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Search Results: 1 - 10 of 62819 matches for " Wen-Hsing Lin "
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SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes
Yi-Der Jiang, Yi-Cheng Chang, Yen-Feng Chiu, Tien-Jyun Chang, Hung-Yuan Li, Wen-Hsing Lin, Hsiang-Yu Yuan, Yuan-Tsong Chen, Lee-Ming Chuang
BMC Medical Genetics , 2010, DOI: 10.1186/1471-2350-11-126
Abstract: We genotyped 10 single nucleotide polymorphisms and one microsatellite spanning 34 kb across the SLC2A10 gene in a prospective cohort of 372 diabetic patients. Their association with the development of peripheral arterial disease (PAD) in type 2 diabetic patients was analyzed.At baseline, several common SNPs of SLC2A10 gene were associated with PAD in type 2 diabetic patients. A common haplotype was associated with higher risk of PAD in type 2 diabetic patients (haplotype frequency: 6.3%, P = 0.03; odds ratio [OR]: 14.5; 95% confidence interval [CI]: 1.3- 160.7) at baseline. Over an average follow-up period of 5.7 years, carriers with the risk-conferring haplotype were more likely to develop PAD (P = 0.007; hazard ratio: 6.78; 95% CI: 1.66- 27.6) than were non-carriers. These associations remained significant after adjustment for other risk factors of PAD.Our data demonstrate that genetic polymorphism of the SLC2A10 gene is an independent risk factor for PAD in type 2 diabetes.Peripheral arterial disease (PAD), defined as lower extremity arterial atherosclerosis, is one of most common diseases of the arteries and is a major complication of type 2 diabetes [1]. Conventional cardiovascular risk factors such as aging, smoking, hyperglycemia, hypertension and dyslipidemia have been shown to be associated with PAD [1]. However, the increased risk for atherosclerotic diseases in diabetic patients can be only partially explained by the conventional risk factors [2]. In fact, a high heritability for ankle-brachial blood pressure index (ABI), an index of PAD, has been obtained in Twin studies in Caucasians [3], indicating that additional genetic factors might be involved in the pathogenesis of PAD. In this respect, the search for genetic causes of PAD remains limited [4].Recently, a genetic form of arterial tortuosity syndrome (ATS; OMIM 208050) was reported to be caused by loss-of-function mutations in the SLC2A10 gene encoding the facilitative glucose transporter GLUT10. A
Creating the Environment for the Prosperity of Cloud Computing Technology
Fa-Chang Cheng,Wen-Hsing Lai
TELKOMNIKA : Indonesian Journal of Electrical Engineering , 2012, DOI: 10.11591/telkomnika.v10i4.878
Abstract: The key point for the success of clouding computing technology in terms of application is whether such operation can produce the sense of trustworthiness to its users. Technical measurement has always been the fundamental preventive precaution, no matter what kind of aspect in dealing with producing the sense of trustworthiness. Except technical measurement, there are two developing issues surrounding the central idea worth notice, which are the protection of information privacy and the jurisdictional issue. The main purpose of this article is to focus on the issue of protecting information privacy and jurisdictional problem through the newly developed cloud computing technology. This article will first introduce the characteristics of cloud computing technology in order to pave the way for further discussion. Then the issue of protecting information privacy and jurisdictional problem will be discussed through disparity of legal protection of information privacy and principles for asserting jurisdiction within Internet. The personal observation and suggestion will be made at the end of this article for a future possible adjustment of infrastructure for the protection of information privacy and jurisdictional decision within cyberspace in order to promote the sense of trustworthiness of the cloud computing technology user.
Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance?
Caroline R. B. Rocourt,Wen-Hsing Cheng
Nutrients , 2013, DOI: 10.3390/nu5041349
Abstract: Selenium was considered a toxin until 1957, when this mineral was shown to be essential in the prevention of necrotic liver damage in rats. The hypothesis of selenium chemoprevention is principally formulated by the observations that cancer incidence is inversely associated with selenium status. However, recent clinical and epidemiological studies demonstrate a role for some selenoproteins in exacerbating or promoting other disease states, specifically type 2 diabetes, although other data support a role of selenium in stimulating insulin sensitivity. Therefore, it is clear that our understanding in the role of selenium in glucose metabolism and chemoprevention is inadequate and incomplete. Research exploring the role of selenium in individual healthcare is of upmost importance and possibly will help explain how selenium is a double-edged sword in the pathologies of chronic diseases.
Using Data Mining in MURA Graphic Problems
Wen-Hsing Kao,Jason C. Hung,Victoria Hsu
Journal of Software , 2008, DOI: 10.4304/jsw.3.8.73-79
Abstract: The MURA phenomenon will result lots of problems in Photomask and TFT-LCD industries as well. In this paper, we designed and developed a MURA related association rules which suitable for the MURA model requirements, and we named MURA Risk rating system. Our purpose is to figure out the effective application of data mining algorithms in monitoring and control of complex Large Area Photomask systems. By combining the Data Mining into MURA risk management. It could be suitable not only for every Photomask company but also companies facing to the MURA problems. And through our scheme and MURA risk rating system, we can shorten the time and reduce the MURA problems. It could also help them to cut down their manufacturing cost as well as promote the quality of their products.
BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells
Chun Hei Antonio Cheung, Wen-Hsing Lin, John Tsu-An Hsu, Tzyh-Chyuan Hour, Teng-Kuang Yeh, Shengkai Ko, Tzu-Wen Lien, Mohane Selvaraj Coumar, Jin-Fen Liu, Wen-Yang Lai, Hui-Yi Shiao, Tian-Ren Lee, Hsing-Pang Hsieh, Jang-Yang Chang
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023485
Abstract: Background Over-expression of Aurora kinases promotes the tumorigenesis of cells. The aim of this study was to determine the preclinical profile of a novel pan-Aurora kinase inhibitor, BPR1K653, as a candidate for anti-cancer therapy. Since expression of the drug efflux pump, MDR1, reduces the effectiveness of various chemotherapeutic compounds in human cancers, this study also aimed to determine whether the potency of BPR1K653 could be affected by the expression of MDR1 in cancer cells. Principal Findings BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. Anti-proliferative activity of BPR1K653 was evaluated in various human cancer cell lines. Results of the clonogenic assay showed that BPR1K653 was potent in targeting a variety of cancer cell lines regardless of the tissue origin, p53 status, or expression of MDR1. At the cellular level, BPR1K653 induced endo-replication and subsequent apoptosis in both MDR1-negative and MDR1-positive cancer cells. Importantly, it showed potent activity against the growth of xenograft tumors of the human cervical carcinoma KB and KB-derived MDR1-positive KB-VIN10 cells in nude mice. Finally, BPR1K653 also exhibited favorable pharmacokinetic properties in rats. Conclusions and Significance BPR1K653 is a novel potent anti-cancer compound, and its potency is not affected by the expression of the multiple drug resistant protein, MDR1, in cancer cells. Therefore, BPR1K653 is a promising anti-cancer compound that has potential for the management of various malignancies, particularly for patients with MDR1-related drug resistance after prolonged chemotherapeutic treatments.
Evaluation of the Antitumor Effects of BPR1J-340, a Potent and Selective FLT3 Inhibitor, Alone or in Combination with an HDAC Inhibitor, Vorinostat, in AML Cancer
Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang, Kuei-Jung Yen, Chun-Hwa Chen, Chin-Ting Huang, Shih-Chieh Yen, Shu-Yi Hsieh, Ling-Hui Chou, Ching-Ping Chen, Chun-Hsien Chiu, Li-Chun Kao, Yu-Sheng Chao, Chiung-Tong Chen, John T.-A. Hsu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0083160
Abstract: Overexpression or/and activating mutation of FLT3 kinase play a major driving role in the pathogenesis of acute myeloid leukemia (AML). Hence, pharmacologic inhibitors of FLT3 are of therapeutic potential for AML treatment. In this study, BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD+ AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibition and regression in FLT3-ITD+ AML murine xenograft models. The combination treatment of the HDAC inhibitor vorinostat (SAHA) with BPR1J-340 synergistically induced apoptosis via Mcl-1 down-regulation in MOLM-13 AML cells, indicating that the combination of selective FLT3 kinase inhibitors and HDAC inhibitors could exhibit clinical benefit in AML therapy. Our results suggest that BPR1J-340 may be further developed in the preclinical and clinical studies as therapeutics in AML treatments.
Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair
Meltem Muftuoglu, Rika Kusumoto, Elzbieta Speina, Gad Beck, Wen-Hsing Cheng, Vilhelm A. Bohr
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001918
Abstract: Background The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription. Methodology/Principal Findings Here, we have investigated the p300 acetylation mediated changes on the function of WRN in base excision DNA repair (BER). We show that acetylation of WRN increases in cells treated with methyl methanesulfonate (MMS), suggesting that acetylation of WRN may play a role in response to DNA damage. This hypothesis is consistent with our findings that acetylation of WRN stimulates its catalytic activities in vitro and in vivo, and that acetylated WRN enhances pol β-mediated strand displacement DNA synthesis more than unacetylated WRN. Furthermore, we show that cellular exposure to the histone deacetylase inhibitor sodium butyrate stimulates long patch BER in wild type cells but not in WRN depleted cells, suggesting that acetylated WRN participates significantly in this process. Conclusion/Significance Collectively, these results provide the first evidence for a specific role of p300 mediated WRN acetylation in regulating its function during BER.
A communication system model for digital image watermarking problems
Pei-Chun Chen,Yung-Sheng Chen,Wen-Hsing Hsu
IAENG International Journal of Computer Science , 2007,
A Film Classifier Based on Low-level Visual Features
Hui-Yu Huang,Weir-Sheng Shih,Wen-Hsing Hsu
Journal of Multimedia , 2008, DOI: 10.4304/jmm.3.3.26-33
Abstract: We propose an approach to classify the film classes by using low level features and visual features. This approach aims to classify the films into genres. Our current domain of study is using the movie preview. A movie preview often emphasizes the theme of a film and hence provides suitable information for classifying process. In our approach, we categorize films into three broad categories: action, dramas, and thriller films. Four computable video features (average shot length, color variance, motion content and lighting key) and visual features (show and fast moving effects) are combined in our approach to provide the advantage information to demonstrate the movie category. The experimental results present that visual features are the useful messages for processing the film classification. On the other hand, our approach can also be extended for other potential applications, including the browsing and retrieval of videos on the internet, video-on-demand, and video libraries.
Methylseleninic Acid Sensitizes Notch3-Activated OVCA429 Ovarian Cancer Cells to Carboplatin
Tiffany J. Tzeng, Lei Cao, YangXin Fu, Huawei Zeng, Wen-Hsing Cheng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101664
Abstract: Ovarian cancer, the deadliest of gynecologic cancers, is usually not diagnosed until advanced stages. Although carboplatin has been popular for treating ovarian cancer for decades, patients eventually develop resistance to this platinum-containing drug. Expression of neurogenic locus notch homolog 3 (Notch3) is associated with chemoresistance and poor overall survival in ovarian cancer patients. Overexpression of NICD3 (the constitutively active form of Notch3) in OVCA429 ovarian cancer cells (OVCA429/NICD3) renders them resistance to carboplatin treatment compared to OVCA429/pCEG cells expressing an empty vector. We have previously shown that methylseleninic acid (MSeA) induces oxidative stress and activates ataxia-telangiectasia mutated and DNA-dependent protein kinase in cancer cells. Here we tested the hypothesis that MSeA and carboplatin exerted a synthetic lethal effect on OVCA429/NICD3 cells. Co-treatment with MSeA synergistically sensitized OVCA429/NICD3 but not OVCA429/pCEG cells to the killing by carboplatin. This synergism was associated with a cell cycle exit at the G2/M phase and the induction of NICD3 target gene HES1. Treatment of N-acetyl cysteine or inhibitors of the above two kinases did not directly impact on the synergism in OVCA429/NICD3 cells. Taken together, these results suggest that the efficacy of carboplatin in the treatment of high grade ovarian carcinoma can be enhanced by a combinational therapy with MSeA.
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