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Search Results: 1 - 10 of 6274 matches for " Xavier Roca "
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Determining indoor air quality and identifying the origin of odour episodes in indoor environments

Eva Gallego,Xavier Roca,Jose Francisco Perales,Xavier Guardino,

环境科学学报(英文版) , 2009,
Abstract: A methodology for identifying volatile organic compounds (VOC) and determining air quality of indoor air has been developed. The air samples are collected using pump samplers by the inhabitants when they perceive odorous and/or discomfort episodes. Glass multi-sorbent tubes are connected to the pump samplers for the retention of VOC. The analysis is performed by automatic thermal desorption (ATD) coupled with gas chromatography-mass spectrometry (GC/MS). This methodology can be applied in cases of sick building syndrome (SBS) evaluation, in which building occupants experience a series of varied symptoms that appear to be linked to time spent in the building. Chemical pollutants concentrations (e.g., VOC) have been described to contribute to SBS. To exemplify the methodology, a qualitative determination and an evaluation of VOC present were performed in a dwelling where the occupants experienced the SBS symptoms. Higher total VOC (TVOC) value was detected in episodes in indoor air (1.33 ( 1.53 mg/m3) compared to outdoor air (0.71 ( 0.46 mg/m3). The concentrations of individual VOCs, such as ethanol, acetone, isopropanol, 1-butanol, acetic acid, acetonitrile and 1-metoxy-2-propanol, were also higher than the expected for a standard dwelling. The external source of VOC was found to be a not declared activity of storage and manipulation of solvents located at the bottom of a contiguous building.
Garvey-Kelson Relations for Nuclear Charge Radii
Jorge Piekarewicz,Mario Centelles,Xavier Roca-Maza,Xavier Vinas
Physics , 2009, DOI: 10.1140/epja/i2010-11051-8
Abstract: The Garvey-Kelson relations (GKRs) are algebraic expressions originally developed to predict nuclear masses. In this letter we show that the GKRs provide a fruitful framework for the prediction of other physical observables that also display a slowly-varying dynamics. Based on this concept, we extend the GKRs to the study of nuclear charge radii. The GKRs are tested on 455 out of the approximately 800 nuclei whose charge radius is experimentally known. We find a rms deviation between the GK predictions and the experimental values of only 0.01 fm. This should be contrasted against some of the most successful microscopic models that yield rms deviations almost three times as large. Predictions - with reliable uncertainties - are provided for 116 nuclei whose charge radius is presently unknown.
Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
Bernard Khoo, Xavier Roca, Shern L Chew, Adrian R Krainer
BMC Molecular Biology , 2007, DOI: 10.1186/1471-2199-8-3
Abstract: We investigated the ability of 2'O-methyl RNA antisense oligonucleotides (ASOs) to induce the skipping of exon 27 in endogenous APOB mRNA in HepG2 cells. These ASOs are directed towards the 5' and 3' splice-sites of exon 27, the branch-point sequence (BPS) of intron 26–27 and several predicted exonic splicing enhancers within exon 27. ASOs targeting either the 5' or 3' splice-site, in combination with the BPS, are the most effective. The splicing of other alternatively spliced genes are not influenced by these ASOs, suggesting that the effects seen are not due to non-specific changes in alternative splicing. The skip 27 mRNA is translated into a truncated isoform, APOB87SKIP27.The induction of APOB87SKIP27 expression in vivo should lead to decreased LDL and cholesterol levels, by analogy to patients with hypobetalipoproteinemia. As intestinal APOB mRNA editing and APOB48 expression rely on sequences within exon 26, exon 27 skipping should not affect APOB48 expression unlike other methods of down-regulating APOB100 expression which also down-regulate APOB48.Apolipoprotein B (APOB – OMIM 107730) is the principal structural apolipoprotein in the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles [1]. The APOB pre-mRNA comprises 29 exons, all constitutively spliced into the mature mRNA. There exist two natural protein isoforms, the full-length APOB100 and the C-terminal truncation APOB48. APOB100 is synthesized in the liver, and this isoform is required for the assembly of VLDL, IDL, LDL, and Lp(a). Along with APOE, APOB100 is the ligand for the LDL receptor. Excess levels of the APOB100-containing particles LDL and Lp(a) have been implicated in atherogenesis [2]. APOB48 is generated by tissue-specific RNA editing of a CAA codon to a premature UAA termination codon in the intestine, and is identical to the N-terminal 48% of APOB100. Editing is performed by a protein complex known as the editosome, which consists of the catalytic subunit APOBEC-1 and accessory f
Experiences of success in industrial plants projects
Forcada,Nuria; Casals,Miquel; Gangolells,Marta ?; Roca,Xavier; Fuertes,Alba;
Revista ingeniería de construcción , 2008, DOI: 10.4067/S0718-50732008000200003
Abstract: success has always been the ultimate goal of construction projects, and different researchers have tried to evaluate it using different factors. although specialized industrial construction usually involves very large scale projects with a high degree of technological complexity, research has mostly focused on civil and residential success factors. experiences in industrial plants projects can help to improve project management and productivity in such a specialized sector. in this kind of projects, the contractual arrangement is one of the core differences on project management and thus project success. this research seeks to develop a schema for classifying critical success factors as well as a methodology for evaluating projects. this methodology was adopted to evaluate critical success factors in industrial plants projects with different contractual arrangements. findings suggest that although the construction stage has been the focus of many studies, the first stages are decisive for the success of projects; contract construction projects consider project planning to be more important; lump sum contract construction projects give greater importance to monitoring the benefits; bidding competition projects consider the available technology with greater rigor, etc. the results indicate that different industrial plants projects involve different success factors and management characteristics to achieve project objectives.
Experiences of success in industrial plants projects Experiencias exitosas en proyectos de plantas industriales
Nuria Forcada,Miquel Casals,Marta Gangolells,Xavier Roca
Revista ingeniería de construcción , 2008,
Abstract: Success has always been the ultimate goal of construction projects, and different researchers have tried to evaluate it using different factors. Although specialized industrial construction usually involves very large scale projects with a high degree of technological complexity, research has mostly focused on civil and residential success factors. Experiences in Industrial Plants projects can help to improve project management and productivity in such a specialized sector. In this kind of projects, the contractual arrangement is one of the core differences on Project management and thus project success. This research seeks to develop a schema for classifying critical success factors as well as a methodology for evaluating projects. This methodology was adopted to evaluate critical success factors in Industrial Plants projects with different contractual arrangements. Findings suggest that although the construction stage has been the focus of many studies, the first stages are decisive for the success of projects; contract construction projects consider project planning to be more important; lump sum contract construction projects give greater importance to monitoring the benefits; bidding competition projects consider the available technology with greater rigor, etc. The results indicate that different Industrial Plants projects involve different success factors and management characteristics to achieve project objectives. En cualquier proyecto de construcción el principal objetivo es que sea exitoso y por lo tanto a lo largo del tiempo diferentes investigadores han tratado de evaluar los factores que influyen en el éxito de proyectos. En el ámbito de la construcción estas investigaciones se han enfocado principalmente a obras civiles y residenciales. Este artículo muestra resultados que provienen de proyectos de construcción industrial especializada que incluyen proyectos de gran escala con un alto grado de complejidad tecnológica, relaciones contractuales más complejas que en las obras residenciales, mayor dificultad en la gestión de proyectos, etc. Las experiencias exitosas en proyectos de Plantas Industriales pueden ayudar a mejorar la gestión de proyectos y la productividad en un sector tan especializado como es la construcción industrial. En esta investigación se desarrolla un esquema de clasificación de factores críticos para el éxito así como una metodología para evaluar proyectos. Esta metodología fue adoptada para evaluar factores críticos para el éxito en distintos proyectos de Plantas Industriales con diferentes relaciones contractuales. Las
Identification of cis-Acting Elements and Splicing Factors Involved in the Regulation of BIM Pre-mRNA Splicing
Wen Chun Juan, Xavier Roca, S. Tiong Ong
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095210
Abstract: Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively. Altering BIM pre-mRNA splicing is an attractive approach to modulate apoptosis because BIM activity is partly determined by the alternative splicing of exons 3 or 4, whereby exon 3-containing transcripts are not apoptotic. Here we identified several cis-acting elements and splicing factors involved in BIM alternative splicing, as a step to better understand the regulation of BIM expression. We analyzed a recently discovered 2,903-bp deletion polymorphism within BIM intron 2 that biased splicing towards exon 3, and which also impaired BIM-dependent apoptosis. We found that this region harbors multiple redundant cis-acting elements that repress exon 3 inclusion. Furthermore, we have isolated a 23-nt intronic splicing silencer at the 3′ end of the deletion that is important for excluding exon 3. We also show that PTBP1 and hnRNP C repress exon 3 inclusion, and that downregulation of PTBP1 inhibited BIM-mediated apoptosis. Collectively, these findings start building our understanding of the cis-acting elements and splicing factors that regulate BIM alternative splicing, and also suggest potential approaches to alter BIM splicing for therapeutic purposes.
Second-order equation of state with the full Skyrme interaction: toward new effective interactions for beyond mean-field models
Kassem Moghrabi,Marcella Grasso,Xavier Roca-Maza,Gianluca Colo'
Physics , 2012, DOI: 10.1103/PhysRevC.85.044323
Abstract: In a quantum Fermi system the energy per particle calculated at the second order beyond the mean-field approximation diverges if a zero-range interaction is employed. We have previously analyzed this problem in symmetric nuclear matter by using a simplified nuclear Skyrme interaction, and proposed a strategy to treat such a divergence. In the present work, we extend the same strategy to the case of the full nuclear Skyrme interaction. Moreover we show that, in spite of the strong divergence ($\sim$ $\Lambda^5$, where $\Lambda$ is the momentum cutoff) related to the velocity-dependent terms of the interaction, the adopted cutoff regularization can be always simultaneously performed for both symmetric and nuclear matter with different neutron-to-proton ratio. This paves the way to applications to finite nuclei.
Regularization of zero-range effective interactions in finite nuclei
Marco Brenna,Gianluca Colò,Xavier Roca-Maza
Physics , 2014, DOI: 10.1103/PhysRevC.90.044316
Abstract: The problem of the divergences which arise in beyond mean-field calculations, when a zero-range effective interaction is employed, has not been much considered so far. Some of us have proposed, quite recently, a scheme to regularize a zero-range Skyrme-type force when it is employed to calculate the total energy, at second-order perturbation theory level, in uniform matter. Although this scheme looked promising, the extension for finite nuclei is not straightforward. We introduce such procedure in the current paper, by proposing a regularization procedure that is similar, in spirit, to the one employed to extract the so-called V_{\rm low-k} from the bare force. Although this has been suggested already by B.G. Carlsson and collaborators, the novelty of our work consists in setting on equal footing uniform matter and finite nuclei; in particular, we show how the interactions that have been regularized in uniform matter behave when they are used in a finite nucleus with the corresponding cutoff. We also address the problem of the validity of the perturbative approach in finite nuclei for the total energy.
La valorización del patrimonio forestal como recurso ecoturístico en zonas de monta a: el caso del Mig Pallars y el Parque Natural del Alt Pirineu (Pirineo de Lérida, Catalu a)
Xavier Basora Roca,Jordi Romero-Lengua,Xavier Sabaté i Rotés,Marc Sogues Marco
Ager : Revista de Estudios Sobre Despoblación y Desarrollo Rural , 2010,
Abstract: Este artículo analiza cómo la valorización del patrimonio forestal como recurso ecoturístico puede contribuir al desarrollo de una zona de monta a, e investiga qué factores y agentes pueden intervenir en este proceso. El caso de estudio es la zona del Mig Pallars, una subcomarca al noroeste del Pirineo leridano donde a principios de los a os noventa se desarrolló un proyecto de gestión forestal sostenible y promoción del turismo financiado por la Unión Europea (Programa LIFE). En el a o 2003 se declaró el Parque Natural del Alt Pirineu, que incluye la mayoría del territorio del Mig Pallars. Este caso ha permitido describir la importancia que ha ido adquiriendo el ecoturismo en esa zona pirenaica gracias a su promoción por parte de la administración local y comarcal, y del sector privado.
Robust Real-Time Background Subtraction Based on Local Neighborhood Patterns
Ariel Amato,Mikhail G. Mozerov,F. Xavier Roca,Jordi Gonzàlez
EURASIP Journal on Advances in Signal Processing , 2010, DOI: 10.1155/2010/901205
Abstract: This paper describes an efficient background subtraction technique for detecting moving objects. The proposed approach is able to overcome difficulties like illumination changes and moving shadows. Our method introduces two discriminative features based on angular and modular patterns, which are formed by similarity measurement between two sets of RGB color vectors: one belonging to the background image and the other to the current image. We show how these patterns are used to improve foreground detection in the presence of moving shadows and in the case when there are strong similarities in color between background and foreground pixels. Experimental results over a collection of public and own datasets of real image sequences demonstrate that the proposed technique achieves a superior performance compared with state-of-the-art methods. Furthermore, both the low computational and space complexities make the presented algorithm feasible for real-time applications.
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