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Search Results: 1 - 10 of 415 matches for " Xianjun Lao "
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Overpressure Identification and Pressure Prediction in Yinggehai Basin  [PDF]
Xianjun Chen
International Journal of Geosciences (IJG) , 2019, DOI: 10.4236/ijg.2019.104026
Abstract: The accurate prediction of overpressure is one of the key issues that restrict the effective development of oil and gas resources in the Yinggehai Basin. In this paper, the formation mechanism of overpressure in Yinggehai Basin is studied. Based on this mechanism, the quantitative prediction model and empirical parameters of overpressure are optimized in Yinggehai Basin and applied in engineering. The results show that the formation mechanism of overpressure in the Yinggehai Basin is complicated, and the causes of overpressure in different blocks of basin are different. The eastern block mainly develops loading-type overpressure, while the Ledong block is dominated by unloading high pressure. Different blocks should employ different abnormal high-pressure prediction models. The East block mainly adopts the Eaton method, and the Ledong block mainly utilizes the Bowers method. The empirical parameters of different models can be determined according to the actual drilling conditions. The practical application demonstrates that the abnormal high-pressure prediction error is within 2%, and it is able to satisfy the requirements of on-site engineering.
DNA Repair Gene XRCC1 Polymorphisms, Smoking, and Bladder Cancer Risk: A Meta-Analysis
Shan Li, Qiliu Peng, Yongbin Chen, Jianpeng You, Zhiping Chen, Yan Deng, Xianjun Lao, Huiling Wu, Xue Qin, Zhiyu Zeng
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073448
Abstract: Background and Objective The X-ray repair cross-complementing group 1 (XRCC1) protein plays a crucial role in base excision repair (BER) pathway by acting as a scaffold for other BER enzymes. Variants in the XRCC1 gene might alter protein structure or function or create alternatively spliced proteins which may influence BER efficiency and hence affect individual susceptibility to bladder cancer. Recent epidemiological studies have shown inconsistent associations between these polymorphisms and bladder cancer. To clarify the situation, a comprehensive meta-analysis of all available studies was performed in this study. Methods PubMed, EMBASE, and Chinese Biomedical Literature database (CBM) databases have been systematically searched to identify all relevant studies for the period up to February 2013. Data were abstracted independently by two reviewers and Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed mainly by ethnicity and smoking status. Results A total of 26 case-control studies, including 24 studies for R399Q polymorphism, 15 studies for R194W polymorphism, and 7 studies for R280H polymorphism met the inclusion criteria and were selected. With respect to R399Q polymorphism, significantly decreased bladder cancer risk was found among smokers (AA vs. GG: OR=0.693, 95%CI= 0.515-0.932, P=0.015 and recessive model AA vs. GA+GG: OR=0.680, 95%CI= 0.515-0.898, P=0.007, respectively). With respect to R194W and R280H polymorphism, significantly increased bladder cancer risk were observed among Asians (TT+CT vs. CC:OR = 1.327, 95% CI 1.086-1.622, P=0.006 for R194W, and AA+GA vs. GG: OR=2.094, 95% CI 1.211–3.621, P=0.008 for R280H, respectively). Conclusions This meta-analysis suggests that the XRCC1 R399Q polymorphism may play a protective role against bladder cancer among smokers. However, the XRCC1 R194W and R280H polymorphisms were both associated with increased bladder cancer risk among Asians. Further studies with larger sample sizes are needed to validate our finds.
Meta-Analysis of the Association between COX-2 Polymorphisms and Risk of Colorectal Cancer Based on Case–Control Studies
Qiliu Peng, Shi Yang, Xianjun Lao, Weizhong Tang, Zhiping Chen, Hao Lai, Jian Wang, Jingzhe Sui, Xue Qin, Shan Li
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094790
Abstract: Objective Cyclooxygenase-2 (COX-2) is an inducible enzyme converting arachidonic acid to prostaglandins and playing important roles in inflammatory diseases as well as tumor development. Previous studies investigating the association between COX-2 polymorphisms and colorectal cancer (CRC) risk reported conflicting results. We performed a meta-analysis of all available studies to explore this association. Methods All studies published up to October 2013 on the association between COX-2 polymorphisms and CRC risk were identified by searching electronic databases PubMed, EMBASE, and Cochrane library. The association between COX-2 polymorphisms and CRC risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Results Ten studies with 6,774 cases and 9,772 controls were included for ?1195A>G polymorphism, 13 studies including 6,807 cases and 10,052 controls were available for ?765G>C polymorphism, and 8 studies containing 5,121 cases and 7,487 controls were included for 8473T>C polymorphism. With respect to ?765G>C polymorphism, we did not find a significant association with CRC risk when all eligible studies were pooled into the meta-analysis. However, in subgroup analyses by ethnicity and cancer location, with a Bonferroni corrected alpha of 0.05/2, statistical significant increased CRC risk was found in the Asian populations (dominant model CC+CG vs. GG: OR = 1.399, 95%CI: 1.113–1.760, P = 0.004) and rectum cancer patients (CC vs. GG: OR = 2.270, 95%CI: 1.295–3.980, P = 0.004; Recessive model CC vs. CG+GG: OR = 2.269, 95%CI: 1.297–3.970, P = 0.004). In subgroup analysis according to source of control, no significant association was detected. With respect to ?1195A>G and 8473T>C polymorphisms, no significant association with CRC risk was demonstrated in the overall and subgroup analyses. Conclusions The present meta-analysis suggests that the COX-2 ?765G>C polymorphism may be a risk factor for CRC in Asians and rectum cancer patients. Further large and well-designed studies are needed to confirm this association.
CASP8 -652 6N Del Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Meta-Analysis
Qiliu Peng, Xianjun Lao, Weizhong Tang, Zhiping Chen, Ruolin Li, Jian Wang, Yan Deng, Taijie Li, Xue Qin, Shan Li
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087925
Abstract: Objective Caspase-8 (CASP8) plays a central role in the apoptotic pathway and aberrant regulation of this pathway may cause cancers. Previous studies investigating the association between CASP8 -652 6N ins/del polymorphism and colorectal cancer (CRC) risk showed inconclusive results. We performed a meta-analysis of all available studies to investigate this association. Methods All studies published up to October 2013 on the association between CASP8 -652 6N ins/del polymorphism and CRC risk were identified by searching electronic databases PubMed, EMBASE, and Cochrane library. The association between CASP8 -652 6N ins/del polymorphism and CRC risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Results Six studies with 6,325 cases and 6,842 controls were included in the meta-analysis. We observed that the CASP8 -652 6N ins/del polymorphism was significantly correlated with CRC risk when all studies were pooled into the meta-analysis (ins/del vs. ins/ins: OR = 0.890, 95%CI 0.821–0.964, P = 0.004; del/del + ins/del vs. ins/ins: OR = 0.899, 95%CI 0.833–0.970, P = 0.006). In stratified analyses by ethnicity, source of control, and quality score, significant association was observed in Asians (ins/del vs. ins/ins: OR = 0.862, 95%CI 0.761–0.977, P = 0.020; del/del + ins/del vs. ins/ins: OR = 0.845, 95%CI 0.749–0.953, P = 0.006), population-based studies (ins/del vs. ins/ins: OR = 0.890, 95%CI 0.813–0.975, P = 0.012; del/del + ins/del vs. ins/ins: OR = 0.901, 95%CI 0.827–0.982, P = 0.018), and high quality studies. However, in subgroup analysis according to cancer location, no significant association was detected. Conclusions The present meta-analysis suggests that the CASP8 is a candidate gene for CRC susceptibility. The CASP8 -652 6N ins/del polymorphism may play a protective role in CRC development especially among Asians. Further large and well-designed studies are needed to confirm this association.
Study on Option Price Model of the Transaction of Information Commodities  [PDF]
Changping HU, Xianjun QI
Journal of Service Science and Management (JSSM) , 2009, DOI: 10.4236/jssm.2009.24047
Abstract: The option is viewed as an important tool of setting price in accordance with objective benefits and actual effectiveness of information commodities, as ensures that the holder of the option right acquires more benefits in the favorable market and reduces losses in the adverse market. And the information market, as a kind of typical monopolistic and com-petitive market, is especially adequate for introducing the option theory to set more reasonable price and further to improve the operational efficiency of information market. Hence, it is quite necessary to apply the option theory to the transaction of information commodities. In this paper, after analyzing the applicability of the option theory to the in-formation market and studying the option price of information commodities, the authors put forward the option price model of the transaction, followed by a case study to demonstrate the validity of the model.
TP53 and MDM2 Gene Polymorphisms, Gene-Gene Interaction, and Hepatocellular Carcinoma Risk: Evidence from an Updated Meta-Analysis
Qiliu Peng, Xianjun Lao, Zhiping Chen, Hao Lai, Yan Deng, Jian Wang, Cuiju Mo, Jingzhe Sui, Junrong Wu, Limin Zhai, Shi Yang, Xue Qin, Shan Li
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082773
Abstract: Background The association between TP53 R72P and/or MDM2 SNP309 polymorphisms and hepatocellular carcinoma (HCC) risk has been widely reported, but results were inconsistent. To clarify the effects of these polymorphisms on HCC risk, an updated meta-analysis of all available studies was conducted. Methods Eligible articles were identified by search of databases including PubMed, Cochrane Library, EMBASE and Chinese Biomedical Literature database (CBM) for the period up to July 2013. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Metaregression and subgroup analyses were performed to identify the source of heterogeneity. Results Finally, a total of 10 studies including 2,243 cases and 3,615 controls were available for MDM2 SNP309 polymorphism and 14 studies containing 4,855 cases and 6,630 controls were included for TP53 R72P polymorphism. With respect to MDM2 SNP309 polymorphism, significantly increased HCC risk was found in the overall population. In subgroup analysis by ethnicity and hepatitis virus infection status, significantly increased HCC risk was found in Asians, Caucasians, Africans, and HCV positive patients. With respect to TP53 R72P polymorphism, no significant association with HCC risk was observed in the overall and subgroup analyses. In the MDM2 SNP309–TP53 R72P interaction analysis, we found that subjects with MDM2 309TT and TP53 Pro/Pro genotype, MDM2 309 TG and TP53 Arg/Pro genotype, and MDM2 309 GG and TP53 Pro/Pro genotype were associated with significantly increased risk of developing HCC as compared with the reference MDM2 309TT and TP53 Arg/Arg genotype. Conclusions We concluded that MDM2 SNP309 polymorphism may play an important role in the carcinogenesis of HCC. In addition, our findings further suggest that the combination of MDM2 SNP 309 and TP53 Arg72Pro genotypes confers higher risk to develop HCC. Further large and well-designed studies are needed to confirm this association.
An Updated Meta-Analysis on the Association of MDM2 SNP309 Polymorphism with Colorectal Cancer Risk
Xue Qin, Qiliu Peng, Weizhong Tang, Xianjun Lao, Zhiping Chen, Hao Lai, Yan Deng, Cuiju Mo, Jingzhe Sui, Junrong Wu, Limin Zhai, Shi Yang, Shan Li, Jinmin Zhao
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076031
Abstract: Background The mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity. The SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Studies investigating the association between MDM2 SNP309 polymorphism and colorectal cancer (CRC) risk reported conflicting results. We performed a meta-analysis of all available studies to explore the association of this polymorphism with CRC risk. Methods All studies published up to July 2013 on the association between MDM2 SNP309 polymorphism and CRC risk were identified by searching electronic databases PubMed, EMBASE, and Chinese Biomedical Literature database (CBM) databases. The association between the MDM2 SNP309 polymorphism and CRC risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Results A total of 14 case-control studies including 4460 CRC cases and 4828 controls were identified. We did not find a significant association between the MDM2 SNP309 polymorphism and CRC risk in all genetic models in overall population. However, in subgroup analysis by ethnicity, significant associations were found in Asians (TG vs. TT: OR = 1.197, 95% CI = 1.055–1.358, P=0.005; GG+TG vs. TT: OR = 1.246, 95% CI = 1.106–1.404, P=0.000) and Africans. When stratified by HWE in controls, significantly increased risk was also found among the studies consistent with HWE (TG vs. TT: OR = 1.166, 95% CI = 1.037–1.311, P= 0.010). In subgroup analysis according to p53 mutation status, and gender, no any significant association was detected. Conclusions The present meta-analysis suggests that the MDM2 is a candidate gene for CRC susceptibility. The MDM2 SNP309 polymorphism may be a risk factor for CRC in Asians.
Study on the Efficiency and Total Factor Productivity of China’s Securities Companies—Based on Hicks-Moorsteen TFP Index Method  [PDF]
Guohao Lao, Bin Mo
Technology and Investment (TI) , 2018, DOI: 10.4236/ti.2018.91004
Abstract: Along with the vigorous development of capital market, the number of security investors and security companies in number and scale has grown rapidly. Based on this, the paper focused on the national 15 large listed security companies as our research object. By using the ODonnell of Hicks-Moorsteen TFP index decomposition, we analyze the efficiency and total factor growth rate of the 15 listed security companies between 2010 and 2015. Research shows that: 1) the efficiency of the 15 listed security companies generally showed “V” shape; 2) the dis-economies of scope led to the decrease of the efficiency of the security companies; 3) in the sample period, the technical efficiency and scale efficiency of listed security companies did not fluctuate a lot.
Corporate Social Responsibility, Internal Control and Enterprise Value—Based on the Chinese Stock Market  [PDF]
Xianjun Gao
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.77004
Abstract: Taking China’s A-share listed companies as the research sample, this paper studies the relationship between corporate social responsibility, internal control and enterprise value. The research results show that there is a positive correlation between the corporate social responsibility and the enterprise value. It shows corporate social responsibility behavior will enhance the enterprise value. At the same time, the behavior of corporate social responsibility also contributes to the improvement of enterprise internal control. Internal control has a partial intermediary role in the process of social responsibility affecting enterprise value. In that way, the corporate social responsibility can affect enterprise value by improving enterprise internal control. Further research shows that compared with the private enterprises, the internal control in the state-owned enterprises has a more significant partial mediating effect in the process of corporate social responsibility affecting enterprise value.
State of Air Quality in Malawi  [PDF]
Harold Wilson Tumwitike Mapoma, Xianjun Xie
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.411146
Abstract:
Air pollution in Malawi is recognized as one of the key environmental issues. Out of nine key issues it is ranked eighth on priority issues. This has led to lagging behind in terms of research and reporting on the issue. However, the Malawi Government has made strides in implementing policies, acts and programs that are directly or indirectly concerned with the improvement and abatement of air quality to meet the millennium development goals (MDGs) especially goal number 7. The inventories and studies show that air quality in Malawi is still good, but future anticipated air quality problems are cause for worry such as impact on human health, global climate change and ozone depletion. Trends in consumption of ozone depleting substances (ODS) show a remarkable drive towards total reduction. Emissions standards are in place in line with World Health Organization (WHO) guidelines. Recommendations on how to deal with air quality issues have been proposed in the national state of environmental report (NSOER) in that: 1) there is a need for an operational framework for climate change programs in Malawi and; 2) there is a need to unify climate change policies dealing with enforcement of ODS phasing out, alternative energy sources, emissions from vehicles and industries, and institutional and human resource capacity.
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