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Search Results: 1 - 10 of 104228 matches for " Xiaoju Zhang "
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Filtering Function Method for the Cauchy Problem of a Semi-Linear Elliptic Equation  [PDF]
Hongwu Zhang, Xiaoju Zhang
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.312184
Abstract: A Cauchy problem for the semi-linear elliptic equation is investigated. We use a filtering function method to define a regularization solution for this ill-posed problem. The existence, uniqueness and stability of the regularization solution are proven; a convergence estimate of H?lder type for the regularization method is obtained under the a-priori bound assumption for the exact solution. An iterative scheme is proposed to calculate the regularization solution; some numerical results show that this method works well.
Study on Influence of Learning Engagement to Employability of Students Upgraded from College to University in Beijing  [PDF]
Yingxia Luo, Xiaoju Zhang
Creative Education (CE) , 2017, DOI: 10.4236/ce.2017.89106
Abstract: Students upgraded from college to university are the outstanding group among college students. Their study status, future employability and career development direction are different from those of college students or undergraduates, which deserves particular concern. Based on The Survey on the Development Status of Students Upgraded from College to University in Beijing in 2014, this study analyzes students’ learning engagement, employability as well as the relationship between the two. It shows that, on the whole, students upgraded from college to university learn positively and their learning motivation presents the dual motivations for achieving success and avoiding failure (An, Cheng, & Sun, 2009). Their learning attitude and objectives to improve abilities play a key role in their employability.
Iterative Method Based on the Truncated Technique for Backward Heat Conduction Problem with Variable Coefficient  [PDF]
Hongwu Zhang, Xiaoju Zhang
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101501
Abstract: We consider a backward heat conduction problem (BHCP) with variable coefficient. This problem is severely ill-posed in the sense of Hadamard and the regularization techniques are required to stabilize numerical computations. We use an iterative method based on the truncated technique to treat it. Under an a-priori and an a-posteriori stopping rule for the iterative step number, the convergence estimates are established. Some numerical results show that this method is stable and feasible.
Stability and Regularization Method for Inverse Initial Value Problem of Biparabolic Equation  [PDF]
Hongwu Zhang, Xiaoju Zhang
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101542
Abstract: We consider an inverse initial value problem of the biparabolic equation; this problem is ill-posed and the regularization methods are needed to stabilize the numerical computations. This paper firstly establishes a conditional stability of Holder type, then uses a modified regularization method to overcome its ill-posedness and gives the convergence estimate under an a-priori assumption for the exact solution. Finally, a numerical example is presented to show that this method works well.
An osmundaceous rhizome with sterile and fertile fronds and in situ spores from the Jurassic of western Liaoning
XiaoJu Yang,Wu Zhang,ShaoLin Zheng
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-010-4191-3
Abstract: A well-preserved permineralized osmundaceous fern was discovered from the Middle Jurassic Tiaojishan Formation of Beipiao, Liaoning Province, China. The rhizome is about 50 cm high and 35–41 cm in diameter and can be attributed to the genus Ashicaulis on the basis of its anatomy. The sterile pinnae are referable to Cladophlebis, the fertile pinnules are of the Todites type with in situ spores of the Osmundacidites type. Osmundaceous rhizomes have been found all over the world including the Jurassic strata of western Liaoning, China. Until now, however, no rhizomes have been reported to be organically connected with leafy organs. Although impressions and compressions of isolated osmundaceous sterile and fertile fronds are common, they were described under separate organ- or morpho-generic names, such as Todites and Cladophlebis. The new discovery provides an opportunity to study an osmundaceous fern in ‘whole plant concept’ to learn more about its morphology and structure, and the paleoclimatic and paleoenvironmental requrirements of this group.
Stem cell therapy for idiopathic pulmonary fibrosis: How far are we from the bench to the bedside?  [PDF]
Zheng Wang, Xiaoju Zhang, Yi Kang, Yanli Zeng, Hongmei Liu, Xiaoqian Chen, Lijun Ma
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.68A2004
Abstract: Idiopathic pulmonary fibrosis (IPF) is characterized by exuberant apoptosis and inadequate regeneration of lung parenchyma cells. Intratracheal alveolar type II epithelial cell instillation alleviates lung inflammation and fibrosis. Resident lung epithelial stem cells, as well as exogenous mesenchymal stem cells, are capable of differentiating into lung epithelial cells and repair the injured lung. It is thus supposed that, either engraftment of exogenous stem cells, or methods facilitating endogenous lung stem cell proliferation, are promising treatments for IPF, a devastating disease. Arrays of cellular and animal studies have shown the potential of stem cells in alleviating experimental lung fibrosis. Moreover, clinical trials have been launched to investigate the potentials of cell-based therapy in IPF patients. We intend to discuss the newest advances on stem cell therapy in pulmonary fibrosis, particularly the advantages, promises, and possible hurdles to pass from the successes in laboratory experiments to the eventual clinical applications.
A Novel Algorithm to Extract Weighted Critical Area
Wang Junping,Hao Yue,Zhang Huining,Zhang Xiaoju,Ren Chunli,
Wang Junping
,Hao Yue,Zhang Huining,Zhang Xiaoju,Ren Chunli

半导体学报 , 2006,
Abstract: 导体故障分析是一种列举与缺陷有关的集成电路版图中可能出现桥连的技术,计算带权关键面积是限制其性能的主要因素.文中提出了一种基于数学形态学和真实缺陷矩形模型提取带权关键面积的新算法,该算法不需要将版图上的线网拆分为矩形,也不需要合并矩形对的带权关键面积.实验结果验证了新算法的有效性.
Degradation Induced by Donor Interface State for Deep-Sub-Micron Grooved-Gate PMOSFET
施主型界面态引起深亚微米槽栅PMOS特性的退化

Ren Hongxia,Zhang Xiaoju,Hao Yue,
任红霞
,张晓菊,郝跃

半导体学报 , 2004,
Abstract: Based on the hydrodynamics energy transport model,the degradation induced by donor interface state is analyzed for deep submicron grooved gate and conventional planar PMOSFET with different channel doping density,and the results are compared with that induced by acceptor interface states.The simulation results indicate that the degradation induced by the same interface state density in grooved gate PMOSFET is larger than that in planar PMOSFET,and in both structure device,the impact of N type donor interface state on device performance is far larger than that of P type.It also manifests that the degradation is different for the device with different channel doping density.
N-Cadherin Expression Is Associated with Acquisition of EMT Phenotype and with Enhanced Invasion in Erlotinib-Resistant Lung Cancer Cell Lines
Xiaoju Zhang, Guangzhi Liu, Yi Kang, Zhaogang Dong, Qiyu Qian, Xitao Ma
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057692
Abstract: Background The epidermal growth-factor receptor tyrosine kinase inhibitors have been effective in non-small cell lung cancer patients. However, acquired resistance eventually develops in most patients despite an initial positive response. Emerging evidence suggests that there is a molecular connection between acquired resistance and the epithelial–mesenchymal transition (EMT). N-cadherin is involved in the EMT and in the metastasis of cancer cells. Here, we analyzed N-cadherin expression and function in erlotinib-resistant lung cancer cell lines. Methods H1650 cell lines were used to establish the subline resistant to erlotinib(H1650ER). Then, induction of the EMT was analyzed using immunostaining and western blots in H1650ER cells. N-cadherin expression in the resistant cells was examined using FACS and western blot. In addition, an invasion assay was performed to characterize the resistant cells. The effects of N-cadherin on cell proliferation and invasion were analyzed. The association of N-cadherin expression with the EMT phenotype was investigated using immunohistochemical analysis of 13 archived, lung adenocarcinoma tissues, before and after treatment with erlotinib. Results In H1650ER cells, N-cadherin expression was upregulated, paralleled by the reduced expression of E-cadherin. The marked histological change and the development of a spindle-like morphology suggest that H1650ER cells underwent an EMT, accompanied by a decrease in E-cadherin and an increase in vimentin. A change in the EMT status between pre-and post-treatment was observed in 11 out of 13 cases (79%). In biopsies of resistant cancers, N-cadherin expression was increased in 10 out of 13 cases. Induction of the EMT was consistent with aggressive characteristics. Inhibition of N-cadherin expression by siRNA was tested to reduce proliferation and invasion of H1650ER cells in vitro. Conclusions Our data provide evidence that induction of the EMT contributes to the acquired resistance to EGFR-TKIs in lung cancer. It suggests that N-cadherin is a potential molecular target in the treatment of NSCLC.
An Analytical Model for Threshold Voltage of Grooved-Gate MOSFET''''s
槽栅MOSFET''s的阈值电压解析模型

Zhang Xiaoju,Ren Hongxia,Feng Qian,Hao Yue,
张晓菊
,任红霞,冯倩,郝跃

半导体学报 , 2004,
Abstract: A simple analytical model of the threshold voltage is given.It reflects the variation of the threshold voltage with different geometry and technical parameters.The accuracy of the model is verified with the help of the simulated values and the result shows that the model is suitable for the grooved-gate MOSFET with small size.
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