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Search Results: 1 - 10 of 126673 matches for " Wenxin Li "
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Two non-coding transcripts of toxins from the scorpion Buthus martensii Karsch: Evidence for the existence of NMD in scorpion venom gland cells
Shunyi Zhu,Wenxin Li
Chinese Science Bulletin , 2002, DOI: 10.1360/02tb9009
Abstract: Two non-coding transcripts of toxins were isolated from the venom gland cDNA library of the Chinese scorpion Buthus martensii Karsch, named BmαTX15-SP and BmTXKβ-SP, respectively. Analysis of nucleotide sequences shows that their 5′ sequences are identical to the 5t’UTR and upstream open reading frame (ORF) sequences of the cDNAs encoding BmαTX15 and BmTXK β, two toxins from Buthus martensii Karsch. But no detectable homology exists in other regions. Two polyadenylated non-coding transcripts encode multiple short ORFs with no more than 34 amino acid residues. The tailing signal (AATAAA) is situated at 14 or 18 bp downstream from the poly(A). The data of genomic sequences provides support for Bmα TX15-SP and BmTXK β-SP not deriving from splicing errors of pre-mRNAs. Our finding provides evidence for the existence of nonsense-mediated mRNA decay (NMD) pathway in scorpion venom gland cells.
Model Selection for Likelihood-free Bayesian Methods Based on Moment Conditions: Theory and Numerical Examples
Cheng Li,Wenxin Jiang
Statistics , 2014,
Abstract: An important practice in statistics is to use robust likelihood-free methods, such as the estimating equations, which only require assumptions on the moments instead of specifying the full probabilistic model. We propose a Bayesian flavored model selection approach for such likelihood-free methods, based on (quasi-)posterior probabilities from the Bayesian Generalized Method of Moments (BGMM). This novel concept allows us to incorporate two important advantages of a Bayesian approach: the expressiveness of posterior distributions and the convenient computational method of MCMC. Many different applications are possible, including modeling the correlated longitudinal data, the quantile regression, and the graphical models based on partial correlation. We demonstrate numerically how our method works in these applications. Under mild conditions, we show that theoretically the BGMM can achieve the posterior consistency for selecting the unknown true model, and that it possesses a Bayesian version of the oracle property, i.e. the posterior distribution for the parameter of interest is asymptotically normal and is as informative as if the true model were known. In addition, we show that the proposed quasi-posterior is valid to be interpreted as an approximate conditional distribution given a data summary.
A Note on Bayesian Oracle Properties
Wenxin Jiang,Cheng Li
Statistics , 2015,
Abstract: We establish a fundamental relation between three different topics: Bayesian model selection, model averaging, and oracle performance. The relatively basic property of model selection consistency is shown to be equivalent to a seemingly more advanced distributional result, the oracle property. The result is very simple and general. There is no restriction on the type of prior or likelihood function used, or on the limiting distribution of the oracle posterior. A number of possible applications are discussed.
The Impact Compression Behaviors of Silica Nanoparticles—Epoxy Composites  [PDF]
Pibo Ma, Gaoming Jiang, Yanyan Li, Wenxin Zhong
Journal of Textile Science and Technology (JTST) , 2015, DOI: 10.4236/jtst.2015.11001
Abstract: The compressive properties of epoxy with different silica nanoparticles (SiO2 nanoparticles) contents at quasi-static and high strain rates loading were investigated via experiment. This article evaluates the compressive failure behaviors and modes at different SiO2 nanoparticles contents and different strain rates. The results indicated that the stress strain curves were sensitive to strain rate, and the compressive failure stress of composites with various SiO2 nanoparticles contents increased with the strain rates, and it increased along with SiO2 nanoparticles contents and then declined. The compressive failure stress and the compressive failure modes of the composites were apparently different from the change of SiO2 nanoparticles contents.
Synthesis of novel organophosphorus C60 dimers
Juanjuan Yin,Qingnuan Li,Wenxin Li
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-005-0394-4
Abstract: Carbon bridged organophosphorus C60 dimers were obtained by the reaction of aminomethylenebisphosphonate anion with C60 and fully characterized by 1HNMR, 31PNMR, 13CNMR, FT-MALDI-MS, FT-IR, UV-Vis, DEPT and HMBC, and the dimeric compounds undergo hydrolysis by using TMSI.
Advances in Diagnosis and Treatment of Multiple Primary Lung Cancer
Wenxin LUO, Ping ZHOU, Weimin LI
- , 2015, DOI: : 10.3779/j.issn.1009-3419.2015.10.07
Abstract: Recently, the incidence and detection rates of multiple primary lung cancer (MPLC) are increasing. The diagnosis of MPLC depends mainly on the Martini-Melamed criterion and ACCP criterion at present, taking all features (histological, genetic, radiologic and clinical) into account. It may be easy to diagnose cases of MPLC that exhibit different histological types, but it is difficult to diagnose cases that exhibit similar histological type. DNA polity, gene mutations, microsatellite alteration and so on provide new methods for the accurate diagnosis of MPLC. They can evaluate the clonal relationship and help differential diagnosis between MPLC and metastasis. The first therapeutic choice for MPLC is curative operation. The surgical approach includes lobectomy, wedge resection and segmentectomy. For those which cannot be resected, we can synthesize chemotherapy, radiotherapy, stereotactic ablative radiotherapy (SABR), radiofrequency ablation (RFA), molecular targeted therapy, etc.
Synthesis of novel organophosphorus C60 dimers
Juanjuan Yin,Qingnuan Li,Wenxin Li,
YIN
,duanjuan,LI,Qingnuan,LI,Wenxin

科学通报(英文版) , 2006,
Abstract: Carbon bridged organophosphorus C60 dimers were obtained by the reaction of aminome- thylenebisphosphonate anion with C60 and fully characterized by 1HNMR, 31PNMR, 13CNMR, FT- MALDI-MS, FT-IR, UV-Vis, DEPT and HMBC, and the dimeric compounds undergo hydrolysis by using TMSI.
Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis
Jie Li, Oluwole Fadare, Li Xiang, Beihua Kong, Wenxin Zheng
Journal of Hematology & Oncology , 2012, DOI: 10.1186/1756-8722-5-8
Abstract: Worldwide, approximately 225,500 women are diagnosed with ovarian cancer annually, with an estimated 140,200 associated deaths [1]. Although ovarian cancer accounts for only 3% of all cancers in women, it has one of the highest death-to-incidence ratios, which has been primarily attributed to the unavailability of effective screening tools, the absence of early phase symptomatology in many patients, and accordingly, its typical presentation at advanced stages when prognosis is poor [2,3].As has become apparent in recent years, one of the greatest obstacles to the detection of early-stage ovarian cancer was our poor understanding of its histogenesis and pathogenesis. Ovarian carcinoma was traditionally thought to originate from the ovarian surface epithelium (OSE) or ovarian epithelial inclusions (OEI), and investigative efforts at early detection have accordingly been centered on the ovary for decades. However, these efforts have not been successful, as evidenced by the fact the overall survival for women with ovarian cancer has not changed in any fundamental manner over the last 50 years [4]. Several emerging lines of evidence indicate that some traditional tenets of ovarian epithelial carcinogenesis and cellular origination are fundamentally flawed.Patients with high-grade serous carcinoma (which constitute 60-80% of ovarian epithelial carcinomas [OEC], and which represent the archetypical "ovarian cancer") most frequently present at advanced clinical stage and have a very poor overall survival [5,6]. Therefore, understanding of the nature and development of this type is extremely important for improving the survival rate of ovarian cancer patients as a group. Recently, studies of both asymptomatic women with germline BRCA1 or BRCA2 mutations as well as those from the general population with pelvic serous carcinoma, have detected precancerous or early cancerous lesions - serous tubal intraepithelial carcinoma (STIC) - in the fallopian tubal fimbria [7-9]. Furtherm
Folate Intake and Methylenetetrahydrofolate Reductase Gene Polymorphisms as Predictive and Prognostic Biomarkers for Ovarian Cancer Risk
Li Zhang,Wenxin Liu,Quan Hao,Lewen Bao,Ke Wang
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13044009
Abstract: Folic acid and methylenetetrahydrofolate reductase (MTHFR) may affect the development of human cancer. However, few studies have evaluated folate intake and MTHFR in susceptibility to and prognosis of patients with ovarian cancer. We conducted a prospective case-control study in 215 ovarian cancer patients and 218 controls (all Chinese) between Jan. 2004 and Jan. 2007. MTHFR C677T genotyping was done by PCR-RFLP. All patients were followed up until Dec. 2010. We found a 2.43-fold increased risk of ovarian cancer among MTHFR 677TT carriers, and a decreased risk of ovarian cancer in individuals with high folate intake (OR = 0.54, 95% CI = 0.32–0.94). Cox regression survival analysis showed that among the ovarian cancer patients, those carrying the 677TT genotype had a higher risk of death (HR = 2.17, 95% CI = 1.20–4.79), while high folate intake was associated with a lower risk of death (HR = 0.43, 95% CI = 0.33–0.88). Moreover, MTHFR 677CC carriers with higher folate intake showed a lower risk of death from ovarian cancer (HR = 0.32, 95% CI = 0.27–0.82). In summary, high folate intake may lessen susceptibility and improve the prognosis of ovarian cancer patients, while the MTHFR 677TT genotype appears to increase ovarian cancer risk and worsen its prognosis in a Chinese population.
Differential molecular information of maurotoxin peptide recognizing IKCa and Kv1.2 channels explored by computational simulation
Hong Yi, Su Qiu, Yingliang Wu, Wenxin Li, Baoshan Wang
BMC Structural Biology , 2011, DOI: 10.1186/1472-6807-11-3
Abstract: A reasonably stable MTX-IKCa complex was obtained by combining various computational methods and by in-depth comparison with the previous model of the MTX-Kv1.2 complex. Similarly, MTX adopted the β-sheet structure as the interacting surface for binding both channels, with Lys23 occluding the pore. In contrast, the other critical residues Lys27, Lys30, and Tyr32 of MTX adopted distinct interactions when associating with the IKCa channel. In addition, the residues Gln229, Ala230, Ala233, and Thr234 on the IKCa channel turret formed polar and non-polar interactions with MTX, whereas the turret of Kv1.2 was almost not involved in recognizing MTX. In all, the pairs of interacting residues on MTX and the IKCa channel of the bound complex indicated that electrostatic and Van der Waal interactions contributed equally to the formation of a stable MTX-IKCa complex, in contrast to the MTX-Kv1.2 binding that is dominantly mediated by electrostatic forces.Despite sharing similar pharmacological profiles toward both IKCa and Kv1.2 channels, MTX adopted totally diverging modes in the two association processes. All the molecular information unveiled here could not only offer a better understanding about the structural differences between the IKCa and Kv1.2 channels, but also provide novel structural clews that will help in the designing of more selective molecular probes to discriminate between these two channels.Scorpion venoms produce a large variety of peptide toxins that target ion channels [1-5]. Especially, the widespread use of scorpion-venom peptides acting on K+-channels as neuroscience tools and excellent ligand models has tremendously increased our knowledge in many fields, including exploration of the 3-dimensional structures and elucidation of the pharmacological characteristics of K+ channels [4,6-8]. In addition, peptide toxins are increasingly recognized as valuable sources of new drugs for channelopathies [9,10]. Although natural toxins often lack sufficient effic
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