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Search Results: 1 - 10 of 37086 matches for " Wenting Yan "
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Effect of organic fertilizers used in sandy soil on the growth of tomatoes  [PDF]
Yongxia Hou, Xiaojun Hu, Wenting Yan, Shuhong Zhang, Libin Niu
Agricultural Sciences (AS) , 2013, DOI: 10.4236/as.2013.45B006

In order to reveal the regulating capacity of organic fertilizers on sandy soil, pots experiments were carried out. The growth of tomatoes planted on sandy soil amended by organic fertilizers was measured. Organic fertilizers can be helpful to improve the plant height, stem diameter, the aerial parts fresh weight, root fresh weight, leaf photosynthetic rates and photosynthesis, and lay a good foundation for the growth of   tomatoes. The effect of organic fertilizer is the most significant. Among all the treatments of adding 2.5%, 5%, 10% organic fertilizers, adding 10% organic fertilizers are the best. It can significantly enhance the growth and photosynthesis of tomatoes, and it is among the best of these three soil treatments for sandy soil.

High Accordance in Prognosis Prediction of Colorectal Cancer across Independent Datasets by Multi-Gene Module Expression Profiles
Wenting Li, Rui Wang, Zhangming Yan, Linfu Bai, Zhirong Sun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033653
Abstract: A considerable portion of patients with colorectal cancer have a high risk of disease recurrence after surgery. These patients can be identified by analyzing the expression profiles of signature genes in tumors. But there is no consensus on which genes should be used and the performance of specific set of signature genes varies greatly with different datasets, impeding their implementation in the routine clinical application. Instead of using individual genes, here we identified functional multi-gene modules with significant expression changes between recurrent and recurrence-free tumors, used them as the signatures for predicting colorectal cancer recurrence in multiple datasets that were collected independently and profiled on different microarray platforms. The multi-gene modules we identified have a significant enrichment of known genes and biological processes relevant to cancer development, including genes from the chemokine pathway. Most strikingly, they recruited a significant enrichment of somatic mutations found in colorectal cancer. These results confirmed the functional relevance of these modules for colorectal cancer development. Further, these functional modules from different datasets overlapped significantly. Finally, we demonstrated that, leveraging above information of these modules, our module based classifier avoided arbitrary fitting the classifier function and screening the signatures using the training data, and achieved more consistency in prognosis prediction across three independent datasets, which holds even using very small training sets of tumors.
Cancer core modules identification through genomic and transcriptomic changes correlation detection at network level
Wenting Li, Rui Wang, Linfu Bai, Zhangming Yan, Zhirong Sun
BMC Systems Biology , 2012, DOI: 10.1186/1752-0509-6-64
Abstract: In this study, we describe a novel network analysis to identify the driver mutation through integrating both cancer genomes and transcriptomes. Our method successfully identified a significant genotype-phenotype change correlation in all six solid tumor types and revealed core modules that contain both significantly enriched somatic mutations and aberrant expression changes specific to tumor development. Moreover, we found that the majority of these core modules contained well known cancer driver mutations, and that their mutated genes tended to occur at hub genes with central regulatory roles. In these mutated genes, the majority were cancer-type specific and exhibited a closer relationship within the same cancer type rather than across cancer types. The remaining mutated genes that exist in multiple cancer types led to two cancer type clusters, one cluster consisted of three neural derived or related cancer types, and the other cluster consisted of two adenoma cancer types.Our approach can successfully identify the candidate drivers from the core modules. Comprehensive network analysis on the core modules potentially provides critical insights into convergent cancer development in different organs.Cancer occurs when cells grow out of control due to genetic mutations [1]. It is not a single disease, but exhibits a wide spectrum of phenotypic variations involving numerous critical genes and pathways, e.g. TGF-β, NK-κB, TNF-α that may play multiple and even opposite roles [2,3]. Accordingly, a wide range of genetic mutations is involved, and the same mutations may exhibit a different impact. Further elucidation of the functional link between the genetic mutations and phenotypic changes in cancer development is of central importance, but remains a challenge [4]. Moreover, these genetic mutations disrupt the DNA repair pathways, resulting in many associated non-functional mutations [5].Thus, this poses a big challenge to the central goal in cancer research to identify
A Tentative Expansion of Variation Theory: A Case Study on “One Belt and One Road”  [PDF]
Shunqing Cao, Wenting Shi
Advances in Journalism and Communication (AJC) , 2016, DOI: 10.4236/ajc.2016.42007
Abstract: Misunderstanding and misinterpretation are common existence when an item of news is put to its global distribution. On the basis of Variation Theory of Comparative Literature (VTCL) proposed by Chinese scholar Cao Shunqing, the present paper makes a case study on various international news reports on “One Road, One Belt” initiated by Chinese government in 2015. The aim of this study is on one hand to reveal how misunderstanding and misinterpretation happen during its circulation, and to test the feasibility of VTCL in the research of Mass Media on the other. The significance of such investigation lies in the construction of a new path to the sought of difference between heterogeneous cultures and further attempt to build up variation theory of communication.
Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population
Zehui Yan, Wenting Tan, Yunjie Dan, Wenli Zhao, Chunqing Deng, Yuming Wang, Guohong Deng
BMC Medical Genetics , 2012, DOI: 10.1186/1471-2350-13-49
Abstract: A total of 1216 unrelated Han Chinese HBV carriers were recruited in this hospital-based case–control study, including 359 HBV surface antigen (HBsAg) carriers affected with ALF and 857 asymptomatic HBsAg carriers. Two ESR1 haplotype tagging polymorphisms, c.30?T?>?C (rs2077647) and c.453-397?T?>?C (rs2234693), were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.We observed a significantly increased susceptibility to HBV-ALF associated with the c.30?C allele (P?=?8.65?×?10-4), c.453-397?C allele (5.37?×?10-4) and [c.30?C; c.453-397?C] haplotype (Dominant model, P =0.0004, odds ratio?=?1.53, 95% CI 1.23?~?1.96) compared with the T alleles and [c.30?T; c.453-397?T] haplotype of c.30?T?>?C and c.453-397?T?>?C polymorphisms, respectively.Our study suggests that [c.30?C; c.453-397?C] hapotype may be a risk factor for genetic susceptibility to HBV-related ALF in the Chinese population. It also emphasizes the importance of ESR1 in the pathophysiology of HBV-related ALF on the population level.
Study on the Value Assessment and Dynamic Change of the Dust Detainment of Hangzhou Scenic Forestland
Wenting Wu
Research Journal of Applied Sciences, Engineering and Technology , 2013,
Abstract: With the rapid development of urbanization and the acceleration of the process of industrialization, environmental pollution is becoming more and more serious. Smoke, dust and dirt are major air pollutants. Urban scenic forestland has the ability to filter and absorb the smoke, dust, dirt and other air pollutants effectively. Dust detainment is an important service function of the ecology system in urban green space. This study makes dynamic evaluation and comparison on the dust detainment of Hangzhou urban forestland in different periods, which shows the value of the dust detainment in Hangzhou urban forestland during the period of the Ninth Five-year Plan, Tenth Five-year Plan and Eleventh Five-year Plan are 8.742 million yuan/a, 9.975 million yuan/a and 9.924 million yuan/a, respectively. The result shows an up trend from the Ninth Five-year Plan period to the Tenth Five-year Plan period, but a down trend from the Tenth Five-year Plan period to the Eleventh Five-year Plan period. Furthermore, in the list of the total value of the annual dust detainment for different community types, the top 3 are broad-leaved evergreen forest, evergreen deciduous broad-leaved mixed forest and deciduous broad-leaved forest, the last one is bamboo and broad-leaved mixed forest. And this result has a close relationship with the green space area and dust detainment ability of different community types.
Leading of Public Facilities from Non-Barrier Design to Universal Design
Wenting Dai
Asian Social Science , 2009, DOI: 10.5539/ass.v5n3p174
Abstract: The universal design is the best way for today’s design of public facilities. It develops from the non-barrier design and turns to be perfect. Starting from concluding the differences of non-barrier design and universal design in practice, this paper analyzes and describes the process of from non-barrier design to universal design, aiming at form a complete, systematic, and correct recognition toward the universal design.
Interlanguage Theory and Emergentism: Reconciliation in Second Language Developmental Index Studies
Wenting Wang
English Language Teaching , 2009, DOI: 10.5539/elt.v2n1p31
Abstract: The present paper generally reviews the history of second language (L2) researchers’ efforts in an attempt to find such an index and the possible reasons for the difficulties in establishing the developmental index from both the theoretical and the empirical viewpoints. Two contradictory views—interlanguage theory and emergentism—can finally reconciled so as to have a comprehensive view of second language acquisition (SLA) process.
Electrochemical investigation on the film of L-cysteine self-assembled to nanoparticles on a gold electrode  [PDF]
Wenting Wang, Chunming Wang, Xiaoquan Lu
Journal of Biophysical Chemistry (JBPC) , 2012, DOI: 10.4236/jbpc.2012.31005
Abstract: The film contained L-cysteine and gold nanoparticles were provided by self-assembled monolayers (SAMs) and potentiostatic electrodeposition technology on the gold electrode. Two methods were used to study the film: In the first, cyclic voltammetry (CV) was used to inspect the functional groups of the film and the same time hydroquinone was chosen to be a probe molecule in the based solution; secondly, based on analytical technology of scanning electrochemical microscopy (SECM), the heterogeneous rate constant (keff) between solid phase (the modified electrode) and liquid phase (K3Fe(CN)6) was obtained. As a result, the better binary catalysis of hydroquinone was demonstrated and the heterogeneous rate constant (keff) is the greater at 8 h for L-cysteine self-assembled monolayers (SAMs).
Decreased Store Operated Ca2+ Entry in Dendritic Cells Isolated from Mice Expressing PKB/SGK-Resistant GSK3
Evi Schmid, Jing Yan, Meerim K. Nurbaeva, Antonella Russo, Wenting Yang, Caterina Faggio, Ekaterina Shumilina, Florian Lang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088637
Abstract: Dendritic cells (DCs), key players of immunity, are regulated by glycogen synthase kinase GSK3. GSK3 activity is suppressed by PKB/Akt and SGK isoforms, which are in turn stimulated by the PI3K pathway. Exposure to bacterial lipopolysaccharides increases cytosolic Ca2+-concentration ([Ca2+]i), an effect augmented in DCs isolated from mutant mice expressing PKB/SGK-resistant GSK3α,β (gsk3KI). Factors affecting [Ca2+]i include Ca2+-release from intracellular stores (CRIS), store-operated Ca2+-entry (SOCE) through STIM1/STIM2-regulated Orai1, K+-dependent Na+/Ca2+-exchangers (NCKX), K+-independent Na+/Ca2+-exchangers (NCX) and calbindin-D28k. The present study explored whether PKB/SGK-dependent GSK3α, β-activity impacts on CRIS, SOCE, NCKX, NCX or calbindin. DCs were isolated from gsk3KI mice and respective wild-type mice (gsk3WT), [Ca2+]i estimated from Fura2 fluorescence, Orai1, STIM1, STIM2 as well as calbindin-D28k protein abundance determined by Western blotting and mRNA levels quantified by real time PCR. As a result, thapsigargin-induced CRIS and SOCE were significantly blunted by GSK3-inhibitors SB216763 (1–10 μM, 30 min) or GSK-XIII (10 μM, 30 min) but were significantly lower in gsk3WT than in gsk3KIDCs. Orai1, STIM1 and STIM2 protein abundance was significantly lower and calbindin-D28k abundance significantly higher in gsk3KI than in gsk3WTDCs. Activity of NCKX and NCX was significantly higher in gsk3KI than in gsk3WTDCs and was significantly increased by SB216763 (1 μM, 30 min) or GSK-XIII (10 μM, 30 min). Treatment of gsk3WT DCs with SB216763 (1 μM, 4–24 h) or GSK-XIII (10 μM, 4–24 h) did not significantly modify the protein abundance of Orai1, STIM1 and STIM2. The present observations point to a dual role of GSK3 in the regulation of Ca2+ in DCs. Acute inhibition of GSK3 blunted the increase of [Ca2+]i following CRIS and SOCE and stimulated NCKX/NCX activity. However, expression of PKB/SGK-resistant GSK3α, β downregulated the increase of [Ca2+]i following CRIS and SOCE, an effect at least partially due to downregulation of Orai1, STIM1 and STIM2 expression as well as upregulation of Na+/Ca2+-exchanger activity and calbindin D28k expression.
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