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Search Results: 1 - 10 of 82149 matches for " Wornei Silva Miranda;Oliveira "
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Molecular characterization of the hepatitis B virus in autochthonous and endogenous populations in the Western Brazilian Amazon
Dias, ádila Liliane Barros;Oliveira, Cintia Mara da Costa;Castilho, Márcia da Costa;Silva, Maria do Socorro Pontes da;Braga, Wornei Silva Miranda;
Revista da Sociedade Brasileira de Medicina Tropical , 2012, DOI: 10.1590/S0037-86822012000100003
Abstract: introduction: hepatitis b virus (hbv) infection is a serious public health issue worldwide. hepatitis b virus is classified into eight genotypes, varying from a to h, with distinct geographical distributions. in brazil, the most frequent genotypes are a, d, and f. methods: this study aimed to characterize the hbv genotypes in cases of hepatitis b virus and hepatitis d virus (hdv) co-infections in an endemic area in the western brazilian amazon. we analyzed 86 serum samples reactive for hbsag from indigenous and non-indigenous populations obtained from previous serological surveys. results: of the 86 reactive serum samples, 39 were found to be hbv-dna-positive by semi-nested pcr. the genotypes were established by sequencing the amplified s gene region. we obtained 20 sequences classified into three genotypes: a, d, and f. genotype a was the most frequent (60%), followed by d (35%) and f (5%). conclusions: the distribution of the hbv genotypes reflected the pattern of historical occupation of the region.
Hepatite cr?nica B oculta: prevalência e aspectos clínicos em popula??o de elevada endemicidade de infec??o pelo vírus da hepatite B na Amaz?nia Ocidental Brasileira
Barros Júnior, Gildo Maia;Braga, Wornei Silva Miranda;Oliveira, Cintia Mara Costa de;Castilho, Márcia da Costa;Araújo, José de Ribamar;
Revista da Sociedade Brasileira de Medicina Tropical , 2008, DOI: 10.1590/S0037-86822008000600010
Abstract: a persistent form of the hepatitis b virus called occult chronic hepatitis b has recently been described. its prevalence and physiopathology are unknown. the aim of this study was to evaluate the occurrence of this clinical entity among patients in the brazilian amazon region. out of 51 anti-hbc total-positive patients who were tested using the polymerase chain reaction, 17% were positive. we did not find any associations with classical risk factors for hepatitis b virus infection or with biochemical tests, hematological tests or histological patterns. however, the jaundiced and hiv-positive patients showed a statistical association with the presence of hepatitis b virus-dna. the results demonstrated that occult hepatitis b occurred among our patients, but at prevalence rates lower than expected for this region. we believe that despite the small sample size, the occurrence might have been found to be greater if we had used primers for the s, c and x regions of the hepatitis b virus genome, thereby increasing the sensitivity of the test.
Serological evidence of hantavirus infection in rural and urban regions in the state of Amazonas, Brazil
Gimaque, Jo?o Bosco Lima;Bastos, Michele de Souza;Braga, Wornei Silva Miranda;Oliveira, Cintia Mara Costa de;Castilho, Márcia da Costa;Figueiredo, Regina Maria Pinto de;Galusso, Elizabeth dos Santos;Itapirema, Evaulino Ferreira;Figueiredo, Luiz Tadeu Moraes de;Mour?o, Maria Paula Gomes;
Memórias do Instituto Oswaldo Cruz , 2012, DOI: 10.1590/S0074-02762012000100019
Abstract: hantavirus disease is caused by the hantavirus, which is an rna virus belonging to the family bunyaviridae. hantavirus disease is an anthropozoonotic infection transmitted through the inhalation of aerosols from the excreta of hantavirus-infected rodents. in the county of itacoatiara in the state of amazonas (am), brazil, the first human cases of hantavirus pulmonary and cardiovascular syndrome were described in july 2004. these first cases were followed by two fatal cases, one in the municipality of maués in 2005 and another in itacoatiara in 2007. in this study, we investigated the antibody levels to hantavirus in a population of 1,731 individuals from four different counties of am. sera were tested by igg/igm- enzyme-linked immune-sorbent assay using a recombinant nucleocapsid protein of the araraquara hantavirus as an antigen. ten sera were igg positive to hantavirus (0.6%). among the positive sera, 0.8% (1/122), 0.4% (1/256), 0.2% (1/556) and 0.9% (7/797) were from atalaia do norte, careiro castanho, itacoatiara and lábrea, respectively. none of the sera in this survey were igm-positive. because these counties are distributed in different areas of am, we can assume that infected individuals are found throughout the entire state, which suggests that hantavirus disease could be a local emerging health problem.
Soroprevalência da infec??o pelo vírus da hepatite B e pelo plasmódio em Lábrea, Amazonas: estimativa da ocorrência de prováveis coinfec??es
Braga, Wornei Silva Miranda;Silva, Eva Batista da;Souza, Rita Auxiliadora Botelho de;Tosta, Carlos Eduardo;
Revista da Sociedade Brasileira de Medicina Tropical , 2005, DOI: 10.1590/S0037-86822005000300002
Abstract: the amazon region is known for the high occurrence of hepatitis b virus (hbv) infection, and accounts for more than 98% of malaria cases in brazil. despite the controversy, it has been proposed that when associated they may lead to important effects in the natural history of both infections. this study estimates the prevalence of coinfection within general population of an endemic region of hbv and malaria in the brazilian amazon. the prevalence of hbsag was 3.3% (95% ci 2.1%-5.1%,) and total anti-hbc 49.9% (95% ci 45.9%-53.8%). the prevalence of antibodies against plasmodium vivax and plasmodium falciparum antigens was 51.4% (311/605) (95% ci 47.3%-55.4%). related to the simultaneous presence of malaria antibodies and hbv serological markers, in 1.8% (11/605), (95% ci 1.0%-3.3%), the presence of hbsag was also demonstrated, mean age 26 years (p <0.001). this study points to similarities in the distribution of these diseases, such as the occurrence mainly among young adults. the events may occur in different times. also shown differences such as the low risk of malaria in the group up to fifteen years, where hbv circulates with moderate intensity. the prevalence of hbv and malaria coinfection is in fact less than the rates of hbsag carriage, showing a heterogeneous pattern related to the clinical spectrum of hbv infection.
Soroprevalência da infec o pelo vírus da hepatite B e pelo plasmódio em Lábrea, Amazonas: estimativa da ocorrência de prováveis coinfec es
Braga Wornei Silva Miranda,Silva Eva Batista da,Souza Rita Auxiliadora Botelho de,Tosta Carlos Eduardo
Revista da Sociedade Brasileira de Medicina Tropical , 2005,
Abstract: A Amaz nia é conhecida pela elevada ocorrência de hepatite B e suas seqüelas. Contribui também com mais de 98% dos casos de malária do país. Apesar de controvérsias, é proposto que quando associadas ocorram altera es na história natural das duas patologias. Este estudo estima a prevalência de prováveis coinfec es em popula o geral de área endêmica de ambas infec es na Amaz nia Brasileira. A taxa de portadores do AgHBs encontrada foi de 3,3% (IC 95% 2,1% a 5,1%,), e a do anti-HBc total 49,9% (IC 95% 45,9% a 53,8%). A prevalência de anticorpos contra antígenos do Plasmodium vivax e Plasmodium falciparum foi de 51,4% (311/605) (IC 95% 47,3% a 55,4%). Em rela o à presen a simultanea de anticorpos contra antígenos do Plasmodium vivax e Plasmodium falciparum com marcadores do VHB, 1,8% (11/605), (IC95% 1,0% a 3,3%), apresentavam também o AgHBs, tendo estes em média 26 anos de idade (p<0,001). Este estudo aponta semelhan as na distribui o dessas enfermidades como, a ocorrência preferencialmente entre adulto jovens. Os eventos provavelmente ocorrem em momentos distintos. Mostra também diferen as como, o baixo risco de malária entre menores de quinze anos, onde o VHB circula com moderada intensidade. As taxas de coinfec es s o provavelmente menores que as de portadores do AgHBs, apresentando padr o heterogêneo em rela o ao espectro clínico da infec o pelo VHB.
Prevalência de marcadores para o vírus da hepatite B em contatos domiciliares no Estado do Amazonas
Brasil Leila Melo,Fonseca José Carlos Ferraz da,Souza Rita Botelho de,Braga Wornei Silva Miranda
Revista da Sociedade Brasileira de Medicina Tropical , 2003,
Abstract: O objetivo do estudo foi analisar o comportamento intrafamiliar da infec o pelo VHB, identificando os possíveis mecanismos de transmiss o dos vírus B no Estado do Amazonas. Foram estudados 97 casos índices e 258 familiares. Na análise dos contatos observou-se uma elevada propor o de familiares com marcadores de infec o pregressa (51,6%) como também indicadores de infec o ativa (12%) para o VHB, e uma alta prevalência entre os irm os (23,6%). Um indicador indireto da transmiss o intrafamiliar foi observado em raz o de elevada freqüência de infec o pelo VHB entre os contatos de casos índices acometidos pela forma fulminante de hepatite. A alta prevalência entre os irm os caracteriza a transmiss o de caráter horizontal e familiar. Em rela o a transmiss o vertical, em nosso estado, é possível que ocorra, mas, como um evento raro. Todas estas observa es apontam para a necessidade de novas investiga es visando o esclarecimento dos mecanismos pelos quais se dá a transmiss o intrafamiliar desse agente viral.
Co-infec o humana pelo plasmódio e o vírus da hepatite B: aspectos clínicos, sorológicos e imunológicos
Braga Wornei Silva Miranda,Souza Rita Auxiliadora Botelho de,Silva Eva Batista da,Fonseca José Carlos Ferraz da
Revista da Sociedade Brasileira de Medicina Tropical , 2006,
Abstract: A Amaz nia é conhecida pela elevada prevalência de infec o pelo vírus da hepatite B, contribui também com mais de 90% dos casos de malária do país. é proposto que a ocorrência de co-infec es seja importante e que na associa o ocorram altera es na história natural dessas enfermidades. O estudo avalia 545 pacientes com malária, em Coari, AM: 333 (61,1%) pelo Plasmodium vivax, 193 (35,4%) pelo Plasmodium falciparum e 19 (3,5%) com infec o mista. A prevalência do AgHBs foi 4,2% e a do anti-HBc total 49,7%. Os pacientes sororreativos para o VHB, n o apresentaram diferen as clínicas dos outros pacientes com malária, nem associa o a sinais clássicos de comprometimento hepático. Apesar de n o ter sido detectada associa o estatisticamente significativa, os indivíduos AgHBs reativos apresentaram baixas parasitemias e índices de reatividade de anticorpos mais elevados, sugerindo a possibilidade da resposta imune em um indivíduo co-infectado ser diferenciada e favorecer varia es em rela o à parasitemia e produ o de anticorpos.
Prevalência de marcadores para o vírus da hepatite B em contatos domiciliares no Estado do Amazonas
Brasil, Leila Melo;Fonseca, José Carlos Ferraz da;Souza, Rita Botelho de;Braga, Wornei Silva Miranda;Toledo, Luciano Medeiros de;
Revista da Sociedade Brasileira de Medicina Tropical , 2003, DOI: 10.1590/S0037-86822003000500004
Abstract: the aim of our investigation was to evaluate, with a prevalence study, the modes of transmission of hepatitis b virus (hbv), within infected subjects and their household contacts in the state of amazon, western brazilian amazon. we studied 97 index cases and 258 household contacts. out of the 258 household contacts of hbv, 51.6% had serological markers of a past infection, 12.0% signs of active infection, suggesting that the virus circulates within household members. the high prevalence among siblings (23.6%) demonstrates the importance of personal contact in the transmission of this virus. another indirect indicator of intra-familial transmission was the high prevalence of hbv markers within contacts of a fulminant hepatitis. the vertical transmission of hbv in our region may or may not occur, but if it does it as a rare event. our results demonstrate the importance of the presence of hbv, and demand other investigations to clarify the inter-familial transmission of these viruses in our region.
Ocorrência da infec o pelo vírus da hepatite B (VHB) e delta (VHD) em sete grupos indígenas do Estado do Amazonas
Braga Wornei Silva Miranda,Brasil Leila Melo,Souza Rita Auxiliadora Botelho de,Castilho Márcia da Costa
Revista da Sociedade Brasileira de Medicina Tropical , 2001,
Abstract: A infec o pelo VHB e VHD s o importantes problemas de saúde na Amaz nia. Este estudo avalia a prevalência da infec o por esses agentes em sete grupos indígenas do Estado do Amazonas. A taxa de infec o passada pelo VHB encontrada foi de 54,5% e a de portadores do AgHBs de 9,7%. Observa-se varia o importante destes marcadores entre as aldeias, inclusive da mesma etnia. N o evidenciamos marcador de infec o aguda, os quatro AgHBe reativos eram todos Apurin , da mesma aldeia, e três da mesma família. O VHD foi encontrado em 13,4% dos AgHBs reativos. O padr o de infec o pelo VHB e VHD encontrado possui as seguintes características: endemicidade elevada, baixo potencial de infectividade, transmiss o marcada em idade precoce, provável transmiss o familiar, e pouca importancia da transmiss o vertical. Entretanto, também sugere que esses vírus n o tenham sido ainda introduzidos efetivamente em algumas das etnias estudadas.
Co-infec??o humana pelo plasmódio e o vírus da hepatite B: aspectos clínicos, sorológicos e imunológicos
Braga, Wornei Silva Miranda;Souza, Rita Auxiliadora Botelho de;Silva, Eva Batista da;Fonseca, José Carlos Ferraz da;Tosta, Carlos Eduardo;
Revista da Sociedade Brasileira de Medicina Tropical , 2006, DOI: 10.1590/S0037-86822006000100005
Abstract: the amazon region is known for a high prevalence of hepatitis b infection, and accounts for more than 90% of malaria cases in brazil. it has been suggested that the occurrence of coinfections may be important, and may influence the natural history of both diseases. this study evaluated 545 patients with acute malaria, in coari, western brazilian amazon. 333 (61.1%) presented plasmodium vivax malaria, 193 (35.4%) plasmodium falciparumand 19 (3.5%) mixed infections. the hbsag prevalence was 4.2% and total anti-hbc 49.7%. patients with hbv serological markers presented no clinical differences than those with malaria only, nor showed any association with classic signs of hepatic disorder. although showing no statistical significance, hbsag reactive subjects presented lower parasitic load and higher antibody titers, suggesting the possibility that the immune response in a coinfected individual is differentiated and leads to a variation in the parasite load and antibody production.
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