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Search Results: 1 - 10 of 1825 matches for " Wound healing "
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The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series  [PDF]
Natsuko Kakudo, Satoshi Kushida, Tsunetaka Ogura, Tomoya Hara, Kenji Suzuki, Kenji Kusumoto
Open Journal of Regenerative Medicine (OJRM) , 2012, DOI: 10.4236/ojrm.2012.13005
Abstract: Platelet rich plasma (PRP) contains a high concentration of thrombocytes and the a granules of platelets contain platelet released growth factors. The usefulness of PRP for regeneration of bone and soft tissues has been reported previously. We firstly reported the efficacy of PRP prepared using the Magellan Autologous Platelet Separator System for intractable skin ulcers such as diabetic and venous ulcers. The system consists of a microprocessor controlled centrifuge, syringe pumps, and necessary single use processing components. No complications occurred in any patients and the wounds achieved complete epithelialization. Our results have shown the efficiency of platelet rich plasma for the treatment of intractable skin ulcers.
Wound Treatment Using Growth Factors  [PDF]
Keisuke Okabe, Ruka Hayashi, Noriko Aramaki-Hattori, Yoshiaki Sakamoto, Kazuo Kishi
Modern Plastic Surgery (MPS) , 2013, DOI: 10.4236/mps.2013.33022
Abstract:

Treatment with growth factors is an effective method to promote wound healing. Several growth factors have been used in wound treatment, including basic fibroblast growth factor (bFGF) discovered in the 1970s, platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and bone morphogenetic protein (BMP). In 2001, Kaken Pharmaceutical Co., Ltd. launched Fiblast Spray in Japan. This product is a topical formulation containing recombinant human bFGF. It is used to treat decubitus ulcers and skin ulcers (burn ulcers and leg ulcers). There is increasing interest in its stimulatory effect on wound healing and its inhibitory effect on scar formation. Wound healing is a physiological phenomenon that involves a complex series of integrated cellular and biochemical responses, characterized by phases of hemostasis, inflammation, proliferation, and maturation. However, much of its detailed mechanism remains unknown. There have been many basic research studies on wound healing using cells and experimental animals. If findings can be used from such studies and clinical practice, development of even more effective treatments might be possible.

Cicatriza??o de feridas
Campos, Antonio Carlos Ligocki;Borges-Branco, Alessandra;Groth, Anne Karoline;
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S?o Paulo) , 2007, DOI: 10.1590/S0102-67202007000100010
Abstract: background: the wound healing consists of a perfect and coordinated cascade of events that result in tissue reconstitution. the healing process is common to all wounds, independently of the agent that has caused it. it is divided didactically into three phases: inflammation, proliferation or granulation and remodelation or maturation. the collagen is the most abundant protein in the human body and is also the main component from the matrix wounds. the collagen is organized in a thick and dynamic net, resulting from constant collagen deposition and reabsorption. the wound scar is the result of the interaction among tissue synthesis, degradation and remodeling. there are several ways to evaluate wound healing. the methods most used are: tensiometry, collagen morphometry, immunohistochemistry and more recently, the dosage of growth factors. methods: all thesis presented at the graduate program in clinical nutrition of the federal university of paraná in the research line of "organs and tissue healing" were reviewed. additionally a literature search on the subject was undertaking by using pubmed as well as bireme . conclusions: the wound healing is a complex process which has been subjected to numerous research studies in order to better understand it. recent studies have attempted to influence the process by using either nutrients or drugs in order to achieve faster recovery after surgical trauma.
Enhancement of Gingival Wound Healing by Local Application of Silver Nanoparticles Periodontal Dressing Following Surgery: A Histological Assessment in Animal Model  [PDF]
Ghanbari Habiboallah, Zakery Mahdi, Zakeri Majid, Saghravanian Nasroallah, Amir Moeen Taghavi, Ali Forouzanfar, Nooshin Arjmand
Modern Research in Inflammation (MRI) , 2014, DOI: 10.4236/mri.2014.33016
Abstract:

Background: The value of periodontal dressing and its effects on periodontal wound healing have been questioned. Besides, the early healing of the gingival and periodontal wounds in oral cavity should be emphasized to promote the treatment outcome. Several studies pointed out a potential positive effect of silver nanoparticles (NPs) on the healing process of skin wounds. The present work aimed to design silver NPs periodontal dressing and then, evaluated its effects on gingival wound healing following operation. Methods: Thirty healthy adolescent female rabbits were used in this study. They had intact teeth and the clinical and radiographic examination revealed no periodontal disease. Silver NPs were added to carbonate methyl cellulose as base with two different concentrations of 25% v/v (Group A) and 50% v/v (Group B). On the basis of simple randomized allocation, gingivectomy was performed at the buccal gingiva of the left and right mandibular incisors and subsequently, untreated wounds in the control area were covered with periodontal pack and periodontal dressings A and B were applied in the test regions. Histological changes were monitored in day 4 and 7 post operation to evaluate the inflammatory and repair stage of healing process. Results: We observed significant difference in the inflammatory and repair parameters of the healing process between surgical sites treated with this periodontal dressing and control group. Besides, wounds treated with silver NPs dressing in general terms had all the hallmarks of relatively complete healing one week post operatively. Conclusion: The results indicated positive potential therapeutic effects for this new formulation of periodontal dressing on acceleration of surgical wound healing that led to improvement of periodontal treatment consequences following operation.

Clinical Use of Growth Factors in the Improvement of Skin Wound Healing  [PDF]
Sarita Mac Cornick, Silvana Aparecida Alves Corrêa de Noronha, Ver?nica Chominski, Samuel Marcos Ribeiro de Noronha, Lydia Masako Ferreira, Alfredo Gragnani
Open Journal of Clinical Diagnostics (OJCD) , 2014, DOI: 10.4236/ojcd.2014.44032
Abstract: To discuss the normal mechanism of wound healing (WH), the role of growth factors (GF) in prec-linical and clinical studies and its importance in the healing of abnormal wound therapy. For search, we used the PUBMED and LILACS database, and the following descriptors: skin, wound healing, growth factor and clinical trials. We also prioritized the analysis of the Clinical Trials in the previous 10 years. Although there are many studies being conducted in the pre-clinical phase, we see that there are few studies in the clinical phase. 274 studies were identified, and 58 were selected. After tissue injury, repair occurs through coordinated biological actions that are healing. The importance of the study of healing in the skin is not only because of its anatomical location, easy access and exposure, but also because of its vital function. There is accumulating evidence that the process of healing after injury may be mediated by several GF. However, may this class of molecules even act effectively on the clinical response of this pathological condition? Many preclinical studies (in vitro and in vivo) reinforce the importance and efficacy of GF in the regeneration of damaged skin. Furthermore, recent studies have reported the use in adjuvant or not, of GF in clinical treatment to improve WH in humans. Therefore, we conclude that it seems to be effective by the use of GF in adjuvant or not in WH. However, it still seems to be necessary to carry out more clinical trials in phase I and II.
Effectiveness of Laser Therapy (AlGaInP) on Cicatrization of Experimental Cutaneous Wound in Rats  [PDF]
Renata dos Santos Vasconcelos, Renata Prado Vasconcelos, Luana Torres Monteiro Melo, Carolina Araújo Castro, Adriana Rolim Campos, Ana Paula Vasconcellos Abdon
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.59072
Abstract:

The use of laser therapy is one of the most effective tools in the prevention and treatment of skin ulcers. It is an effective treatment choice because it potentiates the trophic regenerative, anti inflammatory, and painkiller effects. This study aimed to assess the effectiveness of low level laser therapy in treating induced cutaneous ulcers in rats. An experimental study using 12 female Wistar rats (Rattus novergicus), weighing between 150 and 250 g, from the room of animal husbandry at the Center of Health Sciences of UNIFOR. Rats underwent surgery to induce cutaneous ulcer. Subsequently, the animals were divided into two randomized groups: 1) Control group; and 2) Experimental group. They received nine applications of AlGaInP laser treatment (power of 30 mW) with an intensity of 4 J/cm2, using the scan method, for 15 seconds over the entire ulcer. The cicatrization process was evaluated from the 1st to 19th postoperative (PO) day, but on alternate days. The results showed that animals treated with laser had less area of cutaneous wound than the control group from the 7th until the 17th postoperative day, highlighting the 7th and the 9th PO with a significant reduction in wound area of 28.8% (p = 0.00) and 23,5% (p = 0.01), respectively. Treatment with the AlGaInP laser was effective in the repair of cutaneous wound when compared to the control group—particularly on the 7th postoperative day.

The Effect of Projection Microstereolithographic Fabricated Implant Geometry on Myocutaneous Revascularization  [PDF]
Ross M. Clark, Kirsten N. Cicotte, Paul G. McGuire, Elizabeth L. Hedberg-Dirk, Thomas R. Howdieshell
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.512079
Abstract: Understanding cell behavior inside three-dimensional (3D) microenvironments with controlled spatial patterning of physical and biochemical factors could provide insight into the basic biology of tissue engraftment, vascular anastomosis, and revascularization. A simple layer by layer projection microstereolithography (PμSL) method was utilized to investigate the effects of a nonporous and porous bioinert barrier on myocutaneous flap engraftment and revascularization. A cranial-based, peninsular-shaped myocutaneous flap was surgically created on the dorsum of C57Bl6 mice. Porous (SP) and nonporous (S) silicone implants were tailored to precise flap dimensions and inserted between the flap and recipient bed prior to sutured wound closure. Porous implant myocutaneous flaps became engrafted to the recipient site with complete viability. In contrast, distal cutaneous necrosis and resultant flap dehiscence was evident by day 10 in nonporous implant flap mice. Laser speckle contrast imaging demonstrated flap revascularization in (SP) mice, and markedly reduced distal flap reperfusion in (S) mice. Histologic analysis of day 10 (SP) flaps revealed granulation tissue rich in blood vessels and macrophages growing through the implant pores and robust neovascularization of the distal flap. In contrast, the nonporous implant prevented tissue communication between recipient bed and flap with lack of bridging inflammatory cells and neovasculature and resultant distal tissue necrosis. We have fabricated porous and nonporous silicone implants via a simple and inexpensive technique of PμSL. Using a graded-ischemia wound healing model, we have shown that porous implants allowed contact between flap and recipient bed resulting in proximal flap arteriogenesis and neovascularization of the distal flap. Future research will utilize variations in implant pore size, spacing, and location to gain a better understanding of the cellular and molecular mechanisms responsible for myocutaneous flap engraftment, vascular anastomosis, and revascularization.
Hypoxic Condition Up-Regulates the Expression of Angiopoietin-2 in ADSCs  [PDF]
Lingxiao Ye, Xiaoming Sun, Yuguang Zhang, Ying Zhang
Journal of Biomedical Science and Engineering (JBiSE) , 2019, DOI: 10.4236/jbise.2019.122006
Abstract: Wound healing requires abundant nutrition and blood supply, thus angiogenesis is a vital stage in this process. Angiogenesis involves diverse kinds of immune cells, growth factors, cytokines and inhibitors. ADSCs, especially ADSCs cultured in hypoxic condition, are reported to be able to facilitate angiogenesis and promote wound healing process. Significant efforts have been made on the development of ADSCs-based therapies with wound-healing applications. Here the results showed that expression of Angiopoietin-2 (ANGPT2) in ADSCs was up-regulated in the hypoxic condition.
Cicatrización de los tejidos con interés en cirugía bucal: revisión de la literatura
Felzani1,Odontólogo Ricardo;
Acta Odontológica Venezolana , 2005,
Abstract: resume the purpose of this article was to analyze, by means of a literature review, the wound healing of the tissues, fundamental physiological process to achieve the success of any treatment in the area of oral surgery. the first part defined and characterized wound healing. then, the factors that affect local and general wound healing were studied. besides, types of wound healing were defined according to different criteria. besides, it was studied how mucous, bone and nervous tissues are repaired when the oral surgeon carries out a surgical procedure. finally, some complications can be produced by defective wound healing, so some recommendations were presented which could help to repair with a minimum of disadvantages
Electrical control of cell behaviour and wound healing
McCaig, Colin
GMS Krankenhaushygiene Interdisziplin?r , 2008,
Abstract:
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