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Search Results: 1 - 10 of 18685 matches for " Wafa Al Shakweer "
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Pediatric Non-Hodgkin Lymphoma: A Retrospective 7-Year Experience in Children & Adolescents with Non-Hodgkin Lymphoma Treated in King Fahad Medical City (KFMC)  [PDF]
Nahla Ali Mobark, Suha A. Tashkandi, Wafa Al Shakweer, Khalid Al Saidi, Suha A. Fataftah, Mohammed M. Al Nemer, Awatif Alanazi, Mohammed Rayis, Walid Ballourah, Othman Mosleh, Zaheer Ullah, Fahad El Manjomi, Musa Al Harbi
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.64033
Abstract:

Background: Non-Hodgkin’s lymphoma is an aggressive malignant disease in children and adolescents. Although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin’s lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin’s lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin’s lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8; 1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt’s lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specifically for the t (8; 14) (q24; q32) a characteristic genetic feature of Burkitt’s Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and high risk ALL CCG 1961 Protocol for lymphoblastic lymphoma and international Anaplastic Large Cell Lymphoma 99 Study Protocol for ALCL. The median follow-up in patients not experiencing an adverse event was 53.1 months. The estimated 3-year EFE and OS rates in the entire cohort of patients with newly diagnosed NHL treated in the KFMC were 85.2% and 89.2% respectively; Overall survival (OS) rate of patients with mature

Validation of a Food Frequency Questionnaire for Vitamin D and Calcium Intake in Healthy Female College Students  [PDF]
Dimitrios Papandreou, Nikolaos Rachaniotis, Maryam Lari, Wafa Al Mussabi
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.521216
Abstract: Objective: The objective of this study was to examine the reproducibility and validity of a Food Frequency Questionnaire (FFQ) and assess calcium and vitamin D intake in health female college students. Methods: Thirty-five healthy female students were conveniently selected to participate in the study. None of the subjects were taking any supplements. The FFQ was validated against intakes from a three-day diet food record report (FR). Results: Positive correlations were observed of daily vitamin D (r = 0.82, p < 0.001) and calcium intake (r = 0.74, p < 0.001) derived from FFQ compared with the FR. The mean intake of vitamin D and calcium derived from FFQ and FR were (233 ± 90, 654 ± 391) and (231 ± 79, 611 ± 352), respectively. The FFQ overestimated vitamin D and Calcium by 2 IU /day (95% CI: 8, 9, p < 0.676 and 43 mg/d (95% CI: 20, 65, p < 0.01). Conclusions: The FFQ used in this study shows promising validation evidence to be used in the future for assessing vitamin D and calcium intakes in female students.
Numerical Solutions for Quadratic Integro-Differential Equations of Fractional Orders  [PDF]
Fatheah Alhendi, Wafa Shammakh, Hind Al-Badrani
Open Journal of Applied Sciences (OJAppS) , 2017, DOI: 10.4236/ojapps.2017.74014
Abstract: In this article, variational iteration method (VIM) and homotopy perturbation method (HPM) solve the nonlinear initial value problems of first-order fractional quadratic integro-differential equations (FQIDEs). We use the Caputo sense in this article to describe the fractional derivatives. The solutions of the problems are derived by infinite convergent series, and the results show that both methods are most convenient and effective.
Water loss in Mafraq Governorate, Jordan  [PDF]
Nadhir Al-Ansari, Salem Al-Oun, Wafa Hadad, Sven Knutsson
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.53046
Abstract:

Jordan is located in theMiddle Eastand covers an area of89,342 km2. The total population ofJordanis 6,508,271.Jordanis rapidly facing a severe water supply crisis due to greater demands on a finite quantity of available water. If current trends continue, it has been estimated that the country will experience a chronic water shortage by 2020. Despite these shortages, water loss in the distribution network is relatively high where it reaches 46%. Mafraq Governorate has the maximum water loss. Continuous records and data for the period 1999-2004 for Mafraq water authority were investigated for the water supply and lose. Water losses were evaluated, and suggestions were given to minimize the loss.

Prevalence Intestinal Parasites in Leafy Vegetables in Riyadh, Saudi Arabia
Wafa A.I. Al-Megrin
International Journal of Tropical Medicine , 2012, DOI: 10.3923/ijtmed.2010.20.23
Abstract: Green leafy vegetables are important part of daily diet invarious parts of the world. The present study was carried out to evaluate some of the leafy vegetable plants sold in local markets for human consumption to check whether they harbor different parasites stages. Results of the present study has shown that 76 out of 470 samples (16%) contained parasite stages. Depending on the type of leafy plant examined the prevalence of parasitic stages in these plants was found to be 27.8% (17/61) in lettuce, 22.8% (13/57) in watercress, 20.6% (7/34) in leek, 19.1% (9/47) in green onion, 17.4% (15/87) in parsley, 15.4% (4/26) in spinach, 13.6% (3/22) in basil, 11.5% (3/26) in coriander, 9.4% (3/32) in radish, 5.3% (1/19) in dill and 4.7% (2/42) in mint. No parasites were detected in 17 samples collected from cabbage. Stages of intestinal parasites detected were Entamoeba coli (35.5%), Giardia lamblia (31.6%), Dicrocoelium sp. (28.9%), Ascaris sp. (26.3%), Taenia sp. (19.7%), Blastocystis hominis (17.1%), Fasciola sp. (14.5%), Hymenolepis sp. (14.5%), Ancylostoma sp. (11.8%), Toxoplasma gondii (6.6%) and Trichostrongylus sp. (2.6%). The results indicated a significant seasonal variation (p<0.05), with highest prevalence in spring (23.1%), followed in descending order by summer (17.9%), autumn (10.6%) and winter (9.9%).
Intestinal Parasites Infection among Immunocompromised Patients in Riyadh, Saudi Arabia
Wafa A.I. Al-Megrin
Pakistan Journal of Biological Sciences , 2010,
Abstract: This study was conducted to determine the prevalence of intestinal parasites among immunocompromised patients in Riyadh, Saudi Arabia. Fecal samples were collected from 136 immunocompromised patients (52 females and 84 males), aged 2 to 69 years. Specimens were fixed with 10% formalin for 30 min (2-3 g fecal-1) and then concentrated by a formalin-ether sedimentation technique. Samples were examined as wet saline mounts and in iodine preparation for detection of protozoan oocysts, cysts, helminthic eggs and larvae. Permanent stained smears were performed for intestinal coccidian parasites by the modified Ziehl-Neelsen technique and the modified trichrome stain. Intestinal parasites were detected in 54 (39.7%) most of them (25.7%) were with diarrhea. More specifically the following parasites were detected Cryptosporidium parvum 11(8.1%), Giardia lamblia 9 (6.6%), Cyclospora cayetanensis 8 (5.9%), Blastocystis hominis 7 (5.2%), Entamoeba histolytica 7 (5.2%), Entamoeba coli 5 (3.7%), Strongyloides stercoralis 3 (2.2%), Ascaris lumbricoides 1 (0.7%), Hymenolepis nana 1 (0.7%), Dicrocoelium dendriticum 1 (0.7%) and Hook worm 1 (0.7%). The most common parasite associated with diarrhea in patients, was C. parvum (p<0.001), followed by G. lamblia, C. cayetanensis and E. histolytica. However, differences between different age groups were statistically non-significant. Similarly, no significant difference in the infection rate were found between male and female patients.
Patients′ attitude towards medical students rotating in the dermatology clinic
Bukhari Iqbal,AlAkloby Omar,Al Saeed Wafa
Indian Journal of Dermatology , 2008,
Abstract: Objective: To study the attitudes of the patients towards medical students rotating in the dermatology clinic in the King Fahad Hospital of the University (KFHU). Materials and Methods: One hundred and two adult outpatients attending the KFHU in Alkhobar, Saudi Arabia during the period March to June 2004 completed a questionnaire to evaluate their receptiveness towards medical students attending with the dermatologist. Results: Almost 57% preferred physician and medical student participation in their care and 46% welcomed their presence during physical examination. The majority of patients (64.8%) felt comfortable disclosing personal information to the medical student and (68.7%) enjoyed the interaction with the medical students. Patients (63.7%) agreed that the students understood their healthcare needs. Conclusion: The majority of the patients in this study enjoyed their interactions with the students and felt comfortable disclosing information. Some patients want to spend time alone with the physician so permission for medical student participation should be requested.
Prevalence of Intestinal Parasites in Leafy Vegetables in Riyadh, Saudi Arabia
Wafa A.I. Al-Megrin
International Journal of Zoological Research , 2010,
Abstract: The present study was carried out to evaluate some of the leafy vegetable plants sold in local markets for human consumption to check whether they harbor different parasites stages. A total of 470 leafy vegetable samples were collected from 12 different plant species randomly from local markets in the Riyadh city during the period April and March 2008. The samples were analysed in the laboratory for parasitic stages contained in these samples after washing them in physiological saline and then examining the sediment. Results of the present study has shown that 76 out of 470 samples (16.2%) contained parasite stages. Depending on the type of leafy plant, examined the prevalence of parasitic stages in these plants, was found to be 27.8% (17/61) in lettuce, 22.8% (13/57) in watercress, 20.6% (7/34) in leek, 19.1% (9/47) in green onion, 17.4% (15/87) in parsley, 15.4% (4/26) in spinach, 13.6% (3/22) in basil, 11.5% (3/26) in coriander, 9.4% (3/32) in radish, 5.3% (1/19) in dill and 4.7% (2/42) in mint. No parasites were detected in 17 samples collected from cabbage. Stages of intestinal parasites detected were Entamoeba coli (35.5%), Giardia lamblia (31.6%), Dicrocoelium sp. (28.9%), Ascaris sp. (26.3%), Taenia sp. (19.7%), Blastocystis hominis (17.1%), Fasciola sp. (14.5%), Hymenolepis sp. (14.5%), Ancylostoma sp. (11.8%), Toxoplasma gondii (6.6%) and Trichostrongylus sp. (2.6%). The results indicated a significant seasonal variation (p<0.05), with highest prevalence in spring (23.1%), followed in descending order by Summer (17.9%), Autumn (10.6%) and Winter (9.9%).
A novel cytogenetic abnormality r(7)(::p11.2->q36.3::) in a Philadelphia-positive chronic myeloid leukemia case  [PDF]
Walid Al Achkar, Abdulsamad Wafa, Abdulmunim Aljapawe, Moneeb Abdullah Kassem Othman, Thomas Liehr
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.29135
Abstract:

The so-calledPhiladelphia(Ph) chromosome is present in more than 90% of chronic myeloid leukemia (CML) cases. It results in juxtaposition of the 5' part of the BCR gene on chromosome 22 and the 3' part of the ABL1 gene on chromosome 9. An additional acquired monosomy 7 or deletion of 7q is associated with poor prognosis in a variety of myeloid disorders. Here we report a novel Ph chromosome positive CML case with a ring chromosome 7 [r(7)]. Immunophenotyping was compatible with CML, although 4.5% of total leucocytes appeared like acute myelogeneous leukemia (AML) subtype M2. The r(7) was characterized in detail by array-proven multicolor banding (aMCB), the latter being of enormous significance to characterize breakpoint regions in detail. Underlying mechanisms and prognostic are discussed, as ring chromosomes are rare cytogenetic abnormalities in hematopoietic malignancies.

Partial Trisomy 1q21-qter and Partial Monosomy 7q21-qter Due to a Derivative Chromosome 7 in Myelodysplastic Syndrome Associated with Squamous Cell Carcinoma: Case Report  [PDF]
Abdulsamad Wafa, Faten Moassass, Thomas Liehr, Abdulmunim Aljapawe, Walid Al Achkar
Case Reports in Clinical Medicine (CRCM) , 2016, DOI: 10.4236/crcm.2016.512066
Abstract: Background: Myelodysplastic syndromes (MDS) are subtypes of hematological disorders which are known to have partial bone marrow dysplasia, peripheral cytopenia, and later on an increased risk to develop acute myeloid leukemia. Chromosomal aberrations are detected in ~50% of cases of de novo MDS cases and the most common chromosomal abnormalities of this entity include complete or partial monosomy of chromosomes 5 and 7, partial deletion of 20q and 12p, trisomy 8, and 11q23 aberrations. A few primary and/or secondary MDS cases combined with other cancer have been reported. Case Presentation: We report here an adult MDS associated with squamous cell carcinoma (SCC). G-banding and array-proven multicolor banding (aMCB) revealed an unbalanced translocation der(7)t(1;7)(q21;q21), which led to 1q partial trisomy and 7q partial monosomy. Immunophenotype of this case was consistent with refractory anemia with excess of blasts (RAEB-2) according to World Health Organization (WHO) classification. Conclusions: As far as we know, this is the first adult MDS case associated with SCC and an unbalanced translocation t(1;7). Our patient received first cycle of azacitidine treatment and he showed bilateral pleural effusion as a secondary event. This toxicity is not limited to the first cycle as in previous MDS cases; our case is the first one to shown this toxicity as a secondary event of azacitidine treatment. As less than 10 cytogenetcially comparable cases without SCC were reported before in male MDS, we carefully conclude that this cytogenetic aberration may be a hint on a new gender associated MDS subgroup.
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