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Search Results: 1 - 10 of 104248 matches for " Xiaozhen Zhang "
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Hepatitis C-Associated Mixed Cryoglobulinemic Vasculitis Induces Differential Gene Expression in Peripheral Mononuclear Cells
Sreetha Sidharthan,Xiaozhen Zhang,Shyam Kottilil
Frontiers in Immunology , 2014, DOI: 10.3389/fimmu.2014.00248
Abstract: This study examines the distinct gene expression profile of peripheral blood mononuclear cells from patients with chronic hepatitis C infection and mixed cryoglobulinemic (MC) vasculitis. Our DNA microarray analysis indicates that hepatitis C virus (HCV)-associated MC vasculitis is characterized by compromised neutrophil function, impaired chemotaxis, and increased interferon-stimulated gene (ISG) expression, contributing to overall MC pathogenesis and end-organ damage. Increased ISG expression is suggestive of an enhanced endogenous interferon gene signature. PBMC depletion assays demonstrate that this increased expression is likely due to an activation of monocytes and not a direct result of B cell expansion. Notably, this monocyte activation of ISG expression in HCV-associated MC vasculitis suggests a poor predictor status of interferon-based treatment. Further analysis of PBMC gene expression profiles before and after in vivo B cell depletion therapy is critical to completely understanding the mechanisms of MC vasculitis pathogenesis.
Separation of Kaolinite from Ion-Adsorption Rare Earth Tailings in Southern China and Iron Removal Treatment  [PDF]
Yongqing Wang, Huayin Liang, Qibing Chang, Xiaozhen Zhang, Jian’er Zhou
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2016, DOI: 10.4236/jmmce.2016.41005
Abstract: Several hundred million tons of ion-adsorption rare earth tailings exist in Ganzhou, Southern China, which is a severe environmental hazard. To reduce and reutilize the tailing, kaolinite has been separated from the tailings by mechanical separation in laboratory scale and pilot scale. The results show that the tailing is mainly composed of fine kaolinite and coarse quart. Quartz and kaolinite can be separated by sieves, shaker, spiral chute or hydrocyclone, which has the similar results in laboratory scale and pilot scale. 30.2% of the tailings can be re-sourced and applied in ceramic industries. 41.7% of kaolinite can be obtained after sorting and iron removal by magnetic separator in pilot scale, which can be applied in ceramic industries according to the Chinese national standard (TC-3). The results give a progressive solution to re-source the tailings economically.
Characterization and Iron Removal Treatment of Ion-Adsorption Rare Earth Tailings in Southern China  [PDF]
Yongqing Wang, Xin Nie, Qibing Chang, Huayin Liang, Xiaozhen Zhang, Jian-Er Zhou
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2016, DOI: 10.4236/jmmce.2016.42012
Abstract: The ion-adsorption rare earth tailings have become a serious environmental pollution in Southern China, yet the potential of their economical value has not been fully exploited. In this work, the chemical and mineral compositions of the ion-adsorption rare earth tailings were characterized by Mineral Liberation Analyze (MLA) and XRF. The results show that 91.98 wt% of the tailings are composed of kaolinite and quartz, latter of which was removed by the sieving method. The other minor minerals contain feldspar, biotite, muscovite, titanomagnetite and limonite. Amongst these, the iron-bearing minerals are mostly found in the titanomagnetite and limonite which can be mostly removed by using a periodic high-gradient magnetic separator with a magnetic induction of 0.6 Tesla. The Fe2O3 content of the tailings changed from 2.11 wt% to 1.06 wt% after the sorting process, which met the Chinese national standard of TC-3 grade raw materials for ceramic industry applications. The Fe2O3 content in kaolinite was further decreased after Na2S2O4 treatment.
An Electronic Image Stabilization Algorithm Based on Efficient Block Matching on the Bitplane  [PDF]
Luo Fang, Qin Xiaozhen
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.31B001
Abstract: This paper proposes an electronic image stabilization algorithm based on efficient block matching on the plane. This algorithm uses a hexagonal search algorithm, and uses the bit-planes to estimate and compensate for the translational motion between video sequences at the same time; As for the rotary motion vector generated in the video sequences, in order to highlight the intensity change of the image sequence, the algorithm firstly conducts Laplace transform for the reference frame, then select a number of characteristics at the image edge to make block matching with the current frame, calculate and compensate for the rotational movement that may exist finally. Through theoretical analysis and simula-tion, we prove that, as for a mixed translational and rotational motion video sequences, the proposed algorithm can reduce required time for block matching computation ,while improving the accuracy of the electronic image stabilization.
WANG Shidong,LAM Cheungching,SHEN Guangjun,ZHANG Jinping,WU Xiaozhen
金属学报(英文版) , 1995,
MicroRNA Expression Profiling in HCV-Infected Human Hepatoma Cells Identifies Potential Anti-Viral Targets Induced by Interferon-α
Xiaozhen Zhang, Marybeth Daucher, David Armistead, Rodney Russell, Shyam Kottilil
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055733
Abstract: Objective Increasing evidence suggests that miRNAs have a profound impact on host defense to Hepatitis C virus (HCV) infection and clinical outcome of standard HCV therapy. In this study, we investigated modulation of miRNA expression in Huh7.5 hepatoma cells by HCV infection and in vitro interferon-αtreatment. Methods MiRNA expression profiling was determined using Human miRNA TaqMan? Arrays followed by rigorous pairwise statistical analysis. MiRNA inhibitors assessed the functional effects of miRNAs on HCV replication. Computational analysis predicted anti-correlated mRNA targets and their involvement in host cellular pathways. Quantitative RTPCR confirmed the expression of predicted miRNA-mRNA correlated pairs in HCV-infected Huh7.5 cells with and without interferon-α. Results Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-α treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection. Conclusions HCV differentially modulates miRNAs to facilitate entry and early establishment of infection in vitro. Interferon-α appears to neutralize the effect of HCV replication on miRNA regulation thus providing a potential mechanism of action in eradicating HCV from hepatocytes.
Analysis of Evacuation of Tourists Based on the Louvre’s Emergency  [PDF]
Rui Tang, Xiaozhen Luan, Shiwei Xu, Fuliang Lu, Wei Zhang
Open Journal of Applied Sciences (OJAppS) , 2019, DOI: 10.4236/ojapps.2019.96041
Abstract: Due to France has suffered from many terrorist attacks and the number of visitors to the Louvre has gradually increased in recent years, a good evacuation plan for the Louvre is of vital significance. We use the minimization of the total evacuation time of all tourists as the optimization goal to find an optimal path. For conventional emergencies, a static model is built to evacuate visitors. And then we establish a nonlinear programming model. Using Lingo software, we get the distribution information of the visitors in different exhibition halls. For unconventional emergencies, we establish an adaptive dynamic model of tourist evacuation based on genetic algorithm. The sensitivity analysis of the model is considered by adding new paths. By solving the nonlinear programming problem with the double objective function of maximizing evacuation time and balancing the number of people in every path, we get the evacuation time last 1582.74 s. Finally, according to our result, we built mathematical models for the evacuation after an emergency and analyzed how to adapt and implement our models for other large and crowded structures.
Quantization of Noncommutative Scalar Solitons at finite $θ$
Xiaozhen Xiong
Physics , 2002, DOI: 10.1103/PhysRevD.66.105017
Abstract: We start by discussing the classical noncommutative (NC) Q-ball solutions near the commutative limit, then generalize the virial relation. Next we quantize the NC Q-ball canonically. At very small theta quantum correction to the energy of the Q-balls is calculated through summation of the phase shift. UV/IR mixing terms are found in the quantum corrections which cannot be renormalized away. The same method is generalized to the NC GMS soliton for the smooth enough solution. UV/IR mixing is also found in the energy correction and UV divergence is shown to be absent. In this paper only (2+1) dimensional scalar field theory is discussed.
The solution to the inter-symbol interference with the LFM

Wang Zhensong,Zhang Xiaozhen,

电子与信息学报 , 2003,
Abstract: The technique of the Linear Frequency Modulation (LFM) is proposed to solve the problems of the inter-symbol interference in this paper. For comparing with other modulation techniques, the BER is analyzed, and the simulation results are given. The theoretical prediction and the simulation results indicate that the LFM is very useful to depress the inter-symbol interference. The high transmitting speed is held in some areas where the average of the multi-path time dispersion is larger. The merits of the LFM are that it is not necessary to have an equalizer or the spread spectrum code modulation.
Detection and Molecular Diversity of Spike Gene of Porcine Epidemic Diarrhea Virus in China
Jianfei Chen,Xiaozhen Liu,Da Shi,Hongyan Shi,Xin Zhang,Changlong Li,Yanbin Chi,Li Feng
Viruses , 2013, DOI: 10.3390/v5102601
Abstract: Since late 2010, porcine epidemic diarrhea virus (PEDV) has rapidly disseminated all over the China and caused considerable morbidity and high mortality (up to 100%) in neonatal piglets. 79.66% (141 of 177) pig farms in 29 provinces (excluding Tibet and Hainan, China) and 72.27% (417 of 577) samples were positive for PEDV confirmed by reverse transcription-polymerase chain reaction (RT-PCR). The full-length S genes of representative field strains were sequenced. 33 field strains share 93.5%–99.9% homologies with each other at the nucleotide sequence level and 92.3%–99.8% homologies with each other at the amino acids sequence level. Most field strains have nucleotide deletion and insertion regions, and show lower homologies (93.5%–94.2%) with Chinese classical strain CH/S, however higher homologies (97.1%–99.3%) with recent strain CHGD-1. The phylogenetic analysis showed there are classical strains and variants prevailing in pig herd in China. PEDV has a high detection rate in pig herds in China. Sequence analysis indicated the S genes of recent field strains have heterogeneity and the variants are predominant.
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