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Search Results: 1 - 10 of 7868 matches for " Won Sik Eum1 "
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PEP-1-p18 prevents neuronal cell death by inhibiting oxidative stress and Bax expression
Duk-Soo Kim2,#, Eun Jeong Sohn1,#, Dae Won Kim1, Young Nam Kim1, Seon Ae Eom1, Ga Hyeon Yoon1, Sung-Woo Cho3, Sang-Hyun Lee1, Hyun Sook Hwang1, Yoon Shin Cho1, Jinseu Park1, Won Sik Eum1,* & Soo Young Choi1,*
BMB Reports , 2012,
Abstract: P18, a member of the INK4 family of cyclin-dependent kinaseinhibitors, is a tumor suppressor protein and plays a key cellsurvival role in a variety of human cancers. Under pathophysiologicalconditions, the INK4 group proteins participate in novelbiological functions associated with neuronal diseases andoxidative stress. Parkinson’s disease (PD) is characterized by loss ofdopaminergic neurons, and oxidative stress is important in itspathogenesis. Therefore, we examined the effects of PEP-1-p18 onoxidative stress-induced SH-SY5Y cells and in a PD mouse model.The transduced PEP-1-p18 markedly inhibited 1-methyl-4-phenylpyridinium-induced SH-SY5Y cell death by inhibiting Baxexpression levels and DNA fragmentation. Additionally, PEP-1-p18prevented dopaminergic neuronal cell death in the substantia nigraof a 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-induced PDmouse model. These results indicate that PEP-1-p18 may be auseful therapeutic agent against various diseases and is a potentialtool for treating PD.
Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein
Sun Hwa Lee1,#, Dae Won Kim1,#, Seon Ae Eom1, Se-Young Jun1, Meeyoung Park1, Duk-Soo Kim2, Hyung Joo Kwon3, Hyeok Yil Kwon4, Kyu Hyung Han1, Jinseu Park1, Hyun Sook Hwang1, Won Sik Eum1,* & Soo Young Choi1,*
BMB Reports , 2012,
Abstract: We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammationin animal models using a Tat-ANX1 protein. Topicalapplication of the Tat-ANX1 protein markedly inhibited TPAinducedear edema and expression levels of cyclooxygenase-2(COX-2) as well as pro-inflammatory cytokines such as interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha(TNF-α). Also, application of Tat-ANX1 protein significantlyinhibited nuclear translocation of nuclear factor-kappa B(NF-κB) and phosphorylation of p38 and extracellular signalregulatedkinase (ERK) mitogen-activated protein kinase(MAPK) in TPA-treated mice ears. The results indicate thatTat-ANX1 protein inhibits the inflammatory response byblocking NF-κB and MAPK activation in TPA-induced miceears. Therefore, the Tat-ANX1 protein may be useful as atherapeutic agent against inflammatory skin diseases.
Differential Immune Responses to Segniliparus rotundus and Segniliparus rugosus Infection and Analysis of Their Comparative Virulence Profiles
Jong-Seok Kim, Woo Sik Kim, Keehoon Lee, Choul-Jae Won, Jin Man Kim, Seok-Yong Eum, Won-Jung Koh, Sung Jae Shin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059646
Abstract: Two closely related bacterial species, Segniliparus rotundus and Segniliparus rugosus, have emerged as important human pathogens, but little is known about the immune responses they elicit or their comparative pathophysiologies. To determine the virulence and immune responses of the two species, we compared their abilities to grow in phagocytic and non-phagocytic cells. Both species maintained non-replicating states within A549 epithelial cells. S. rugosus persisted longer and multiplied more rapidly inside murine bone marrow-derived macrophages (BMDMs), induced more pro-inflammatory cytokines, and induced higher levels of macrophage necrosis. Activation of BMDMs by both species was mediated by toll-like receptor 2 (TLR2), followed by mitogen-activated protein kinases (MAPK) and nuclear factor κB (NF-κB) signaling pathways, indicating a critical role for TLR2 in Segniliparus-induced macrophage activation. S. rugosus triggered faster and stronger activation of MAPK signaling and IκB degradation, indicating that S. rugosus induces more pro-inflammatory cytokines than S. rotundus. Multifocal granulomatous inflammations in the liver and lung were observed in mice infected with S. rugosus, but S. rotundus was rapidly cleared from all organs tested within 15 days post-infection. Furthermore, S. rugosus induced faster infiltration of innate immune cells such as neutrophils and macrophages to the lung than S. rotundus. Our results suggest that S. rugosus is more virulent and induces a stronger immune response than S. rotundus.
PEP-1-PON1 Protein Regulates Inflammatory Response in Raw 264.7 Macrophages and Ameliorates Inflammation in a TPA-Induced Animal Model
Mi Jin Kim, Hoon Jae Jeong, Dae Won Kim, Eun Jeong Sohn, Hyo Sang Jo, Duk-Soo Kim, Hyun Ah Kim, Eun Young Park, Jong Hoon Park, Ora Son, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Choi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086034
Abstract: Paraoxonase 1 (PON1) is an antioxidant enzyme which plays a central role in various diseases. However, the mechanism and function of PON1 protein in inflammation are poorly understood. Since PON1 protein alone cannot be delivered into cells, we generated a cell permeable PEP-1-PON1 protein using protein transduction domains, and examined whether it can protect against cell death in lipopolysaccharide (LPS) or hydrogen peroxide (H2O2)-treated Raw 264.7 cells as well as mice with 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced skin inflammation. We demonstrated that PEP-1-PON1 protein transduced into Raw 264.7 cells and markedly protected against LPS or H2O2-induced cell death by inhibiting cellular reactive oxygen species (ROS) levels, the inflammatory mediator’s expression, activation of mitogen-activated protein kinases (MAPKs) and cellular apoptosis. Furthermore, topically applied PEP-1-PON1 protein ameliorates TPA-treated mice skin inflammation via a reduction of inflammatory response. Our results indicate that PEP-1-PON1 protein plays a key role in inflammation and oxidative stress in vitro and in vivo. Therefore, we suggest that PEP-1-PON1 protein may provide a potential protein therapy against oxidative stress and inflammation.
Histamine-induced itch and its relationship with pain
Won-Sik Shim, Uhtaek Oh
Molecular Pain , 2008, DOI: 10.1186/1744-8069-4-29
Abstract: Itch is a sensation felt on skin, which causes the desire to scratch. Although itch might constitute an alert system against certain stimuli like mosquito bites, it can become stressful and exhausting when excessive. Indeed, patients with severe pruritus often find it difficult to lead a normal life due to itch-associated psychological disturbances, such as, depression or sleep deprivation [1,2]. Atopic dermatitis patients suffer from severe itch, and this disease is inadequately addressed by currently available medications. Therefore, an understanding of the mechanism of itch is essential in order to treat severe symptoms.Although numerous substances are known to cause pruritus, such as, substance P, cytokines, proteases and so forth (for a detailed review on pruritogenic agents, see [3,4]), histamine is best known to evoke experimental itch when applied to the skin [5-9]. Recent itch-related studies have focused on non-histaminergic itch symptoms, but it is also of considerable importance that we understand the manner in which histamine induces itch. In this regard, it is worth mentioning that antihistamines are among the most widely-used drugs in the United States [10]. Therefore, in this review, we will focus mainly on experimental findings concerning histamine-induced itch.Histamine is released from mast cells when tissues are inflamed or stimulated by allergens [11,12], and once released, histamine induces itch is triggered by the excitation of a subset of unmyelinated C-fibers [13]. Histamine receptors are known to mediate histamine-induced responses, and are members of the G-protein-coupled receptors. Four subtypes of histamine receptors have been identified to date, and histamine receptor subtype I (H1R) has been studied most extensively in the context of histamine-induced itch. In fact, H1R blockers (antihistamines) are widely used to manage and alleviate itch symptoms [14]. However, the itch-reducing efficacies of these classical H1R antihistamines are de
N,N,N′,N′-Tetrakis(pyridin-4-yl)methanediamine monohydrate
Jong Won Shin,Kil Sik Min
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812019010
Abstract: In the title compound, C21H18N6·H2O, two 4,4′-dipyridylamine groups are linked by a methylene C atom, which sits on a twofold axis. The lattice water molecule is located slightly off a twofold axis, and is therefore disordered over two positions. In the crystal, the organic molecules and the water molecule are linked by O—H...N hydrogen bonds. The organic molecules exhibit extensive offset face-to-face π–π interactions to symmetry equivalents [centroid–centroid distances = 3.725 (3) and 4.059 (3) ].
trans-{1,8-Bis[(R)-α-methylbenzyl]-1,3,6,8,10,13-hexaazacyclotetradecane}dithiocyanatonickel(II)
Jong Won Shin,Kil Sik Min
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809002700
Abstract: The title compound, [Ni(NCS)2(C24H38N6)], is a thiocyanate-coordinated azamacrocyclic nickel(II) complex. There are two independent molecules in the asymmetric unit and their bond lengths and angles are similar. Both Ni atoms have a tetragonally distorted octahedral geometry, in which the NiII ion is coordinated by the four secondary N atoms of the azamacrocyclic ligand and by two N atoms of the thiocyanate ions. The average equatorial Ni—N bond lengths are shorter than the average axial Ni—N bond lengths [2.071 (1) and 2.115 (2) , respectively]. N—H...S hydrogen-bonding interactions between a secondary amine N atom and the adjacent thiocyanate ion leads to a polymeric chain along [100].
trans-Diazido(1,8-dibenzyl-1,3,6,8,10,13-hexaazacyclotetradecane)nickel(II)
Jong Won Shin,Kil Sik Min
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808018199
Abstract: In the centrosymmetric title compound, [Ni(N3)2(C22H34N6)], the NiII ion is coordinated by the four secondary N atoms of the macrocyclic ligand in a square-planar fashion with two N atoms of the azide ions in axial positions, resulting in a tetragonally distorted octahedron. An N—H...N hydrogen-bonding interaction between the secondary amine N atom of the macrocycle and an adjacent azide ion gives rise to a chain structure.
SIP-based Service and Device Portability Across OSGi Domains
Faisal Adeem Siddiqui,Won-Sik Yoon
Information Technology Journal , 2005,
Abstract: As Open Services Gateway Initiative (OSGi) is getting widespread industry support, there is a need for service and device portability across OSGi domains. This will enable the users in one OSGi environs to enjoy the same services when they locomote to other OSGi environs. Users will have access to services not only on their personal devices like mobile phones, PDAs, laptops etc. but also on any available device at the visiting location. We propose a novel architecture for this service and device portability across OSGi domains based on the Session Initiation Protocol (SIP). We outline the requirements and investigate how SIP meets these requirements while other solutions miscarry. Next, we present a lightweight SIP-Agent service in OSGi to enable service and device portability across OSGi domains of home, vehicle and mobile devices. We elaborate by giving example scenarios and SIP message flows based on OSGi reference architecture. Our OSGi enabled SIP-Agent service can either be the part of the framework or can be downloaded like any other OSGi service.
Data Aggregation with Error Correction for Wireless Sensor Networks
Qiang Ma,Won-Sik Yoon
Information Technology Journal , 2005,
Abstract: In-network aggregation as a power-efficient mechanism for collecting data in wireless sensor networks has been emphasized with the development of other WSN network protocols. In this study, we firstly propose a general architecture to seamlessly integrate data aggregation into wireless sensor networks and then present one error correction algorithm for data aggregation by exploiting the inherent correlations that exist between sensor nodes. This approach is orthogonal to other works and thus can work complementally to enhance the reliability of aggregation algorithms
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