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Search Results: 1 - 10 of 27894 matches for " Xiuqiang Ma "
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Epidemiology of Functional Abdominal Bloating and Its Impact on Health Related Quality of Life: Male-Female Stratified Propensity Score Analysis in a Population Based Survey in Mainland China
Meijing Wu, Yanfang Zhao, Rui Wang, Wenxin Zheng, Xiaojing Guo, Shunquan Wu, Xiuqiang Ma, Jia He
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0102320
Abstract: Background The epidemiology of Functional abdominal bloating (FAB) and its impact on health-related quality of life (HRQoL) in Chinese people remains unclear. Methods Randomised, stratified, multi-stage sampling methodology was used to select a representative sample of the general population from five cities in China (n = 16,078). All respondents completed the modified Rome II questionnaire; 20% were asked to complete the 36-item Short Form (SF-36). The associated factors of FAB were analyzed. The effects of FAB on HRQoL were estimated with gender stratification using propensity score techniques in 20% subsample. Results Overall, 643 individuals (4.00%) had FAB and it was more prevalent in males than in females (4.87% vs. 3.04%, P<0.001). For males, self-reported history of dyspepsia was most strongly associated with FAB (OR = 2.78; 95% CI: 1.59, 4.72). However, the most strongly associated factor was self-reported health status for females (moderate health vs. good health: OR = 2.06, 95% CI: 1.07, 3.96. P = 0.030; poor health vs. good health: OR = 5.71, 95% CI: 2.06, 15.09). Concerning HRQoL, FAB was found to be related to two domains: role limitation due to physical problems (P = 0.030) and bodily pain (P<0.001) in females. While, in males, there were significant differences in multiple domains between those with and without FAB. Conclusion The prevalence of FAB in China was lower than previous reports. Males who had ever been diagnosed with dyspepsia and females who were in a poor self-reported health status were correlated with a higher prevalence of FAB. FAB affected only physical health in females, but impaired both physical and mental health in males.
Health related quality of life measured by SF-36: a population-based study in Shanghai, China
Rui Wang, Cheng Wu, Yanfang Zhao, Xiaoyan Yan, Xiuqiang Ma, Meijing Wu, Wenbin Liu, Zheng Gu, June Zhao, Jia He
BMC Public Health , 2008, DOI: 10.1186/1471-2458-8-292
Abstract: A total of 1034 subjects were randomly sampled using a stratified multiple-stage sampling method in Shanghai. Demographic information was collected, and SF-36 was used to measure HRQL.Internal reliability coefficients were greater than 0.7 in six of the eight SF-36 dimensions, except social function and mental health. Intraclass correlation coefficients ranged from 0.689 to 0.972. Split-half reliability coefficients were higher than 0.9 in five SF-36 dimensions. Validity was assessed by factor analysis and correlation analysis. Our results were basically in accordance with the theoretical construction of SF-36. The average scores of most SF-36 dimensions were higher than 80. The primary influencing risk factors of HRQL included chronic diseases, age, frequency of activities, and geographical region, which were identified using multivariate stepwise regression.Overall, HRQL in the population of Shanghai is quite good. The Mandarin version of SF-36 is a valid and reliable tool for assessing HRQL.Conception of health has been changed with the development of medicine and medical sciences since 1970's. Health is defined as a dynamic state of human wellbeing characterized by a physical, mental, and social potential which satisfies the demands of a life corresponding to age, culture, and personal responsibility, and not merely the absence of disease or infirmity. Health related quality of life (HRQL) is an individual's satisfaction or happiness with the dimensions of life insofar as they affect or are affected by "health" as defined above. HRQL has been introduced to assess people's health status. To date, a number of questionnaires have been developed to evaluate HRQL, and the 36-item Short Form Health Survey (SF-36) is the most commonly used one.SF-36 was developed from the Medical Outcomes Study or RAND Health Insurance Experiment [1]. It is a short-form derived from a larger 149-item instrument and is more precise than its predecessor, SF-20 [2]. SF-36 has been proven
Possible developmental mechanisms underlying the origin of the crown lineages of arthropods
Xiuqiang Wang,Junyuan Chen
Chinese Science Bulletin , 2004, DOI: 10.1007/BF02901742
Abstract: The extraordinarily preserved, diverse arthropod fauna from the Lower Cambrian Maotianshan shale, central Yunnan (southwest China), represents different evolutionary stages stepping from stem lineages towards crown arthropods (also called euarthropods), which makes this fauna extremely significant for discussion of the origin and early diversification of the arthropods. Anatomical analyses of the Maotianshan shale arthropods strongly indicate that the origin of crown arthropods involved three major evolutionary events, arthrodisation, arthropodisation and cephalization. We try to explore possible evolutionary changes of the developmental mechanism that may have underlain origins of euarthropod appendage and head. Fossil evidence suggests that the formation of a jointed limb known as arthropodisation and formation of multi-segmented head (called cephalization), which characterize euarthropods, is an event after arthrodisation characterized with the formation of segmented-exoskeleton and the joint membrane between tergites. We propose that the Hox complex was already operating at least as early as in the Early Cambrian and is responsible for the formation of the joint membrane between two semgents through Hox gene regulation along the D-V and P-D axis. Fossil evidence indicates that the head in ground state of arthropods consists only of two segments, an ocular and an antennal one. The formation of multiple segmented, euarthropod head (called syncephalon) from the two-segmented head was a separate event, which is called cephalization. Presence of the Hox gene head expression domain and change of developmental mechanism in head segments might be responsible for the formation of the syncephalon and this event has been broadly finished in the Early Cambrian arthropods. The post-oral limbs in the early syncephalons as evidenced from the Lower Cambrian Maotianshan shale arthropods however were almost identical to those in trunk. Therefore we proposed that the Hox genes specifiedexpression in individual segment was a late evolutionary step postdating the formation of syncephalon.
Peculiar long-range supercurrent in SFS junction containing a noncollinear magnetic domain in the ferromagnetic region
Hao Meng,Xiuqiang Wu
Physics , 2014, DOI: 10.1063/1.4905608
Abstract: We study the supercurrent in a superconductor-ferromagnet-superconductor heterostructure containing a noncollinear magnetic domain in the ferromagnetic region. It is demonstrated that the magnetic domain can lead to a spin-flip process, which can reverse the spin orientations of the singlet Cooper pair propagating through the magnetic domain region. If the ferromagnetic layers on both sides of magnetic domain have the same features, the long-range proximity effect will take place. That is because the singlet Cooper pair will create an exact phase-cancellation effect and gets an additional $\pi$ phase shift as it passes through the entire ferromagnetic region. Then the equal spin triplet pair only exists in the magnetic domain region and can not diffuse into the other two ferromagnetic layers. So the supercurrent mostly arises from the singlet Cooper pairs and the equal spin triplet pairs are not involved. This behavior is quite distinct from the common knowledge that long-range supercurrent induced by inhomogeneous ferromagnetism stems from the equal spin triplet pairs. The result we presented here provides a new way for generating the long-range supercurrent.
JAK2 Exon 14 Deletion in Patients with Chronic Myeloproliferative Neoplasms
Wanlong Ma,Hagop Kantarjian,Xi Zhang,Xiuqiang Wang,Zhong Zhang,Chen-Hsiung Yeh,Susan O'Brien,Francis Giles,Jean Marie Bruey,Maher Albitar
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012165
Abstract: The JAK2 V617F mutation in exon 14 is the most common mutation in chronic myeloproliferative neoplasms (MPNs); deletion of the entire exon 14 is rarely detected. In our previous study of >10,000 samples from patients with suspected MPNs tested for JAK2 mutations by reverse transcription-PCR (RT-PCR) with direct sequencing, complete deletion of exon 14 (Δexon14) constituted <1% of JAK2 mutations. This appears to be an alternative splicing mutation, not detectable with DNA-based testing.
A Retrospective Survey of Research Design and Statistical Analyses in Selected Chinese Medical Journals in 1998 and 2008
Zhichao Jin,Danghui Yu,Luoman Zhang,Hong Meng,Jian Lu,Qingbin Gao,Yang Cao,Xiuqiang Ma,Cheng Wu,Qian He,Rui Wang,Jia He
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010822
Abstract: High quality clinical research not only requires advanced professional knowledge, but also needs sound study design and correct statistical analyses. The number of clinical research articles published in Chinese medical journals has increased immensely in the past decade, but study design quality and statistical analyses have remained suboptimal. The aim of this investigation was to gather evidence on the quality of study design and statistical analyses in clinical researches conducted in China for the first decade of the new millennium.
Identification and characterization of novel amphioxus microRNAs by Solexa sequencing
Xi Chen, Qibin Li, Jin Wang, Xing Guo, Xiangrui Jiang, Zhiji Ren, Chunyue Weng, Guoxun Sun, Xiuqiang Wang, Yaping Liu, Lijia Ma, Jun-Yuan Chen, Jun Wang, Ke Zen, Junfeng Zhang, Chen-Yu Zhang
Genome Biology , 2009, DOI: 10.1186/gb-2009-10-7-r78
Abstract: We combined Solexa sequencing with computational techniques to identify novel miRNAs in the amphioxus species B. belcheri (Gray). This approach allowed us to identify 113 amphioxus miRNA genes. Among them, 55 were conserved across species and encoded 45 non-redundant mature miRNAs, whereas 58 were amphioxus-specific and encoded 53 mature miRNAs. Validation of our results with microarray and stem-loop quantitative RT-PCR revealed that Solexa sequencing is a powerful tool for miRNA discovery. Analyzing the evolutionary history of amphioxus miRNAs, we found that amphioxus possesses many miRNAs unique to chordates and vertebrates, and these may thus represent key steps in the evolutionary progression from cephalochordates to vertebrates. We also found that amphioxus is more similar to vertebrates than are tunicates with respect to their miRNA phylogenetic histories.Taken together, our results indicate that Solexa sequencing allows the successful discovery of novel miRNAs from amphioxus with high accuracy and efficiency. More importantly, our study provides an opportunity to decipher how the elaboration of the miRNA repertoire that occurred during chordate evolution contributed to the evolution of the vertebrate body plan.When the class of RNA regulatory genes known as microRNAs (miRNAs) was discovered it introduced a whole new layer of gene regulation in eukaryotes [1]. Since the discovery of the first miRNA (lin-4) in Caenorhabditis elegans, thousands of miRNAs have been identified experimentally or computationally from a variety of species [1]. miRNAs are currently estimated to comprise 1 to 5% of animal genes and collectively regulate up to 30% of genes, making them one of the most abundant classes of regulators [2]. However, while the importance of miRNAs in animal ontogeny has been rapidly elucidated, their role in phylogeny currently remains largely unknown. Recent studies have provided important clues indicating that these approximately 22-nucleotide non-coding R
A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China
Jia He, Xiuqiang Ma, Yanfang Zhao, Rui Wang, Xiaoyan Yan, Hong Yan, Ping Yin, Xiaoping Kang, Jiqian Fang, Yuantao Hao, Qiang Li, John Dent, Joseph JY Sung, Duowu Zou, Mari-Ann Wallander, Saga Johansson, Wenbin Liu, Zhaoshen Li
BMC Gastroenterology , 2010, DOI: 10.1186/1471-230x-10-94
Abstract: A representative sample of 18 000 adults (aged 18-80 years) were selected equally from rural and urban areas in each region (n = 1800). According to the Montreal Definition, GERD is present when mild symptoms of heartburn and/or regurgitation occur on ≥2 days a week, or moderate-to-severe symptoms of heartburn and/or regurgitation occur on ≥1 day a week.In total, 16 091 participants completed the survey (response rate: 89.4%) and 16 078 responses were suitable for analysis. Applying the Montreal criteria, the prevalence of symptom-defined GERD was 3.1% and varied significantly (p < 0.001) among the five regions (from 1.7% in Guangzhou to 5.1% in Wuhan) and between rural and urban populations (3.8% vs 2.4%). Factors significantly associated with GERD included living in a rural area and a family history of gastrointestinal diseases.This population-based survey found that the prevalence of symptom-defined GERD in China was 3.1%, which is lower than that found in Western countries.Gastroesophageal reflux disease (GERD) is a chronic disease that is associated with a range of troublesome symptoms, which can in turn have a significant impact on health-related quality of life and work productivity [1-4]. It is also associated with esophageal complications such as reflux esophagitis and Barrett's esophagus [1].Interest in the epidemiology of GERD has grown during the past few decades, but interpretation of epidemiological studies of GERD has often been hampered by the use of inconsistent symptom-based definitions of the disease [5]. In 2005, Dent and colleagues performed a systematic review of studies that defined GERD as symptoms of heartburn and/or regurgitation occurring on at least 1 day per week [5]. They concluded that the prevalence of GERD was 10-20% in Western countries and approximately 5% in Asia based on this definition.Since then, a global evidence-based consensus (the Montreal Definition of GERD) has recommended that in population-based surveys GERD should be d
Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodology
Xiaoyan Yan, Rui Wang, Yanfang Zhao, Xiuqiang Ma, Jiqian Fang, Hong Yan, Xiaoping Kang, Ping Yin, Yuantao Hao, Qiang Li, John Dent, Joseph Sung, Duowu Zou, Saga Johansson, Katarina Halling, Wenbin Liu, Jia He
BMC Gastroenterology , 2009, DOI: 10.1186/1471-230x-9-86
Abstract: A randomized, stratified, multi-stage sampling methodology was used to select 18 000 adults aged 18-80 years from Shanghai, Beijing, Xi'an, Wuhan and Guangzhou. Participants from Shanghai were invited to provide blood samples and undergo upper gastrointestinal endoscopy. All participants completed Chinese versions of the Reflux Disease Questionnaire (RDQ) and the modified Rome II questionnaire; 20% were also invited to complete the 36-item Short Form Health Survey (SF-36) and Epworth Sleepiness Scale (ESS). The psychometric properties of the questionnaires were evaluated statistically.The study was completed by 16 091 individuals (response rate: 89.4%), with 3219 (89.4% of those invited) completing the SF-36 and ESS. All 3153 participants in Shanghai provided blood samples and 1030 (32.7%) underwent endoscopy. Cronbach's alpha coefficients were 0.89, 0.89, 0.80 and 0.91, respectively, for the RDQ, modified Rome II questionnaire, ESS and SF-36, supporting internal consistency. Factor analysis supported construct validity of all questionnaire dimensions except SF-36 psychosocial dimensions.This population-based study has great potential to characterize the relationship between gastrointestinal symptoms and endoscopic findings in China.The epidemiology of common gastrointestinal diseases differs between populations in Asian and in Western countries, and in Asia particularly, the pattern of these diseases seems to be changing [1]. The prevalence of peptic ulcer disease has been declining at the same time as the prevalence of gastroesophageal reflux disease (GERD) and its complications have been increasing [2]. Gastric cancer remains a common cancer in Asia, but its prevalence has also been declining in recent years [1]. These changes may reflect the experience of Western countries several decades ago, and comparisons of the epidemiology of gastrointestinal diseases between Western and Asian countries continue to be of interest.GERD is a chronic disease in which reflux o
Impact of gastroesophageal reflux disease on daily life: the Systematic Investigation of Gastrointestinal Diseases in China (SILC) epidemiological study
Rui Wang, Duowu Zou, Xiuqiang Ma, Yanfang Zhao, Xiaoyan Yan, Hong Yan, Jiqian Fang, Ping Yin, Xiaoping Kang, Qiang Li, John Dent, Joseph J Sung, Katarina Halling, Saga Johansson, Wenbin Liu, Jia He
Health and Quality of Life Outcomes , 2010, DOI: 10.1186/1477-7525-8-128
Abstract: In total, 18 000 residents were randomly selected from across five regions of China and asked to complete a general information questionnaire and a Chinese version of the Reflux Disease Questionnaire (RDQ). A randomly selected subsample of one-fifth of subjects (20% from each region) completed Chinese versions of the 36-item self-administered (SF-36) questionnaire and Epworth Sleepiness Scale (ESS) questionnaire. Reflux symptoms were defined as the presence of heartburn and/or regurgitation. Symptom-defined GERD was diagnosed as mild heartburn and/or regurgitation ≥2 days per week, or moderate/severe heartburn and/or regurgitation ≥1 day a week, based on the Montreal Definition of GERD for population-based studies.The response rate was 89.4% for the total sample (16 091/18 000), and for the 20% subsample (3219/3600). Meaningful impairment was observed in all 8 SF-36 dimensions in participants with symptom-defined GERD, in 7 of the 8 SF-36 dimensions in participants with troublesome reflux symptoms, and in 6 of the 8 SF-36 dimensions in participants with reflux symptoms below the threshold for symptom-defined GERD. Meaningful daytime sleepiness was also observed in each of these groups. The proportion of individuals reporting troublesome symptoms increased as reflux symptom frequency and severity approached the threshold for symptom-defined GERD, and this was associated with concomitant decreases in all HRQoL measures. Troublesome symptoms were reported by 68.2% (75/110) of individuals with symptom-defined GERD.GERD diagnosed using symptom/frequency criteria (recommended for population-based studies), or based on troublesome reflux symptoms (recommended for the clinic), is associated with significantly impaired HRQoL in Chinese individuals. However, patient groups identified using these definitions do not overlap completely, suggesting that they capture slightly different, though clinically relevant, GERD populations.Gastroesophageal reflux disease (GERD) has been sh
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