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Search Results: 1 - 10 of 120161 matches for " Wang LR "
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Sevoflurane attenuates pulmonary inflammation and ventilator-induced lung injury by upregulation of HO-1 mRNA expression in mice
Xiong XQ, Lin LN, Wang LR, Jin LD
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S41625
Abstract: flurane attenuates pulmonary inflammation and ventilator-induced lung injury by upregulation of HO-1 mRNA expression in mice Original Research (263) Total Article Views Authors: Xiong XQ, Lin LN, Wang LR, Jin LD Published Date March 2013 Volume 2013:8 Pages 1075 - 1081 DOI: http://dx.doi.org/10.2147/IJN.S41625 Received: 14 December 2012 Accepted: 26 January 2013 Published: 13 March 2013 Xiang-qing Xiong, Li-na Lin, Liang-rong Wang, Li-da Jin Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, People's Republic of China Background: Mechanical ventilation has been documented to paradoxically cause lung injury. As a commonly used volatile anesthetic, sevoflurane has been proven to possess antiinflammatory and antioxidative properties. This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice. Methods: The adult healthy mice were divided into four groups, each consisting of ten subjects: mice in group Con-LVT and group Sev-LVT were ventilated with tidal volumes of 8 mL/kg for 4 hours, while those in group Con-HVT and group Sev-HVT were ventilated with tidal volumes of 16 mL/kg instead. Control mice (group Con-LVT and Con-HVT) were subjected to fresh air, while sevoflurane-treated mice (groups Sev-LVT and Sev-HVT) were subjected to air mixed with 1 vol% sevoflurane. After 4 hours of ventilation, the bronchoalveolar lavage (BAL) fluid was collected and analyzed for the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10. Lung homogenates were harvested to detect the expression of nuclear factor-kppa B (NF-кB) and heme oxygenase (HO)-1 mRNA by reverse transcription-polymerase chain reaction method. Lung damage was evaluated using the modified Ventilator-Induced Lung Injury histological scoring system. Results: Compared to group Con-LVT, the levels of TNF-α, IL-1β, IL-6, and IL-10 in BAL fluid, mRNA expressions of NF-кB and HO-1 in lung tissue, and lung injury scores were significantly increased in group Con-HVT; compared to group Con-HVT, group Sev-HVT BAL samples showed decreased levels of TNF-α, IL-1β, and IL-6; they also showed increased levels of IL-10, the downregulation of NF-кB mRNA, and HO-1 mRNA upregulation; the lung injury scores were significantly lower in group Sev-HVT than group Con-HVT. Conclusion: Mechanical ventilation with high tidal volume might lead to lung injury, which could be significantly, but not completely, attenuated by sevoflurane inhalation by inhibiting the NF-кB-mediated proinflammatory cytokine generation and upregulating HO-1 expression.
Sevoflurane attenuates pulmonary inflammation and ventilator-induced lung injury by upregulation of HO-1 mRNA expression in mice
Xiong XQ,Lin LN,Wang LR,Jin LD
International Journal of Nanomedicine , 2013,
Abstract: Xiang-qing Xiong, Li-na Lin, Liang-rong Wang, Li-da JinDepartment of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, People's Republic of ChinaBackground: Mechanical ventilation has been documented to paradoxically cause lung injury. As a commonly used volatile anesthetic, sevoflurane has been proven to possess antiinflammatory and antioxidative properties. This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice.Methods: The adult healthy mice were divided into four groups, each consisting of ten subjects: mice in group Con-LVT and group Sev-LVT were ventilated with tidal volumes of 8 mL/kg for 4 hours, while those in group Con-HVT and group Sev-HVT were ventilated with tidal volumes of 16 mL/kg instead. Control mice (group Con-LVT and Con-HVT) were subjected to fresh air, while sevoflurane-treated mice (groups Sev-LVT and Sev-HVT) were subjected to air mixed with 1 vol% sevoflurane. After 4 hours of ventilation, the bronchoalveolar lavage (BAL) fluid was collected and analyzed for the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10. Lung homogenates were harvested to detect the expression of nuclear factor-kppa B (NF-кB) and heme oxygenase (HO)-1 mRNA by reverse transcription-polymerase chain reaction method. Lung damage was evaluated using the modified Ventilator-Induced Lung Injury histological scoring system.Results: Compared to group Con-LVT, the levels of TNF-α, IL-1β, IL-6, and IL-10 in BAL fluid, mRNA expressions of NF-кB and HO-1 in lung tissue, and lung injury scores were significantly increased in group Con-HVT; compared to group Con-HVT, group Sev-HVT BAL samples showed decreased levels of TNF-α, IL-1β, and IL-6; they also showed increased levels of IL-10, the downregulation of NF-кB mRNA, and HO-1 mRNA upregulation; the lung injury scores were significantly lower in group Sev-HVT than group Con-HVT.Conclusion: Mechanical ventilation with high tidal volume might lead to lung injury, which could be significantly, but not completely, attenuated by sevoflurane inhalation by inhibiting the NF-кB-mediated proinflammatory cytokine generation and upregulating HO-1 expression.Keywords: mechanical ventilation, sevoflurane, inflammation, lung injury
The balance in research between biotechnology and traditional crop improvement
LR House
African Crop Science Journal , 1995,
Abstract:
Nature of the genetic control of ovulation rate and its relationship with litter size
JP Hanrahan, LR Piper
Genetics Selection Evolution , 1982, DOI: 10.1186/1297-9686-14-4-578b
Abstract:
Best linear unbiased prediction when error vector is correlated with other random vectors in the model
LR Schaeffer, CR Henderson
Genetics Selection Evolution , 1983, DOI: 10.1186/1297-9686-15-3-395
Abstract:
Estimation of covariance components between one continuous and one binary trait
H Simianer, LR Schaeffer
Genetics Selection Evolution , 1989, DOI: 10.1186/1297-9686-21-3-303
Abstract:
Spatial distribution of Phyllocnistis citrella Stainton (Lepidoptera: Gracillariidae) larvae in three scales
Jesus, CR.;Redaelli, LR.;
Brazilian Journal of Biology , 2008, DOI: 10.1590/S1519-69842008000100030
Abstract: the spatial distribution of larvae of phyllocnistis citrella stainton (lepidoptera: gracillariidae), the citrus leaf miner, in leaves, shoots, and tree crowns of montenegrina tangerine (citrus deliciosa tenore) and murcott tangor (citrus sinensis l. osbeck x citrus reticulata blanco) was determined. fortnightly samplings from july/2001 to june/2003, in orchards located in montenegro (29o 68? s and 51o 46? w), rs, brazil, were carried out. at each sampling occasion eighth shoots randomly selected were collected. the spatial distribution pattern of p. citrella larvae between tree crowns and in the shoots was aggregated in most sampling occasions in both citrus species. nevertheless, on the leaves, this pattern followed a random distribution, as indicated by the indices i, id and k parameter.
Children at Risk: A Study of the Psychosocial Impact of HIV on Orphans and other Vulnerable Children in Benin
LR stergaard, DW Meyrowitsch
Africa Development , 2008,
Abstract: This paper describes the effect of parental HIV on the life of children in Benin. A total of 2,043 children aged from 10 to 16 were surveyed on health, diet, violence, school attendance and psychosocial state. The results indicate that, while Beninese children who have had a parent living with HIV are not necessarily subjected to different economic and material conditions than those who have not, they do experience a much greater lack of psychosocial support. In contrast to children whose parents are not known to have HIV, these affected children are less prone to general illness (OR=0.69, 95 per cent CI 0.55-0.86). However, when they are sick, HIV-affected children are significantly more likely to undertake self-treatment (OR=1.38; 95 per cent CI 1.04-1.86) and more likely to work (OR=1.65, 95 per cent CI 1.04-2.60). They are also offered fewer meals than unaffected children (OR=1.94; 95 per cent CI 1.52-2.47). With respect to psychosocial factors, the data suggest that children who have had a parent with HIV have significantly higher levels of psychological distress than those who have not. Governments and civil society organisations need to address not only the material deprivation, especially hunger, of children thus affected by HIV, but also their need for social services.
Impact of Information and Communication Technology on Distance Education: The case of National Open University of Nigeria
SD Osaat, LR Nsereka
African Research Review , 2012,
Abstract: This study investigates the impacts of information and communication technology media on effective distance learning education in Nigeria. It implores the use of questionnaire as instrument with reliability index of 0.89 (using Cronbach) to generate data. The data were analyzed using mean scores, cluster mean scores and criterion mean scores to answer the 4 research questions. The paper finds out that information and communication technology media have greater positive impacts on distance education enhancing academic success; that the National Open University of Nigeria (NOUN) has not fully employed ICT media such as radio/television broadcast of lectures, computer aided instruction and tele/video conferencing exception of e-library, sms and email/internet. The study also shows that methods of teaching employed include email for assignment collection and submission, e-library and to lesser extent internet bracing and radio/television broadcast. The authors recommend more government assistance and urge the lecturers and students to be receptive of all the teaching/learning methods akin to ICT media as to improve on their achievements.
Managing AIDS stigma
WL Holzemer, LR Uys
SAHARA J (Journal of Social Aspects of HIV/AIDS Research Alliance) , 2004,
Abstract: ccording to anecdotal reports, AIDS stigma and discrimination continue to influence people living with and affected by HIV disease as well as their health care providers, particularly in southern Africa where the burden of AIDS is so significant. Stigma is perceived as a major limiting factor in primary and secondary HIV/AIDS prevention and care. It reportedly interferes with voluntary testing and counselling, and with accessing care and treatments, thereby increasing suffering and shortening lives. Many health care workers in southern Africa have come to the conclusion that unless stigma is conquered, the illness will not be defeated. While there is substantial anecdotal evidence of the impact of stigma on AIDS care, very little rigorous research has been conducted. This article explores three questions: What is AIDS stigma? What is the impact of AIDS stigma? How can health care providers help to manage AIDS stigma?
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