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Search Results: 1 - 10 of 22034 matches for " Woo Joo Kim "
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Involvement of Transient Receptor Potential Melastatin 7 Channels in Orostachys japonicus-induced Apoptosis in Cancer Cells
Min-Woo Hwang,Hyung Woo Kim,Byung Joo Kim
International Journal of Pharmacology , 2012,
Abstract: Orostachys japonicus (OJ) herbal preparations have a history of use in Korean folk medicine for the treatment of cancer. The aim of this study was to clarify the potential role of OJ extract on transient receptor potential melastatin 7 (TRPM7) channels in the growth and survival of AGS and MCF-7 cells, the most common human gastric and breast adenocarcinoma cell line. The AGS and MCF-7 cells were treated with varying concentrations of OJ extract. Caspase-3 activity, mitochondrial depolarization and sub-G1 analysis were conducted to determine if AGS and MCF-7 cell death occurs by apoptosis. Also, TRPM7 channels were overexpressed in Human Embryonic Kidney (HEK) 293 cells to identify the role of TRPM7 channels in AGS and MCF-7 cell growth and survival. Addition of OJ extract to the culture medium inhibited AGS and MCF-7 cells growth and survival. Experimental results showed caspase-3 activity, mitochondrial depolarization and sub-G1 were elevated. OJ extract inhibited the TRPM7-like current in AGS and MCF-7 cells and TRPM7 channel overexpressed HEK293 cells by whole cell voltage-clamp recordings. Furthermore, TRPM7 overexpression in HEK 293 cells exacerbated OJ extract-induced cell death. These findings indicate that OJ extract inhibits the growth and survival of gastric and breast cancer cell which is due to the blockade of TRPM7 channel activity. Therefore, OJ extract has an important role in regulation of the survival of gastric and breast cancer cells through TRPM7 channels.
Thermal Conductivity Measurement of Zr-ZrO2 Simulated Inert Matrix Nuclear Fuel Pellet  [PDF]
Dong-Joo Kim, Young Woo Rhee, Jong Hun Kim, Jang Soo Oh, Keon Sik Kim, Jae Ho Yang
World Journal of Nuclear Science and Technology (WJNST) , 2013, DOI: 10.4236/wjnst.2013.32008

For an evaluation of a thermal conductivity of Zr + 30 vol% ZrO2 simulated inert matrix nuclear fuel pellet, a simulated fuel pellet was fabricated using a hot-pressing method at 800°C in a vacuum and at a 20 MPa load. And several thermophysical properties of the simulated inert matrix fuel pellet were measured and calculated. The thermal diffusivity and linear thermal expansion as a function of temperature of the simulated fuel pellet were measured using a laser flash method and a dilatometry, respectively. Finally, based on the experimental data, the thermal conductivity of the simulated inert matrix fuel pellet was calculated and evaluated.

A Study on Quantitative Methodology to Assess Cyber Security Risk of Smart Grid  [PDF]
Pil Sung Woo, Byung-Hyun Ko, Dong-Joo Kang, Balho H. Kim
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B249

This paper aims to identify and clarify the cyber security risks and their interaction with the power system in Smart Grid. The SCADA system and other communication networks interact with the power system on a real time basis, so it is important to understand the interaction between two layers to protect the power system from potential cyber threats. This paper has shown the risks of the open architecture SCADA in a quantitative method and proposed effective security measures through case studies.

Cognitive Profiles and Subtypes of Patients with Mild Cognitive Impairment: Data from a Clinical Follow-Up Study  [PDF]
Kyung Won Park, Eun-Joo Kim, Hwan Joo, Sung-Man Jeon, Seong-Ho Choi, Jay C. Kwon, Byoung Gwon Kim, Jae Woo Kim
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.35068
Abstract: Background: Mild cognitive impairment (MCI) is a heterogeneous condition with a variety of clinical outcomes, the presence of which correlates with risk of Alzheimer’s disease as well as pre-clinical stages of other dementia subtypes. The aims of this study were to assess the specific patterns of cognitive profiles and to identify changes from baseline to 24 weeks in patients with MCI using detailed neuropsychological testing. Methods: We consecutively recruited 120 MCI patients at baseline according to the Petersen’s clinical diagnostic criteria, who were admitted to the Dementia and Memory Clinics. We analyzed patients who fulfilled both inclusion and exclusion criteria for MCI and classified them into four subtypes according to deficits in major cognitive domains; amnestic MCI single domain (aMCI-s), amnestic multiple domain MCI (aMCI-m), non-amnestic single domain MCI (naMCI-s) and non-amnestic multiple domain MCI (naMCI-m). Four groups of MCI were evaluated by a detailed neuropsychological battery test. Results: 83 patients with MCI at the 24-week follow-up were classified into four subtypes. The most frequent subtype was amnestic multi-domain MCI, with the frequency of MCI subtypes as follows: aMCI-s (n = 21, 25.3%), aMCI-m (n = 53, 63.9%), naMCI-s (n = 5, 6.0%) and naMCI-m (n = 4, 4.8%). In the major cognitive items of the SNSB-D, there were significant changes between the initial and follow-up tests in the domains of language, memory and the fron-tal/executive function (p < 0.05), except for attention, in all MCI patient subtypes. At 24-weeks follow-up, the conversion rate to Alzheimer’s disease was 2.4% (n = 2) from a subtype of amnestic multi-domain MCI. Conclusions: Our study revealed the most frequent subtype of MCI to be multiple domain amnestic MCI, with this subtype having a higher tendency of conversion to Alzheimer’s disease.
Immediate impact of exercise on arterial stiffness in humans  [PDF]
Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.31009

Background and objectives: Increased arterial stiffness is an accepted cardiovascular risk factor. Several studies have shown that regular exercise is associated with reduced arterial stiffness. However, the acute effect is not well known. The aim of this study was to evaluate the immediate impact of exercise on arterial stiffness measured by pulse wave velocity (PWV). Subjects and Methods: Data from 100 consecutive patients who underwent graded maximal aerobic exercise test and pulse wave velocity study due to chest pain were analyzed. Results: With respect to brachial-ankle pulse wave velocity (baPWV), it decreased after the exercise test (before vs. after; 1420 ± 260 vs. 1358 ± 245, 1428 ± 255, vs. 1360 ±239 cm/sec; left and right, respectively). Upper extremity systolic blood pressure did not change from baseline. However, upper extremity diastolic blood pressure increased slightly. In addition, lower extremity blood pressure decreased in both systolic and diastolic phases. In both normotensives and hypertensives, baPWV decreased after exercise test. Conclusion: Exercise immediately decreases arterial stiffness.

Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst
Hyun Joo Lee,Saet Byeol Woo,Dae Young Kim
Molecules , 2012, DOI: 10.3390/molecules17067523
Abstract: The enantioselective conjugate addition reaction of 3-aryl-substituted oxindoles with methyl vinyl ketone promoted by binaphthyl-modified bifunctional organocatalysts was investigated. The corresponding Michael adducts, containing a quaternary center at the C3-position of the oxindoles, were generally obtained in high yields with excellent enantioselectivities (up to 91% ee).
A case of successful survival from ventricular free wall micro-rupture without surgery  [PDF]
Jae-Bin Seo, Ki-Hyun Jeon, Jin-Hyun Park, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim, Woo-Young Chung
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.32029

We report a case of successful survival from ventricular free wall rupture without surgery, which was not overt rupture but micro-rupture. The patient was diagnosed with acute myocardial infarction (AMI) and underwent primary percutaneous coronary intervention (PCI). Myocardial blood leakage could be detected on transthoracic echocardiography with intravenous infusion of contrast dye 3 days after PCI. This examination revealed that there was not overt perforation but diffuse fissure. Because of his critical condition, he was treated conservatively without surgery. Nevertheless, he survived eventually.

Physical Status of Human Papillomavirus Integration in Cervical Cancer Is Associated with Treatment Outcome of the Patients Treated with Radiotherapy
Hye-Jin Shin, Jungnam Joo, Ji Hyun Yoon, Chong Woo Yoo, Joo-Young Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0078995
Abstract: Integration of human papillomavirus (HPV) DNA into the host genome is a critical aetiological event in the progression from normal cervix to intraepithelial neoplasm, and finally to invasive cervical cancer. However, there has been little work on how HPV integration status relates to treatment outcome for cervical carcinomas. In the current study, HPV E2 and E6 gene copy numbers were measured in 111 cervical cancer tissues using real-time QPCR. Integration patterns were divided into four groups: single copy-integrated with episomal components (group 1), single copy-integrated without episomal components (group 2), multicopy tandem repetition-integrated (group 3), and low HPV (group 4) groups. A relapse-predicting model was constructed using multivariable Cox proportional hazards model to classify patients into different risk groups for disease-free survival (DFS). The model was internally validated using bootstrap resampling. Oligonucleotide microarray analysis was performed to evaluate gene expression patterns in relation to the different integration groups. DFS rate was inferior in the order of the patients in group 4, group 2/3, and group 1. Multivariate analysis showed that histologic grade, clinical stage group, and integration pattern were significant prognostic factors for poor DFS. The current prognostic model accurately predicted the risk of relapse, with an area under the receiver operating characteristic curve (AUC) of 0.74 (bootstrap corrected, 0.71). In conclusion, these data suggest that HPV integration pattern is a potent prognostic factor for tailored treatment of cervical cancer.
Behavioral Aspects of Social Network Analysis
Sung Joo Park,Jong Woo Kim,Hong Joo Lee,Hyun Jung Park,Peter Gloor
Computer Science , 2015,
Abstract: Contrary to the structural aspect of conventional social network analysis, a new method in behavioral analysis is proposed. We define behavioral measures including self-loops and multiple links and illustrate the behavioral analysis with the networks of Wikipedia editing. Behavioral social network analysis provides an explanation of human behavior that may be further extended to the explanation of culture through social phenomena.
Cardiac Transcription Factor Nkx2.5 Is Downregulated under Excessive O-GlcNAcylation Condition
Hoe Suk Kim, Ji Soo Woo, Hyun Jung Joo, Woo Kyung Moon
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038053
Abstract: Post-translational modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) is linked the development of diabetic cardiomyopathy. We investigated whether Nkx2.5 protein, a cardiac transcription factor, is regulated by O-GlcNAc. Recombinant Nkx2.5 (myc-Nkx2.5) proteins were reduced by treatment with the O-GlcNAcase inhibitors STZ and O-(2-acetamido-2-deoxy-D-glucopyroanosyli?dene)-amino-N-phenylcarbamate; PUGNAC) as well as the overexpression of recombinant O-GlcNAc transferase (OGT-flag). Co-immunoprecipitation analysis revealed that myc-Nkx2.5 and OGT-flag proteins interacted and myc-Nkx2.5 proteins were modified by O-GlcNAc. In addition, Nkx2.5 proteins were reduced in the heart tissue of streptozotocin (STZ)-induced diabetic mice and O-GlcNAc modification of Nkx2.5 protein increased in diabetic heart tissue compared with non-diabetic heart. Thus, excessive O-GlcNAcylation causes downregulation of Nkx2.5, which may be an underlying contributing factor for the development of diabetic cardiomyopathy.
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