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Search Results: 1 - 10 of 85680 matches for " W Parker "
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Enhancing Christian School Experiences for Pre-Service Teachers through Service-Learning Partnerships
Karen L. Parker,Beth E. Ackerman,Leonard W. Parker
Christian Perspectives in Education , 2007,
Abstract: The mission of the Teacher Licensure Program at Liberty University is to develop competent professionals with a Christian worldview for Christian, public, and private schools. To be consistent with the mission, classroom experience in both Christian and public schools should be required for each teacher candidate who successfully completes Liberty’s program. One of the challenges in the implementation of the mission has been an inadequate number of field experience placements available in Christian school settings.
Redefining Lumpectomy Using a Modification of the “Sick Lobe” Hypothesis and Ductal Anatomy
W. Dooley,J. Bong,J. Parker
International Journal of Breast Cancer , 2011, DOI: 10.4061/2011/726384
Abstract: Objectives. The “Sick Lobe” hypothesis states that breast cancers evolve from entire lobes or portions of lobes of the breast where initiation events have occurred early in development. The implication is that some cancers are isolated events and others are truly multi-focal but limited to single lobar-ductal units. Methods. This is a single surgeon retrospective review of early stage breast cancer lumpectomy patients treated from 1/2000 to 2/2005. Ductal endoscopy was used direct lumpectomy surgical margins by defining ductal anatomy and mapping proliferative changes within the sick lobe for complete excision. Results. Breast conservation surgery for stage 0–2 breast cancer with an attempt to perform endoscopy in association with therapeutic lumpectomy was performed in 554 patients (successful endoscopy in 465 cases). With an average followup of >5 years for the entire group, annual hazard rate for local failure in traditional lumpectomy without ductal mapping was 0.97%/yr. and for lumpectomy with ductal mapping and excision of entire sick lobe was 0.18%/yr. With endoscopy, 42% of patients were found to have extensive disease within their “sick lobe.” Conclusions. Targeting breast cancer lumpectomy using endoscopy and excision of regional associated proliferation seems associated with lower recurrence in this non-randomized series. 1. Introduction The “Sick Lobe” hypothesis was proposed by Tibor Tot in 2005 [1]. His work was really a culmination of collecting relevant clinical and pathologic observations of the last century and a half. His first observations and predictions were based upon DCIS. The breast is defined as a single organ made of multiple lobes. Each lobe is identified by a single orifice on the nipple papilla connecting to branching tree of ducts and hundreds to thousands of individual lobules in the periphery. He proposed that for many cases of DCIS (especially extensive ones) the initiating events of carcinogenesis occurred perhaps as early as in the womb. Then throughout life as the lobe both grew and contracted from hormonal and other influences progression would occur at varying rates in different regions of the ductal tree. This led to the situation of apparent multifocality within the ductal tree and pathologic “skips” between DCIS patches. With further whole mount examination, extensive dissection of extensive intraductal component small invasive cancer cases, and multifocal invasive cancers, the findings support this theory [2–7]. Further molecular studies would seem to indicate that serious adverse genetic events are present
Revised Lithostratigraphy of the Sonsela Member (Chinle Formation, Upper Triassic) in the Southern Part of Petrified Forest National Park, Arizona
Jeffrey W. Martz,William G. Parker
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009329
Abstract: Recent revisions to the Sonsela Member of the Chinle Formation in Petrified Forest National Park have presented a three-part lithostratigraphic model based on unconventional correlations of sandstone beds. As a vertebrate faunal transition is recorded within this stratigraphic interval, these correlations, and the purported existence of a depositional hiatus (the Tr-4 unconformity) at about the same level, must be carefully re-examined.
Género y educación en México
Susan W. Parker,Carla Pederzini V.
Estudios Demográficos y Urbanos , 2000,
Abstract:
Scanning acoustic microscopy for mapping the microstructure of soft materials
N. G. Parker,M. J. W. Povey
Physics , 2009,
Abstract: Acoustics provides a powerful modality with which to 'see' the mechanical properties of a wide range of elastic materials. It is particularly adept at probing soft materials where excellent contrast and propagation distance can be achieved. We have constructed a scanning acoustic microscope capable of mapping the microstructure of such materials. We review the general principles of scanning acoustic microscopy and present new examples of its application in imaging biological matter, industrial materials and particulate systems.
Ultrasonic study of the gelation of gelatin: phase diagram, hysteresis and kinetics
N. G. Parker,M. J. W. Povey
Physics , 2010, DOI: 10.1016/j.foodhyd.2011.04.016
Abstract: We map the ultrasonic (8 MHz) speed and attenuation of edible-grade gelatin in water, exploring the key dependencies on temperature, concentration and time. The ultrasonic signatures of the sol-gel transition, confirmed by rheological measurements, and incomplete gel formation at low concentrations, enable a phase diagram of the system to be constructed. Sensitivity is also demonstrated to the kinetics of gel formation and melting, and associated hysteresis effects upon cyclic temperature sweeps. Furthermore, simple acoustic models of the sol and gel state enable estimation of the speed of sound and compressibility of gelatin. Our results demonstrate the potential of ultrasonic measurements to characterise the structure and visco-elasticity of gelatin hydrogels.
The diameter of the commuting graph of a finite group with trivial centre
G. L. Morgan,C. W. Parker
Mathematics , 2013,
Abstract: The commuting graph of a finite group with trivial centre is examined. It is shown that the connected components of the commuting graph have diameter at most 10.
Nutrition interventions in the workplace: Evidence of best practice
NP Steyn, W Parker, EV Lambert, Z Mchiza
South African Journal of Clinical Nutrition , 2009,
Abstract: Aim: The aim of this desktop study was to review all workplace interventions having a nutrition component, published in peer-reviewed literature between 1995 and 2006 by WHO, and to document activities that were successful, as well as possible barriers to their success. Methodology: A systematic review of workplace studies revealed 41 interventions, of which 30 complied with the predetermined search criteria. The following outcome measures were considered in the evaluation of the interventions: (i) changes in nutritional knowledge, attitudes, self-efficacy, intentions and stage of change; (ii) changes in dietary behaviours; (iii) changes in clinical/physical markers, such as: body weight or body-mass index (BMI), blood pressure (BP) or serum cholesterol concentrations; and (iv) process and/or policy outcomes. Results: A large number of diverse workplace interventions were successful in changing outcomes positively in the interventions evaluated. The following were key success factors: i) there was a nutrition and physical activity component; ii) dietitians were involved in nutrition education; iii) changes occurred in the cafeteria/canteen, which increased the availability of healthy food options and advertised them accordingly; iv) tailored feedback on diet (and clinical values) was given to subjects; v) employees were involved in planning and managing programmes; vi) the reduced prices (of healthy food items) in vending machines encouraged employees to buy healthier options; and vii) the stages of change theory was most commonly associated with best practice outcomes. Conclusions: Numerous workplace interventions have shown significant improvements in employees’ health and behaviours. However, it is necessary to plan intervention programmes based on the existing evidence of best practice.
mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging
Yadav Rahul B,Burgos Pierre,Parker Anthony W,Iadevaia Valentina
BMC Cell Biology , 2013, DOI: 10.1186/1471-2121-14-3
Abstract: Background The mammalian target of rapamycin (mTOR) signalling pathway has a key role in cellular regulation and several diseases. While it is thought that Rheb GTPase regulates mTOR, acting immediately upstream, while raptor is immediately downstream of mTOR, direct interactions have yet to be verified in living cells, furthermore the localisation of Rheb has been reported to have only a cytoplasmic cellular localization. Results In this study a cytoplasmic as well as a significant sub-cellular nuclear mTOR localization was shown , utilizing green and red fluorescent protein (GFP and DsRed) fusion and highly sensitive single photon counting fluorescence lifetime imaging microscopy (FLIM) of live cells. The interaction of the mTORC1 components Rheb, mTOR and raptor, tagged with EGFP/DsRed was determined using fluorescence energy transfer-FLIM. The excited-state lifetime of EGFP-mTOR of ~2400 ps was reduced by energy transfer to ~2200 ps in the cytoplasm and to 2000 ps in the nucleus when co-expressed with DsRed-Rheb, similar results being obtained for co-expressed EGFP-mTOR and DsRed-raptor. The localization and distribution of mTOR was modified by amino acid withdrawal and re-addition but not by rapamycin. Conclusions The results illustrate the power of GFP-technology combined with FRET-FLIM imaging in the study of the interaction of signalling components in living cells, here providing evidence for a direct physical interaction between mTOR and Rheb and between mTOR and raptor in living cells for the first time.
Temperature dependence of bulk viscosity in water using acoustic spectroscopy
M. J. Holmes,N. G. Parker,M. J. W. Povey
Physics , 2010, DOI: 10.1088/1742-6596/269/1/012011
Abstract: Despite its fundamental role in the dynamics of compressible fluids, bulk viscosity has received little experimental attention and there remains a paucity of measured data. Acoustic spectroscopy provides a robust and accurate approach to measuring this parameter. Working from the Navier-Stokes model of a compressible fluid one can show that the bulk viscosity makes a significant and measurable contribution to the frequency-squared acoustic attenuation. Here we employ this methodology to determine the bulk viscosity of Millipore water over a temperature range of 7 to 50 degrees Celsius. The measured attenuation spectra are consistent with the theoretical predictions, while the bulk viscosity of water is found to be approximately three times larger than its shear counterpart, reinforcing its significance in acoustic propagation. Moreover, our results demonstrate that this technique can be readily and generally applied to fluids to accurately determine their temperature dependent bulk viscosities.
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