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Search Results: 1 - 10 of 43134 matches for " Xiaolin Xu "
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Free Cholesterol Induces Higher β-Sheet Content in Aβ Peptide Oligomers by Aromatic Interaction with Phe19
Xiaolin Zhou, Jie Xu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046245
Abstract: Accumulating experimental evidence support an enhancing effect of free cholesterol on amyloid-beta (Aβ) aggregation. To probe the mechanisms of cholesterol-mediated Aβ aggregation, we applied all-atom molecular dynamic simulations on Aβ42 peptides in presence of free cholesterol. Several control systems were also designed to examine the specificity of cholesterol-residue interactions, including mutation on aromatic residue, substitution of cholesterol with sphingomyelin (SM) and DPPC bilayer, and a mixing SM and cholesterol. Each system was performed 4 independent simulations, with a total time of 560 ns. It was found that cholesterol increased β-sheet formation by 4 folds, but the Phe19→Ser mutation on Aβ42 peptide totally eliminated cholesterol’s effect. A stable contact was recognized between the steroid group of cholesterol and the Benzyl group of Phe19. Interestingly, our simulation revealed a regular 1 ns time interval between the establishment of cholesterol-phenylalanine contact and consequent β-sheet formation, suggesting an important role of steroid-benzyl interaction in cholesterol-mediated aggregation. The presence of SM slightly increased β-sheet formation, but the mixture of cholesterol and SM had a strong induction effect. Also, the measurement of Phe19-lipid distance indicates that aromatic side chains of peptides prone to bind to cholesterol on the surface of the mixed micelle. In the DPPC system, polar chains were attracted to the surface of membrane, yielding moderate increase of β-sheet formation. These results shed light on the mechanism of cholesterol-mediated fibrillogenesis, and help to differentiate the effects of cholesterol and other lipids on β-sheet formation process.
A new iguanodontid (Jinzhousaurus yangi gen. et sp. nov.) from the Yixian Formation of western Liaoning, China
Xiaolin Wang,Xing Xu
Chinese Science Bulletin , 2001, DOI: 10.1007/BF02900633
Abstract: A new iguanodontid,Jinzhousaurus yangi gen. et sp. nov., is erected based on the cranial and dental morphology of a specimen from the Yixian Formation of western Liaoning. Although a few primitive characteristics remain,Jinzhousaurus yangi display a number of characteristics similar to those seen in derived iguanodontids. Other interesting characteristics include the absence of antorbital fenestra and the frontal excluded from the participation in orbit, which are closer to the condition in hadrosaurids. The unusual combination of the characteristics provides important data for assessing morphological evolution toward hadrosaurs. The new discovery also represents the first reported large-sized dinosaur from Jehol fauna in western Liaoning, and increases the diversity of this famous fauna. Furthermore, the discovery of a derived iguanodontid from the Yixian Formation provides further evidence supporting a Cretaceous age of the Jehol fauna, which is consistent with an isotopic age.
Left Pulmonary Artery Sling Associated with Patent Ductus Arteriosus and Atrial Septal Defect: Evaluation with Multidetector CT  [PDF]
Rukeshman Shakya, Jianhua Liu, Mohit Godar, Qinghai Yuan, Xiaolin Xu
Advances in Computed Tomography (ACT) , 2012, DOI: 10.4236/act.2012.13004

We report a case of left pulmonary artery sling associated with patent ductus arteriosus and atrial septal defect in a 21-month-old child. 256-slice MDCT provides valuable information, such as abnormal origin of the left pulmonary artery, the relationship between pulmonary artery and airway, the diameter of the patent ductus artery and atrial septal defect. The information is helpful in diagnosis, pre-operative evaluation and post-operative follow-up of LPS.

A VLSI algorithm for calculating the tree to tree distance
A VLSI Algorithm for Calculating the Tree to Tree Distance

Meirui Xu,Xiaolin Liu,
Xu Meirui
,Liu Xiaolin

计算机科学技术学报 , 1993,
Abstract: Given two ordered, labeled trees β and α, to find the distance from tree β to tree α is an important problem in many fields, for example, the pattern recognition field. In this paper, a VLSI algorithm for calculating the tree to tree distance is presented. The computation structure of the algorithm is a 2-D Mesh with the sizem*n and the time isO(m+n), wherem,n are the numbers of nodes of the tree β and tree α, respectively.
Public-Private Partnerships: The Underlining Principles of Infrastructure Investment, Finance and Development Projects
Ikechukwu Ikea Chinyere,Xiaolin Xu
International Journal of Business and Management , 2011, DOI: 10.5539/ijbm.v7n1p109
Abstract: In a lot of countries, paucity and inadequate of resources upon the public investments available for infrastructural projects have led government to request the private sector to go into long-term contractual agreements for the investing and maintenance of capital intensive development projects. This paper analyzes the underlining principles of infrastructure investment, finance and development projects, centering on Public Sector (PS) and Public-Private Partnerships (PPPs). We demonstrated that project investments are suitable for PPP infrastructure projects, since properties and development projects are situated in a precise location. Furthermore, in the scenario of an accurately formulated PPP contract, the higher expenditure of capital and investment are perhaps the compensation for competence, effectiveness and advantages of PPPs. Lastly, we anticipated that PPP modification will continue to advance in the future, when more detailed and specialize academic research has been adequately conducted with the aids of innovative ideas and results oriented outcomes reported accordingly.
Imaging Features of Eyelid Pilomatraixoma  [PDF]
Bhoj Raj Sharma, Xiaolin Xu, Nannan Xu, Manisha Bajracharya, Madhu Gupta, Qinghai Yuan
Advances in Computed Tomography (ACT) , 2014, DOI: 10.4236/act.2014.32003

Pilomatrixoma is an uncommon benign tumor of matrix cells of hair follicles that rarely involves eyelids. Here we present a case of 4-year-old girl who was brought to hospital with swelling in the left upper eyelid which increased gradually in 1 year. Computed tomography revealed calcified soft tissue mass. The mass was excised successfully and sent for histopathological examination that showed encapsulated tumor composed of eosinophilic ghost cells and basophilic cells suggestive of pilomatrixoma.

Combined Sales Effort and Inventory Control under Demand Uncertainty
Weili Xue,Xiaolin Xu,Ruxian Wang
Discrete Dynamics in Nature and Society , 2013, DOI: 10.1155/2013/984513
PCHD-Based Passivity Control of VSC-HVDC Connected Large Wind Farm  [PDF]
Xinming Fan, Lin Guan, Chengjun Xia, Jianming He, Xiaolin Li, Shukai Xu
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B229
Abstract: Concentrated integration of large scale wind power demands stronger robustness of VSC-HVDC transmission. Based on PCHD (Port Controled Hamiltonian with Dissipation) equation, the PCHD model of voltage source converter (VSC) in abc frame and d-q rotating frame are built and the strict passivity of VSC is proved. Desired energy function is constructed and used as Lyapunov function by assigning link matrix and damping matrix. Impact from VSC equivalent dc resistance is eliminated by additional damping matrix. The IDA-PB (Interconnection and Damping Assignment Passivity-based) controller is designed based on desired equilibrium point and state variable. With different operation conditions, VSC-HVDC and its control system are simulated by software PSCAD/EMTDC, the results show the proposed control strategy has good performance and strong robustness.
Acoustophoresis in Variously Shaped Liquid Droplets
Gan Yu,Xiaolin Chen,Jie Xu
Physics , 2012, DOI: 10.1039/c1sm05871a
Abstract: The ability to precisely trap, transport and manipulate micrometer-sized objects, including biological cells, DNA-coated microspheres and microorganisms, is very important in life science studies and biomedical applications. In this study, acoustic radiation force in an ultrasonic standing wave field is used for micro-objects manipulation, a technique termed as acoustophoresis. Free surfaces of liquid droplets are used as sound reflectors to confine sound waves inside the droplets. Two techniques were developed for precise control of droplet shapes: edge pinning and hydrophilic/hydrophobic interface pinning. For all tested droplet shapes, including circular, annular and rectangular, our experiments show that polymer micro particles can be manipulated by ultrasound and form into a variety of patterns, for example, concentric rings and radial lines in an annular droplet. The complexity of the pattern increases with increasing frequency, and the observations are in line with simulation results. The acoustic manipulation technique developed here has the potential to be integrated into a more complex on-chip microfluidic circuit. Especially because our method is well compatible with electrowetting technology, which is a powerful tool for manipulating droplets with free surfaces, the combination of the two methods can provide more versatile manipulation abilities and may bring a wealth of novel applications. In the end, we demonstrate for the first time that acoustophoresis can be used for manipulating Caenorhabditis elegans.
Base-X Notation and Tri-Value Logic  [PDF]
Xiaolin Li
American Journal of Computational Mathematics (AJCM) , 2012, DOI: 10.4236/ajcm.2012.23033
Abstract: This paper introduces the base-X notation and discusses the conversion between numbers of different bases. It also introduces the tri-value logic that is associated with the base-3 system.
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