Significance of Golgi Protein 73, Alpha-Fetoprotein and Vascular Endothelial Growth Factor Expression in Diagnosis of Primary Hepatic Cancer
Journal of Cancer Therapy (JCT)
0.092 ± 0.016, respectively; all p < 0.05) and normal liver tissue (0.124 ± 0.027 vs. 0.088 ± 0.029, 0.098 ± 0.014 vs. 0.073 ± 0.011, and 0.092 ± 0.016 vs. 0.076 ± 0.018, respectively; all p < 0.05), respectively. GP73
expression was positively correlated with pathological grade and cirrhosis, but
not with tumor size, nodules, clinical stage and serum AFP. VEGF expression was
positively correlated with tumor size, nodules, portal vein tumor thrombus, and
clinical stage, but not with the degree of tumor differentiation and serum AFP.
Expression of GP73 and VEGF was greater than that of AFP in PHC (both p < 0.05). Conclusion: GP73 is highly
expressed in PHC and may be a diagnostic marker. Combined detection of GP73,
AFP, and VEGF is helpful for diagnosis of PHC.