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Search Results: 1 - 10 of 23591 matches for " Wenxin Zheng "
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Endometrial Glandular Dysplasia (EmGD): morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers
Oluwole Fadare, Wenxin Zheng
Diagnostic Pathology , 2008, DOI: 10.1186/1746-1596-3-6
Abstract: Endometrial cancers are the most frequently diagnosed malignancies of the female genital tract in the United States, with 39,080 new cases projected for 2007 [1]. Since 1983, two broad clinicopathologic subtypes of endometrial carcinomas have been recognized [2]. This conceptual classification has largely been supported by subsequent molecular-cytogenetic data, which has facilitated the acceptance of the so-called dualistic model of endometrial carcinogenesis [3-8]. Type I cancers, the prototype of which is the endometrioid histotype, occur in comparatively younger age group [3-8], appear to be related to unopposed estrogen stimulation [9-14], frequently express the estrogen and progesterone receptors [7,13,14], arise in a background of glandular hyperplasia [5,7,13,14], and has a relatively favorable prognostic profile [15]. Genetic alterations in Type 1 cancers include PTEN inactivation [16-19], beta-catenin (CTNNB1) mutations [17], and less frequently, microsatellite instability (related to inactivation of the MLH1 gene) [20,21], and activational mutations of the K-ras gene [22]. Type II cancers, the prototype of which is the endometrial serous carcinoma (ESC), and which was previously termed uterine papillary serous carcinoma (UPSC), typically occur in an older age group [3-8], frequently arise in a background of inactive or resting endometrium [3-8], and display a low frequency of expression of hormonal receptors [13,14,23,24]. Type II cancers also display frequent mutation and overexpression of the p53 [24-26] and HER2/neu [27,28] genes and proteins respectively, and have a comparatively poor prognosis independent of other factors [29-32]. This model has provided a valuable framework for the study of various aspects of endometrial carcinogenesis and for the potential development of therapeutic modalities that are pathway specific. Nonetheless, approximately 7400 deaths attributable to uterine corpus malignancies are projected for 2007 [1]. This relatively high
Model of On-line Room Reservation System Based on Web Service and XPMS
Jiali Wang,Jun Zheng,Wenxin Hu
Computer and Information Science , 2009, DOI: 10.5539/cis.v1n3p42
Abstract: This article analyzed the on-line hotel room reservation systems which had being widely used. Aiming at the advantages and disadvantages of the systems, this article introduced the XPMS theory and put forward a sort of optimized model by using the Web Service technology. The new model can provide sorts of ports aiming at different commercial demands and exchange real-time data under the premise of semantic consistency, which can attract more product providers to join in this network platform and minimize the network cost in the effective range.
Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis
Jie Li, Oluwole Fadare, Li Xiang, Beihua Kong, Wenxin Zheng
Journal of Hematology & Oncology , 2012, DOI: 10.1186/1756-8722-5-8
Abstract: Worldwide, approximately 225,500 women are diagnosed with ovarian cancer annually, with an estimated 140,200 associated deaths [1]. Although ovarian cancer accounts for only 3% of all cancers in women, it has one of the highest death-to-incidence ratios, which has been primarily attributed to the unavailability of effective screening tools, the absence of early phase symptomatology in many patients, and accordingly, its typical presentation at advanced stages when prognosis is poor [2,3].As has become apparent in recent years, one of the greatest obstacles to the detection of early-stage ovarian cancer was our poor understanding of its histogenesis and pathogenesis. Ovarian carcinoma was traditionally thought to originate from the ovarian surface epithelium (OSE) or ovarian epithelial inclusions (OEI), and investigative efforts at early detection have accordingly been centered on the ovary for decades. However, these efforts have not been successful, as evidenced by the fact the overall survival for women with ovarian cancer has not changed in any fundamental manner over the last 50 years [4]. Several emerging lines of evidence indicate that some traditional tenets of ovarian epithelial carcinogenesis and cellular origination are fundamentally flawed.Patients with high-grade serous carcinoma (which constitute 60-80% of ovarian epithelial carcinomas [OEC], and which represent the archetypical "ovarian cancer") most frequently present at advanced clinical stage and have a very poor overall survival [5,6]. Therefore, understanding of the nature and development of this type is extremely important for improving the survival rate of ovarian cancer patients as a group. Recently, studies of both asymptomatic women with germline BRCA1 or BRCA2 mutations as well as those from the general population with pelvic serous carcinoma, have detected precancerous or early cancerous lesions - serous tubal intraepithelial carcinoma (STIC) - in the fallopian tubal fimbria [7-9]. Furtherm
Age dependent association of endometrial polyps with increased risk of cancer involvement
Denise Hileeto, Oluwole Fadare, Maritza Martel, Wenxin Zheng
World Journal of Surgical Oncology , 2005, DOI: 10.1186/1477-7819-3-8
Abstract: All cases of EMPs were retrieved from the files of Yale-New Haven Hospital for the period 1986–1995. The patients were divided into 5 age groups: Each group was further subclassified based on an association (or lack thereof) of EMPs with endometrial carcinoma. Chi-square test was used to compare the proportion of malignancy associated EMPs between the age groups.We identified 513 EMPs, of which 209 (41%) were from biopsy specimens and 304 (59%) from hysterectomy specimens. Sixty six (13%) of all EMPs were malignant. The 66 malignant EMPs included 58 endometrioid, 6 serous, 1 carcinosarcoma, and 1 clear cell carcinoma. In age group >35, only 1(2.5%) of 40 EMPs was associated with endometrial malignancy. In contrast, 37(32%) of 115 EMPs were associated with malignancy in the age group > 65. The frequency of malignant EMPs increased with age and reached statistical significance in the age group >65 (p < 0.001). The most common histologic type of malignancy was endometrioid adenocarcinoma.EMPs show statistically significant age dependent association with malignant tumor involvement. Careful search for malignancy, particularly in women with multiple risk factors is advised in daily practice. Additional studies are needed to address the histological features and immunohistochemical profiles in the context of association between endometrioid and high-grade endometrial carcinoma and endometrial polyps.Endometrial polyps (EMPs) are generally considered benign proliferative lesions and are commonly encountered in routine surgical pathology practice. The usual histological pattern of endometrial polyps is characterized by irregular proliferative glands, with a fibrotic stroma containing thick-walled blood vessels [1]. The morphologic diversity of endometrial polyps is reflective of the morphologic spectrum of the background endometrium from which EMPs arise. As such, EMPs may range from atrophic to hyperplastic to carcinomatous. However, opinions differ on whether EMPs are int
Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo
Luyang Cao, Chao Dai, Zhongjie Li, Zheng Fan, Yu Song, Yingliang Wu, Zhijian Cao, Wenxin Li
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040135
Abstract: BmKn2 is an antimicrobial peptide (AMP) characterized from the venom of scorpion Mesobuthus martensii Karsch by our group. In this study, Kn2-7 was derived from BmKn2 to improve the antibacterial activity and decrease hemolytic activity. Kn2-7 showed increased inhibitory activity against both Gram-positive bacteria and Gram-negative bacteria. Moreover, Kn2-7 exhibited higher antibacterial activity against clinical antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). In addition, the topical use of Kn2-7 effectively protected the skin of mice from infection in an S. aureus mouse skin infection model. Kn2-7 exerted its antibacterial activity via a bactericidal mechanism. Kn2-7 killed S. aureus and E. coli rapidly by binding to the lipoteichoic acid (LTA) in the S. aureus cell wall and the lipopolysaccharides (LPS) in the E. coli cell wall, respectively. Finally, the hemolytic activity of Kn2-7 was significantly decreased, compared to the wild-type peptide BmKn2. Taken together, the Kn2-7 peptide can be developed as a topical therapeutic agent for treating bacterial infections.
E-cadherin and β-catenin expression in early stage cervical carcinoma: a tissue microarray study of 147 cases
Oluwole Fadare, Harini Reddy, Jun Wang, Denise Hileeto, Peter E Schwartz, Wenxin Zheng
World Journal of Surgical Oncology , 2005, DOI: 10.1186/1477-7819-3-38
Abstract: A tissue microarray of 147 cases of FIGO stage 1A and 1B cervical carcinomas [96 squamous cell carcinomas (SCC), 35 adenocarcinomas (AC), 12 adenosquamous carcinomas (ASQ), 4 miscellaneous types] was constructed from our archived surgical pathology files and stained with monoclonal antibodies to E-Cadherin and β-Catenin. Cases were scored by multiplying the intensity of staining (1 to 3 scale) by the percentage of cells stained (0–100%) for a potential maximum score of 300. For both markers, "preserved" expression was defined as bright membranous staining with a score of 200 or above. "Impaired" expression included any of the following: negative staining, a score less than 200, or exclusively cytoplasmic or nuclear delocalization.Impaired expression of β-Catenin was found in 85.7%, 66.7%, & 58.3% of AC, SCC & ASQ respectively. Impaired expression of E-Cadherin was found in 94.3%, 86.5% & 100% of cases of AC, SCC, & ASQ respectively. The differences between the histologic subtypes were not significant. For the whole cohort, a comparsion of cases showing impaired versus preserved of E-Cadherin and β-Catenin expression showed no significant differences with respect to recurrence free survival, overall survival, patient age, histologic grade, and frequency of lymphovascular invasion or lymph node involvement. There was no correlation between the status of both markers for all three histological subtypes (overall spearman correlation co-efficient r = 0.12, p = 0.14)Impairment of E-Cadherin and β-Catenin expression is very frequent in early stage cervical cancers, and alterations in the E-Cadherin/β-Catenin cell adhesion complex are therefore likely involved in the pathogenesis of cervical carcinomas even at their earliest stages. None of the three major histological subtypes of cervical carcinoma (SCC, ADCA, ADSQ) is significantly more likely than the others to show impairment in E-Cadherin and β-Catenin expression. Overall, the expression of both markers does not signif
Epidemiology of Functional Abdominal Bloating and Its Impact on Health Related Quality of Life: Male-Female Stratified Propensity Score Analysis in a Population Based Survey in Mainland China
Meijing Wu, Yanfang Zhao, Rui Wang, Wenxin Zheng, Xiaojing Guo, Shunquan Wu, Xiuqiang Ma, Jia He
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0102320
Abstract: Background The epidemiology of Functional abdominal bloating (FAB) and its impact on health-related quality of life (HRQoL) in Chinese people remains unclear. Methods Randomised, stratified, multi-stage sampling methodology was used to select a representative sample of the general population from five cities in China (n = 16,078). All respondents completed the modified Rome II questionnaire; 20% were asked to complete the 36-item Short Form (SF-36). The associated factors of FAB were analyzed. The effects of FAB on HRQoL were estimated with gender stratification using propensity score techniques in 20% subsample. Results Overall, 643 individuals (4.00%) had FAB and it was more prevalent in males than in females (4.87% vs. 3.04%, P<0.001). For males, self-reported history of dyspepsia was most strongly associated with FAB (OR = 2.78; 95% CI: 1.59, 4.72). However, the most strongly associated factor was self-reported health status for females (moderate health vs. good health: OR = 2.06, 95% CI: 1.07, 3.96. P = 0.030; poor health vs. good health: OR = 5.71, 95% CI: 2.06, 15.09). Concerning HRQoL, FAB was found to be related to two domains: role limitation due to physical problems (P = 0.030) and bodily pain (P<0.001) in females. While, in males, there were significant differences in multiple domains between those with and without FAB. Conclusion The prevalence of FAB in China was lower than previous reports. Males who had ever been diagnosed with dyspepsia and females who were in a poor self-reported health status were correlated with a higher prevalence of FAB. FAB affected only physical health in females, but impaired both physical and mental health in males.
Potentiel d’adaptation du CECR dans les facultés de fran ais en Chine
Wang Wenxin
Synergies Europe , 2011,
Abstract: Depuis trois décennies, l’enseignement du fran ais a connu un essor dans les établissements d’enseignement supérieur de Chine. Le ministère chinois de l’Education, par les soins d’une commission spéciale, exerce sa tutelle sur les facultés de fran ais. Celles-ci doivent établir leurs cours conformément à un programme national et leurs étudiants sont incités à participer à un test national. Ce programme et ce test sont très peu connus des pays étrangers, encore moins que le CECR ne l’est des facultés chinoises. Or chacun a ses atouts : le programme chinois fut élaboré sur les caractéristiques des étudiants chinois et le besoin de l’Etat et veille dans une large mesure à construire des connaissances linguistiques, littéraires et culturelles, tandis que le CECR met son accent sur la formation de compétences communicatives. Les acteurs chinois du FLE auraient alors tout intérêt à renouveler le programme en s’inspirant des apports du CECR, et celui-ci, en revanche, ne pourrait parvenir à faire référence parmi les facultés de fran ais en Chine que par l’entremise de leur programme national.
Developing a Chinese Medicine programme in a western medical university
Wenxin Zhou
International e-Journal of Science, Medicine & Education , 2012,
Abstract: Chinese medicine is one of the most famoustraditional medicines in the world with a glorious andlong written history of at least 2000 years. Recently,acupuncture and the use of other herbal medicineare being gradually accepted globally. In 2011,the International Medical University (IMU) startedthe Chinese Medicine programme which is the first ofits kind in a western medicine university in Malaysia.The author introduced the background of Chinesemedicine and the curriculum of the Chinese Medicineprogramme established in IMU, analyzed the situationregarding the quality of lectures given by internal andexternal lecturers in this programme and also discussedon ways to integrate western and traditional medicine inIMU or in Malaysia. The launching of Chinese medicinein IMU is a great step in the development of IMU andalso an important step in the development of medicaleducation in Malaysia or even in South-east Asia.
Entanglement Entropy in Many-Fermion System
Wenxin Ding
Physics , 2009,
Abstract: In this four-part prospectus, we first give a brief introduction to the motivation for studying entanglement entropy and some recent development. Then follows a summary of our recent work about entanglement entropy in states with traditional long-range order. After that we demonstrate calculation of entanglement entropy in both one-dimensional spin-less fermionic systems as well as bosonic systems via different approaches, and connect them using one-dimensional bosonization. In the last part, we briefly sketch the idea of bosonization in high-dimensions, and discuss the possibility and advantage of approaching the scaling behavior of entanglement entropy of fermions in arbitrary dimensions via bosonization.
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