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Flaporhexis, a technique to make the femtosecond laser corneal flap was developed primarily to reduce the mechanical trauma associated with separating the corneal tissue by taking advantage of the cornea’s natural anatomy and was first described in a peer reviewed artice in 2008. The anterior part of the cornea tends to be stronger, thereby allowing tearing (Greek “rhexis”) along the preformed cuts of the femtosecond photo disruption. Flaporhexis differs from Binder’s technique of “hinge opening” as published in 2006 by opening the flap from the opposite side. If a femtosecond flap lift is performed correctly, the surgeon will find a virgin, uniform, dry stromal bed, which had not been manipulated by any surgical instrument and is therefore perfect for wavefront guided laser surgery as “Sub-Bowman’s Keratomileusis”.
is a serious health problem of our time. Dysfunction of adipogenesis, the
differentiation of adipocytes, is a hallmark of obesity. Therefore here we
investigate the role of the COP9 signalosome and of CHOP in the differentiation
of LiSa-2 preadipocytes.
there are only few ideas for an integrated governance, risk and compliance
(GRC) management available with these referring to the management process of
GRC only. In literature, mainly specific questions at a detailed level, like
the automation of different controls, are discussed in the GRC context. To be
in the position to entirely realise benefit potentials (e.g. improvement of
processes), it is necessary to have an integrated GRC-Management focusing on
the strategic business objectives. Starting from the requirements, this article
deals with general guidelines for strategic GRC-Management showing which
aspects have to be considered in terms of an integral approach. On this basis,
a data-centred reference model explicates the structural connections of
GRC-related data, and lays the basis for the implementation in practice.