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Search Results: 1 - 10 of 44462 matches for " Xiaobo Wu "
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Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis
Jindrich Soltys, Xiaobo Wu
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-20
Abstract: Mouse EAMG was induced by s.c. administrations of purified acetylcholine receptor (AChR) to Crry ?/? and age- matched WT (C57BL/6) mice. Disease severity was assessed by clinical score assessment and muscle grip strength measurements. Serum complement activity was determined by hemolytic assay. ELISA was used to detect the level of AChR specific antibodies. Splenic cells were analyzed for T and B cells subsets distribution, release of cytokines and AChR specific recall responses. Deposition of complement components at the NMJ was assessed by immunofluorescence staining.In comparison to WT EAMG, Crry ?/? EAMG mice showed signs of augmented muscle weakness but differences, except for one time point, were not statistically significant. Serum complement activity was reduced in Crry ?/? EAMG mice and no substantial changes in deposition of C3, C3b/iC3b and C5b-9 (MAC) at the NMJ between WT EAMG and Crry ?/? EAMG mice were detected. Lack of Crry affected adaptive immune response. Crry ?/? EAMG mice showed increases in the number of AChR specific splenic T-cells secreting IFN-γ and IL-4. Production of complement fixing antibodies (IgG2b, IgG2c) was also augmented. More Th1, Th2 and Th17 cytokines were released into the bloodstream of Crry ?/? EAMG mice.Data suggest that Crry deficiency modulates the adaptive immune response in EAMG, but its effect on disease outcome is limited. This was due to the generally lower serum complement level caused by increased C3 turnover. Modulation of complement activity with soluble or membrane bound regulators of complement activity represents a potentially effective approach to modify autoimmune processes in MG and EAMG.
Power Optimization for Pipeline ADC Via Systematic Automation Design
Qiao Yang,Xiaobo Wu
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
Calculation and Management for Mining Loss and Dilution under 3D Visualization Technical Condition  [PDF]
Weijing Wang, Shaofeng Huang, Xiaobo Wu, Qingfei Ma
Journal of Software Engineering and Applications (JSEA) , 2011, DOI: 10.4236/jsea.2011.45037
Abstract: The mining loss rate and dilution rate are the key indicators for the mining technology and management level of mining enterprises. Aiming at the practical problems such as the large workload but inaccurate data of the traditional loss and dilution calculation method, this thesis introduces the operating principle and process of calculating the loss rate and dilution rate at the mining fields by adopting geological models. As an example, authors establishes 3D models of orebody units in the exhausted area and mining fields in Yangshu Gold Mine in Liaoning Province, and conduct Boolean calculation among the models to obtain the calculation parameters of loss and dilution, and thereby calculate out the dilution rate and loss rate of the mining fields more quickly and accurately.
One-Stage Repair and Reconstruction of Craniomaxillofacial Bone Defects  [PDF]
Jianhua Wang, Chao Hu, Gang Zhang, Songbo Qiu, Jun Cai, Xiaobo Wu, Zhao Xiang, Yinghui Tan
Modern Plastic Surgery (MPS) , 2013, DOI: 10.4236/mps.2013.31002
Abstract:

Objective: Severe craniomaxillofacial injuries and craniomaxillofacial tumors can lead to craniomaxillofacial bone defects and deformities. Seriously affect the patients’ appearance and quality of life. So one-stage repair and reconstruction of craniomaxillofacial bone defects is of great significance. The current study summarizes the clinical experience of one-stage repair and reconstruction of craniomaxillofacial bone defects. Material and Methods: Data in one-stage repair and reconstruction of craniomaxillofacial bone defects performed on 13 patients were retrospectively analyzed out of 34 patients with craniomaxillofacial injuries or tumors who received treatment at the outpatient department between January 2002 and March 2011. Surgical indications and approaches were explored after two typical cases were detected. Results: One-stage repair and reconstruction of bone defects was suitable for patients with craniomaxillofacial injuries and excised craniomaxillofacial benign tumors. Adjacent autogenous bones and artificial materials (such as titanium plates, titanium mesh, and so on) work well for the repair of the craniomaxillofacial bone frame and restoration of facial features. Conclusions: Surgical indications should be strictly selected in one-stage repair and reconstruction of craniomaxillofacial bone defects and deformities. Furthermore, the adoption of autogenous bones and artificial materials is a good choice in restoring the craniofacial features.

A Low Power Small Area Multi-bit Quantizer with A Capacitor String in Sigma-Delta Modulator
Xuxia Wang,Jian Xu,Xiaobo Wu
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
A Low Power Audio Delta-Sigma Modulator with Opamp-Shared and Opamp-Switched Techniques
Hanqing Wang,Jian Xu,Xiaobo Wu
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
A 20uW 95dB DR Single-Bit Delta-Sigma Modulator for Portable Measurement Applications
Jian Xu,Hanqing Wang,Xiaobo Wu
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
A MOSFET-Only Delta-Sigma Modulator for Implantable Neural Signal Sensors
Rui Fan,Jian Xu,Xiaobo Wu
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
A High Precision Bandgap Reference Used in Power Management ICs
Gu Shurong,Wu Xiaobo,Yan Xiaolang
Engineering Letters , 2007,
Abstract:
Analysis of Hybrid Translinear Circuit and Its Application
Cheng Yuhua,Wu Xiaobo,Yan Xiaolang
Engineering Letters , 2007,
Abstract:
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