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Search Results: 1 - 10 of 23470 matches for " Xingming Shi "
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Arthroscopy Assisted Lesion Clearance and Bone Graft, Titanium Rod Support Treatment of Early Stage Osteonecrosis of the Femoral Head of the Postoperative Survival Rate Analysis  [PDF]
Xingming Yang, Wei Shi, Yakun Du, Lei Zhang
Surgical Science (SS) , 2017, DOI: 10.4236/ss.2017.81005
Abstract: Objective: To assess the curative effect of the stage II femoral head necrosis treated by arthroscopy assisted lesion clearance, bone graft and titanium rod support. Methods: All the patients (including 58 patients 74 hips) were diagnosed as stage II femoral head necrosis according to the ARCO staging system during 2003-2013. In these patients, 15 hips were stage IIA, 34 hips were stage IIB and 25 hips were stage IIC. Located by C-arm and assisted by arthroscopy, minimally-invasive percutaneous pulp core decompression and lesion clearance within the femoral head were accurately performed, and then, the OAM composite of autologous bone marrow was implanted and the femoral head was supported using the titanium rod. Follow-up including the pain score, the Harris hip score and X-ray observation for disease progression were achieved at 6, 12, 24 and 36 months postoperatively, Kaplan-Meier survival curve was used for the survival analysis. Result: The VAS score and the Harris score after operation were better THRAn THRAt of before the surgery, the difference had statistical significance (p < 0.05). As for the X-ray staging, 5 cases (5 hips) progressed from stage IIB to stage IIC, the femoral head of 6 cases (6 hips) staged IIC collapsed at 24 months after the operation and then underwent THRA after 30 months. In this study, the total improvement rate after the surgery was 79.72% (93.33% for IIA, 82.35% for IIB and 68% for IIC). The total survival rate of these patients was 64.2% (95% CI, 64.2% - 90.1%). Conclusion: Arthroscopy assisted lesion clearance, bone graft and titanium rod support to treat the stage II osteonecrosis of the femoral head are effective and can prevent the femoral head from collapsing. But for stage IIC patients who had a history of the use of hormone, this surgery should be chosen carefully because the outcome is always very poor.
Energy Balance, Myostatin, and GILZ: Factors Regulating Adipocyte Differentiation in Belly and Bone
Xingming Shi,Mark Hamrick,Carlos M. Isales
PPAR Research , 2007, DOI: 10.1155/2007/92501
Abstract: Peroxisome proliferator-activated receptor gamma (PPAR-γ) belongs to the nuclear hormone receptor subfamily of transcription factors. PPARs are expressed in key target tissues such as liver, fat, and muscle and thus they play a major role in the regulation of energy balance. Because of PPAR-γ's role in energy balance, signals originating from the gut (e.g., GIP), fat (e.g., leptin), muscle (e.g., myostatin), or bone (e.g., GILZ) can in turn modulate PPAR expression and/or function. Of the two PPAR-γ isoforms, PPAR-γ2 is the key regulator of adipogenesis and also plays a role in bone development. Activation of this receptor favors adipocyte differentiation of mesenchymal stem cells, while inhibition of PPAR-γ2 expression shifts the commitment towards the osteoblastogenic pathway. Clinically, activation of this receptor by antidiabetic agents of the thiazolidinedione class results in lower bone mass and increased fracture rates. We propose that inhibition of PPAR-γ2 expression in mesenchymal stem cells by use of some of the hormones/factors mentioned above may be a useful therapeutic strategy to favor bone formation.
Mono- or Double-Site Phosphorylation Distinctly Regulates the Proapoptotic Function of Bax
Qinhong Wang,Shi-Yong Sun,Fadlo Khuri,Walter J. Curran,Xingming Deng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013393
Abstract: Bax is the major multidomain proapoptotic molecule that is required for apoptosis. It has been reported that phosphorylation of Bax at serine(S) 163 or S184 activates or inactivates its proapoptotic function, respectively. To uncover the mechanism(s) by which phosphorylation regulates the proapoptotic function of Bax, a series of serine (S)→ alanine/glutamate (A/E) Bax mutants, including S163A, S184A, S163E, S184E, S163E/S184A (EA), S163A/S184E (AE), S163A/S184A (AA) and S163E/S184E (EE), were created to abrogate or mimic, respectively, either single or double-site phosphorylation. The compound Bax mutants (i.e. EA and AE) can flesh out the functional contribution of individual phosphorylation site(s). WT and each of these Bax mutants were overexpressed in Bax?/? MEF or lung cancer H157 cells and the proapoptotic activities were compared. Intriguingly, expression of any of Bax mutants containing the mutation S→A at S184 (i.e. S184A, EA or AA) represents more potent proapoptotic activity as compared to WT Bax in association with increased 6A7 epitope conformational change, mitochondrial localization/insertion and prolonged half-life. In contrast, all Bax mutants containing the mutation S→E at S184 (i.e. S184E, AE or EE) have a mobility-shift and fail to insert into mitochondrial membranes with decreased protein stability and less apoptotic activity. Unexpectedly, mutation either S→A or S→E at S163 site does not significantly affect the proapoptotic activity of Bax. These findings indicate that S184 but not S163 is the major phosphorylation site for functional regulation of Bax's activity. Therefore, manipulation of the phosphorylation status of Bax at S184 may represent a novel strategy for cancer treatment.
Effects of Reticuloendotheliosis Virus Infection on Cytokine Production in SPF Chickens
Mei Xue, Xingming Shi, Yan Zhao, Hongyu Cui, Shunlei Hu, Xianlan Cui, Yunfeng Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083918
Abstract: Infection with reticuloendotheliosis virus (REV), a gammaretrovirus in the Retroviridae family, can result in immunosuppression and subsequent increased susceptibility to secondary infections. The effects of REV infection on expression of mRNA for cytokine genes in chickens have not been completely elucidated. In this study, using multiplex branched DNA (bDNA)?technology, we identified molecular mediators that participated in the regulation of the immune response during REV infection in chickens. Cytokine and chemokine mRNA expression levels were evaluated in the peripheral blood mononuclear cells (PBMCs). Expression levels of interleukin (IL)-4, IL-10, IL-13 and?tumor necrosis factor (TNF)-α were significantly up-regulated while interferon (IFN)-α, IFN-β, IFN-γ, IL-1β,IL-2, IL-3, IL-15, IL-17F, IL-18 and colony-stimulating factor (CSF)-1 were markedly decreased in PBMCs at all stages of infection. Compared with controls, REV infected chickens showed greater expression levels of IL-8 in PBMCs 21 and 28 days post infection. In addition, REV regulates host immunity as a suppressor of T cell proliferative responses. The results in this study will help us to understand the host immune response to virus pathogens.
Stromal Cell-Derived Factor-1β Mediates Cell Survival through Enhancing Autophagy in Bone Marrow-Derived Mesenchymal Stem Cells
Samuel Herberg, Xingming Shi, Maribeth H. Johnson, Mark W. Hamrick, Carlos M. Isales, William D. Hill
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058207
Abstract: Bone marrow-derived mesenchymal stem/stromal cells (BMSCs) hold great potential for cell-based therapy, yet the therapeutic efficacy remains uncertain. Transplanted BMSCs often fail to engraft within the bone marrow (BM), in part due to the poor survival of donor cells in response to inflammatory reactions, hypoxia, oxidative stress, or nutrient starvation. Two basic cell processes, apoptosis and autophagy, could potentially be responsible for the impaired survival of transplanted BMSCs. However, the functional relationship between apoptosis and autophagy in BMSC homeostasis is complex and not well understood. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) signaling axis appears to be critical in maintaining proliferation and survival of BM stem cell populations through improving cell proliferation and survival in response to stress; however, the exact mechanisms remain unclear. We recently described novel genetically engineered Tet-Off-SDF-1β BMSCs, which over-express SDF-1β under tight doxycycline-control, thus providing an ideal model system to investigate the isolated effects of SDF-1β. In this study we tested the hypothesis that SDF-1β can mediate cell survival of BMSCs in vitro through increasing autophagy. We found that SDF-1β had no effect on BMSC proliferation; however, SDF-1β significantly protected genetically engineered BMSCs from H2O2-induced cell death through increasing autophagy and decreasing caspase-3-dependent apoptosis. Taken together, we provide novel evidence that the SDF-1/CXCR4 axis, specifically activated by the SDF-1β isoform, plays a critical role in regulating BMSC survival under oxidative stress through increasing autophagy.
The initial boundary value problem of a mixed-typed hemivariational inequality
Guo Xingming
International Journal of Mathematics and Mathematical Sciences , 2001, DOI: 10.1155/s0161171201003994
Abstract: A mixed-typed differential inclusion with a weakly continuous nonlinear term and a nonmonotone discontinuous nonlinear multi-valued term is studied, and the existence and decay of solutions are established.
On weak solution of a hyperbolic differential inclusion with nonmonotone discontinuous nonlinear term
Guo Xingming
International Journal of Mathematics and Mathematical Sciences , 1999, DOI: 10.1155/s0161171299225872
Abstract: In this paper, a hyperbolic differential inclusion with nonmonotone discontinuous and nonlinear term, which the generalized velocity acts as its variable, is studied and the existence and decay of its weak solution are obtained.
Xingming Chen
Physics , 1995,
Abstract: The global structure of optically thin hot accretion disks with radial advection included has been investigated. We solve the full energy conservation equation explicitly and construct the radial structure of the disk. It is found that advection is a real cooling process and that there are two solutions co-exist for a given mass accretion rate less than a critical limit. One is fully advection cooling dominated and the other is dominated by local radiative cooling. The advection dominated accretion disks are hotter than the local cooling dominated disks; they are most probably in the two-temperature regime and effects such as electron-positron pair production and annihilation may need to be considered to study the microphysics of the hot plasma. However, the global disk structure will not be much affected by the local radiative process.
Xingming Chen
Physics , 1995, DOI: 10.1086/176008
Abstract: Cold optically thick accretion disks with hot coronae and radial advection have been investigated. Within the framework of $\alpha$-viscosity models, we assume that all the mass accretion and angular momentum transport take place in the cold disk, but that a fraction of the gravitational energy released is dissipated in the corona. Both the coronal energy dissipation and the advection heat transport have a stabilization effect on the thermal and viscous instabilities of the disk. If that more than $\sim 95$ percent of the total power is dissipated in the corona, then the locally unstable behavior of the disk is restricted to a relatively narrow spatial region and is found to lie in a small range of mass accretion rates. The global temporal variability of the disk can be very mild or may disappear, and which may be applicable to the low-frequency ($\sim 0.04$~Hz) quasi-periodic oscillations observed in black hole candidates Cyg X--1 and GRO J0422+32.
Instabilities of Advection-Dominated Accretion Flows
Xingming Chen
Physics , 1996,
Abstract: Accretion disk instabilities are briefly reviewed. Some details are given to the short-wavelength thermal instabilities and the convective instabilities. Time-dependent calculations of two-dimensional advection-dominated accretion flows are presented.
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