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Search Results: 1 - 10 of 85814 matches for " Xin-Yan Lu "
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High-Tech Acupuncture and Integrative Laser Medicine
Gerhard Litscher,Xin-Yan Gao,Lu Wang,Bing Zhu
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/363467
Abstract:
High-Tech Acupuncture and Integrative Laser Medicine 2013
Gerhard Litscher,Xin-Yan Gao,Lu Wang,Bing Zhu
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/590718
Abstract:
Brain-Modulated Effects of Auricular Acupressure on the Regulation of Autonomic Function in Healthy Volunteers
Xin-Yan Gao,Lu Wang,Ingrid Gaischek,Yvonne Michenthaler,Bing Zhu,Gerhard Litscher
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/714391
Abstract: Auricular acupuncture has been described in ancient China as well as Egypt, Greece, and Rome. At the end of the 1950s, ear acupuncture was further developed by the French physician Dr. Paul Nogier. The goal of this study was to develop a new system for ear acupressure (vibration stimulation) and to perform pilot investigations on the possible acute effects of vibration and manual ear acupressure on heart rate (HR), heart rate variability (HRV), pulse wave velocity (PWV), and the augmentation index (AIx) using new noninvasive recording methods. Investigations were performed in 14 healthy volunteers (mean age ± SD: 26.3±4.3 years; 9 females, 5 males) before, during, and after acupressure vibration and manual acupressure stimulation at the “heart” auricular acupuncture point. The results showed a significant decrease in HR (≤0.001) and a significant increase in HRV total (=0.008) after manual ear acupressure. The PWV decreased markedly (yet insignificantly) whereas the AIx increased immediately after both methods of stimulation. The increase in the low-frequency band of HRV was mainly based on the intensification of the related mechanism of blood pressure regulation (10-s-rhythm). Further studies in Beijing using animal models and investigations in Graz using human subjects are already in progress.
catena-Poly[[aquanickel(II)]-μ-pyridine-2,6-dicarboxylato-[aquanickel(II)]-μ-2,5-di-4-pyridyl-1,3,4-thiadiazole]
Xin-Yan Zhang
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809012628
Abstract: The two independent NiII ions in the one-dimensional title complex, [Ni2(C7H3NO4)2(C12H8N4S)(H2O)2]n or [Ni2(pydc)2(bpt)(H2O)2]n (H2pydc = pyridine-2,6-dicarboxylic acid and bpt = 2,5-di-4-pyridyl-1,3,4-thiadiazole), have different coordination environments. One NiII ion is in a slightly-distorted octahedral coordination environment formed by three O atoms from two adjacent pydc ligands, two N atoms from bpt and pydc ligands, and one water molecule, while the other NiII ion is in distorted square-pyramidal geometry, coordinated by two O atoms from two carboxylate groups and two N atoms from the pyridine rings of the pydc and bpt ligands in the basal plane, while a coordinated water molecule occupies the apical site. In the crystal structure, the H atoms of both water molecules are involved in intermolecular hydrogen bonds with the O atoms of uncoordinated carboxylate groups, which link chains into a three-dimensional network.
Tetra-μ-methacrylato-κ8O:O′-bis[(pyridin-2-amine-κN1)copper(II)]
Xin-Yan Zhang
Acta Crystallographica Section E , 2009, DOI: 10.1107/s160053680901352x
Abstract: In the title carboxylate-bridged binuclear copper complex, [Cu2(C4H5O2)4(C5H6N2)2], each CuII ion has a distorted square-based pyramidal environment formed by one N and four O atoms. The asymmetric unit contains two halves of two centrosymmetric molecules, with Cu...Cu separations of 2.6498 (8) and 2.6528 (8) .
Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma
Pulivarthi H Rao, Hugo Arias-Pulido, Xin-Yan Lu, Charles P Harris, Hernan Vargas, Fang F Zhang, Gopeshwar Narayan, Achim Schneider, Mary Terry, Vundavalli VVS Murty
BMC Cancer , 2004, DOI: 10.1186/1471-2407-4-5
Abstract: We used a genome-wide screening method – comparative genomic hybridization (CGH) to identify DNA copy number changes in 77 patients with cervical cancer. We applied categorical and survival analyses to analyze whether chromosomal changes were related to clinico-pathologic characteristics and patients survival.The CGH analysis revealed a loss of 2q33-q37 (57.1%), gain of 3q (54.5%) and chromosomal amplifications (20.77%) as frequent genetic changes. A total of 15 amplified chromosomal sites were detected in 16 cases that include 1p31, 2q32, 7q22, 8q21.2-q24, 9p22, 10q21, 10q24, 11q13, 11q21, 12q15, 14q12, 17p11.2, 17q22, 18p11.2, and 19q13.1. Recurrent amplified sites were noted at 11q13, 11q21, and 19q13.1. The genomic alterations were further evaluated for prognostic significance in CC patients, and we did not find any correlation with a number of clinical or histological parameters. The tumors harboring HPV18 exhibited higher genomic instability compared to tumors with HPV 16.This study demonstrated that 2q33-q37 deletions, 3q gains and chromosomal amplifications as characteristic changes in invasive CC. These genetic alterations will aid in the identification of novel tumor suppressor gene(s) at 2q33-q37 and oncogenes at amplified chromosomal sites. Molecular characterization of these chromosomal changes utilizing the current genomic technologies will provide new insights into the biology and clinical behavior of CC.Cervical Cancer (CC) is the second most common malignancy among women in both incidence and mortality [1]. The HPV infection has been implicated as the most important etiologic factor in the development of CC [2]. Although 95% of the patients with precancerous lesions harbor HPV, only a small fraction of the cases eventually progress to invasive cancer [3]. Therefore, HPV infection alone was considered insufficient for the malignant conversion suggesting role of other genetic changes in the development of CC. Further identification of such genetic alt
Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma
Tsz-Kwong Man, Xin-Yan Lu, Kim Jaeweon, Laszlo Perlaky, Charles P Harris, Shishir Shah, Marc Ladanyi, Richard Gorlick, Ching C Lau, Pulivarthi H Rao
BMC Cancer , 2004, DOI: 10.1186/1471-2407-4-45
Abstract: We used a genome-wide screening method – array based comparative genomic hybridization (array-CGH) to identify DNA copy number changes in 48 patients with osteosarcoma. We applied fluorescence in situ hybridization (FISH) to validate some of amplified clones in this study.Clones showing gains (79%) were more frequent than losses (66%). High-level amplifications and homozygous deletions constitute 28.6% and 3.8% of tumor genome respectively. High-level amplifications were present in 238 clones, of which about 37% of them showed recurrent amplification. Most frequently amplified clones were mapped to 1p36.32 (PRDM16), 6p21.1 (CDC5L, HSPCB, NFKBIE), 8q24, 12q14.3 (IFNG), 16p13 (MGRN1), and 17p11.2 (PMP22 MYCD, SOX1,ELAC27). We validated some of the amplified clones by FISH from 6p12-p21, 8q23-q24, and 17p11.2 amplicons. Homozygous deletions were noted for 32 clones and only 7 clones showed in more than one case. These 7 clones were mapped to 1q25.1 (4 cases), 3p14.1 (4 cases), 13q12.2 (2 cases), 4p15.1 (2 cases), 6q12 (2 cases), 6q12 (2 cases) and 6q16.3 (2 cases).This study clearly demonstrates the utility of array CGH in defining high-resolution DNA copy number changes and refining amplifications. The resolution of array CGH technology combined with human genome database suggested the possible target genes present in the gained or lost clones.Osteosarcoma (OS) is a primary malignant tumor of bone arising from primitive bone-forming mesenchymal cells and it accounts for approximately 60% of malignant bone tumors in the first two decades of life [1]. These tumors typically arise in the metaphyseal regions of long bones, with the distal femur, proximal tibia and proximal humerus. A significant number of osteosarcomas are of conventional type which can be subdivided into three major categories based on their predominant differentiation of tumor cells: osteoblastic, chondroblastic, and fibroblastic. Currently, only the histological response (degree of necrosis) to therapy
SPATIAL AND TEMPORAL VARIABILITY IN OCEAN TEMPERATURE IN WEST PACIFIC WARM POOL AND ITS EFFECT IN ENSO CYCLE
西太平洋暖池海温的时空变化及其在ENSO循环中的作用

WANG Hong-Na,CHEN Jin-Nian,LU Xin-Yan,
王宏娜
,陈锦年,吕心艳

海洋与湖沼 , 2009,
Abstract: 应用SODA_1.4.2版本资料,分析研究了热带西太平洋暖池(以下简称WPWP)海温场的变化特征,讨论了WPWP海温的时空变化特征与ENSO之间的联系途径.分析结果表明,在上层海洋,WPWP的海温场在垂向结构上具有显著的年际变化特征,在不同深度存在较大差异.表层的异常海温出现明显的增温趋势,在47年期间(1958-2004)增温幅度达0.15℃.而随着深度的增加,异常海温出现明显的降低趋势,次表层(120-170 m)的降温幅度最大,其降温可达-0.72℃.这种变化可能与20世纪70年代末WPWP区域的海温场发生突变过程存在一定关系.另外,在热带太平洋温跃层曲面上,WPWP区域海温变化与赤道东太平洋海温变化存在"跷跷板"现象.据此,定义了赤道东西太平洋温跃层曲面上异常海温变化强度指数,为ENSO循环过程的研究提供了又一参考依据.通过对WPWP不同深度的异常海温和海流分析发现,WPWP异常海温的东传过程与赤道潜流的强弱变化存在密切关系.
Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8
Massimiliano De Bortoli, Robert C Castellino, Xin-Yan Lu, Jeffrey Deyo, Lisa Sturla, Adekunle M Adesina, Laszlo Perlaky, Scott L Pomeroy, Ching C Lau, Tsz-Kwong Man, Pulivarthi H Rao, John YH Kim
BMC Cancer , 2006, DOI: 10.1186/1471-2407-6-223
Abstract: We analyzed 71 primary medulloblastomas for chromosomal copy number aberrations (CNAs) using comparative genomic hybridization (CGH). Among 64 tumors that we previously analyzed by gene expression microarrays, 27 were included in our CGH series. We analyzed clinical outcome with respect to CNAs and microarray results. We filtered microarray data using specific CNAs to detect differentially expressed candidate genes associated with survival.The most frequent lesions detected in our series involved chromosome 17; loss of 16q, 10q, or 8p; and gain of 7q or 2p. Recurrent amplifications at 2p23-p24, 2q14, 7q34, and 12p13 were also observed. Gain of 8q is associated with worse overall survival (p = 0.0141), which is not entirely attributable to MYC amplification or overexpression. By applying CGH results to gene expression analysis of medulloblastoma, we identified three 8q-mapped genes that are associated with overall survival in the larger group of 64 patients (p < 0.05): eukaryotic translation elongation factor 1D (EEF1D), ribosomal protein L30 (RPL30), and ribosomal protein S20 (RPS20).The complementary use of CGH and expression profiles can facilitate the identification of clinically significant candidate genes involved in medulloblastoma growth. We demonstrate that gain of 8q and expression levels of three 8q-mapped candidate genes (EEF1D, RPL30, RPS20) are associated with adverse outcome in medulloblastoma.Medulloblastoma is the most common malignant brain tumor of childhood. Treatment with surgery, radiation, and chemotherapy successfully cures many patients, but survivors can suffer significant long-term toxicities affecting their neurocognitive and growth potential. Despite clinical advances, up to 30% of children with medulloblastoma experience tumor progression or recurrence, for which no curative therapy exists [1]. The lack of more effective, less toxic therapies and the inability to stratify patients biologically result from imperfect understanding of the m
Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma
Chung-Che Chang, Xiaobo Zhou, Jesalyn J Taylor, Wan-Ting Huang, Xianwen Ren, Federico Monzon, Yongdong Feng, Pulivarthi H Rao, Xin-Yan Lu, Facchetti Fabio, Susan Hilsenbeck, Chad J Creighton, Elaine S Jaffe, Ching-Ching Lau
Journal of Hematology & Oncology , 2009, DOI: 10.1186/1756-8722-2-47
Abstract: Examination of genomic data in PL revealed that the most frequent segmental gain (> 40%) include: 1p36.11-1p36.33, 1p34.1-1p36.13, 1q21.1-1q23.1, 7q11.2-7q11.23, 11q12-11q13.2 and 22q12.2-22q13.3. This correlated with segmental gains occurring in high frequency in DLBCL (AIDS-related and non AIDS-related) cases. There were some segmental gains and some segmental loss that occurred in PL but not in the other types of lymphoma suggesting that these foci may contain genes responsible for the differentiation of this lymphoma. Additionally, some segmental gains and some segmental loss occurred only in PL and AIDS associated DLBCL suggesting that these foci may be associated with HIV infection. Furthermore, some segmental gains and some segmental loss occurred only in PL and PCM suggesting that these lesions may be related to plasmacytic differentiation.To the best of our knowledge, the current study represents the first genomic exploration of PL. The genomic aberration pattern of PL appears to be more similar to that of DLBCL (AIDS-related or non AIDS-related) than to PCM. Our findings suggest that PL may remain best classified as a subtype of DLBCL at least at the genome level.Plasmablastic lymphoma (PL), one of the most frequent oral malignancies in human immunodeficiency virus (HIV) infected patients, was first characterized by Delecluse et al [1]. They proposed that this constituted a new subtype of diffuse large B cell lymphoma (DLBCL); it was suggested as a distinct entity based on its blastic morphology, its clinical behavior involving predominantly extramedullary sites (particularly oral cavity), and its limited antigenic phenotype data suggesting differentiation toward plasmacytic differentiation (CD20-, CD79a+ and VS38c+). The incidence of PL has increased following the introduction of highly active antiretroviral therapy (HAART) [2,3]. By WHO Classification, PL is categorized as a subtype of DLBCL associated with HIV and Epstein-Barr virus [1,4,5].Recent morph
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