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Search Results: 1 - 10 of 23422 matches for " Xiangjun He "
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Elevated Plasma Levels but Decreased Platelet-Associated Expression of LIGHT in Patients with Acute Atherothrombotic Stroke  [PDF]
Guangzhi Liu, Yang He, Tingting Yang, Hong Jiang, Yajuan Xiang, Qi Zhang, Xiangjun He, Peter Hjelmstrom, Xuguang Gao
World Journal of Neuroscience (WJNS) , 2014, DOI: 10.4236/wjns.2014.44042
Abstract: Background: As a member of the tumor necrosis factor superfamily (TNFSF), LIGHT (TNFSF14) is expressed by a variety of immune cells and exists in membrane-bound and soluble forms. Recently, LIGHT was found to be associated with platelets and released upon activation. Activation of endothelia cells by recombinant LIGHT protein results in pro-inflammatory and pro-thrombotic changes. Several studies have reported increased plasma levels of LIGHT in patients with stroke and cardiovascular diseases. However, the form-associated roles of LIGHT in ischemic atherosclerotic stroke remain unclear. Mater?als and Methods: In this study, the platelet LIGHT expression and soluble LIGHT protein were analyzed by flow cytometry and enzyme-linked immunosorbent assay (ELISA) in peripheral blood of patients with acute ischemic atherosclerotic stroke, asymptomatic carotid stenosis (ACS) and normal controls. RESULTS: During the initial 24 h after onset, the stroke patients had decreased LIGHT expression on their platelets (5.9% ± 4.9%) and increased plasma LIGHT levels (36.1 ± 21.0 pg/ml) as compared with normal controls (9.5% ± 3.0%, p < 0.05; 20.4 ± 13.4 pg/ml, p < 0.05). Moreover, the platelet LIGHT expression correlated with total plaque area in the stroke patients (r = 0.4572, p = 0.0247). Conclus?ons: The dysregulated LIGHT expression reflects a persistent chronic inflammatory
Studies on the Interactions of Copper and Zinc Ions with β-Amyloid Peptides by a Surface Plasmon Resonance Biosensor
Fujun Yao,Ruiping Zhang,He Tian,Xiangjun Li
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms130911832
Abstract: The aggregation of β-amyloid peptide (Aβ) into fibrils plays an important role in the pathogenesis of Alzheimer’s disease (AD). Metal ions including copper and zinc are closely connected to the precipitation and toxicity of Aβ. In this study, a surface plasmon resonance (SPR) biosensor was constructed to investigate the interactions between Aβ and metal ions. Aβ peptide was immobilized on the SPR chip surface through a preformed alkanethiol self-assembled monolayer (SAM). Our observations indicate that the immobilized Aβ undergoes a conformational change upon exposure to the metal ions. A difference in metal binding affinity between Aβ 1– 28 and Aβ 1– 42 was also detected. The results suggest that SPR is an effective method to characterize the interactions between Aβ and metal ions.
Using Harmonic Mean to Replace Tsallis' q-Average
Xiangjun Feng
Physics , 2010,
Abstract: In this paper, a unified mathematical expression for the constraints leading to the equilibrium distributions of both extensive and non-extensive systems is presented. Based on this expression, a recommendation is made to replace Tsallis' q-average without obvious physical meaning with the statistical harmonic mean for a generalized system.
The Constraints Determining Forms of Entropy and Inducing Equilibrium Distributions
Xiangjun Feng
Physics , 2007,
Abstract: The ideas of the constraint-based statistics are introduced. The axiom and six theorems of the constraint-based statistics are established.
A Semigroup Theory of Rate Independent Hysteresis
Xiangjun Xing
Physics , 2007,
Abstract: We explore a macroscopic, algebraic approach to rate independent hysteresis using semigroup theory. A macroscopic description of metastable states relevant to rate independent hysteresis is introduced using field history. The semigroup structure of the history space is identified. Using semigroup theory and related mathematical techniques, the general relation between return point memory (RPM) and partial order is discovered. For hysteresis system with RPM, a variational principle is identified. The erasing properties of field histories are also characterized. The connection between this semigroup approach and other models are also discussed.
Topology of Smectic Order on Compact Substrates
Xiangjun Xing
Physics , 2007, DOI: 10.1103/PhysRevLett.101.147801
Abstract: Smectic orders on curved substrates can be described by differential forms of rank one (1-forms), whose geometric meaning is the differential of the local phase field of density modulation. The exterior derivative of 1-form is the local dislocation density. Elastic deformations are described by superposition of exact differential forms. Applying this formalism to study smectic order on torus as well as on sphere, we find that both systems exhibit many topologically distinct low energy states, that can be characterized by two integer topological charges. The total number of low energy states scales as the square root of the substrate area. For smectic on a sphere, we also explore the motion of disclinations as possible low energy excitations, as well as its topological implications.
Topology and Geometry of Smectic Order on Compact Curved Substrates
Xiangjun Xing
Physics , 2008, DOI: 10.1007/s10955-009-9681-9
Abstract: Smectic order on arbitrary curved substrate can be described by a differential form of rank one (1-form), whose geometric meaning is the differential of the local phase field of the density modulation. The exterior derivative of 1-form is the local dislocation density. Elastic deformations are described by superposition of exact differential forms. We use the formalism of differential forms to systematically classify and characterize all low energy smectic states on torus as well as on sphere. A two dimensional smectic order confined on either manifold exhibits many topologically distinct low energy states. Different states are not accessible from each other by local fluctuations. The total number of low energy states scales as the square root of the system area. We also address the energetics of 2D smectic on a curved substrate and calculate the mean field phase diagram of smectic on a thin torus. Finally, we discuss the motion of disclinations for spherical smectics as low energy excitations, and illustrate the interesting connection between spherical smectic and the theory of elliptic functions.
The Tsallis Entropy Barrier or the Roundness Barrier Based Dynamic Stochastic Resonance --A New Family of SR ?
Xiangjun Feng
Physics , 2008,
Abstract: The Tsallis entropy barrier or the roundness barrier based dynamic stochastic resonance mechanisms are put forward and simulated. The systems with various Tsallis q values exhibit the effects of emergence as a result of the noise-induced cooperative phenomena.
Biaxial Deformations of Rubber: Entanglements or Elastic Fluctuations?
Xiangjun Xing
Physics , 2010, DOI: 10.1103/PhysRevE.84.021801
Abstract: The classical theory of rubber elasticity fails in the regime of large deformation. The un- derlying physical mechanism has been under debate for long time. In this work, we test the recently proposed mechanism of thermal elastic fluctuations by Xing, Goldbart and Radzi- hovsky1 against the biaxial stress-strain data of three distinct polymer networks with very different network structures, synthesized by Urayama2 and Kawabata3 respectively. We find that both the two parameters version and the one-parameter version of the XGR theory provide satisfactory description of the elasticity in whole deformation range. For comparison, we also fit the same sets of data using the slip-link model by Edwards and Vilgis with four parameters. The fitting qualities of two theories are found to be comparable.
The Poisson-Boltzmann Theory for Two Parallel Uniformly Charged Plates
Xiangjun Xing
Physics , 2010, DOI: 10.1103/PhysRevE.83.041410
Abstract: We solve the nonlinear Poisson-Boltzmann equation for two parallel and likely charged plates both inside a symmetric elecrolyte, and inside a 2 : 1 asymmetric electrolyte, in terms of Weierstrass elliptic functions. From these solutions we derive the functional relation between the surface charge density, the plate separation, and the pressure between plates. For the one plate problem, we obtain exact expressions for the electrostatic potential and for the renormalized surface charge density, both in symmetric and in asymmetric electrolytes. For the two plate problems, we obtain new exact asymptotic results in various regimes.
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