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Search Results: 1 - 10 of 323 matches for " Vita Direnzo "
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Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis
Damiano Paolicelli, Vita Direnzo, Maria Trojano
Biologics: Targets and Therapy , 2009, DOI: http://dx.doi.org/10.2147/BTT.S4038
Abstract: f interferon beta-1b in the treatment of early and relapsing multiple sclerosis Review (5849) Total Article Views Authors: Damiano Paolicelli, Vita Direnzo, Maria Trojano Published Date July 2009 Volume 2009:3 Pages 369 - 376 DOI: http://dx.doi.org/10.2147/BTT.S4038 Damiano Paolicelli, Vita Direnzo, Maria Trojano Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy Abstract: Multiple sclerosis (MS) is the most common autoimmune illness of the central nervous system. For many years the inflammatory manifestations of MS were treated using only corticosteroids. Since the 1990s the results of several clinical trials with immunomodulatory agents have changed the therapeutic approach to this disease. Interferon beta (IFNβ)-1b represents the pioneer of those therapies. There is growing evidence from clinical trials on relapsing-remitting MS and clinically isolated syndromes suggestive of MS that IFNβ-1b reduces the frequency and severity of relapses and the development of new and active brain lesions as assessed by magnetic resonance imaging. Long-term data suggest a persistent efficacy of IFNβ-1b on disease activity and a positive effect in slowing disability worsening. Furthermore a reduction of relapse rate and a slight positive effect on the progression were demonstrated when IFNβ-1b was administered to still-active secondary progressive MS. IFNβ-1b therapy is well tolerated and relatively free of long-term side effects. In spite of the emergence of new agents for the treatment of MS, IFNβ-1b still remains a first-line therapy with a fundamental role in all stages of the disease.
Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis
Damiano Paolicelli,Vita Direnzo,Maria Trojano
Biologics: Targets and Therapy , 2009,
Abstract: Damiano Paolicelli, Vita Direnzo, Maria TrojanoDepartment of Neurological and Psychiatric Sciences, University of Bari, Bari, ItalyAbstract: Multiple sclerosis (MS) is the most common autoimmune illness of the central nervous system. For many years the inflammatory manifestations of MS were treated using only corticosteroids. Since the 1990s the results of several clinical trials with immunomodulatory agents have changed the therapeutic approach to this disease. Interferon beta (IFNβ)-1b represents the pioneer of those therapies. There is growing evidence from clinical trials on relapsing-remitting MS and clinically isolated syndromes suggestive of MS that IFNβ-1b reduces the frequency and severity of relapses and the development of new and active brain lesions as assessed by magnetic resonance imaging. Long-term data suggest a persistent efficacy of IFNβ-1b on disease activity and a positive effect in slowing disability worsening. Furthermore a reduction of relapse rate and a slight positive effect on the progression were demonstrated when IFNβ-1b was administered to still-active secondary progressive MS. IFNβ-1b therapy is well tolerated and relatively free of long-term side effects. In spite of the emergence of new agents for the treatment of MS, IFNβ-1b still remains a first-line therapy with a fundamental role in all stages of the disease.Keywords: interferon beta-1b, relapsing-remitting multiple sclerosis, clinically isolated syndromes, efficacy, safety, neutralizing antibodies
Low Serum Urate Levels Are Associated to Female Gender in Multiple Sclerosis Patients
Stefano Zoccolella, Carla Tortorella, Pietro Iaffaldano, Vita Direnzo, Mariangela D’Onghia, Elena Luciannatelli, Damiano Paolicelli, Paolo Livrea, Maria Trojano
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040608
Abstract: Background Urate is a natural antioxidant and may prevent CNS tissue damage and the clinical manifestations of experimental autoimmune encephalitis. Results from clinical studies are conflicting and the contribution of urate to the pathogenesis of Multiple Sclerosis (MS) remains uncertain. Objective To evaluate serum urate levels in MS patients and their relationships with clinical, demographic and MRI variables. Methods Levels of non-fasting serum uric acid and creatinine were determined by an automated enzymatic assay and glomerular filtration rate was assessed in 245 MS patients, in 252 age/sex-matched neurological controls (NC) and in 59 Healthy controls (HC). Results Median serum urate levels did not differ between MS patients (3.8 mg/dL), HC (4.0 mg/dl) and NC (4.0 mg/dL). Serum urate levels were lower in females than in males in all groups (p = <0.0001). In female-MS, serum urate levels (3.2 mg/dL) were lower compared to those in female HC (3.8; p = 0.01) and NC (3.5 mg/dL; p = 0.02), whereas in male-MS they(4.8 mg/dL) did not differ from those in male HC (4.5 mg/dl) and NC (4.8 mg/dL). Urate concentrations trended to be lower in Clinically isolated syndromes suggestive of MS (3.7 mg/dL) and in relapsing MS (3.7 mg/dL), compared to patients with progressive MS (4.4 mg/dL; p = 0.06), and in patients with an annual relapse rate (ARR) >2 (3.3 mg/dL) than in those with an ARR ≤2: 3.9 mg/dL; p = 0.05). Significant lower serum urate levels were found in females than in males in all clinical MS subtypes (p<0.01), separately evaluated. Female sex (beta: ?0.53; p<0.00001) was the most significant determinant of serum urate concentrations in MS patients on multivariate regression analysis. Conclusions Our findings suggest that low urate levels could be of significance in predominantly inflammatory phases of MS even at the early stage and mainly in females.
Impact of Natalizumab on Cognitive Performances and Fatigue in Relapsing Multiple Sclerosis: A Prospective, Open-Label, Two Years Observational Study
Pietro Iaffaldano, Rosa Gemma Viterbo, Damiano Paolicelli, Guglielmo Lucchese, Emilio Portaccio, Benedetta Goretti, Vita Direnzo, Mariangela D'Onghia, Stefano Zoccolella, Maria Pia Amato, Maria Trojano
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035843
Abstract: Background and Objectives Natalizumab reduces the relapse rate and magnetic resonance imaging activity in patients with Relapsing-Remitting Multiple Sclerosis (RRMS). So far the influence of natalizumab on cognitive functions and fatigue in MS remains uncertain. The aim of this prospective, open-label, observational study was to evaluate the possible effects of natalizumab on cognition and fatigue measures in RRMS patients treated for up to two years. Methods Cognitive performances were examined by the Rao's Brief Repeatable Battery (BRB), the Stroop test (ST) and the Cognitive Impairment Index (CII), every 12 months. Patients who failed in at least 3 tests of the BRB and the ST were classified as cognitively impaired (CI). Fatigue Severity Scale (FSS) was administered every 12 months to assess patient's self-reported fatigue. One hundred and 53 patients completed 1 and 2 year-natalizumab treatment, respectively. Results After 1 year of treatment the percentage of CI patients decreased from 29% (29/100) at baseline to 19% (19/100) (p = 0.031) and the mean baseline values of CII (13.52±6.85) and FSS (4.01±1.63) scores were significantly reduced (10.48±7.12, p<0.0001 and 3.61±1.56, p = 0.008). These significant effects were confirmed in the subgroup of patients treated up to two years. Conclusions These results demonstrate that a short-term NTZ treatment may significantly improve cognitive performances and fatigue in RRMS patients.
Analysis and Causal Formulation Proof of an Optimal Iterative Learning Algorithm  [PDF]
Vassiliki Vita
Intelligent Control and Automation (ICA) , 2010, DOI: 10.4236/ica.2010.12010
Abstract: Iterative learning control (ILC) is used to control systems that operate in a repetitive mode, improving track-ing accuracy of the control by transferring data from one repetition of a task, to the next. In this paper an op-timal iterative learning algorithm for discrete linear systems is analyzed and a solution for its attainment is proposed. Finally the mathematical proof of the algorithm’s causal formulation is also provided in its com-plete form, since its implementation requires its causal formulation.
Infrared Renormalons and Finite Volume
F. DiRenzo,G. Marchesini,E. Onofri
Physics , 1996, DOI: 10.1016/S0550-3213(97)00243-5
Abstract: We analyze the perturbative expansion of a condensate in the O(N) non-linear sigma model for large N on a two dimensional finite lattice. On an infinite volume this expansion is affected by an infrared renormalon. We extrapolate this analysis to the case of the gluon condensate of Yang-Mills theory and argue that infrared renormalons can be detected by performing perturbative studies even on relatively small lattices.
Ancient comedy: testimony of sources. Antikin komedija: altini liudijimai
Vita Paparinska
Literatura , 2010,
Abstract: Straipsnyje nagrin jami pagrindiniai i lik antikini altini liudijimai apie komedijos anrin specifik – Aristotelio Poetika ir Retorika bei vienintelis i lik s komedijai skirtas kūrinys, vadinamasis Tractatus Coislinianus. Autor i vadose teigia, kad Tractatus Coislinianus negali būti laikomas savaranki ku ir reik mingu informacijos apie komedij altiniu, nes jo autorius komedijos anr apra o remdamasis Aris-totelio tragedijos teorija. Visa nei likusi Aristotelio Poetika vis d lto yra pagrindinis, nors ir labai skurdus (d l nei likusios komedijai skirtos dalies) informacijos apie antikin s komedijos anr altinis.
Text tradition of Aristotle‘s On Rhetoric: from post-Aristotelian Athens to Rome. Aristotelio Retorikos teksto tradicija po Aristotelio: nuo At n iki Romos
Vita Paparinska
Literatura , 2009,
Abstract: io straipsnio tikslas – i tirti Aristotelio Retorikos recepcij rom n retorin je kultūroje. Kultūrini id j recepcija paprastai remiasi tekstais. Tod l Aristotelio Retorikos teksto istorija v lesniais laikais padeda atskleisti id j perimamum .Tyrimas remiasi antikiniais altiniais, kuriuose pateikiama informacija apie Aristotelio ezoterini veikal istorij , taip pat antikin s retorikos alti-niais, kuriuose Aristotelio Retorika nagrin jama bendrame retoriniame kontekste ir kurie atspindi Aristotelio retorini id j recepcij . iuo po iūriu ypa svarbūs tekstai yra du Cicerono traktatai (De oratore, De inventione) ir Rhetorica ad Herennium. Aristotelio takos rom n retorikai (ypa Cicerono traktatui De oratore) aptarimas koncentruojasi koreliuojan i s vok suvokimo bei interpretavimo graik ir rom n kultūrose pana umus bei skirtu-mus, kurie gali duoti atsakym , kod l Aristotelio Retorikos taka rom n retorinei tradicijai buvo palyginti nedidel .
Karen Barad, Meeting the Universe Halfway: Quantum Physics and the Entanglement of Matter and Meaning
Vita Peacock
Opticon1826 , 2010, DOI: 10.5334/opt.081013
Abstract: Barad raises the curtain with a play, the recently dramatized encounter between two German quantum physicists, Niels Bohr and Werner Heisenberg in 1941, an historical event of which of which little is known. The scientists discuss the possible development of a German atom bomb. Having previously been close, thereafter the two part company. Opening her substantial monograph with a lengthy critique of the play crystallizes Barad’s intentions, and reveals her strongest card. Science, even, (perhaps especially) that of the most microscopic kind, quantum physics, which explores the world at the level of the atomic, may have geopolitical, ethical, and historical implications. The practice of science is shaped by what is deemed to matter, at any given time. Reaching willingly into another domain, in this case the world of art, foreshadows the greatest merit of the book, the ease with which Barad dances across disciplinary boundaries with a trickster-like fluidity. In style and content the introduction supports her two-pronged agenda, a novel theory of scientific objects, as well as a novel theory of science-as-object.
Eigenschaften des Subjekts bzw. der Subjektphrase und des Pr dikats bzw. der Pr dikatsphrase in der deutschen Fach- und Wissenschaftssprache. Veiksnio bei veiksnio fraz s ir tarinio bei tarinio fraz s savyb s vokie i dalykin je ir mokslin je kalboje
Vita Banionyt?
Kalbotyra , 2008,
Abstract: Straipsnyje analizuojami tarinio bei tarinio fraz s ir veiksnio bei veiksnio fraz s ypatumai vokie i kalbos dalykiniuose bei moksliniuose tekstuose. angoje pateikiami terminai, padedantys charak-terizuoti nagrin jamas sakinio dalis dalykin je bei mokslin je kalboje. Tai selekcija (Selektion) – da nai pasitaikan i form bei konstrukcij atranka ir funkcijos pasikeitimas (Funktionswandel). Toliau pateikiama veiksnio bei veiksnio fraz s ir tarinio bei tarinio fraz s charakteristika. I ry kinami aspektai, kuriuos reikia inoti, norint identifikuoti ias sakinio dalis. Tai struktūra, forma, funkcija, vieta sakinyje, i sakinio dali tarpusavio santykis.Galima teigti, kad vokie i dalykin s ir mokslin s kalbos tarinys bei tarinio fraz ir veiksnys bei veiksnio fraz skiriasi nuo bendrin s kalbos i sintaksini rei kini varda odini konstrukcij gau-sumu. Veiksnio varda odin s konstrukcijos i ry kina tokius kokybinius bruo us kaip dalyki kum , glaustum . Tarinio varda odin s fraz s s lygoja ias jo savybes: anonimi kum , beasmeni kum .Veiksniams, tariniams bei j fraz ms yra būdingi metaforiniai santykiai. Metafori kai vartojami pasakymai da nai tampa dalykin s bei mokslin s kalbos terminais. Tai daro dalykin kalb gyvesn , lengviau prieinam .
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