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Search Results: 1 - 10 of 28718 matches for " Wenjie Sun "
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Tuberculosis in China  [PDF]
Tian Hu, Wenjie Sun
Journal of Tuberculosis Research (JTR) , 2013, DOI: 10.4236/jtr.2013.12002
Abstract: Tuberculosis in China
Blood Pressure and Depressive Symptoms  [PDF]
Yongpin Mu, Yongqing Gao, Wenjie Sun
Open Journal of Depression (OJD) , 2013, DOI: 10.4236/ojd.2013.24009
Abstract: The topic of blood pressure and depression is an old question. Depression is common in the elderly population (Sun, School- ing, Chan, Ho, & Lam, 2011). Although several epidemiologic studies have assessed the relationship between low blood pres- sure and depressive symptoms in geriatric populations, the results have been inconsistent. Depressive symptoms used to be been considered a risk factor associated with development of hypertension (Hildrum, Romild, & Holmen, 2011).
Proposing the lymphatic target volume for elective radiation therapy for pancreatic cancer: a pooled analysis of clinical evidence
Wenjie Sun, Cheng N Leong, Zhen Zhang, Jiade J Lu
Radiation Oncology , 2010, DOI: 10.1186/1748-717x-5-28
Abstract: Literature search using electronic databases including MEDLINE, EMBASE, and CANCERLIT from January 1970 to June 2009 was performed, supplemented by review of references. Eighteen original researches and a total of 5954 pancreatic cancer patients underwent radical surgical resection were included in this analysis. The probability of metastasis in regional lymph nodal stations (using Japan Pancreas Society [JPS] Classification) was calculated and analyzed based on the location and other characteristics of the primary disease.Commonly involved nodal regions in patients with pancreatic head tumor include lymph nodes around the common hepatic artery (Group 8, 9.79%), posterior pancreaticoduodenal lymph nodes (Group 13, 32.31%), lymph nodes around the superior mesenteric artery (Group 14, 15.85%), paraaortic lymph nodes (Group 16, 10.92%), and anterior pancreaticoduodenal lymph nodes (Group 17, 19.78%); The probability of metastasis in other lymph nodal regions were <9%.Commonly involved nodal regions in patients with pancreatic body/tail tumor include lymph nodes around the common hepatic artery (Group 8, 15.07%), lymph nodes around the celiac trunk (Group 9, 9.59%), lymph nodes along the splenic artery (Group 11, 35.62%), lymph nodes around the superior mesenteric artery (Group 14, 9.59%), paraaortic lymph nodes (Group 16, 16.44%), and inferior body lymph nodes (Group 18, 24.66%). The probability of metastasis in other lymph nodal regions were <9%.Pancreatic cancer has a high propensity of regional lymphatic metastases; however, clear patterns including the site and probability of metastasis can be identified and used as a guide of treatment in patients with resectable pancreatic cancer. Further clinical investigation is needed to study the efficacy of elective treatment to CTV defined based on these patterns using high-dose conformal or intensity-modulated radiation therapy.Pancreatic cancer is a highly malignant neoplasm of GI system, and radical surgery is its only c
Heat shock protein 90 in neurodegenerative diseases
Wenjie Luo, Weilin Sun, Tony Taldone, Anna Rodina, Gabriela Chiosis
Molecular Neurodegeneration , 2010, DOI: 10.1186/1750-1326-5-24
Abstract: Hsp90 is a molecular chaperone with important roles in maintaining the functional stability and viability of cells under a transforming pressure [1-3]. For neurodegenerative disorders associated with protein aggregation, the rationale has been that inhibition of Hsp90 activates heat shock factor-1 (HSF-1) to induce production of Hsp70 and Hsp40, as well as of other chaperones, which in turn, promote disaggregation and protein degradation [4-6]. However, recent evidence reveals an additional role for Hsp90 in neurodegeneration. Namely, Hsp90 maintains the functional stability of neuronal proteins of aberrant capacity, thus, allowing and sustaining the accumulation of toxic aggregates [7,8]. Below, we summarize the current understanding on these Hsp90 biological roles and review potential applications of pharmacological Hsp90 inhibition in neurodegenerative diseases.Exposed to conditions of stress, cells normally respond by activation of the heat shock response (HSR) accompanied by increased synthesis of a number of cytoprotective heat shock proteins (Hsps) which dampen cytotoxicity, such as caused by misfolded and denatured proteins [4-6]. The most prominent part of this transition occurs on the transcriptional level. In mammals, protein-damaging stress is regulated by activation of HSF-1, which binds to upstream regulatory sequences in the promoters of heat shock genes [9]. The activation of HSF-1 proceeds through a multi-step pathway, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications (Fig. (1A)). The function of HSF-1 is regulated by Hsp90 [10]. Namely, under non-stressed conditions, Hsp90 binds to HSF-1 and maintains the transcription factor in a monomeric state. Stress, heat shock or inhibition of Hsp90 release HSF-1 from the Hsp90 complex, which results in its trimerization (Fig. (1B)), activation and translocation to the nucleus where it initiates a heat shock response, manifested in the production of H
Endothelin-1 induces intracellular [Ca2+] increase via Ca2+ influx through the L-type Ca2+ channel, Ca2+-induced Ca2+ release and a pathway involving ETA receptors, PKC, PKA and AT1 receptors in cardiomyocytes
QingHua Zeng,XingTing Li,GuoGan Zhong,WenJie Zhang,ChengWen Sun
Science China Life Sciences , 2009, DOI: 10.1007/s11427-009-0046-z
Abstract: Using fura-2-acetoxymethyl ester (AM) fluorescence imaging and patch clamp techniques, we found that endothelin-1 (ET-1) significantly elevated the intracellular calcium level ([Ca2+]i) in a dose-dependent manner and activated the L-type Ca2+ channel in cardiomyocytes isolated from rats. The effect of ET-1 on [Ca2+]i elevation was abolished in the presence of the ETA receptor blocker BQ123, but was not affected by the ETB receptor blocker BQ788. ET-1-induced an increase in [Ca2+]i, which was inhibited 46.7% by pretreatment with a high concentration of ryanodine (10 μmol/L), a blocker of the ryanodine receptor. The ET-1-induced [Ca2+]i increase was also inhibited by the inhibitors of protein kinase A (PKA), protein kinase C (PKC) and angiotensin type 1 receptor (AT1 receptor). We found that ET-1 induced an enhancement of the amplitude of the whole cell L-type Ca2+ channel current and an increase of open-state probability (NPo) of an L-type single Ca2+ channel. BQ123 completely blocked the ET-1-induced increase in calcium channel open-state probability. In this study we demonstrated that ET-1 regulates calcium overload through a series of mechanisms that include L-type Ca2+ channel activation and Ca2+-induced Ca2+ release (CICR). ETA receptors, PKC, PKA and AT1 receptors may also contribute to this pathway.
Improved HPLC Method for the Determination of Moxifloxacin in Application to a Pharmacokinetics Study in Patients with Infectious Diseases
Nan Wang,Liqin Zhu,Xuequn Zhao,Wenjie Yang,He Sun
ISRN Pharmacology , 2013, DOI: 10.1155/2013/462918
Abstract: Objective. To develop a simple and rapid high-performance liquid chromatography (HPLC) method for measuring moxifloxacin concentration in human plasma. Methods. Following a single step liquid-liquid extraction, analytes along with an internal standard (IS) were separated using an isocratic mobile phase of 0.1% triethylamine (adjusted pH to 4.8 with phosphoric acid)/acetonitrile (80/20, v/v) at flow rate of 1?mL/min on reverse phase Kromasil C18 column (250?mm?×?4.6?mm, 5?μm) at room temperature. Results. Total analytical run time for selecting moxifloxacin was 15?min. The assays exhibited good linearity ( ) over the studied range of 25 to 5000?ng/mL. The absolute recovery rate of low, medium, and high concentrations were 69.88%, 78.86%, and 78.51%, respectively. The relative recovery rates were 98.50%, 96.61%, and 101.79%, respectively. Coefficient of variation and error at both of the intraday and interday assessments were less than 4.7%. Conclusions. The results indicated that this method is a simple, rapid, precise and accurate assay for the determination of moxifloxacin concentrations in human plasma. This validated method is sensitive and reproducible enough to be used in pharmacokinetic studies. 1. Introduction Moxifloxacin is a fourth-generation fluoroquinolone antibiotic that exerts its effects by trapping a DNA drug enzyme complex and specifically inhibiting ATP-dependent enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. Currently, moxifloxacin is being extensively used in the treatment of respiratory system diseases such as community-acquired pneumonia (CAP), chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) for the broad spectrum of antimicrobial activity against respiratory tract pathogens, including Gram-positive and Gram negative organisms, anaerobic bacteria, and atypical respiratory tract pathogens [1–4]. The favorable pharmacokinetics of moxifloxacin, including a high mean apparent volume of distribution and a long terminal half life, supports a once-daily dosing regimen in the treatment of infectious disease [5]. It is revealed that moxifloxacin is primarily eliminated in the liver [6]. In recent years, a variety of methods on high-performance liquid chromatography (HPLC) for measuring moxifloxacin concentration in plasma have been reported. Fluorescence detector was applied in several methods for its advantage of sensitivity [7–12]. However, some complex techniques such as gradient elution and on-column focusing [7], precolumn derivatisation [8], or special column [9], were employed. In addition, these
Dispersive shock waves with nonlocal nonlinearity
Christopher Barsi,Wenjie Wan,Can Sun,Jason W. Fleischer
Physics , 2007, DOI: 10.1364/OL.32.002930
Abstract: We consider dispersive optical shock waves in nonlocal nonlinear media. Experiments are performed using spatial beams in a thermal liquid cell, and results agree with a hydrodynamic theory of propagation.
Controlling Surface-plasmon-polariton Launching with Hot Spot Cylindrical Waves in a Metallic Slit Structure
Wenjie Yao,Chengwei Sun,Jianjun Chen,Qihuang Gong
Physics , 2015,
Abstract: Plasmonic nanostructures, which are used to generate surface plasmon polaritions (SPPs), always involve sharp corners where the charges can accumulate. This can result in strong localized electromagnetic fields at the metallic corners, forming hot spots. The influence of the hot spots on the propagating SPPs are investigated theoretically and experimentally in a metallic slit structure. It is found that the electromagnetic fields radiated from the hot spots, termed as the hot spot cylindrical wave (HSCW), can greatly manipulate the SPP launching in the slit structure. The physical mechanism behind the manipulation of the SPP launching with the HSCW is explicated by a semi-analytic model. By using the HSCW, unidirectional SPP launching is experimentally realized in an ultra-small metallic step-slit structure. The HSCW bridges the localized surface plasmons and the propagating surface plasmons in an integrated platform and thus may pave a new route to the design of plasmonic devices and circuits.
Component-Enhanced Chinese Character Embeddings
Yanran Li,Wenjie Li,Fei Sun,Sujian Li
Computer Science , 2015,
Abstract: Distributed word representations are very useful for capturing semantic information and have been successfully applied in a variety of NLP tasks, especially on English. In this work, we innovatively develop two component-enhanced Chinese character embedding models and their bigram extensions. Distinguished from English word embeddings, our models explore the compositions of Chinese characters, which often serve as semantic indictors inherently. The evaluations on both word similarity and text classification demonstrate the effectiveness of our models.
结直肠癌患者外周血循环肿瘤细胞的检测及临床研究进展
Research progress on circulating tumor cells and their detection in colorectal cancer

孙文洁,章 真
SUN Wenjie
, ZHANG Zhen

- , 2015, DOI: 10.3969/j.issn.1007-3969.2015.11.003
Abstract: 结直肠癌是最常见的恶性肿瘤之一,虽然综合治疗的开展使其疗效有较大改善,但仍有较多患者死于术后的复发和转移。循环肿瘤细胞(circulating tumor cell,CTC)来源于肿瘤组织,与肿瘤转移及预后密切相关。对CTC检测方法及其在结直肠癌中的临床研究进行综述。
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