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Search Results: 1 - 10 of 48902 matches for " Xiao-Ou Shu "
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IGFBP3 mRNA expression in benign and malignant breast tumors
Zefang Ren, Aesun Shin, Qiuyin Cai, Xiao-Ou Shu, Yu-Tang Gao, Wei Zheng
Breast Cancer Research , 2007, DOI: 10.1186/bcr1634
Abstract: To understand the role of IGFBP-3 in breast tumorigenesis, we investigated IGFBP3 mRNA expression levels in benign and malignant breast tumors and their adjacent normal tissues using real-time quantitative PCR.Cancer tissues had significantly lower IGFBP3 expression than benign tumor tissues (p < 0.001). IGFBP3 expressions in both tumor and adjacent tissues were higher in patients who had proliferative benign tumors than in those who had non-proliferative benign tumors. Among patients with benign breast disease, IGFBP3 expression in the tumor was significantly higher than that in their adjacent normal tissue. There were no apparent associations of IGFBP3 expression in cancer tissues with either overall survival or disease-free survival in a cohort of 521 patients with breast cancer.Our findings suggest that the expression level of IGFBP3 in breast tissues may be involved in breast tumorigenesis.The insulin-like growth factor (IGF) system is important in regulating cell proliferation, differentiation, apoptosis, and transformation [1]. In vitro studies have consistently shown that members of the IGF family not only regulate the growth of various cancer cells but also interact with other cancer-related molecules [1,2]. Insulin-like growth factor binding protein 3 (IGFBP-3) is the most abundant IGFBP in circulation [3]. IGFBPs can either suppress or enhance the action of IGFs. Because the affinity of IGFBPs for IGFs is the same as or greater than that of the IGF-I receptors, the presence of IGFBPs could inhibit IGF activity by decreasing levels of free IGFs available to activate the receptor [2,3]. However, the binding of IGFBPs to IGFs protects IGFs from proteolytic degradation, thus enhancing the action of IGFs by increasing their bioavailability in local tissues [3]. In meta-analyses of the association between the blood concentration of IGFBP-3 and breast cancer risk, high blood levels of IGFBP-3 were associated with an increased risk of premenopausal breast cancer
Genetic polymorphisms in the matrix metalloproteinase 12 gene (MMP12) and breast cancer risk and survival: the Shanghai Breast Cancer Study
Aesun Shin, Qiuyin Cai, Xiao-Ou Shu, Yu-Tang Gao, Wei Zheng
Breast Cancer Research , 2005, DOI: 10.1186/bcr1033
Abstract: Included in the study were 1,129 cases and 1,229 age-frequency-matched population controls. Breast cancer patients were followed up to determine the intervals of overall survival and disease-free survival.The frequencies of the G allele in the A-82G and A1082G polymorphism among controls were 0.029 and 0.107, respectively. There were no associations between MMP12 polymorphisms and breast cancer risk. Patients with the AG or GG genotype of the A1082G polymorphism showed poorer overall survival (though the difference was not statistically significant) than patients with the AA genotype (hazard ratio 1.36, 95% CI 0.92 to 2.00).This result suggests that MMP12 A1082G polymorphism may be related to prognosis in breast cancer patients. Additional studies with larger sample sizes are warranted.Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that are involved in tumor angiogenesis, migration, and invasion as well as the regulation of immune surveillance [1,2]. With a few exceptions, the expression and activity of MMPs are increased in almost every type of human cancer and are correlated with advanced tumor stage, increased invasion and metastasis, and shortened survival [2,3]. In transplantation assays, relatively benign cancer cells acquire malignant properties when the expression of certain MMPs is up-regulated. Conversely, highly malignant cells become less aggressive when the expression or activity of certain MMPs is reduced [2].Substrates of MMP12 are various extracellular matrix and non-extracellular-matrix proteins [4]. MMP12 may inhibit angiogenesis through cleavage of plasminogen and collagen XVIII, resulting in the generation of angiostatin and endostatin, which have an angiostatic effect [2,5,6]. On the other hand, MMP12 may promote angiogenesis by cleaving structural components of the extracellular matrix, such as collagen type IV and fibrin [2]. It has been shown that increased expression of MMP12 may reflect a favorable progn
Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study
Qiuyin Cai, Xiao-Ou Shu, Wanqing Wen, Jia-Rong Cheng, Qi Dai, Yu-Tang Gao, Wei Zheng
Breast Cancer Research , 2004, DOI: 10.1186/bcr929
Abstract: We evaluated this genetic polymorphism in association with breast cancer risk using data from the Shanghai Breast Cancer Study, a population-based case–control study conducted in urban Shanghai from 1996 to 1998. The MnSOD Val-9Ala polymorphism was examined in 1125 breast cancer cases and 1197 age-frequency-matched control individual.Breast cancer risk was slightly elevated in women with Ala/Ala genotype (odds ratio [OR] 1.3, 95% confidence interval [CI] 0.7–2.3), particularly among premenopausal women (OR 1.8, 95% CI 0.9–3.7), as compared with those with Val/Val genotype. The increased risk with the Ala/Ala genotype was stronger among premenopausal women with a higher body mass index (OR 2.5, 95% CI 0.9–7.0) and more years of menstruation (OR 2.6, 95% CI 0.8–8.0). The risk among premenopausal women was further increased twofold to threefold among those with a low intake of fruits, vegetables, vitamin supplements, selenium, or antioxidant vitamins, including carotenes and vitamins A, C, and E. However, the frequency of the Ala allele was low (14%) in the study population, and most of the ORs provided above were not statistically significant.The present study provides some evidence that genetic polymorphism in the MnSOD gene may be associated with increased risk of breast cancer among Chinese women with high levels of oxidative stress or low intake of antioxidants. Studies with a larger sample size are needed to confirm the findings.More than 90% of the body's oxygen is consumed by the electron transport chain in mitochondria [1], and about 1–5% of it is released as superoxide (O2?-) and hydrogen peroxide (H2O2) [2]. Reactive oxygen species (ROS) may also be generated from estrogen metabolism through catechol estrogen redox cycling [3,4]. Because of a high level of internally generated ROS, lack of histone protection, and a low level of DNA repair, mitochondrial DNA is particularly vulnerable to oxidative damage [5]. It has been suggested that mitochondrial DNA damag
Exome sequencing generates high quality data in non-target regions
Yan Guo, Jirong Long, Jing He, Chung-I Li, Qiuyin Cai, Xiao-Ou Shu, Wei Zheng, Chun Li
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-194
Abstract: We performed whole exome sequencing on 22 subjects using Agilent SureSelect capture reagent and 6 subjects using Illumina TrueSeq capture reagent. We also downloaded sequencing data for 6 subjects from the 1000 Genomes Project Pilot 3 study. Using these data, we examined the quality of SNPs detected outside target regions by computing consistency rate with genotypes obtained from SNP chips or the Hapmap database, transition-transversion (Ti/Tv) ratio, and percentage of SNPs inside dbSNP. For all three platforms, we obtained high-quality SNPs outside target regions, and some far from target regions. In our Agilent SureSelect data, we obtained 84,049 high-quality SNPs outside target regions compared to 65,231 SNPs inside target regions (a 129% increase). For our Illumina TrueSeq data, we obtained 222,171 high-quality SNPs outside target regions compared to 95,818 SNPs inside target regions (a 232% increase). For the data from the 1000 Genomes Project, we obtained 7,139 high-quality SNPs outside target regions compared to 1,548 SNPs inside target regions (a 461% increase).These results demonstrate that a significant amount of high quality genotypes outside target regions can be obtained from exome sequencing data. These data should not be ignored in genetic epidemiology studies.
Physical Activity, Smoking, and Alcohol Consumption in Association with Incidence of Type 2 Diabetes among Middle-Aged and Elderly Chinese Men
Liang Shi, Xiao-Ou Shu, Honglan Li, Hui Cai, Qiaolan Liu, Wei Zheng, Yong-Bing Xiang, Raquel Villegas
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077919
Abstract: Background Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease worldwide. The prevalence of T2DM is increasing rapidly in China. Understanding the contribution of modifiable lifestyle factors on T2DM risk is imperative to prevent the development of T2DM in China. Methods We examined associations between lifestyle factors including physical activity, smoking and alcohol consumption with incidence of T2DM among middle-aged and elderly men in urban Shanghai. Information on socio-demographics, lifestyle habits, dietary habits, and disease history was collected via in-person interviews. Anthropometric measurements were taken. A total of 51 464 Chinese men aged 40–74 years free of T2DM, coronary heart disease (CHD), and stroke at baseline were included in the current study. Incident T2DM was identified through follow-up surveys conducted every 2–3 years. Cox proportional hazard analyses were conducted to evaluate associations between lifestyle risk factors and incidence of T2DM. Results We documented 1304 new cases of T2DM during 276 929 person-years of follow-up (average: 5.4 years). Physical activity was inversely associated with T2DM risk. Daily living, commuting, and total physical activity METs had inverse negative dose-response relationships with T2DM (P-trend = 0.0033, 0.0022, and <0.0001, respectively). Regular participation in exercise or sports reduced T2DM risk (HR = 0.86, 95%CI: 0.76–0.98). Moderate alcohol intake (1–3 drinks/day) was inversely related to T2DM risk (HR = 0.80, 95%CI: 0.67–0.94). Cigarette smoking, on the other hand, was associated with increased T2DM risk; HRs were 1.25 (95%CI: 1.00–1.56) for smoking more than 20 cigarettes per day and 1.28 (95%CI: 1.04–1.57) for smoking more than 40 pack-years. Conclusions Physical activity and moderate alcohol intake are inversely associated with T2DM risk, whereas smoking was positively associated with T2DM risk among middle-age and elderly Chinese men. Preventive measures should be developed to focus on these modifiable lifestyle habits to reduce the upward trend of T2DM.
Menopausal Symptoms among Breast Cancer Patients: A Potential Indicator of Favorable Prognosis
Yong Chen, Tsogzolmaa Dorjgochoo, Ping-Ping Bao, Ying Zheng, Hui Cai, Wei Lu, Xiao-Ou Shu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075926
Abstract: Menopausal symptoms have been suggested to be an indicator of better prognosis among patients treated for breast cancer, because women who experience these symptoms usually have a lower level of estrogen. We tested this hypothesis in a population-based, prospective cohort study involving 4,842 women with stage 0 to III primary breast cancer who were enrolled in the Shanghai Breast Cancer Survival Study between March 2002 and April 2006, were aged 20 to 75 years, and were recruited 6 months post-diagnosis. They were followed-up by in-person surveys and record linkages with the vital statistics registry. Cox regression analysis was used to evaluate the association of menopausal symptoms at baseline with breast cancer recurrence. Approximately 56% of patients experienced at least one menopausal symptom, including hot flashes, night sweats, and/or vaginal dryness at baseline. During a median follow-up period of 5.3 years, 720 women had a recurrence. Experiencing hot flashes or having ≥2 menopausal symptoms was associated with lower risk of recurrence among premenopausal women (hazard ratio [HR]=0.77, 95% confidence interval [CI]: 0.62-0.96 for hot flashes; 0.73, 0.56-0.96 for ≥2 menopausal symptoms). Lower recurrence risk in relation to hot flashes was also observed among women who were not overweight/obese (HR=0.78, 95% CI: 0.64-0.99), those with relatively low waist-to-hip ratio (WHR) (HR=0.77, 95% CI: 0.61-0.97), and those who used tamoxifen (HR=0.75, 95% CI: 0.58-0.98). Consistently experiencing multiple menopausal symptoms was associated with lower recurrence risk among women with low WHR or who used tamoxifen. This large, population-based cohort study of women with breast cancer confirms that experiencing menopausal symptoms is an indicator of favorable breast cancer prognosis.
Age at Menarche, the Leg Length to Sitting Height Ratio, and Risk of Diabetes in Middle-Aged and Elderly Chinese Men and Women
Baqiyyah N. Conway, Xiao-Ou Shu, Xianglan Zhang, Yong-Bing Xiang, Hui Cai, Honglan Li, Gong Yang, Yu-Tang Gao, Wei Zheng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030625
Abstract: Aims To evaluate the associations of age at menarche and the leg length-to-sitting-height ratio, markers of adolescent growth, with risk of diabetes in later life. Materials and Methods Information from 69,385 women and 55,311 men, aged 40–74 years from the Shanghai Women's Health Study and Shanghai Men's Health Study, were included in the current analyses. Diabetes status was ascertained through biennial in person follow-up. Cox models, with age as the time scale, were used. Results There were 2369 cases of diabetes (1831 women; 538 men) during an average of 7.3 and 3.6 years of follow-up of the women and men, respectively. In females, menarche age was inversely associated with diabetes risk after adjustment for birth cohort, education, and income (HR = 0.95, 0.92–0.98). In both genders, leg length-to-sitting-height ratio was inversely related to diabetes (HR = 0.88, 0.80–0.97 for men; HR = 0.91, 0.86–0.96 for women) after adjustment for birth cohort, education, and income. Further adjustment for adult BMI at study enrollment completely eliminated the associations of age at menarche (HR = 0.99, 0.96–1.02) and the leg length-to-sitting-height ratio (HR = 1.00, 0.91–1.10 for men; HR = 1.01, 0.96–1.07 for women) with diabetes risk. Conclusions Our study suggests that markers of an early age at peak height velocity, i.e. early menarche age and low leg-length-to-sitting height ratio, may be associated with diabetes risk later in life and this association is likely to be mediated through obesity.
Patterns and correlates of physical activity: a cross-sectional study in urban Chinese women
Adriana L Jurj, Wanqing Wen, Yu-Tang Gao, Charles E Matthews, Gong Yang, Hong-Lan Li, Wei Zheng, Xiao-Ou Shu
BMC Public Health , 2007, DOI: 10.1186/1471-2458-7-213
Abstract: Study population consisted of 74,942 Chinese women, 40–70 years of age, participating in the baseline survey of the Shanghai Women's Health Study (1997–2000), an ongoing population-based cohort study. A validated, interviewer-administered physical activity questionnaire was used to collect information about several physical activity domains (exercise/sports, walking and cycling for transportation, housework). Correlations between physical activity domains were evaluated by Spearman rank-correlation coefficients. Associations between physical activity and socio-demographic and lifestyle factors were evaluated by odds ratios derived from logistic regression.While more than a third of study participants engaged in regular exercise, this form of activity contributed only about 10% to daily non-occupational energy expenditure. About two-thirds of women met current recommendations for lifestyle activity. Age was positively associated with participation in exercise/sports and housework. Dietary energy intake was positively associated with all physical activity domains. High socioeconomic status, unemployment (including retirement), history of chronic disease, small household, non-smoking status, alcohol and tea consumption, and ginseng intake were all positively associated with exercise participation. High socioeconomic status and small household were inversely associated with non-exercise activities.This study demonstrates that physical activity domains other than sports and exercise are important contributors to total energy expenditure in women. Correlates of physical activity are domain-specific. These findings provide important information for research on the health benefits of physical activity and have public health implications for designing interventions to promote participation in physical activity.Substantial data from the literature indicates that physical activity is an important modifiable risk factor for many diseases. Regular physical activity has been link
Association of Genetic Markers in the BCL-2 Family of Apoptosis-Related Genes with Endometrial Cancer Risk in a Chinese Population
Tsogzolmaa Dorjgochoo, Yong-Bing Xiang, Jirong Long, Jiajun Shi, Sandra Deming, Wang-Hong Xu, Hui Cai, Jiarong Cheng, Qiuyin Cai, Wei Zheng, Xiao-Ou Shu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060915
Abstract: Background In vitro studies have demonstrated the role of the BCL-2 family of genes in endometrial carcinogenesis. The role of genetic variants in BCL-2 genes and their interactions with non-genetic factors in the development of endometrial cancer has not been investigated in epidemiological studies. Patients and Methods We examined the relationship between BCL-2 gene family variants and endometrial cancer risk among 1,028 patients and 1,922 age-matched community controls from Shanghai, China. We also investigated possible interactions between genetic variants and established risk factors (demographic, lifestyle and clinical). Individuals were genotyped for 86 tagging single nucleotide polymorphisms (SNPs) in the BCL2, BAX, BAD and BAK1 genes. Results Significant associations with endometrial cancer risk were found for 9 SNPs in the BCL2 gene (P trend<0.05 for all). For SNPs rs17759659 and rs7243091 (minor allele for both: G), the associations were independent. The odds ratio was 1.27 (95% CI: 1.04–1.53) for women with AG genotype for the SNP rs17759659 and 1.82 (95% CI: 1.21–2.73) for women with the GG genotype for the SNP rs7243091. No interaction between these two SNPs and established non-genetic risk factors of endometrial cancer was noticed. Conclusion Genetic polymorphisms in the BCL2 gene may be associated with the risk of endometrial cancer in Chinese women.
Red Meat and Poultry Intakes and Risk of Total and Cause-Specific Mortality: Results from Cohort Studies of Chinese Adults in Shanghai
Yumie Takata, Xiao-Ou Shu, Yu-Tang Gao, Honglan Li, Xianglan Zhang, Jing Gao, Hui Cai, Gong Yang, Yong-Bing Xiang, Wei Zheng
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056963
Abstract: Most previous studies of meat intake and total or cause-specific mortality were conducted in North America, whereas studies in other areas have been limited and reported inconsistent results. This study investigated the association of red meat or poultry intake with risk of total and cause-specific mortality, including cancer and cardiovascular disease (CVD), in two large population-based prospective cohort studies of 134,290 Chinese adult women and men in Shanghai. Meat intakes were assessed through validated food frequency questionnaires administered in person at baseline. Vital status and dates and causes of deaths were ascertained through annual linkage to the Shanghai Vital Statistics Registry and Shanghai Cancer Registry databases and home visits every 2–3 years. Cox regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of death associated with quintiles of meat intake. During 803,265 person-years of follow up for women and 334,281 person-years of follow up for men, a total of 4,210 deaths in women and 2,733 deaths in men accrued. The median intakes of red meat were 43 g/day among women and 54 g/day among men, and pork constituted at least 95% of total meat intake for both women and men. Red meat intake was associated with increased total mortality among men, but not among women; the HR (95% CI) comparing the highest with the lowest quintiles were 1.18 (1.02–1.35) and 0.92 (0.82–1.03), respectively. This sex difference was statistically significant (P = 0.01). Red meat intake was associated with increased risk of ischemic heart disease mortality (HR = 1.41, 95% CI = 1.05–1.89) and with decreased risk of hemorrhagic stroke mortality (HR = 0.62, 95% CI = 0.45–0.87). There were suggestive inverse associations of poultry intake with risk of total and all-CVD mortality among men, but not among women. Further investigations are needed to elucidate the sex-specific associations between red meat intake and mortality.
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