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Search Results: 1 - 10 of 8468 matches for " Vladimir Chubanov "
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Drosophila TRPM Channel Is Essential for the Control of Extracellular Magnesium Levels
Thomas Hofmann,Vladimir Chubanov,Xiaodi Chen,Anna S. Dietz,Thomas Gudermann,Craig Montell
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010519
Abstract: The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is unusual in that it consists of a single member. Currently, the functional requirements for this channel have not been reported. Here, we found that the Drosophila TRPM protein was expressed in the fly counterpart of mammalian kidneys, the Malpighian tubules, which function in the removal of electrolytes and toxic components from the hemolymph. We generated mutations in trpm and found that this resulted in shortening of the Malpighian tubules. In contrast to all other Drosophila trp mutations, loss of trpm was essential for viability, as trpm mutations resulted in pupal lethality. Supplementation of the diet with a high concentration of Mg2+ exacerbated the phenotype, resulting in growth arrest during the larval period. Feeding high Mg2+ also resulted in elevated Mg2+ in the hemolymph, but had relatively little effect on cellular Mg2+. We conclude that loss of Drosophila trpm leads to hypermagnesemia due to a defect in removal of Mg2+ from the hemolymph. These data provide the first evidence for a role for a Drosophila TRP channel in Mg2+ homeostasis, and underscore a broad and evolutionarily conserved role for TRPM channels in Mg2+ homeostasis.
TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells
Silke Kaske, Gabriele Krasteva, Peter K?nig, Wolfgang Kummer, Thomas Hofmann, Thomas Gudermann, Vladimir Chubanov
BMC Neuroscience , 2007, DOI: 10.1186/1471-2202-8-49
Abstract: Here, we systematically investigated the expression of TRPM5 in rat and mouse tissues. Apart from taste buds, where we found TRPM5 to be predominantly localized on the basolateral surface of taste receptor cells, TRPM5 immunoreactivity was seen in other chemosensory organs – the main olfactory epithelium and the vomeronasal organ. Most strikingly, we found solitary TRPM5-enriched epithelial cells in all parts of the respiratory and gastrointestinal tract. Based on their tissue distribution, the low cell density, morphological features and co-immunostaining with different epithelial markers, we identified these cells as brush cells (also known as tuft, fibrillovesicular, multivesicular or caveolated cells). In terms of morphological characteristics, brush cells resemble taste receptor cells, while their origin and biological role are still under intensive debate.We consider TRPM5 to be an intrinsic signaling component of mammalian chemosensory organs, and provide evidence for brush cells being an important cellular correlate in the periphery.Transient receptor potential (TRP) proteins form a large gene family of ion channels characterized by distinct activation mechanisms and biophysical properties. By sequence homology, members of the family fall into six subfamilies (TRPC, TRPV, TRPM, TRPML, TRPP, and TRPA). There is mounting evidence that TRP channels are involved in thermosensation, mechanosensation, smell and taste. A subset of TRP channels, called 'thermo-TRPs' (TRPV1-TRPV4, TRPA1 and TRPM8), have been found to be highly temperature dependent and are directly involved in heat and cold sensation in the peripheral nervous system [1]. Several TRP channels are mechanosensitive or activated by hypotonic challenge (TRPV4, TRPA1, TRPM3, PKD1 and TRPP2) [2]. TRPC2 is specifically expressed in the rodent sensory epithelium of the vomeronasal organ (VNO) where it plays a critical role in signaling processes triggered by pheromones [3,4]. More recently, evidence was obtai
Edge states and topological properties of electrons on the bismuth on silicon surface with giant spin-orbit coupling
D. V. Khomitsky,A. A. Chubanov
Physics , 2013, DOI: 10.1134/S1063776114020101
Abstract: We derive a model of localized edge states in the finite width strip for two-dimensional electron gas formed in the hybrid system of bismuth monolayer deposited on the silicon interface and described by the nearly-free electron model with giant spin-orbit splitting. The edge states have the energy dispersion in the bulk energy gap with the Dirac-like linear dependence on the quasimomentum and the spin polarization coupled to the direction of propagation, demonstrating the properties of topological insulator. The topological stability of edge states is confirmed by the calculations of the $Z_2$ invariant taken from the structure of the Pfaffian for the time reversal operator for the filled bulk bands in the surface Brillouin zone which is shown to have a stable number of zeros with the variations of material parameters. The proposed properties of the edge states may support future advances in experimental and technological applications of this new material in nanoelectronics and spintronics.
Regular and irregular dynamics of Dirac-Weyl wavepackets in a mesoscopic quantum dot at the edge of topological insulator
D. V. Khomitsky,A. A. Chubanov,A. A. Konakov
Physics , 2014,
Abstract: The dynamics of Dirac-Weyl spin-polarized wavepackets driven by periodic electric field is considered for the electrons in a mesoscopic quantum dot formed at the edge of two-dimensional HgTe/CdTe topological insulator with Dirac-Weyl massless energy spectra, where the motion of carriers is less sensitive to disorder and impurity potentials. The investigation of quasienergy spectrum by Floquet approach reveals the presence of non-Poissonian level statistics which indicates the possibility of chaotic quantum dynamics. We found that even in the quantum system without the classical analogue one can observe certain traits of the development of irregular phenomena which are present in classical chaotic systems. It was observed that the interplay of strongly coupled spin and charge degrees of freedom creates the regimes of irregular dynamics both in coordinate and spin channels. We found that the influence of weak disorder leads to partial suppression of the dynamical chaos. Our findings are of interest both for progress in a fundamental field of quantum chaotic dynamics and for further experimental and technological applications of spin-dependent phenomena in nanostructures based on topological insulators.
Weak Interaction and the Nature of Virtual Particles  [PDF]
Vladimir Konushko
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.22009
Abstract: The granular structure of space, the nature of virtual particles and the unity of physical interactions are under study. The mass of an elementary cell in the Universe is determined, as a whole, with the physical meaning of the renormalization procedure changing in this case.
Granular Space and the Problem of Large Numbers  [PDF]
Vladimir Konushko
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.25038
Abstract: Two and a half thousand years ago the ancient atomists made a suggestion that space has a cellular structure, is material and consists of elementary cells. In 1900 Plank found the elementary length L*=10-33 cm. This notion has been widely used in modern physics ever since. The properties of granular space are studied in this article on the assumption that a three-dimensional material cell with the size of Planck’s elementary length is the only material for the construction of the whole Universe. This approach allows one to account for such mysterious phenomena as inertia, ultimate velocity of transfer of material body interactions and huge difference between gravitational and Coulomb forces - the so called “Large Numbers Problem”, as well essence of electric charge and Pauli exclusions principle.
Gravitational Energy Level and the Nature of Microwave Background of Universe  [PDF]
Vladimir Konushko
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.24026
Abstract: In 1965, Penzias and Wilson discovered thermal radiation with T0 ~ 2.7 K further on called “relict”. This article is concerned with the new phenomenon, i.e. the formation of gravitational energy levels by any body, with the result that photons are produced whose spectrum close to the Earth is similar to that of a blackbody with T0 ~ 2.7 K. The critical analysis of the experiments performed with the cosmic observatories COBE and WMAP completely confirms this prediction.
Translational Motion of a Free Large Polaron and Broadening of Absorption Spectra  [PDF]
Vladimir Mukhomorov
Journal of Modern Physics (JMP) , 2010, DOI: 10.4236/jmp.2010.11002
Abstract: The translational motion of a large polaron as whole is analyzed in the context of its effect on the broadening of an absorption optical spectrum. It was open question how important the role of translational degrees of freedom and the corresponding velocities are on the broadening. The Bogolyubov method of canonical transformation of coordinates is formulated for a system of an electron and field, taking into account rigorous fulfillment of the conservation laws. Separation of variables is carried out for the coordinates describing the translational degrees of freedom and the electron oscillations in a polarization well. The equations obtained for the electronic states explicitly depend on the velocity of the free polaron as a whole. An estimate is made for free polaron in ammonia.
Possible schemes of calculation modeling in a quantum computer  [PDF]
Vladimir Voronov
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.28114
Abstract: In the present work a possibility of computation modeling, which should be realized in a real quantum computer, is discussed. In this connection two models of a device, which work is determined by the structure and dynamics of real molecular systems are reported.
Stability of Atoms, Causality in Elementary Processes and the mystery of Interference and Hyroscope  [PDF]
Vladimir Konushko
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.33032
Abstract: An investigation into real structure of space allows solving in a new way the problem of stability of atom: an electron on the ground level is a rest. The absolute causality of all the phenomena in the Universe is substantiated. Heisenberg inequalities make some sense only when it is impossible to conjugated physical values. The work is concern with the mystery of interference and hyroscope.
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