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Search Results: 1 - 10 of 28021 matches for " Wen LP "
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Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability
Zha YY, Yang B, Tang ML, Guo QC, Chen JT, Wen LP, Wang M
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S30934
Abstract: ncentration-dependent effects of fullerenol on cultured hippocampal neuron viability Original Research (2460) Total Article Views Authors: Zha YY, Yang B, Tang ML, Guo QC, Chen JT, Wen LP, Wang M Published Date June 2012 Volume 2012:7 Pages 3099 - 3109 DOI: http://dx.doi.org/10.2147/IJN.S30934 Received: 16 February 2012 Accepted: 17 April 2012 Published: 29 June 2012 Ying-ying Zha,1 Bo Yang,1 Ming-liang Tang,2 Qiu-chen Guo,1 Ju-tao Chen,1 Long-ping Wen,3 Ming Wang1 1CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 2Suzhou Institute of NanoTech and NanoBionics, Chinese Academy of Sciences, Suzhou, 3Laboratory of Nano-biology, School of Life Sciences, University of Science and Technology of China, Hefei, People's Republic of China Background: Recent studies have shown that the biological actions and toxicity of the water-soluble compound, polyhydroxyfullerene (fullerenol), are related to the concentrations present at a particular site of action. This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons. Methods and results: Fullerenol at low concentrations significantly enhanced hippocampal neuron viability as tested by MTT assay and Hoechst 33342/propidium iodide double stain detection. At high concentrations, fullerenol induced apoptosis confirmed by Comet assay and assessment of caspase proteins. Conclusion: These findings suggest that fullerenol promotes cell death and protects against cell damage, depending on the concentration present. The concentration-dependent effects of fullerenol were mainly due to its influence on the reduction-oxidation pathway.
Psalm 51: Take not your Holy Spirit away from me
LP Maré
Acta Theologica , 2008,
Abstract: Even a cursory reading of the New Testament makes one aware of numerous references to the Holy Spirit. The New Testament is thus normally the focus for studies on pneumatology. However, there are many references to jwr in the Old Testament of which 107 refer to God’s activities in nature and in the lives of human beings. In these passages jwr is translated as “spirit”, indicating the work of the Spirit of God. Pentecostals believe that the presence of the Spirit of God in the lives of believers during the Old Testament period was sporadic and temporary. It was only after the outpouring of God’s Spirit on the Day of Pentecost that the Spirit came to dwell permanently within believers. This article challenges that assumption by analysing Psalm 51. Such analysis reveals that the Spirit of God lived permanently in the life of an Old Testament believer, and ascertains the role of the Spirit of God in the life of the worshipper.
L-Glutamine Metabolism Is Not A Major Source Of Increased Free Radical Generation In Goldblatt Renovascular Hypertension
LP Odigie
Nigerian Journal of Physiological Sciences , 2003,
Abstract: Glutamine has been implicated in the generation of free radicals and free radicals-induced impairment of vascular responses to nitrovasodilators may underlie the pathogenesis of vasospasm in 2K-1C hypertension. Plasma glutamine levels were therefore determined in 2K-1C and 1K-1C hypertensive rats in order to ascertain the direction of change of this amino acid in this model of renovascular hypertension. Hypertension was induced in male SD rats (99±2.3 g) by subjecting them to left renal artery clamping using a 0.2mm silver clip (2K-1C, n=7) under ether anesthesia. Control rats (n=7) were sham-operated (Sh-Op). Rats with 1K-1C hypertension (n=8) and uni-nephrectomized controls (1K:, n=8), additionally underwent right nephrectomy. 10 weeks (2K-1C) and 4 weeks (1K-1C) respectively after renal artery clamping, clipped rats exhibited elevated blood pressures (P<0.001), which was sustained under anaesthesia. No significant difference in plasma glutamine levels were found in hypertensive rats compared to controls (11.3±1.3 mg/l in 2K-1C vs. 12.3±2.1 mg/l in Sh-Op, n=7 and 9.0±1.4 mg/l in 1K-1C vs. 9.6±1.4 mg/l in 1K:, n=8). Serum creatinine and. serum electrolyte concentrations were not significantly different in clipped rats compared to their respective controls. This study shows that plasma glutamine level is not altered in the established stages of Goldblatt renovascular hypertension. The significance of this observation is unclear. Nevertheless, these findings suggest that glutamine is not in the main stream of free radicals generation and is therefore not a reliable index of oxidative stress in this model of renovascular hypertension.
DATA ANALYSIS IN QUALITATIVE RESEARCH: A BRIEF GUIDE TO USING NVIVO
WONG LP
Malaysian Family Physician , 2008,
Abstract: Qualitative data is often subjective, rich, and consists of in-depth information normally presented in the form of words. Analysing qualitative data entails reading a large amount of transcripts looking for similarities or differences, and subsequently finding themes and developing categories. Traditionally, researchers `cut and paste’ and use coloured pens to categorise data. Recently, the use of software specifically designed for qualitative data management greatly reduces technical sophistication and eases the laborious task, thus making the process relatively easier. A number of computer software packages has been developed to mechanise this `coding’ process as well as to search and retrieve data. This paper illustrates the ways in which NVivo can be used in the qualitative data analysis process. The basic features and primary tools of NVivo which assist qualitative researchers in managing and analysing their data are described.
QUALITATIVE RESEARCH METHODS IN FAMILY MEDICINE: WHAT AND WHY?
WONG LP
Malaysian Family Physician , 2008,
Abstract:
Accumulated heat unit and phenology of diverse maize varieties as affected by planting dates under Rampur condition, Nepal
LP Amgain
Agronomy Journal of Nepal , 2011, DOI: 10.3126/ajn.v2i0.7526
Abstract: Accumulated heat unit and phenology of a full season open pollinated and three specialty corn (Zea mays L.) cultivars (Hybrid, QPM and Pop) were studied by growing them on three different planting dates (September 1, October 1 and November 1) in RCB design at Rampur Chitwan, Nepal during the winter season of 2009-10. The results indicated that the number of days required to attain different phenological stages were short for the early winter and gradually long for late winter plantings. For all the phenological studies, plants of normal sowing condition (September 1) recorded comparatively higher heat units than the late planting (October 1 and November 1) for all cultivars. Both early and late plantings recorded the higher helio-thermal units at advanced growth phases than at the early stages. The pheno-thermal indices at the earlier growth stages were significantly higher for early planting than the late plantings. The heat use efficiency (HUE) was found to be higher under normal planting as compared to the late plantings. Popular maize variety Rampur Composite was found to be the most suitable to produce stable HUE than the other varieties tested. The specialty corn cultivars could not show stable yield in late planting conditions suggesting their planting could be better for September sowing during early winter seasons. DOI: http://dx.doi.org/10.3126/ajn.v2i0.7526 Agronomy Journal of Nepal (Agron JN) Vol. 2: 2011 pp.111-120
Le gène de nanisme dw et les performances des poules dans une souche de type femelle-chair
FH Ricard, LP Cochez
Genetics Selection Evolution , 1971, DOI: 10.1186/1297-9686-3-3-391
Abstract:
Efficacy of Helicobacter pylori eradication therapies: a single centre observational study
Ian LP Beales
BMC Gastroenterology , 2001, DOI: 10.1186/1471-230x-1-7
Abstract: 469 patients receiving eradication therapy in routine clinical practice were evaluated. The successes of individual regimes as first, second and third line therapy were determined.Overall success after one, two and three courses of therapy were 73% (95% confidence intervals 69–77%), 94% (91–96%) and 98% (97–99%) respectively. 10 different regimens, including many non-recommended ones were used as primary therapy. Ranitidine bismuth citrate-amoxicillin-clarithromycin triple therapy (94.8%, 90–99%) was significantly more effective than any other combination as primary therapy, including all proton pump inhibitor based triple therapies. Quadruple therapy with bismuth chelate-proton pump inhibitor-tetracycline and a nitroimidazole (70%, 52–88%) and ranitidine bismuth citrate-based triple therapy (73%, 56–90%) where more effective second line combinations than proton pump inhibitor-triple therapies (37.5%, 12–58%). Third line therapy directed by the results of sensitivity testing improved eradication compared to further empirical antibiotics. The use of a proton pump inhibitor with clarithromycin and a nitroimidazole as initial therapy was associated with a significantly worse overall eradication rate than other combinations.Helicobacter pylori eradication rates can be maximised by using ranitidine bismuth citrate-clarithromycin-amoxicillin containing triple therapy, followed by bismuth and nitroimidazle containing second-line therapy, with third line combinations directed by sensitivity testing. Proton pump inhibitor-clarithromycin-metronidazole combinations should be avoided.Treatment of gastric H. pylori infection with combinations of antimicrobials is recognised as the treatment of choice for those patients carrying the infection with peptic ulcer disease and gastric MALT-lymphoma [1-3]. Antimicrobial therapy is usually recommended following potentially curative resection of gastric cancer and in the presence of dysplasia [1]. The place of H. pylori eradication thera
Effect of Interlukin-1β on proliferation of gastric epithelial cells in culture
Ian LP Beales
BMC Gastroenterology , 2002, DOI: 10.1186/1471-230x-2-7
Abstract: AGS cells were cultured with IL-1β. DNA synthesis was assed by [3H]thymidine incorporation and total viable cell numbers by MTT assay.IL-1β dose dependently increased DNA synthesis and cell numbers. The enhanced proliferation was blocked by interleukin-1 receptor antagonist. Addition of neutralising antibody to GM-CSF reduced IL-1β-stimulated proliferation by 31 ± 4 %. GM-CSF alone significantly stimulated proliferation. Addition or neutralisation of IL-8 had no effect on basal or IL-1β-stimulated proliferation. The tyrosine kinase inhibitor genistein completely blocked IL-1β-stimulated proliferation and inhibition of the extracellular signal related kinase pathway with PD 98059 inhibited IL-1β stimulated proliferation by 58 ± 5 %.IL-1β stimulates proliferation in gastric epithelial cells. Autocrine stimulation by GM-CSF contributes to this proliferative response. Signalling via tyrosine kinase activity is essential to the mitogenic response to IL-1β. The extracellular signal related kinase pathway is involved in, but not essential to downstream signalling. IL-1β may contribute to the hyperproliferation seen in H. pylori- infected gastric mucosa, and be involved in the carcinogenic process.Helicobacter pylori is believed to be the major aetiological factor in the development of non-cardia gastric adenocarcinoma. Large-scale epidemiological studies have confirmed a strong association between H. pylori infection and both cancer [1-3] and the earlier histological stages, atrophy and intestinal metaplasia [4,5]; both of which increase the risk of later neoplastic transformation. Animal models have also demonstrated the importance of H. pylori in gastric carcinogenesis [6,7]. Increased rates of proliferation of the gastric mucosa are typical in H. pylori infection [8-11], and hyperproliferation within the gastrointestinal tract appears to be a marker for later malignant change [12]. The cause of the increased rate of proliferation is not clear, but the increased rates re
Treino Proprioceptivo na Preven??o e Reabilita??o de Les?es nos Jovens Atletas
Domingues,Márcio LP;
Motricidade , 2008,
Abstract: the risk of injury comes with sport participation. the functional limitation quite often comes from the instability originated from an articular injury. proprioception is, in fact, a sum of reactions that result on a cumulative neural input into the central nervous system (cns) of mechanoreceptors in the articulations, ligaments, muscles, tendons and skin. functional rehabilitation is an extension of normal physical therapy. its purpose is to allow rapid recovery of the athlete to its high sports motor patterns. we will review injuries form various articulations in respect to proprioceptive training. there is a lot of evidence that proprioceptive training diminishes the incidence of some injuries, and that proprioceptive reeducation contributes a lot to the lost of fear and quick return to work, as well as to sport activities.
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