production estimates in the usual form and in the exponential form are obtained for these solutions. Finally for the Grad angular cutoff, we also establish uniqueness and strong stability estimate on these solutions.
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