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Search Results: 1 - 10 of 44015 matches for " Weikang Wu "
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Translational Chinese Medicine: A Way for Development of Traditional Chinese Medicine  [PDF]
Xuegang Sun, Donglan Lin, Weikang Wu, Zhiping Lv
Chinese Medicine (CM) , 2011, DOI: 10.4236/cm.2011.24029
Abstract: Translational Chinese medicine is one of the latest developing fields in traditional Chinese medicine. In this paper, we discuss the “3 w” namely, “what is”, “why to advance”, “how to carry out” and the significance of translational Chinese medicine. To overcome the innate drawbacks of traditional Chinese medicine (TCM), the basic theory of TCM had better be refreshed. The safety and efficacy of classic formulae and therapy experience of TCM should be evaluated based on strict quality control and reaffirmed with evidence based medicine. The significance of translational Chinese medicine is to transform Chinese medicine into a balanced, personalized medicine with sound safety, good efficacy and strict quality control.
The Structural Difference of Shanghai Stock Index before and after 2008: A Copula Based Analysis  [PDF]
Chuan Wu, Ke Huang, Xue Tian, Weikang Geng, H. J. Cai
Technology and Investment (TI) , 2012, DOI: 10.4236/ti.2012.34035
Abstract: The year 2008 witnessed the greatest joint stock reform and financial crisis in Chinese history. After these two cases, significant changes have taken place in investors’ behaviors worldwide, along with which is the occurrence of structure change in stock market. In this paper, we employ copula model to simulate the joint distribution between Shanghai Stock Index (SSE) and Chinese Shanghai Index 300 (CSI 300), to find out structure change in Chinese stock market before and after 2008. From results of empirical studies, we get conclusions that the main nature of Chinese stocks market is symmetric, in both marginal and joint distributions. Via the changes of Copula types, upper and lower tail coefficients and Kendall coefficients, we can measure the structure change in Chinese stock market, and get further conclusion about investors’ behaviors change. Before 2008, there is an equal power in quitting market and longing, while diversified investors adjusted their expectation uniformly after this year. Testing results show that the general dependence structure of CSI 300 and SSE is highly dependent and symmetric in most cases. From the distribution of upper and lower tail coefficients, we can draw the conclusion that stratified investors are mainly focused on two tasks, after this year, to close the position on stocks with high correlated stocks market and to maintain market value of stocks.
Polysaccharide from Fuzi (FPS) Prevents Hypercholesterolemia in Rats
Xiongqing Huang, Juan Tang, Qin Zhou, Hanping Lu, Yiling Wu, Weikang Wu
Lipids in Health and Disease , 2010, DOI: 10.1186/1476-511x-9-9
Abstract: Male rats were fed either a normal or high cholesterol (HC) diet for two-weeks. Half of the rats on the HC diet were orally gavaged with FPS (224 mg/kg, 448 mg/kg or 896 mg/kg diet) daily. Serum lipid levels were quantified at end of the study period as were liver levels of LDL-R protein and mRNA expression of CYP7α-1 and HMG-CoA. Serum cholesterol and LDL-C concentrations were significantly elevated from control in HC rats, but not in those treated with FPS (P < 0.05). LDL-R expression was significantly decreased in the HC group compared to control (P < 0.05), but significantly increased in the FPS group (P < 0.05). HMG-CoA mRNA levels were significantly increased in the HC group compared both other groups (P < 0.05), while CYP7α-1 expression was significantly higher in the FPS group compared to both other groups (P < 0.05).These findings suggest that the cholesterol lowering effect of FPS in hypercholesteremic rats is caused at least in part by increased hepatic LDL-R and CYP7α-1 expression and decreased HMG-CoA expression. Further study is needed to determine precisely where and how FPS exerts these effects. FPS offers potential as a therapeutic agent for the treatment of hypercholesterolemia.Hypercholesterolemia is an important risk factor for atherosclerosis and consequent cardiovascular and cerebrovascular disease. Increased circulating levels of low-density lipoprotein (LDL) underlie the development of atherosclerosis [1,2]. Statins have been shown to effectively lower LDL levels and reduce both mortality and morbidity associated with coronary heart disease by 30% [3]. However, as noted Steinberg and colleagues in a recent review [4], this still leaves a significant percentage of individuals for whom statin therapy will not prevent the occurrence of adverse events. There is an obvious need for more efficacious and alternative treatment options.Many Chinese herbal medicines contain polysaccharides which can exert a wide range of pharmacological effects, includ
Distribution of Giant Particles of Sea-Salt Nuclei in Guangzhou During Summer
广州盛夏期海盐核(Cl~-)巨粒子的分布特征

Wu Dui,Guan Yuejian,Mao Weikang and,
吴兑
,关越坚,毛伟康,

大气科学 , 1991,
Abstract: 本文分析了1987年8至9月间在广州观测的Cl~-巨盐核资料。主要结果有:①干直径大于2μm的Cl~-核平均浓度31个/L,平均含盐量0.84μg /m~3,其中于直径大于4μm的特大核平均为3个/L,最大于直径25μm,均远低于南海海域的值。②浓度谱呈典型的单峰型幂函数递减谱,谱型窄而光滑;质量谱也表现为单峰分布。③盐核的日际变化与天气系统有密切关系,台风活动可造成海盐粒子浓度的大量增多,形成所谓“盐核暴”现象。
广州盛夏期海盐核(Cl~-)巨粒子的分布特征
吴兑 Wu Dui,关越坚 Guan Yuejian,毛伟康 Mao Weikang,等 et al
大气科学 , 1991, DOI: 10.3878/j.issn.1006-9895.1991.05.15
Abstract: 本文分析了1987年8至9月间在广州观测的Cl~-巨盐核资料。主要结果有:①干直径大于2μm的Cl~-核平均浓度31个/L,平均含盐量0.84μg/m~3,其中于直径大于4μm的特大核平均为3个/L,最大于直径25μm,均远低于南海海域的值。②浓度谱呈典型的单峰型幂函数递减谱,谱型窄而光滑;质量谱也表现为单峰分布。③盐核的日际变化与天气系统有密切关系,台风活动可造成海盐粒子浓度的大量增多,形成所谓“盐核暴”现象。
Dynamics between Cancer Cell Subpopulations Reveals a Model Coordinating with Both Hierarchical and Stochastic Concepts
Weikang Wang, Yi Quan, Qibin Fu, Yu Liu, Ying Liang, Jingwen Wu, Gen Yang, Chunxiong Luo, Qi Ouyang, Yugang Wang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084654
Abstract: Tumors are often heterogeneous in which tumor cells of different phenotypes have distinct properties. For scientific and clinical interests, it is of fundamental importance to understand their properties and the dynamic variations among different phenotypes, specifically under radio- and/or chemo-therapy. Currently there are two controversial models describing tumor heterogeneity, the cancer stem cell (CSC) model and the stochastic model. To clarify the controversy, we measured probabilities of different division types and transitions of cells via in situ immunofluorescence. Based on the experiment data, we constructed a model that combines the CSC with the stochastic concepts, showing the existence of both distinctive CSC subpopulations and the stochastic transitions from NSCCs to CSCs. The results showed that the dynamic variations between CSCs and non-stem cancer cells (NSCCs) can be simulated with the model. Further studies also showed that the model can be used to describe the dynamics of the two subpopulations after radiation treatment. More importantly, analysis demonstrated that the experimental detectable equilibrium CSC proportion can be achieved only when the stochastic transitions from NSCCs to CSCs occur, indicating that tumor heterogeneity may exist in a model coordinating with both the CSC and the stochastic concepts. The mathematic model based on experimental parameters may contribute to a better understanding of the tumor heterogeneity, and provide references on the dynamics of CSC subpopulation during radiotherapy.
Ceramide Mediates Ox-LDL-Induced Human Vascular Smooth Muscle Cell Calcification via p38 Mitogen-Activated Protein Kinase Signaling
Lizhen Liao, Qin Zhou, Yan Song, Weikang Wu, Huimin Yu, Sheng Wang, Yanling Chen, Meihong Ye, Lihe Lu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082379
Abstract: Vascular calcification is associated with significant cardiovascular morbidity and mortality, and has been demonstrated as an actively regulated process resembling bone formation. Oxidized low density lipoprotein (Ox-LDL) has been identified as a regulatory factor involved in calcification of vascular smooth muscle cells (VSMCs). Additionally, over-expression of recombinant human neutral sphingomyelinase (N-SMase) has been shown to stimulate VSMC apoptosis, which plays an important role in the progression of vascular calcification. The aim of this study is to investigate whether ceramide regulates Ox-LDL-induced calcification of VSMCs via activation of p38 mitogen-activated protein kinase (MAPK) pathway. Ox-LDL increased the activity of N-SMase and the level of ceramide in cultured VSMCs. Calcification and the osteogenic transcription factor, Msx2 mRNA expression were reduced by N-SMase inhibitor, GW4869 in the presence of Ox-LDL. Usage of GW4869 inhibited Ox-LDL-induced apoptosis in VSMCs, an effect which was reversed by C2-ceramide. Additionally, C2-ceramide treatment accelerated VSMC calcification, with a concomitant increase in ALP activity. Furthermore, C2-ceramide treatment enhanced Ox-LDL-induced VSMC calcification. Addition of caspase inhibitor, ZVAD-fmk attenuated Ox-LDL-induced calcification. Both Ox-LDL and C2-ceramide treatment increased the phosphorylation of p38 MAPK. Inhibition of p38 MAPK by SB203580 attenuated Ox-LDL-induced calcification of VSMCs. These data suggest that Ox-LDL activates N-SMase-ceramide signaling pathway, and stimulates phosphorylation of p38 MAPK, leading to apoptosis in VSMCs, which initiates VSMC calcification.
On GID-testable two-dimensional iterative arrays
On GID-Testable Two-Dimensional Iterative Arrays

Weikang Huang,F Lombard,
Huang WeiKang
,F.Lombard

计算机科学技术学报 , 1994,
Abstract: A new approach is presented for easily testable two-dimensional iterative arrays.It is an improvment on GI-testability (Group Identical testability) and is referred to as GID-testability (Group Identical and Different testability). In a GID-testable twodimensional array, the primary x and y outputs are organized into groups and every group has more than one output. This is similar to the GI-testable arrays. However,GID-testability not only ensures that identical test responses can be obtained from every output in the same group when an array is fault free, but also ensures that at least one output has different test responses (from the other outputs in a group) when a cell in the array is faulty Therefore, all faults can be detected under the assumption of a single faulty cell model. It is proved that an arbitrary two-dimensional iterative array is GID-testable if seven x-states and seven y-states are added to the original flow table of the basic cell of the array.GID-testability simplifies the response verification of built-in-self testing in a way similar to PL- and GI-testability6-9]. Therefore, it is suitable for BIST design.
Repairing VLSI/WSI Redundant Memories with Minimum Cost
Huang Weikang,F.Lombardi
计算机科学技术学报 , 1990,
Abstract: A new approach to repair memory chips with redundancy is proposed.This approach s based on the minimization of the repair cost.Algorithms for cost driven repair are presented.The algorithms can be executed either on -line(concurrently with the testing of the memory),or off-lin(at completion of testing).Analytical expressions for the repair cost under both circumstances are given.The presented algorithms are also perfect in the sense that they can correctly diagnose a repairable/unrepairable memory and find the optimal repair-solution.
Limits to the fraction of high-energy photon emitting gamma-ray bursts
Carl W. Akerlof,WeiKang Zheng
Physics , 2012, DOI: 10.1088/0004-637X/764/2/190
Abstract: After almost 4 years of operation, the two instruments onboard the Fermi Gamma-ray Space Telescope have shown that the number of gamma-ray bursts with high energy photon emission above 100 MeV cannot exceed roughly 9% of the total number of all such events, at least at the present detection limits. In a recent paper (Zheng et al. 2012c), we found that GRBs with photons detected in the Large Area Telescope (LAT) have a surprisingly broad distribution with respect to the photon number above background. Extrapolation of our empirical fit to numbers of photons below our quoted detection limit suggests that the overall rate of such events could be determined by standard image co-adding techniques. In this case, we have taken advantage of the excellent angular resolution of the Swift mission to provide accurate reference points for 79 GRB events which have eluded any previous correlations with high energy photons. We find a small but significant signal. Guided by the power law fit obtained previously for the number distribution of GRBs, the data suggests that only a small fraction of GRBs are sources of high energy photons.
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