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Search Results: 1 - 10 of 10583 matches for " Xinghong Ding "
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Rapid Resolution Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics Approach to Study the Effects of Jieduquyuziyin Prescription on Systemic Lupus Erythematosus
Xinghong Ding, Jinbo Hu, Chengping Wen, Zhishan Ding, Li Yao, Yongsheng Fan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088223
Abstract: Jieduquyuziyin prescription (JP), a traditional Chinese medicine (TCM) prescription, has been widely used for the clinical treatment of systemic lupus erythematosus (SLE). However, the complex chemical constituents of JP and the multifactorial pathogenesis of SLE make research on the therapeutic mechanism of JP in SLE challenging. In this paper, a serum metabolomics approach based on rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (RRLC-Q-TOF/MS) was employed to acquire the metabolic characteristics of serum samples obtained from mice in the SLE model group, JP-treated group, prednisone acetate (PA)-treated group and control group. The orthogonal partial least squares (OPLS) was applied to recognize metabolic patterns, and an obvious separation of groups was obtained. Thirteen metabolites, namely, phosphatidylethanolamine (PE 20:3), hepoxilin B3, lyso- phosphatidylethanolamine (lyso-PE 22:6), 12S-hydroxypentaenoic acid (12S-HEPE), traumatic acid, serotonin, platelet-activating factor (PAF), phosphatidylcholine (PC 20:5),eicosapentaenoic acid (EPA), 12(S)-hydroxyei- cosatetraenoic acid (12S-HETE), 14-hydroxy docosahexaenoic acid (14-HDOHE), lyso-phosphatidylcholine (lyso-PC 20:4), and indole acetaldehyde, were identified and characterized as differential metabolites involved in the pathogenesis of SLE. After treatment with JP, the relative content of 12(S)-HETE, PAF, 12(S)-HEPE, EPA, PE (20:3), Lyso-PE(22:6), and 14-HDOHE were effectively regulated, which suggested that the therapeutic effects of JP on SLE may involve regulating disturbances to the metabolism of unsaturated fatty acid, tryptophan and phospholipid. This research also demonstrated that metabolomics is a powerful tool for researching complex disease mechanisms and evaluating the mechanism of action of TCM.
Antioxidant, Antityrosinase and Antitumor Activity Comparison: The Potential Utilization of Fibrous Root Part of Bletilla striata (Thunb.) Reichb.f.
Fusheng Jiang, Weiping Li, Yanfen Huang, Yitao Chen, Bo Jin, Nipi Chen, Zhishan Ding, Xinghong Ding
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058004
Abstract: This study was carried out to evaluate the utilization probability of the fibrous root part (FRP) of Bletilla striata, which was usually discarded and harvesting pseudobulb part (PSP). The chemical composition, total phenolic content, DPPH radical scavenging activity, Ferric-reducing antioxidant power and tyrosinase inhibition activity were compared between FRP and PSP. Antioxidant and pro-oxidant effect as well as antitumor effect of the extract of FRP and PSP were analyzed by in vitro cell system as well. Thin layer chromatography and high performance liquid chromatography analysis indicated that the chemical compositions in the two parts were similar, but the content in FRP was much higher than PSP. Meanwhile, the FRP extracts showed higher phenolic content, stronger DPPH scavenging activity, Ferric-reducing antioxidant capacity and tyrosinase inhibition activity. Sub-fraction analysis revealed that the distribution characteristic of phenolic components and other active constituents in FRP and PSP were consistent, and mainly deposited in chloroform and acetoacetate fractions. Especially, the chloroform sub-fraction (sch) of FRP showed extraordinary DPPH scavenging activity and tyrosinase inhibition activity, with IC50 0.848 mg/L and 4.3 mg/L, respectively. Besides, tyrosinase inhibition activity was even stronger than the positive compound arbutin (31.8 mg/L). Moreover, In vitro cell system analysis confirmed that FRP extract exerts comparable activity with PSP, especially, the sub-fraction sch of FRP showed better antioxidant activity at low dosage and stronger per-oxidant activity at high dosage, and both sch of FRP and PSP can dose-dependent induce HepG2 cells apoptosis, which implied tumor therapeutic effect. Considering that an additional 0.3 kg FRP would be obtained when producing 1.0 kg PSP, our work demonstrated that FRP is very potential to be used together with PSP.
Diurnal Variations of Air Pollution and Atmospheric Boundary Layer Structure in Beijing During Winter 2000/2001
Diurnal Variations of Air Pollution and Atmospheric Boundary Layer Structure in Beijing During Winter 2000/2001

ZHOU Li,XU Xiangde,DING Guoan,ZHOU Mingyu,CHENG Xinghong,
,XU Xiangde,DING Guoan,ZHOU Mingyu,CHENG Xinghong

大气科学进展 , 2005,
Abstract: The diurnal variations of gaseous pollutants and the dynamical and thermodynamic structures of the atmospheric boundary layer (ABL) in the Beijing area from January to March 2001 are analyzed in this study using data from the Beijing City Air Pollution Observation Field Experiment (BECAPEX). A heavy pollution day (22 February) and a good air quality day (24 February) are selected and individually analyzed and compared to reveal the relationships between gaseous pollutants and the diurnal variations of the ABL. The results show that gaseous pollutant concentrations exhibit a double-peak-double-valley-type diurnal variation and have similar trends but with different magnitudes at different sites in Beijing. The diurnal variation of the gaseous pollutant concentrations is closely related to (with a 1-2 hour delay of)changes in the atmospheric stability and the mean kinetic energy in the ABL.
Remarks on 1-D Euler Equations with Time-Decayed Damping
Xinghong Pan
Mathematics , 2015,
Abstract: We study the 1-d isentropic Euler equations with time-decayed damping \begin{equation} \left\{ \begin{aligned} &\partial_t \rho+\partial_x(\rho u)=0, \\ &\partial_t(\rho u)+ \partial_x(\rho u^2)+\partial_xp(\rho)=-\frac{\mu}{1+t}\rho u,\\ &\rho|_{t=0}=1+\varepsilon\rho_0(x),u|_{t=0}=\varepsilon u_0(x). \end{aligned} \right. \nonumber \end{equation} This work is inspired by a recent work of F. Hou, I. Witt and H.C. Yin \cite{Hou01}. In \cite{Hou01}, they proved a global existence and blow-up result of 3-d irrotational Euler flow with time-dependent damping. In the 1-d case, we will prove a different result when the damping decays of order $-1$ with respect to the time $t$. More precisely, when $\mu>2$, we prove the global existence of the 1-d Euler system. While when $0\leq\mu\leq2 $, we will prove the blow up of $C^1$ solutions.
Regularity of Solution to Axis-symmetric Navier-Stokes Equations with a Slightly Supercritical Condition
Xinghong Pan
Mathematics , 2014,
Abstract: Consider an axis-symmetric suitable weak solution of 3D incompressible Navier-Stokes equation with nontrivial swirl. If the solution satisfies a slightly supercritical assumption, we will prove that v is regular. This extends the results of Chen-Strain-Tsai-Yau, Koch-Nadirashvili-Seregin-Sverak and Lei-Zhang where regularities under critical assumptions were proven.
Architectural Technology Strategies of Zero Energy Solar House  [PDF]
Ding Ding, Chongjie Wang
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B055
Abstract: Taking I-Magic Cube - the entry of Shandong Jianzhu University for Solar Decathlon 2013 - for example, the paper analyzes the conceptual, technological, functional and aesthetic solutions of zero energy solar house coping with ecological, economic, social and cultural challenges. Passive strategies, the solar thermal and PV system, and the building integrated solar system tactics are elaborated. Finally, industrialization and marketing viability of the solar house prototypes are discussed.
Aquaporin 1, a potential therapeutic target for migraine with aura
Guang-Yin Xu, Fen Wang, Xinghong Jiang, Jin Tao
Molecular Pain , 2010, DOI: 10.1186/1744-8069-6-68
Abstract: Migraine is a chronic, paroxysmal, neurovascular disorder that can start at any age, and affects up to 6% of males and 18% of females in the general population [1]. Two major forms of migraine exist: migraine without aura and migraine with aura. An often debilitating, unilateral, throbbing headache typically characterizes attacks of migraine without aura. This type of headache which may last 4 to 72 hours is aggravated by physical activity, and is accompanied by autonomic symptoms such as vomiting, nausea, photophobia, and phonophobia [2]. However, the attack may also be preceded by premonitory symptoms (prodrome) in some patients. In one third of migraineurs, the headache phase is preceded or accompanied by transient focal symptoms of neurologic aura (migraine with aura). These are usually visual but may also involve sensory disturbances, speech difficulties, and motor symptoms [1].Much progress has now been made in elucidating the mechanisms underlying the aura and headache phases of migraine attacks [3]. The migraine aura is thought to be caused by "cortical spreading depression" (CSD), a wave of intense neuronal activity that slowly progresses over the cortex and is followed by a period of neuronal inactivity. Elevated extracellular levels of potassium and glutamate might be crucial for the initiation and propagation of CSD. During the headache phase, activation of the trigeminovascular system (TGVS) plays a crucial role. The TGVS consists of the meningeal and superficial cortical blood vessels that are innervated by the trigeminal nerve, which projects into the trigeminal nucleus caudalis in the brainstem, which in turn, projects to higher-order pain centers (Figure 1). Evidence from animal experiments suggests that CSD might activate the TGVS, potentially linking the mechanisms for aura and headache [3]. Although the mechanisms of the aura and headache are relative well understood, hardly is anything known about how migraine attacks are initiated. Such knowled
A New Way to Explore Microgravity Effect by Drop Tube Experiment

CHEN Liang,LUO Xinghong,

金属学报 , 2007,
Abstract: Based on calculating the thermal history and the gravity level of some metallic droplets during their dropping in drop tube under different conditions,the limitation of drop tube investigation on rnicrogravity was analyzed and discussed.In order to solve the problem that the effects of microgravity and undercooling were usually coupled and difficult to distinguish,some liquid metals with low melt points,low radiant emissivities and relative high specific heats,such as Al and Cu alloys,were quenched into silieone oil before and after falling.The difference of microstructures between the both conditions was analyzed both theoretically and experimentally.The results showed that this way could make the temperature difference of droplets before and after falling to be neglected, and thus the microgravity effects on alloy solidification would be much more conspicuously identified. Therefore,the extent of material investigations by drop tubes was expanded.

HU Xiaoqiang,XIAO Namin,LUO Xinghong,LI Dianzhong,

金属学报 , 2009,
Abstract: The tungsten–alloyed 10%Cr (mass fraction) steel, one of the advanced 9%—12%Cr steels, has been widely considered as a preferred candidate for making key components in ultra–supercritical (USC) steam turbines. Due to large amounts of ferrite former in the steel, the formation temperature of δ–ferrite is lowered down, and therefore δ–ferrite is apt to be produced during hot working. However, understanding of the formation mechanism of δ–ferrite and its influence on the mechanic properties of ultra–supercritical steels is still either ambiguous or conflicting. To clarify this problem, in this paper, the microstructure and morphology of δ–ferrite were investigated by optical microscope, scanning electron microscope and energy dispersive spectrum (EDS) analysis. Also, the mechanical properties including the tensile strength, ductility and impact toughness of the studied steel with various volume fraction of δ–ferrite were tested at room temperature. Experimental results indicate that the transformation mechanism of δ–ferrite is closely dependent on the austenitizing temperature. Extremely small amounts of acicular δ–ferrite preferentially nucleate and grow inside the prior austenite grains, if the austenitizing temperature is just a little higher than the equilibrium transformation point of δ–ferrite. While, as the austenitizing temperature increases further, some polygonal δ–ferrites subsequently form on prior grain boundaries and grow quickly. Meanwhile, the repartitioning of solute elements occurrs between δ–ferrite and prior austenite. Both acicular and polygonal δ–ferrites will damage the impact toughness of the studied steel. And in spite of its few amounts, the detrimental effect of acicular δ–ferrite on the mechanical properties, especially the impact toughness, is more severe than that of polygonal δ–ferrite. Additionally, the tensile strength and the area reduction of the studied steel decrease as the amount of δ–ferrite increases, while the elongation hardly changes with the amount of δ–ferrite increasing. As a conclusion, accurately controlling the austenitizing temperature to prevent from the formation of any δ–ferrite is not only necessary but also very important in obtaining perfect overall mechanical properties.

ZHANG Xinghong,HOU Zuofu,

力学与实践 , 2007,
Abstract: The uncoupled governing equations in terms of radial displacement u and lateral displacement w for elastic circular plate with temperature-dependent properties subjected to combined heat and lateral force under large deflections are derived by use of Berger approximation.The general series expressions of variables u and w are obtained by Galerkin approximation.As an example,the deflections of a plate heated and compressed uniformly on its surfaces are calculated.The result of this present theory and that of the finite element numerical simulation are compared,and they are in good agreement.The bifurcation line of nonlinear deformation of the plate vs.temperature change and lateral force is obtained.The effect of temperature dependence of material's Young's modulus E on deformation of the plate heated and compressed is discussed,and the geometric nonlinear effect is found to be more significant than the temperature-dependent effect with respect to material's properties.
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