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Search Results: 1 - 10 of 14178 matches for " Xifeng Jia "
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The Hematopoietic and Immunomodulatory Effect of rhIL-12 for Liver Cancer  [PDF]
Xiaojing Gong, Na Guo, Lingqin Wan, Xifeng Jia, Yishan Wang
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2016, DOI: 10.4236/ijmpcero.2016.51004
Abstract: Purpose: To explore the effect of rhIL-12 on the number of the blood cells and CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells in liver cancer patients following radiation therapy. Methods: We selected forty liver cancer patients who carried out by cyber knife (the patients were given 5 Gy every time for 5 times continuously) to observe the size of the tumor. After thirty hours, rhIL-12 was injected into the liver cancer patients via subcutaneous at the concentration of 50 ng/kg, 100 ng/kg, 200 ng/kg and 300 ng/kg in different patients, respectively. And there were ten patients in the four groups, respectively. The twenty patients who were selected from the hospital without rhIL-12 treatment were used as controls. All the blood cells were collected from different groups on day 0, hour 12, day 7, day 14, day 21 and day 28 after rhIL-12 treatment, respectively. The full number of blood cells in every group was analyzed by ELISA. The number of CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells were detected by Flow Cytometry. After one month with rhIL-12 treatment, ECOG and WHO were used to evaluate the prognosis of liver cancer. Results: In present study, we found that the number of blood cells was significantly decreased on day 0 - day 3, while recovered from day 7 - day 14 and down-regulated on day 21 after rhIL-12 treatment. The number of CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells was elevated with any concentration of rhIL-12. Furthermore, results showed that number of white blood cells was obviously higher than in patients without rhIL-12 treatment (P < 0.05). However, there was no significant difference of erythrocyte and platelet, between groups treated with rhIL-12 and control groups. In addition, the immune cells including CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells were reduced on day 0 - day 3, recovered from day 7, and then decreased from day 21 in rhIL-12 treatment groups related to control groups (P < 0.05). Furthermore, studies showed that five patients developed symptoms of fever, bilirubin increased and liver dysfunction with the dose of 300 ng/kg. So we found that the safe and well-tolerated human dose of 200 ng/kg is within this efficacious range based on exposure parameters through the research. Higher ECOG and WHO scores were observed in rhIL-12 treatment groups compared to control groups (P = 0.025, P = 0.044, respectively). Conclusion: Our results suggested that rhIL-12 could recover the liver cancer induced aberrant blood cell number and CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells , which may be an effective method to
Identification of a protein associated with circulative transmission of barley yellow dwarf virus from cereal aphids, Schizaphis graminum and Sitobion avenae
Xifeng Wang,Guanghe Zhou
Chinese Science Bulletin , 2003, DOI: 10.1360/03wc0153
Abstract: Using 2-D electrophoresis and virus overlay assay, a 50-kDa protein (P50) exhibiting specific binding to purified virus particles of BYDV-GAV was found in the protein extracts from Schizaphis graminum and Sitobion avenae, two aphid species transmitting BYDV-GAV. P50 in the extracts of S. graminum was isolated by preparation electrophoresis and electro-eluted proteins from the gel slices for antiserum preparation. After feeding the antiserum through membrane, the transmission efficiencies of S. graminum and S. avenae for BYDV-GAV decreased significantly. It was suggested that P50 should be related with transmission process. Location of P50 was found at the plasma membrane surrounding the accessory salivary gland (ASG) in the head tissues of S. graminum by immunogold-labelling experiment. The ascertainment of the protein associated with virus transmission has a significance influence on further understanding the transmission mechanism and genetic engineering for resistant to vector transmission.
Advanced Research on the Response of EGFR Tyrosine Kinase Inhibitors for Non-small Cell Lung Cancer Therapy
Xifeng DONG,Qiang SONG
Chinese Journal of Lung Cancer , 2009,
Weak KAM theorem for Hamilton-Jacobi equations
Xifeng Su,Jun Yan
Mathematics , 2013,
Abstract: In this paper, we generalize weak KAM theorem from positive Lagrangian systems to "proper" Hamilton-Jacobi equations. We introduce an implicitly defined solution semigroup of evolutionary Hamilton-Jacobi equations. By exploring the properties of the solution semigroup, we prove the convergence of solution semigroup and existence of weak KAM solutions for stationary equations: \begin{equation*} H(x, u, d_x u)=0. \end{equation*}
Convergence of discrete Aubry-Mather model in the continuous limit
Xifeng Su,Philippe Thieullen
Mathematics , 2015,
Abstract: Let $H(x,p)$ be a Tonelli Hamiltonian defined on $\mathbb{T}^d \times \mathbb{R}^d$. We show how to approximate the solutions of the cell equation $H(x,d_xu)=\bar H$ by discrete weak KAM solutions. The cell equation is a degenerate PDE of first order that can be solved using the weak KAM theory developed by Mather and Fathi [Mat91, Mat93, Fat08]. Discrete weak KAM theory is similar to the Frenkel-Kontorova theory developed by Aubry and Le Daeron [ALD83] or Chou and Griffiths [CG86] in dimension one. The theory has then been more thoroughly developed by Gomes [Gom05] and by Garibaldi and Thieullen [GT11] in higher dimension. The discrete weak KAM approach approximates the Lagrangian trajectories by one-dimensional chains of atoms. By introducing a family of discrete actions $\{\mathcal{L}_\tau(x,y)\}_{\tau>0}$ related to the Legendre-Fenchel transform of $H$, we show that the solutions of additive eigenvalue problem $u_\tau(y) + \bar{\mathcal{L}}_\tau=\inf_{x\in\mathbb{R}^d} \{ u_\tau(x)+\mathcal{L}_\tau(x,y) \}$ with unknowns $(\bar{\mathcal{L}}_\tau,u_\tau)$ converges in a sense to be defined to a solution of the cell equation with unknowns $(\bar H,u)$.
Total destruction of invariant tori for the generalized Frenkel-Kontorova model
Xifeng Su,Lin Wang
Mathematics , 2011, DOI: 10.1063/1.3683233
Abstract: We consider generalized Frenkel-Kontorova models on higher dimensional lattices. We show that the invariant tori which are parameterized by continuous hull functions can be destroyed by small perturbations in the $C^r$ topology with $r<1$.
Corrosion properties of bio-oil and its emulsions with diesel
Qiang Lu,Jian Zhang,XiFeng Zhu
Chinese Science Bulletin , 2008, DOI: 10.1007/s11434-008-0499-7
Abstract: Bio-oil is a new liquid fuel but very acidic. In this study, bio-oil pyrolyzed from rice husk and two bio-oil/diesel emulsions with bio-oil concentrations of 10 wt% and 30 wt% were prepared. Tests were carried out to determine their corrosion properties to four metals of aluminum, brass, mild steel and stainless steel at different temperatures. Weight loss of the metals immersed in the oil samples was recorded. The chemical states of the elements on metal surface were analyzed by X-ray photoelectron spectroscopy (XPS). The results indicated that mild steel was the least resistant to corrosion, followed by aluminum, while brass exhibited slight weight loss. The weight loss rates would be greatly enhanced at elevated temperatures. Stainless steel was not affected under any conditions. After corrosion, increased organic deposits were formed on aluminum and brass, but not on stainless steel. Mild steel was covered with many loosely attached corrosion materials which were easy to be removed by washing and wiping. Significant metal loss was detected on surface of aluminum and mild steel. Zinc was etched away from brass surface, while metallic copper was oxidized to Cu2O. Increased Cr2O3 and NiO were presented on surface of stainless steel to form a compact passive protection film. The two emulsions were less corrosive than the bio-oil. This was due to the protection effect of diesel. Diesel was the continuous phase in the emulsions and thus could limit the contact area between bio-oil and metals.
Microstructure variation and growth mechanism of hypoeutectic Al-Si alloy solidifi ed under high pressure
Zhang Guozhi,Yu Xifeng,Liu Xinggang
China Foundry , 2009,
Abstract: The microstructure of hypoeutectic Al-9.21wt.%Si alloy solidified under 5.5 GPa was studied. The results show that the solidifi cation microstructure is refi ned. The primary α phase is the extended solid solution. The solid solubility of Si in α phase is up to 8.26wt.%. The growth mode of the α phase is cellular, and this cellular growth mechanism is interpreted in terms of the decrease of the diffusivity and the extended solid solution under high pressure. By calculation, it can be known that the the diffusivity of solute in the liquid under normal pressure is as high as two hundred times that under high pressure. The microhardness of the hypoeutectic Al-Si alloy solidified under high pressure is higher than that of solidifi ed under normal pressure. After annealing, Si precipitates from the solid solution, the microhardness of the alloy decrease, but, still higher than that of solidifi ed under normal pressure.
Extraction of Top Backgrounds in the Higgs Boson Search with the $H\rightarrow WW^{\star}\rightarrow\ell\ell+\met$ Decay with a Full-Jet Veto at the LHC
Bruce Mellado,Xifeng Ruan,Zhiqing Zhang
Physics , 2011, DOI: 10.1103/PhysRevD.84.096005
Abstract: The search for a Standard Model Higgs boson with the $H\rightarrow WW^{\star}\rightarrow\ell\ell+\met$ decay and the application of a full-jet veto yields a strong sensitivity in the mass range $130
On Homology Roses and the D(2)-problem
Xifeng Jin,Yang Su,Li Yu
Mathematics , 2013,
Abstract: For a commutative ring $R$ with a unit, an $R$-homology rose is a topological space whose homology groups with $R$-coefficients agree with those of a bouquet of cirlces. In this paper, we study some special properties of covering spaces and fundamental groups of $R$-homology roses, from which we obtain some result supporting the Carlsson conjecture on free $(Z_p)^r$ actions. In addition, for a group $G$ and a field $F$, we define an integer called the $F$-gap of $G$, which is an obstruction for $G$ to be realized as the fundamental group of a 2-dimensional $F$-homology rose. Furthermore, we discuss how to search candidates of the counterexamples of Wall's D(2)-problem among $F$-homology roses and $F$-acyclic spaces.
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