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Search Results: 1 - 10 of 14082 matches for " William Boadi "
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Biological Evaluation of New Schiff Bases: Synthesized from 4-Amino-3,5-dimethyl-1,2,4-triazole, Phenathroline and Bipyridine Dicarboxaldehydes  [PDF]
Md. Shafiqul Islam, Mohammad R. Karim, William Boadi, Seyi Falekun, Aminul H. Miza
Advances in Biological Chemistry (ABC) , 2016, DOI: 10.4236/abc.2016.66016
Abstract: Four new Schiff bases with promising anticancer activity have been synthesized from 4-amino-3,5-dimethyl-1,2,4-triazole and di-pyridyl-aldehydes. Structures have been established by various spectroscopic methods. The compounds were tested in vitro to study their cytotoxicity and anti-oxidative activity in human lung carcinoma (A549), breast carcinoma (BT549), prostate adenocarcinoma (PC3) and mouse preadipocytes (3T3-L1) cells. Compound 1 was found to increase Glutathione (GSH) level slightly in all four cell lines. Compound 4 showed better selectivity and cytotoxicity against both BT549 and A549 cells compared to the anticancer drug tamoxifen. With the exception of compound 4 which reduced GSH levels in A549 and BT549, all other compounds maintained GSH levels in comparison to their respective controls.
Synthesis and Antiproliferative Activities of Triphenylmethanol Conjugates of Leuprorelin  [PDF]
Ryan Beni, William Boadi, Kaleh Karim, Jawzah Alnakhli, Samiyah Alhamed
Open Journal of Medicinal Chemistry (OJMC) , 2019, DOI: 10.4236/ojmc.2019.92002
Abstract: Leuprorelin® (LEP) is an FDA drug for breast cancer and prostate cancer treatment. There are several reported adverse effects such as transient hypertension, excessive salivation, and increased dysuria during treatment with LEP. In this study, the efficacy and toxicity of LEP were modified by using a drug delivery system to adjust the physicochemical properties. In this regard, Leuprorelin® conjugates of triphenylmethanol derivatives (TPMs) were synthesized as prodrugs. Comparative antiproliferative assays showed that LEP-TPMs conjugates had significantly higher antiproliferative activities than the corresponding non-covalent physical mixtures of the TPMs and LEP against human invasive ductal carcinoma (BT-549), human prostate carcinoma (PC3), human lung cancer (A549) and mouse pre-adipocytes (3T3-L1) cells.
Triphenylmethanol Conjugates of Triptorelin as Anti-Lipid Peroxidation Prodrugs  [PDF]
Samiyah Alhamed, Jawzah Alnakhli, William Boadi, Ryan Beni
Open Journal of Medicinal Chemistry (OJMC) , 2019, DOI: 10.4236/ojmc.2019.93003
Abstract: Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable molecules that the body produces as a reaction to environmental and other pressures. Free radicals may play a role in heart disease, cancer and other diseases. If the body cannot process and remove free radicals efficiently, oxidative stress can result. This can harm cells and body function. Free radicals are also known as reactive oxygen species (ROS). In this research, Triptorelin® (TRP) conjugates of triphenylmethanol derivatives (TPMs) were synthesized to evaluate their in vitro lipid peroxidation potency. Comparative lipid peroxidation assays between TRP-TPMs conjugates and the corresponding TPMs derivatives were measured using thiobarbituric reactive substance (TBARS) in a dose- and time-dependent manner following the Fenton’s pathway. Overall, TBARS decreased between 20% - 30% for the treated samples of synthesized conjugates compared to their respective control physical mixtures. These data suggest that TRP-TPMs derivatives can be used to improve the biological activity of TRP.
Triphenylmethanol and Tris(2-(hydroxymethyl)phenol) Derivatives: Synthesis and Application as Indicators for Acid-Base Volumetric Titration  [PDF]
Ryan Beni, William Boadi, Jawzah Alnakhli, Samiyah Alhamed, Tiffany Robinson, Melanie Mootry, Nahom Iyob, Jamill Jackson, Natalie Spicer, Anterrial Harris, Ibrahim Bamidad, Renner Antwi, Shania Richardson, Tralynn Williams
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2019, DOI: 10.4236/jasmi.2019.92002
Polyphenols are naturally occurring compounds found largely in fruits, vegetables, cereals and beverages. Currently, there is much interest in the potential health benefits of dietary plant polyphenols as antioxidants. The effect of polyphenols on human cancer cells is most often protective and induces a reduction in the number of tumors or rate of growth. During our course of study on anticancer prodrugs, twelve triphenylmethanol and one tris(2-(hydroxymethyl) phenol derivatives were synthesized as a carrier of several drugs with optimized lipophilicity. Besides application of these compounds as a foundation for anticancer drug delivery systems, these compounds were evaluated as indicators for the acid-base volumetric titration of a standard solution of hydrochloric acid with a standard solution of sodium hydroxide. The experiments indicated a moderate-to-sharp color transition of the solutions near the neutralization point for most indicators. These indicators may have potential applications for acid-base titrations in a narrow range.
Effects of Lignocellulosic in Wood Used as Substrate on the Quality and Yield of Mushrooms  [PDF]
Mercy Badu, Sylvester K. Twumasi, Nathaniel O. Boadi
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.27107
Abstract: The objective of this study was to find out if the sawdust generated from some of the Ghanaian wood species can be used in the cultivation of pleurotus ostreatus (oyster mushroom) and their subsequent effect on the quality and yield of the mushrooms produced. Sawdust from three Ghanaian wood species (Triplochiton scleraxylon, Ceiba pentandra and Terminalia superba) were collected and their cellulose, hemicelluloses, lignin and nitrogen contents determined using standard methods. Triplochiton scleraxylon gave 46.76%, 15.69%, 27.55%, 0.01% w/w, Ceiba pentandra gave 44.79%, 15.32%, 34.08%, 0.02% w/w and Terminalia superba gave 46.64%, 16.29%, 31.17%, 0.02% w/w of the cellulose, hemicelluloses, lignin and nitrogen content respectively. Compost was then made from each of the wood and used as substrate for the cultivation of pleurotus ostreatus. The highest yield of mushroom was obtained from T. scleraxylon 334g followed by T. superba 277 g and C. pentandra gave the lowest yield of 193 g fresh weight after 3 flushes. The proximate composition of the mushrooms produced gave crude protein ranging 16.33 - 18.20, fat 1.67 - 2.07, carbohydrate 40.86 - 50.53, fibre 4.14 - 6.73 and ash content of 4.40% - 5.80%. The report has shown that the yield and nutritional content of the oyster mushroom on sawdust depends on the chemical constituents such as the cellulose content, the hemicellulose content, the lignin content, the nitrogen content of the particular substrate used. Triplochiton scleraxylon gave the best yield and nutritional content, considering that these substrates are freely available and regarded as “waste”, it can be used to cultivate edible mushrooms to supplement nutritional requirement and source of income to make life better for many people.
Assessing the Effectiveness of Distance Education within the Context of Traditional Classroom  [PDF]
Gabriel Kofi Boahen Nsiah, Mable Oti-Boadi
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.68072
Abstract: Distance education has become a platform for delivery of education around the globe. Nations are seizing the opportunities. This learning tool is offering and thereby providing anytime anywhere forms of education to bridge the educational gap in respective nations. In view of this expansion, assessing the effectiveness of distance education within the context of traditional classroom delivery of instruction is expedient. This will better inform educational institutions in planning a distance education program.
Determinants of Bank Deposits in Ghana: Does Interest Rate Liberalization Matters?  [PDF]
Eric Kofi Boadi, Yao Li, Victor Curtis Lartey
Modern Economy (ME) , 2015, DOI: 10.4236/me.2015.69094
Abstract: This research paper examines the effect of interest rate liberalization on bank deposits in a developing country Ghana. A deposit function model was specified with long term deposit as the main dependent variable with real savings rate, real treasury bill rate, exchange rate movement and gross domestic product as independent variables while controlling for inflation. Ordinary Least Squares (OLS) method was used to estimate the specified model which covered seasonally adjusted quarterly data drawn from Bank of Ghana and Ghana Statistical Service. The data were input into a spreadsheet and exported into Econometric View 7 which was used for processing the data. The results of the study revealed that the interest rate liberalization and gross domestic product jointly accounted for about 78% of the variation in the level of bank savings deposits in Ghana. The study has also shown that the liberalization of the interest rates has made it attractive for people with idle funds to save with financial institutions especially the banks. It also revealed a negative relationship between real savings rate and the real treasury bill rate expected in a high inflationary environment. All the independent variables were significant. It is therefore recommended that the Bank of Ghana remains resilience on interest rate liberalization so that surplus funds can be made available for investors and also to reduce the level of inflation in Ghana.
Lauretta Wamunza,Benzies Boadi,Stephen Mutula
Lex et Scientia , 2007,
Abstract: Presents part of the findings of a study that was carried out at the University of Botswana to determine in general how HIV/AIDS information is disseminated to and used by undergraduate students. Both qualitative and quantitative approaches were used. A survey design was used to study a population of 9000 plus undergraduate students. Questionnaires and interviews were used to collect data. SPSS was used to analyse quantitative data while qualitative data was analysed using thematic categorization.Key findings revealed that the HIV/AIDS information disseminated to students include information on behaviour change; information on HIV/AIDS prevention; transmission and treatment. The means of disseminating information to students include the use of multiple channels such as the university Health and Wellness Centre, Lectures, peer groups, seminars/workshops, students meetings, the University Clinic and the library. The study found that the most common media used to disseminate information to students include video, print, CDs and verbal means. Finally, factors that affect access to and use of HIV/AIDS information by students include: religious orientations, substance abuse, low income levels, multiple relationships, age and gender.There is need for the University of Botswana to review its overall approach of disseminating HIV/AIDS information to students in order to make it more effective. Moreover, strong liaison among agencies involved in the fight against the spread of HIV/AIDS at the University is needed. Furthermore, a more rigorous research into issues of students’ attitudes and values in relation to HIV/AIDS is needed. Similarly, more efforts are needed to create awareness and educate students on the dangers associated with substance abuse, multiple partners and practicing unprotected sex. The need to encourage testing for HIV/AIDS among students is needed so that appropriate interventions can be put in place.The world over, HIV/AIDS has borne devastating effects on social, political and economic front of largely all countries, with Africa suffering most from the negative effects of the pandemic. Botswana has one of the highest prevalence rates of HIV/AIDS in the world. Government, the private sector, civil society and education institutions in Botswana are engaged one way or the other in the fight against the HIV/AIDS pandemic. HIV/AIDS in Botswana affects the most productive age groups, between twenty-five and forty years of the population. This results in a shortage of skilled labour needed for development and seriously reduces the level of product
Green Bio-Based CaO from Guinea Fowl Eggshells  [PDF]
Mary-Magdalene Pedavoah, Mercy Badu, Nathaniel O. Boadi, Johannes A. M. Awudza
Green and Sustainable Chemistry (GSC) , 2018, DOI: 10.4236/gsc.2018.82015
Abstract: Eggshells are among the emerging hazardous waste from the food processing industry. This work sought to valorize waste guinea fowl eggshells. Guinea fowl eggshells (GFEs) were evaluated in the production of CaO for chemical and industrial application. The functionality, thermal stability, elemental composition, phase distribution and surface morphology properties of uncalcined GFEs and GFEs calcined at 700°C, 800°C, 900°C, 1000°C and 1100°C were systematically studied by FTIR, TGA, XRF, XRD and SEM-EDX respectively. The elemental analysis revealed Ca as the main element in the GFEs. The uncalcined GFEs showed intense peaks that corresponded to calcite (CaCO3) phases. These transformed into Ca(OH)2 as the temperature of calcination increased and finally to CaO in the FTIR analysis. In the XRD diffractograms, the main peaks at 2θ values were 29.466° for the uncalcined GFESs and at 37.377° for the sample treated at 1100°C. The phases were confirmed as CaO when compared with JCPDS files. Using the Scherer equation, the CaO crystallite size for the sample calcined at 1100°C was found to be 50.68 nm along the (2 0 0) orientation. All the samples showed multi-step decomposition patterns in the thermogravimetric analyses (TGA), with weight loss of up to 47% for the uncalcined GFEs sample, which was mainly due to the transformation of the calcite (CaCO3) phase to CaO by removal of bound water, organic components, and CO2. Samples calcined at 1100°C showed mainly CaO phases in XRD analyses and fairly stable with 7% loss in weight after treatment at 800°C. SEM images of samples calcined at 900°C were irregular compared to samples treated at 1100°C. EDX data revealed that the surface structure was 100% calcium and oxygen. GFEs are a potential source of pure calcium oxide for various industrial uses.
Geophysical Interpretation of Possible Gold Mineralization Zones in Kyerano, South-Western Ghana Using Aeromagnetic and Radiometric Datasets  [PDF]
David Dotse Wemegah, Kwasi Preko, Reginald Mensah Noye, Benjamin Boadi, Aboagye Menyeh, Sylvester Kojo Danuor, Thomas Amenyoh
Journal of Geoscience and Environment Protection (GEP) , 2015, DOI: 10.4236/gep.2015.34008
Abstract: Airborne magnetic and radiometric datasets are used to interpret the geology and geological structural patterns which serve as potential gold mineralization zones in the Kyerano area located at south-western boundary of the prospective Sefwi Gold Belt and the Kumasi Basin in south-western Ghana. The geophysical data processing approach adopted concentrated on mapping geological boundaries, geological structures and possible gold mineralization zones is link to hydrothermally altered zones. The application of the enhancement filtering algorithms such as the reduction to the pole and analytic signal to the magnetic data, as well as the ternary radiometric image aided in the mapping of the mafic metavolcanics, basin metasediments and the belt-type granitoid complexes. The first vertical derivative and tilt angle derivative filters helped to delineate fractures, folds, and the contact zones of the formations such as that of the metavolcanics-metasediments that host the main Bibiani Shear Zone. Lineament analysis of the structures using rose diagram, reveals two main tectonic episodes in the area. These are NE-SW and NNW-SSE trending regional structures which account for about 90% of the extracted structures and are associated with the D1 and D2 deformational episodes of the Birimian Formation respectively. These structures are major fracture systems and play a pivotal role in the localization of gold mineralization in the study area.
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