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Search Results: 1 - 10 of 13715 matches for " Wa'el Salhab "
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Genomic analysis of a heterogeneous Mendelian phenotype: multiple novel alleles for inherited hearing loss in the Palestinian population
Tom Walsh, Amal Rayan, Judeh Sa'ed, Hashem Shahin, Jeanne Shepshelovich, Ming K Lee, Koret Hirschberg, Mustafa Tekin, Wa'el Salhab, Karen B Avraham, Mary-Claire King, Moien Kanaan
Human Genomics , 2006, DOI: 10.1186/1479-7364-2-4-203
Abstract:
EMCAR: Expert Multi Class Based on Association Rule
Wa'el Hadi
International Journal of Modern Education and Computer Science , 2013, DOI: 10.5815/ijmecs.2013.03.05
Abstract: Several experimental studies revealed that expert systems have been successfully applied in real world domains such as medical diagnoses, traffic control, and many others. However, one of the major drawbacks of classic expert systems is their reliance on human domain experts which require time, care, experience and accuracy. This shortcoming also may result in building knowledge bases that may contain inconsistent rules or contradicting rules. To treat the abovementioned we intend to propose and develop automated methods based on data mining called Associative Classification (AC) that can be easily integrated into an expert system to produce the knowledge base according to hidden correlations in the input database. The methodology employed in the proposed expert system is based on learning the rules from the database rather than inputting the rules by the knowledge engineer from the domain expert and therefore, care and accuracy as well as processing time are improved. The proposed automated expert system contains a novel learning method based on AC mining that has been evaluated on Islamic textual data according to several evaluation measures including recall, precision and classification accuracy. Furthermore, five different classification approaches: Decision trees (C4.5, KNN, SVM, MCAR and NB) and the proposed automated expert system have been tested on the Islamic data set to determine the suitable method in classifying Arabic texts.
Human Exposure to Ecballium elaterium Fruit Juice: Fatal Toxicity and Possible Remedy  [PDF]
Abdulazim S. Salhab
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.45064
Abstract: The human serious adverse reactions of the folkloric plant, Ecballium elaterium (EE), are well documented in the literature. This report is presenting the medical literature of 74 cases, which experienced severe adverse reactions or deaths that resulted from the administration of the plant juice. The survey of these human cases exhibits several adverse effects such as: acute rhinitis, uvular edema, soft palate, upper airway edema. In conclusion, the use of EE juice in folk medicine can cause severe adverse reactions that should not be ignored but it should be medically treated.
Comprehensive online Atomic Database Management System (DBMS) with Highly Qualified Computing Capabilities
Amani Tahat,Wael Salah
International Journal of Database Management Systems , 2011,
Abstract: The intensive need of atomic data is expanding continuously in a wide variety of applications (e.g, fusionenergy and astrophysics, laser-produced, plasma researches, and plasma processing).This paper willintroduce our ongoing research work to build a comprehensive, complete, up-to-date, user friendly andonline atomic Database Management System (DBMS) namely called AIMS by using SQLite(http://www.sqlite.org/about.html)(8). Programming language tools and techniques will not be coveredhere. The system allows the generation of various atomic data based on professional online atomiccalculators. The ongoing work is a step forward to bring detailed atomic model accessible to a widecommunity of laboratory and astrophysical plasma diagnostics. AIMS is a professional worldwide tool forsupporting several educational purposes and can be considered as a complementary database of IAEAatomic databases. Moreover, it will be an exceptional strategy of incorporating the output data of severalatomic codes to external spectral models.
Comprehensive online Atomic Database Management System (DBMS) with Highly Qualified Computing Capabilities
Amani Tahat,Wa'el Salah
Physics , 2011,
Abstract: The intensive need of atomic data is expanding continuously in a wide variety of applications (e.g. fusion energy and astrophysics, laser-produced, plasma researches, and plasma processing).This paper will introduce our ongoing research work to build a comprehensive, complete, up-to-date, user friendly and online atomic Database Management System (DBMS) namely called AIMS by using SQLite (http://www.sqlite.org/about.html)(8). Programming language tools and techniques will not be covered here. The system allows the generation of various atomic data based on professional online atomic calculators. The ongoing work is a step forward to bring detailed atomic model accessible to a wide community of laboratory and astrophysical plasma diagnostics. AIMS is a professional worldwide tool for supporting several educational purposes and can be considered as a complementary database of IAEA atomic databases. Moreover, it will be an exceptional strategy of incorporating the output data of several atomic codes to external spectral models.
A History of Fraud and Deceit in Medical Research
Mohammad Salhab
Surgery Journal , 2012, DOI: 10.3923/sjour.2010.1.6
Abstract: There have been many cases of fraudulent research work in recent years. Science has progressed through years of research and trial of pioneering ideas. However, the intentions for promoting such research have not always been pure. In some cases, fraudulent research has been used as means to promote personal and financial gains. In this study, cases of previous fraudulent research are reviewed. Grey areas of misconduct and fraud are clarified. The aims of the study are to define misconduct and grey areas of research fraud. The study will also review famous cases of research fraud and the reasons of why such cases may have been committed are outlined. A review of Medline between the years 1960-2009 has yielded studies reviewed by this study. Cases involving research misconduct and fraud are identified. All cases are discussed and inferences to why such acts committed are outlined. There are insufficient protocols in place to limit fraudulent research. However, an international coordination of effort in defining research misconduct and invoking legal and procedural accountability may be a solution to this problem.
Islam, juda sme et cinéma. Interdits religieux, questionnements identitaires Islam, Judaism and cinema
Sabine Salhab
Cahiers d'études du Religieux , 2012, DOI: 10.4000/cerri.1132
Abstract: La méfiance traditionnelle des monothéismes vis-à-vis des images par crainte de l’idolatrie n’empêche pas le développement du cinéma au sein de sociétés majoritairement juives ou musulmanes dès le début du XXe siècle. Dans le monde à majorité musulmane, la représentation des figures coraniques reste le tabou ultime qui empêche l’émergence d’un véritable cinéma religieux, malgré quelques tentatives ponctuelles. Les communautés juives d’Europe et des Etats-Unis réalisent quant à elles de nombreux films yiddish entre 1910 et 1950. La notion de film juif ou musulman au sens esthétique du terme, interrogée dans cet article, se révèle insuffisante pour cerner ces uvres complexes. The traditional distrust of monotheism towards images by fear of idolatry did not prevent the development of cinema in Jewish or Muslim societies at the beginning of the 20th century. Despite some attempts, an Islamic religious cinema never emerged in the predominantly Muslim world since the representation of Coranic figures remains the ultimate taboo. Jewish communities in Europe and the United States produced many Yiddish films between 1910 and 1950. The aesthetic notion of Muslim or Jewish film, explored in this article, appears to be unsufficient to define these complex works.
Antimutagenic and antioxidant activity of novel 4-substituted phenyl-2,2'-bichalcophenes and aza-analogs
El-Sayed WM, Hussin WA
Drug Design, Development and Therapy , 2013, DOI: http://dx.doi.org/10.2147/DDDT.S40129
Abstract: ntimutagenic and antioxidant activity of novel 4-substituted phenyl-2,2'-bichalcophenes and aza-analogs Original Research (927) Total Article Views Authors: El-Sayed WM, Hussin WA Published Date February 2013 Volume 2013:7 Pages 73 - 81 DOI: http://dx.doi.org/10.2147/DDDT.S40129 Received: 09 November 2012 Accepted: 30 November 2012 Published: 07 February 2013 Wael M El-Sayed,1,2 Warda A Hussin3 1King Faisal University, Faculty of Science, Departments of Biological Sciences and Chemistry, Al-Hufof, Ahsa, Kingdom of Saudi Arabia; 2University of Ain Shams, Faculty of Science, Department of Zoology, Cairo, Egypt; 3Al-Azhr University, Faculty of Science, Department of Botany and Microbiology, Cairo, Egypt Abstract: Evaluation of the potential antimutagenic activities of new compounds by Ames assay has been of great interest for the development of novel therapeutics for many diseases including cancer. Ten novel bichalcophenes with in vitro and in vivo broad spectrum activities against various microbial strains were investigated throughout the present study for their cytotoxic, antioxidant, and antimutagenic potential in a Salmonella reverse mutation assay system against sodium azide (NaN3) and benzo[a]pyrene (B[a]P). At nontoxic concentrations, all bichalcophenes alone or in combination with NaN3 (1 μg/plate) or B[a]P (20 μM) with S9 mix were not mutagenic. The bichalcophenes significantly reduced NaN3- and B[a]P-induced mutagenicity under pre-exposure and co-exposure conditions in a concentration-independent manner. However, the antimutagenic activity of bichalcophenes against B[a]P varied depending on the exposure regimen, being more effective under pre-exposure conditions. The antimutagenic activity was correlated with a high antioxidant activity that could promote the DNA repair system. Bichalcophenes are least likely to interfere with the microsomal bioactivation of B[a]P. Monocationic bichalcophenes were superior to the corresponding mononitriles as antimutagenic agents against both mutagens investigated, possibly due to the higher nucleophilic centers they have which could bind and protect the bacterial DNA. Three monocationic compounds were shown to have a strong anticancer activity against the 58 cell line. Based on the results of the present investigation, monocationic compounds (1, 4, and 5B) will be selected for further time consuming and costly chemoprevention studies in animal models.
Antimutagenic and antioxidant activity of novel 4-substituted phenyl-2,2'-bichalcophenes and aza-analogs
El-Sayed WM,Hussin WA
Drug Design, Development and Therapy , 2013,
Abstract: Wael M El-Sayed,1,2 Warda A Hussin31King Faisal University, Faculty of Science, Departments of Biological Sciences and Chemistry, Al-Hufof, Ahsa, Kingdom of Saudi Arabia; 2University of Ain Shams, Faculty of Science, Department of Zoology, Cairo, Egypt; 3Al-Azhr University, Faculty of Science, Department of Botany and Microbiology, Cairo, EgyptAbstract: Evaluation of the potential antimutagenic activities of new compounds by Ames assay has been of great interest for the development of novel therapeutics for many diseases including cancer. Ten novel bichalcophenes with in vitro and in vivo broad spectrum activities against various microbial strains were investigated throughout the present study for their cytotoxic, antioxidant, and antimutagenic potential in a Salmonella reverse mutation assay system against sodium azide (NaN3) and benzo[a]pyrene (B[a]P). At nontoxic concentrations, all bichalcophenes alone or in combination with NaN3 (1 μg/plate) or B[a]P (20 μM) with S9 mix were not mutagenic. The bichalcophenes significantly reduced NaN3- and B[a]P-induced mutagenicity under pre-exposure and co-exposure conditions in a concentration-independent manner. However, the antimutagenic activity of bichalcophenes against B[a]P varied depending on the exposure regimen, being more effective under pre-exposure conditions. The antimutagenic activity was correlated with a high antioxidant activity that could promote the DNA repair system. Bichalcophenes are least likely to interfere with the microsomal bioactivation of B[a]P. Monocationic bichalcophenes were superior to the corresponding mononitriles as antimutagenic agents against both mutagens investigated, possibly due to the higher nucleophilic centers they have which could bind and protect the bacterial DNA. Three monocationic compounds were shown to have a strong anticancer activity against the 58 cell line. Based on the results of the present investigation, monocationic compounds (1, 4, and 5B) will be selected for further time consuming and costly chemoprevention studies in animal models.Keywords: bichalcophenes, Salmonella typhimurium, sodium azide, benzo[a]pyrene, antimutagenicity
Efficacy of two novel 2,2’-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin
El-Sayed WM, Hussin WA, Ismail MA
Drug Design, Development and Therapy , 2012, DOI: http://dx.doi.org/10.2147/DDDT.S36437
Abstract: acy of two novel 2,2’-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin Original Research (1617) Total Article Views Authors: El-Sayed WM, Hussin WA, Ismail MA Published Date October 2012 Volume 2012:6 Pages 279 - 287 DOI: http://dx.doi.org/10.2147/DDDT.S36437 Received: 28 July 2012 Accepted: 06 September 2012 Published: 12 October 2012 Wael M El-Sayed,1,2 Warda A Hussin,3 Mohamed A Ismail1,4 1Departments of Biological Sciences and Chemistry, King Faisal University, Al-Hofuf, Saudi Arabia; 2Department of Zoology, University of Ain Shams, Cairo, Egypt; 3Department of Botany and Microbiology, Al-Azhr University, Cairo, Egypt; 4Department of Chemistry, Mansoura University, Mansoura, Egypt Abstract: The therapeutic efficacy of two novel bifurans and vancomycin in an animal model of a methicillin-resistant Staphylococcus aureus (MRSA) infection was compared. Adult male CF-1 mice (25–35 g) were intraperitoneally injected with 200 μL/mouse containing 107 cell-forming units of MRSA. After 16 hours, animals were treated with 110 mg/kg of vancomycin, or 5 mg/kg of mononitrile bifuran (1A) or monocationic bifuran (1B) and killed after 8 hours. Treatment with bifurans did not cause any toxicity. Treatment of MRSA-infected animals with bifurans resulted in significant reductions in the viable bacterial count in blood, liver, kidney, and spleen. Colonies recovered from livers and kidneys of mice injected with 1A or 1B lost the initial resistance pattern and became susceptible to methicillin and ciprofloxacin. MRSA elevated the serum urea level and activities of alanine aminotransferase and γ-glutamyl transpeptidase. MRSA also elevated the hepatic level of malondialdehyde, and serum levels of tumor necrosis factor and interleukin-6. MRSA also reduced the glutathione content and activities of catalase and glutathione S-transferase in liver. Similar to vancomycin, bifurans ameliorated most of the previous effects. Compound 1B was superior to 1A, and sometimes both provided better antistaphylococcal agents than vancomycin against MRSA pathogenesis. The present findings along with our previous studies support further evaluation of the efficacy of these bifurans in clinical studies.
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