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Search Results: 1 - 10 of 678744 matches for " W. K. B. A. Owiredu "
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Serum Lipid Profile of Breast Cancer Patients
W.K.B.A. Owiredu,S. Donkor,B. Wiafe Addai,N. Amidu
Pakistan Journal of Biological Sciences , 2009,
Abstract: The purpose of this study was to carry out a comparative study to investigate the effect of lipid profile, oestradiol and obesity on the risk of a woman developing breast cancer. This study was carried out at the Komfo Anokye Teaching Hospital (KATH), Peace and Love Hospital, Oduom, Kumasi and Redeemed Clinic, Nima, Accra between May 2002 and March 2003. In this study, 200 consented women comprising 100 breast cancer patients (43 pre- and 57 post-menopausal) and 100 controls (45 pre- and 55 post-menopausal) with similar age range (25 to 80 years) were assessed for lipid profile, oestradiol and BMI. There was a significant increase in Body Mass Index (BMI) (p = 0.011), Total Cholesterol (TC) (p<0.001), triglyceride (p = 0.026) and low density lipoprotein (LDL-cholesterol) (p = 0.001) of the breast cancer patients compared to the controls. With the exception of oestradiol (EST) that decreased, the lipid profile generally increased with age in both subjects and controls with the subjects having a much higher value than the corresponding control. There was also a significant positive correlation between BMI and TC (r2 = 0.022; p = 0.002) and also between BMI and LDL-cholesterol (r2 = 0.031; p = 0.0003). Apart from EST and LDL-cholesterol that were increased significantly only in the postmenopausal phase in comparison to the controls, BMI, TC and TG were increased in both pre-menopausal and post menopausal phases with HDL-cholesterol remaining unchanged. This study confirms the association between dyslipidaemia, BMI and increased breast cancer risk.
Antidepressant-Like Effects of an Ethanolic Extract of Sphenocentrum jollyanum Pierre Roots in Mice
E. Woode,N. Amidu,W.K.B.A. Owiredu,E. Boakye-Gyasi
International Journal of Pharmacology , 2009,
Abstract: In the present study, the effect of an ethanolic extract of the roots of the plant in two animal models of depression the Forced Swimming Test (FST) and Tail Suspension Test (TST) has been reported. The extract (100-1000 mg kg-1; p.o.), dose-dependently reduced the duration of immobility in both the FST (ED50: 296.20 ± 53.97 mg kg-1) and TST (203.90 ± 39.01 mg kg-1).The effect of the extract was 20-50 times less potent than imipramime and fluoxetine which were used as standards. Pretreatment with α-methydopa (400 mg kg-1; 3 h; p.o.) attenuated the anti-immobility effects of imipramime but not SJE and fluoxetine. Similarly, pretreatment with reserpine (1 mg kg-1; 24 h; s.c.) abolished the effect of imipramime and partially the effects of SJE but not fluoxetine. A concomitant treatment with α-methyldopa and reserpine attenuated the effects of all but fluoxetine. The extract, imipramime and fluoxetine did not modify motor performance on the rotarod test at all doses tested. Putting all together, present results suggest that SJE has antidepressant-like effects in the model employed and may possibly exert its effects by modifying monoamine transport and/or metabolism.
Lipid Profile and Lipid Peroxidation among Ghanaian Pregnancy-Induced Hypertensives
L. Ahenkorah,W.K. B.A. Owiredu,E. F. Laing,N. Amidu
Journal of Medical Sciences , 2008,
Abstract: This study was aimed at investigating oxidative stress among Ghanaian women with Pregnancy-Induced Hypertension (PIH). One hundred Pregnancy-Induced Hypertension women: Thirty with preeclampsia, seventy with gestational hypertension and fifty normotensive pregnant women (controls) in the second half of pregnancy were recruited for this study. There was a significant increase in triglycerides and LDL-cholesterol in the subject groups compared to the control. Malondialdehyde (MDA), the lipid peroxidation marker among the PIH subjects was significantly increased as compared to the normotensive pregnant women (controls). A significant positive correlation between MDA and blood pressure (Systolic and Diastolic blood pressure) was also observed. This study clearly indicates that Ghanaian women presenting with PIH are very prone to dyslipidemia as well as lipid peroxidation, this might in part explain the oxidative stress and endothelial vascular dysfunction observed in these group of women.
Precision and Accuracy of Three Blood Glucose Meters: Accu-Chek Advantage, One Touch Horizon and Sensocard
W.K.B.A. Owiredu,G. Amegatcher,N. Amidu
Journal of Medical Sciences , 2009,
Abstract: This study evaluated the accuracy and precision associated with the use of three popular alternative-site blood glucose monitors, Accu-chek Advantage, Onetouch Horizon and Sensocard, using forearm venous blood samples and capillary blood samples. The study was conducted from January to March, 2009 at the Komfo Anokye Teaching Hospital, Kumasi. One hundred and ninety consenting subjects were included in the study. The blood glucose levels were analyzed on glucose meters; Accu-chek Advantage, Sensocard and Onetouch Horizon by finger stick, using amperometry Technology. At the same time venous blood glucose was analyzed using the WHO reference Glucose Oxidase Method (GOD). The mean value generated by the WHO reference method (7.91±0.35) was not significantly different (p = 0.2816) from that produced by the Accu-chek Advantage (8.46±0.36), Sensocard (7.72±0.35; p = 0.7028) and Onetouch Horizon (7.97±0.35; p = 0.9044). Bland-Altman analysis indicates that Onetouch Horizon and Accu-chek Advantage have the tendency of overestimating blood glucose with a bias of -0.1 and -0.5, respectively. Sensocard could under-estimate with a bias of 0.2. In terms of rating, while all the glucose meters gave precisions at about the same level (i.e., 1.0), Onetouch Horizon is generating the closest value to the reference method with a difference between mean of -0.06, followed by Sensocard of 0.19 and Accu-chek Advantage with a value of -0.55. The precision of the Accu-chek Advantage, Onetouch Horizon and Sensocard for blood glucose monitoring from about 3.1-33.3 mmol L-1 is good. However, the Accu-chek Advantage has the tendency to overestimate at the hypoglycaemic levels. The Accu-chek Advantage is capable of estimating both capillary and venous blood glucose to the same level of accuracy. The Onetouch Horizon and Sensocard are however incapable of efficiently estimating venous blood glucose.
Obesity and Cardiovascular Risk Factors in a Pentecostal Population in Kumasi-Ghana
W. K.B.A. Owiredu,M. S. Adamu,N. Amidu,E. Woode
Journal of Medical Sciences , 2008,
Abstract: The purpose of this study was to examine the risk associations between indices of obesity [Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip Ratio (WHR) and Waist-to-Height Ratio (WHtR)], cardiovascular risk factors [plasma glucose and cholesterol and blood pressure] and morbidity conditions (Type 2 diabetes mellitus, hypertension and dyslipidemia) among Penteco-Charismatic Ghanaians. Three hundred and eighty three Penteco-Charismatic Ghanaian subjects (18-85 years of age) were recruited from Pentecost Church, Santasi (101), Assembly of God Bantama (192) and, Assembly of God, Old Tafo (90) in Kumasi, Ghana. The mean BMI were 25.72±5.97 kg m-2, 22.61±3.48 and 27.10±6.33 kg m-2 for the study population, male and female subjects, respectively. The mean WC measurement for the subjects was 90.21±12.29 cm and 85.91±8.77 and 92.10±13.13 cm in male and females, respectively. There were increasing trends between indices of obesity and the severity of cardiovascular risk factors and the prevalence of morbidity conditions (all p-values for trend <0.05). Patients with a greater number of comorbidities also had higher BMI, WC, WHR and WHtR measurements (all p-values for the trend were <0.05 with adjustment for age and gender). Despite Penteco-Charismatic Ghanaian subjects being less obese than subjects from Caucasians countries, the intimate relationships among obesity, cardiovascular risk factors and morbidity conditions remain. This study support using lower BMI and WC levels to define obesity and its associated health risks rather than using the criteria established for Caucasians who generally have larger body frames. Obesity is becoming increasingly common among Ghanaian adults. There is, therefore, the need for broad-based programs that facilitate healthy eating and activity patterns for all age groups. Health professionals should incorporate measurement of BMI and WHR into the routine examinations of patients to enhance their evaluation of the health status of their patients.
Prevalence of metabolic syndrome among Psychiatric Patients in the Kumasi Metropolis, Ghana
Owiredu, W.K.B.A.,Osei, O.,Amidu, N.,Appiah-Poku, J.
Journal of Medical and Biomedical Sciences , 2012,
Abstract: This cross-sectional study seeks to find the prevalence of the metabolic syndrome (MetS), its indi-vidual components and oxidative stress in psychiatric patients on antipsychotic medication com-pared to newly diagnosed patients attending the Psychiatric Department of the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana, between February 2009 and July 2010. A total of 200 psychiatric patients comprising 100 newly diagnosed antipsychotic-na ve patients and 100 patients on antipsychotic medication were sampled for the study. MetS was diagnosed using the World Health Organization (WHO), International Diabetes Federation (IDF) and the National Choles-terol Education Programme, Adult Treatment Panel III (NCEP ATP III) criteria. The overall prevalence of MetS was 11.5%, 13.5% and 15.5% using NCEP ATP III, WHO and IDF criteria re-spectively. The prevalence was significantly higher among psychiatric patients on treatment as compared to treatment-na ve group using NCEP ATP III (21.0% vs. 2.0%; p < 0.0001) and IDF (29.0% vs. 2.0%; p < 0.0001) criteria but not WHO (13.0% vs. 14.0%; p = 0.8372). These overall prev-alence rates were higher compared to the general Ghanaian population prevalence rates of 3.9%, 2.2% and 7.8% determined with the NCEP ATP III, WHO and IDF criteria respectively. Regular monitoring of metabolic parameters should be considered as a standard part of their medical care.
Prevalence of Metabolic Syndrome and its Individual Components among Diabetic Patients in Ghana
Felix-Val K. Titty,W.K. B.A. Owiredu,M. T. Agyei-Frempong
Journal of Biological Sciences , 2008,
Abstract: The aim of this study was to determine the prevalence of metabolic syndrome and its individual components in diabetic patients in Ghana. This prospective study included 456 diabetic patients and was conducted at the Komfo Anokye Teaching Hospital in the Ashanti Region of Ghana from January 2006 to May 2007. Metabolic syndrome was defined according to the National Cholesterol Education Programme Adult Treatment Panel 3 diagnostic criteria. The prevalence of metabolic syndrome was 55.9% in the studied population. Low HDL cholesterol was the commonest component (47.4%) of metabolic syndrome, followed by hypertension (46.9%). Female diabetic patients had higher prevalence of metabolic syndrome and its components and individually carried more components than male diabetics. Future cardiovascular disease (CVD) prevention strategies in Ghana should not overlook metabolic disease risk factors.
The impact of seminal zinc and fructose concentration on human sperm characteristic
Amidu, N.,Owiredu, W.K.B.A.,Bekoe, M.A.T.,Quaye, L.
Journal of Medical and Biomedical Sciences , 2012,
Abstract: This study assessed the association between the estimated fructose and zinc concentration and various seminal characteristics. The study participants include 90 male subjects visiting the Komfo Anokye Teaching Hospital between January and July, 2010 for semen analysis as part of routine fertility investigations prior to treatment. Seminal fructose concentration was significantly lower when the normozoospermic group was compared to the oligozoospermic group (P < .0001) and in the normozoospermic group compared to the azoospermic group (P = 0.0096). A comparison be-tween the oligospermic group and the azoospermic group gave no statistically significant differ-ence. Fructose correlated positively with volume (r = 0.36, P < 0.0001) and head defect (r = 0.07, P > 0.05) and negatively with count (r = -0.21, P < 0.05). Zinc correlated negatively with volume (r = -0.09) and head defect (r = -0.20) and positively with motility (r = 0.18), count (r = 0.15) and tail de-fect (r = 0.11). Seminal fructose and zinc concentrations correlated negatively (r = -0.26, P < 0.05). The role of seminal fructose concentration does not only lie in the assessment of seminal vesicle dysfunction but in conjunction with other seminal properties could give a useful indication of male reproductive function whilst seminal zinc concentration might not be most appropriate for the as-sessment of male reproductive dysfunction.
The Prevalence of the Metabolic Syndrome Among Ghanaian Pregnancy-Induced Hypertensive Patients Using the World Health Organisation and the National Cholesterol Education Program III Criteria
C.A. Turpin,L. Ahenkorah,W.K.B.A. Owiredu,E.F. Laing
Journal of Medical Sciences , 2008,
Abstract: The aim of this study was to determine the risk factors among Ghanaian women with Pregnancy-Induced Hypertension (PIH). Thirty women with preeclampsia, seventy with gestational hypertension and fifty normotensive pregnant women (controls) in the second half of pregnancy were recruited for this study. There was a significant increase in the prevalence of metabolic syndrome among the PIH subjects as compared to the normotensive pregnant women (controls) using the National Cholesterol Education Program (NCEPIII) and World Health Organisation criteria. Ghanaian women presenting with PIH are very prone to the development of the metabolic syndrome, thus the indices must be screened for during antenatal care.
The Impact of Blood Glucose and Cholesterol Levels on the Manifestation of Psychiatric Disorders
W.K.B.A. Owiredu,J. Appiah-Poku,F. Adusei-Poku,N. Amidu
Pakistan Journal of Biological Sciences , 2009,
Abstract: This study examined possible association of fasting glucose, and lipid abnormalities in psychiatric patients on conventional antipsychotic medications. A total of 305 subjects were used for the study, comprising 203 clinically diagnosed psychiatric patients and 102 non-psychiatric subjects used as control at the psychiatric clinic at Komfo Anokye Teaching Hospital (KATH). Questionnaires were administered, blood pressure and anthropometric measurements undertaken. Fasting blood samples were taken for glucose and total cholesterol. The patients included those treated with conventional antipsychotic agents. It was noted, that there were higher rates of diabetes (22.17%) and lipid abnormalities (42.43%) with lower rate of hypertension (5.91%) and obesity (5.91%) across the sample as compared to control. This finding suggests that the high prevalence of diabetes and lipid abnormalities, in a young, psychiatrically ill population makes the case for aggressive screening.
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